| Title : Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones - Hasan_2005_J.Enzyme.Inhib.Med.Chem_20_41 |
| Author(s) : Hasan A , Khan KM , Sher M , Maharvi GM , Nawaz SA , Choudhary MI , Atta ur R , Supuran CT |
| Ref : J Enzyme Inhib Med Chem , 20 :41 , 2005 |
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Abstract :
A series of variably substituted chalcones were synthesized by condensation of substituted acetophenones with mono-, di- or trisubstituded benzaldehydes. It was observed that some of these compounds have the potential to inhibit acetylcholinesterase, whereas others show activity against butyrylcholinesterase, depending on the substitution pattern at the two aromatic rings of these chalcones. Similarly, lipoxygenase was inhibited by two of these compounds. It has been observed that inhibition of the three enzymes was concentration dependent with the IC50 values ranging from 28.2-134.5 microM against acetylcholinesterase, 16.0-23.1 microM against butyrylcholinesterase and 57.6-71.7 microM against lipoxygenase, respectively. |
| PubMedSearch : Hasan_2005_J.Enzyme.Inhib.Med.Chem_20_41 |
| PubMedID: 15895683 |
Hasan A, Khan KM, Sher M, Maharvi GM, Nawaz SA, Choudhary MI, Atta ur R, Supuran CT (2005)
Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones
J Enzyme Inhib Med Chem
20 :41
Hasan A, Khan KM, Sher M, Maharvi GM, Nawaz SA, Choudhary MI, Atta ur R, Supuran CT (2005)
J Enzyme Inhib Med Chem
20 :41