Balle T

General

Full name : Balle Thomas

First name : Thomas

Mail : Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Pharmacy\/Bank Building, 2006 Sydney

Zip Code :

City :

Country : Australia

Email : thomas.balle@sydney.edu.au

Phone :

Fax :

Website : \/\/sydney.edu.au\/pharmacy\/about\/people\/profiles\/thomas.balle.php

Directory :

References (37)

Title : Delta-containing GABA(A) receptors in pain management: Promising targets for novel analgesics - Luo_2021_Neuropharmacol_195_108675
Author(s) : Luo Y , Kusay AS , Jiang T , Chebib M , Balle T
Ref : Neuropharmacology , 195 :108675 , 2021
PubMedID: 34153311

Title : Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors - Tran_2021_J.Med.Chem_64_17326
Author(s) : Tran W , Kusay AS , Hawkins PME , Cheung CY , Nagalingam G , Pujari V , Ford DJ , Stoye A , Ochoa JL , Audette RE , Hortle E , Oehlers SH , Charman SA , Linington RG , Rubin EJ , Dowson CG , Roper DI , Crick DC , Balle T , Cook GM , Britton WJ , Payne RJ
Ref : Journal of Medicinal Chemistry , 64 :17326 , 2021
PubMedID: 34845906

Title : Heterologous expression of concatenated nicotinic ACh receptors: Pros and cons of subunit concatenation and recommendations for construct designs - Liao_2020_Br.J.Pharmacol_177_4275
Author(s) : Liao VWY , Kusay AS , Balle T , Ahring PK
Ref : British Journal of Pharmacology , 177 :4275 , 2020
PubMedID: 32627170

Title : Structure-Based Discovery of Dual-Target Hits for Acetylcholinesterase and the alpha7 Nicotinic Acetylcholine Receptors: In Silico Studies and In Vitro Confirmation - Oddsson_2020_Molecules_25_
Author(s) : Oddsson S , Kowal NM , Ahring PK , Olafsdottir ES , Balle T
Ref : Molecules , 25 : , 2020
PubMedID: 32580406

Title : Novel Approach for the Search for Chemical Scaffolds with Dual Activity with Acetylcholinesterase and the alpha7 Nicotinic Acetylcholine Receptor-A Perspective for the Treatment of Neurodegenerative Disorders - Kowal_2019_Molecules_24_
Author(s) : Kowal NM , Indurthi DC , Ahring PK , Chebib M , Olafsdottir ES , Balle T
Ref : Molecules , 24 : , 2019
PubMedID: 30691196

Title : Galantamine is not a positive allosteric modulator of human alpha4beta2 or alpha7 nicotinic acetylcholine receptors - Kowal_2018_Br.J.Pharmacol_175_2911
Author(s) : Kowal NM , Ahring PK , Liao VWY , Indurti DC , Harvey BS , O'Connor SM , Chebib M , Olafsdottir ES , Balle T
Ref : British Journal of Pharmacology , 175 :2911 , 2018
PubMedID: 29669164

Title : Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors - Petersen_2015_ACS.Med.Chem.Lett_6_472
Author(s) : Petersen IN , Crestey F , Jensen AA , Indurthi DC , Pedersen H , Andreasen JT , Balle T , Kristensen JL
Ref : ACS Med Chem Lett , 6 :472 , 2015
PubMedID: 25941557

Title : From shellfish poisoning to neuroscience - Shahsavar_2015_Structure_23_979
Author(s) : Shahsavar A , Balle T
Ref : Structure , 23 :979 , 2015
PubMedID: 26039347

Title : Pinnatoxins E, F and G target multiple nicotinic receptor subtypes - Hellyer_2015_J.Neurochem_135_479
Author(s) : Hellyer SD , Indurthi DC , Balle T , Runder-Varga V , Selwood AI , Tyndall JD , Chebib M , Rhodes L , Kerr DS
Ref : Journal of Neurochemistry , 135 :479 , 2015
PubMedID: 26173951

Title : Engineered alpha4beta2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity alpha4-alpha4 interface - Ahring_2015_Neuropharmacol_92_135
Author(s) : Ahring PK , Olsen JA , Nielsen EO , Peters D , Pedersen MH , Rohde LA , Kastrup JS , Shahsavar A , Indurthi DC , Chebib M , Gajhede M , Balle T
Ref : Neuropharmacology , 92 :135 , 2015
PubMedID: 25595102

Title : Poster: Exploring the structure activity relationships of halogen containing N-(pyridin-3-yl)-piperazines and homopiperazines at alpha4beta2 nAChRs -
Author(s) : Rudner-Varga V , Ahring PK , Indurthi D , Peters D , Orton H , Kanizaj N , McLeod MD , Chebib M , Balle T
Ref : Biochemical Pharmacology , 97 :623 , 2015
PubMedID:

