| Title : Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) - Hansen_2009_Bioorg.Med.Chem.Lett_19_87 |
| Author(s) : Hansen CP , Jensen AA , Balle T , Bitsch-Jensen K , Hassan MM , Liljefors T , Frolund B |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :87 , 2009 |
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Abstract :
Compounds based on the 3-(dimethylamino)butyl dimethylcarbamate (DMABC) scaffold were synthesized and pharmacologically characterized at the alpha(4)beta(2), alpha(3)beta(4,) alpha(4)beta(4) and alpha(7) neuronal nicotinic acetylcholine receptors (nAChRs). The carbamate functionality and a small hydrophobic substituent in the C-3 position were found to be vital for the binding affinity to the nAChRs, whereas the carbamate nitrogen substituents were important for nAChR subtype selectivity. Finally, the compounds were found to be agonists at the alpha(3)beta(4) nAChR. |
| PubMedSearch : Hansen_2009_Bioorg.Med.Chem.Lett_19_87 |
| PubMedID: 19027295 |
Hansen CP, Jensen AA, Balle T, Bitsch-Jensen K, Hassan MM, Liljefors T, Frolund B (2009)
Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC)
Bioorganic & Medicinal Chemistry Lett
19 :87
Hansen CP, Jensen AA, Balle T, Bitsch-Jensen K, Hassan MM, Liljefors T, Frolund B (2009)
Bioorganic & Medicinal Chemistry Lett
19 :87