Title : Poster: Modulation of alpha4beta2 NACHRs via an extracellular binding site: Structural studies and novel engineered receptors to aid drug discovery -
Author(s) : Balle T , Olsen JA , Shahsavar A , Kastrup JS , Peter D , Gajhede M , Ahring PK
Ref : Biochemical Pharmacology , 97 :623 , 2015
PubMedID:

Title : Poster: Exploiting ligand selectivity to understand allosteric receptor opening -
Author(s) : Indurthi DC , Balle T , Ahring PK , Chebib M , Lewis TM , Absalom NL
Ref : Biochemical Pharmacology , 97 :624 , 2015
PubMedID:

Title : Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at alpha4beta2 nicotinic acetylcholine receptors - Olsen_2014_J.Biol.Chem_289_24911
Author(s) : Olsen JA , Ahring PK , Kastrup JS , Gajhede M , Balle T
Ref : Journal of Biological Chemistry , 289 :24911 , 2014
PubMedID: 24982426

Title : Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors - Olsen_2014_PLoS.One_9_e91232
Author(s) : Olsen JA , Balle T , Gajhede M , Ahring PK , Kastrup JS
Ref : PLoS ONE , 9 :e91232 , 2014
PubMedID: 24637639

Title : Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists - Crestey_2013_J.Med.Chem_56_9673
Author(s) : Crestey F , Jensen AA , Borch M , Andreasen JT , Andersen J , Balle T , Kristensen JL
Ref : Journal of Medicinal Chemistry , 56 :9673 , 2013
PubMedID: 24187998

Title : Two distinct allosteric binding sites at alpha4beta2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors - Olsen_2013_J.Biol.Chem_288_35997
Author(s) : Olsen JA , Kastrup JS , Peters D , Gajhede M , Balle T , Ahring PK
Ref : Journal of Biological Chemistry , 288 :35997 , 2013
PubMedID: 24169695

Title : Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors - Harpsoe_2013_J.Biol.Chem_288_2559
Author(s) : Harpsoe K , Hald H , Timmermann DB , Jensen ML , Dyhring T , Nielsen EO , Peters D , Balle T , Gajhede M , Kastrup JS , Ahring PK
Ref : Journal of Biological Chemistry , 288 :2559 , 2013
PubMedID: 23229547

Title : Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations - Eildal_2013_J.Am.Chem.Soc_135_12998
Author(s) : Eildal JN , Hultqvist G , Balle T , Stuhr-Hansen N , Padrah S , Gianni S , Stromgaard K , Jemth P
Ref : Journal of the American Chemical Society , 135 :12998 , 2013
PubMedID: 23705582

Title : Synthesis, pharmacology, and biostructural characterization of novel alpha4beta2 nicotinic acetylcholine receptor agonists - Ussing_2013_J.Med.Chem_56_940
Author(s) : Ussing CA , Hansen CP , Petersen JG , Jensen AA , Rohde LA , Ahring PK , Nielsen EO , Kastrup JS , Gajhede M , Frolund B , Balle T
Ref : Journal of Medicinal Chemistry , 56 :940 , 2013
PubMedID: 23256554

Title : Covalent trapping of methyllycaconitine at the alpha4-alpha4 interface of the alpha4beta2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed - Absalom_2013_J.Biol.Chem_288_26521
Author(s) : Absalom NL , Quek G , Lewis TM , Qudah T , von Arenstorff I , Ambrus JI , Harpsoe K , Karim N , Balle T , McLeod MD , Chebib M
Ref : Journal of Biological Chemistry , 288 :26521 , 2013
PubMedID: 23893416

Title : Poster: An additional binding site for methyllycaconitine (MLA) and analogs occurs at the alpha4-alpha4 interface of the (alpha4)3(beta2)2 nAChR -
Author(s) : Chebib M , Absalom NL , Quek G , Indurthi DC , Lewis TM , Qudah T , von Arenstorff I , Halliday JI , Ambrus JI , Harpsoe K , Karim N , Balle T , McLeod MD
Ref : Biochemical Pharmacology , 86 :1225 , 2013
PubMedID:

Title : Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: unique role of halogen bonding revealed - Rohde_2012_J.Biol.Chem_287_4248
Author(s) : Rohde LA , Ahring PK , Jensen ML , Nielsen EO , Peters D , Helgstrand C , Krintel C , Harpsoe K , Gajhede M , Kastrup JS , Balle T
Ref : Journal of Biological Chemistry , 287 :4248 , 2012
PubMedID: 22170047

Title : Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHbetaE suggests a unique mode of antagonism - Shahsavar_2012_PLoS.One_7_e40757
Author(s) : Shahsavar A , Kastrup JS , Nielsen EO , Kristensen JL , Gajhede M , Balle T
Ref : PLoS ONE , 7 :e40757 , 2012
PubMedID: 22927902

Title : Covalent attachment of antagonists to the alpha7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides - Ambrus_2012_Chem.Commun.(Camb)_48_6699
Author(s) : Ambrus JI , Halliday JI , Kanizaj N , Absalom N , Harpsoe K , Balle T , Chebib M , McLeod MD
Ref : Chem Commun (Camb) , 48 :6699 , 2012
PubMedID: 22627701

Title : A 3D-QSAR-driven approach to binding mode and affinity prediction - Tosco_2012_J.Chem.Inf.Model_52_302
Author(s) : Tosco P , Balle T
Ref : J Chem Inf Model , 52 :302 , 2012
PubMedID: 22087561

Title : Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site - Trattnig_2012_J.Biol.Chem_287_25241
Author(s) : Trattnig SM , Harpsoe K , Thygesen SB , Rahr LM , Ahring PK , Balle T , Jensen AA
Ref : Journal of Biological Chemistry , 287 :25241 , 2012
PubMedID: 22589534

Title : G protein- and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations - Isberg_2011_J.Chem.Inf.Model_51_315
Author(s) : Isberg V , Balle T , Sander T , Jorgensen FS , Gloriam DE
Ref : J Chem Inf Model , 51 :315 , 2011
PubMedID: 21261291

Title : Open3DALIGN: an open-source software aimed at unsupervised ligand alignment - Tosco_2011_J.Comput.Aided.Mol.Des_25_777
Author(s) : Tosco P , Balle T , Shiri F
Ref : J Comput Aided Mol Des , 25 :777 , 2011
PubMedID: 21792629

Title : Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors - Harpsoe_2011_J.Neurosci_31_10759
Author(s) : Harpsoe K , Ahring PK , Christensen JK , Jensen ML , Peters D , Balle T
Ref : Journal of Neuroscience , 31 :10759 , 2011
PubMedID: 21795528

Title : Poster: The (alpha4)3(\/beta2)2 nAChR has a benzodiazepine-like modulatory binding site in the alphaalpha-subunit interface as revealed by studies with NS9283 -
Author(s) : Ahring PK , Peters D , Christensen JK , Jensen ML , Harpsoe K , Balle T
Ref : Biochemical Pharmacology , 82 :1029 , 2011
PubMedID:

Title : Docking to flexible nicotinic acetylcholine receptors: a validation study using the acetylcholine binding protein - Sander_2010_J.Mol.Graph.Model_29_415
Author(s) : Sander T , Bruun AT , Balle T
Ref : J Mol Graph Model , 29 :415 , 2010
PubMedID: 20884263

Title : Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) - Hansen_2009_Bioorg.Med.Chem.Lett_19_87
Author(s) : Hansen CP , Jensen AA , Balle T , Bitsch-Jensen K , Hassan MM , Liljefors T , Frolund B
Ref : Bioorganic & Medicinal Chemistry Lett , 19 :87 , 2009
PubMedID: 19027295

Title : Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives - Armishaw_2009_J.Biol.Chem_284_9498
Author(s) : Armishaw C , Jensen AA , Balle T , Clark RJ , Harpsoe K , Skonberg C , Liljefors T , Stromgaard K
Ref : Journal of Biological Chemistry , 284 :9498 , 2009
PubMedID: 19131337

Title : Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands - Tosco_2009_J.Med.Chem_52_2311
Author(s) : Tosco P , Ahring PK , Dyhring T , Peters D , Harpsoe K , Liljefors T , Balle T
Ref : Journal of Medicinal Chemistry , 52 :2311 , 2009
PubMedID: 19301898

Title : Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist - Hansen_2008_J.Med.Chem_51_7380
Author(s) : Hansen CP , Jensen AA , Christensen JK , Balle T , Liljefors T , Frolund B
Ref : Journal of Medicinal Chemistry , 51 :7380 , 2008
PubMedID: 18989912

Title : New ligands with affinity for the alpha4beta2 subtype of nicotinic acetylcholine receptors. Synthesis, receptor binding, and 3D-QSAR modeling - Audouze_2006_J.Med.Chem_49_3159
Author(s) : Audouze K , Nielsen EO , Olsen GM , Ahring P , Jorgensen TD , Peters D , Liljefors T , Balle T
Ref : Journal of Medicinal Chemistry , 49 :3159 , 2006
PubMedID: 16722635