| Title : [Inhibitory effects of sinapine on activity of acetylcholinesterase in cerebral homogenate and blood serum of rats] - He_2008_Zhongguo.Zhong.Yao.Za.Zhi_33_813 |
| Author(s) : He L , Li HT , Guo SW , Liu LF , Qiu JB , Li F , Cai BC |
| Ref : Zhongguo Zhong Yao Za Zhi , 33 :813 , 2008 |
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Abstract :
OBJECTIVE: The present study investigated the inhibitory effects of Chinese herb component sinapine on activity of acetylcholinesterase (AChE) in cerebral homogenate and blood serum of rats. METHOD: AChE was prepared from cerebral homogenate and blood serum of rats, respectively. Acetylcholinesterase activity assay kit and Chromatometry were used to detect the AChE activity. RESULT: Sinapine significantly inhibited AChE activity in vitro, with more effective on cerebral homogenate (IC50 3.66 micromol x L(-1)) than blood serum (IC50 22.1 micromol x L(-1)). CONCLUSION: Sinapine could significantly inhibit the cerebral AChE activity and may be a promising drug used for prevention and cure of Alzheimer's disease as a cholinesterase inhibitor. |
| PubMedSearch : He_2008_Zhongguo.Zhong.Yao.Za.Zhi_33_813 |
| PubMedID: 18589789 |
He L, Li HT, Guo SW, Liu LF, Qiu JB, Li F, Cai BC (2008)
[Inhibitory effects of sinapine on activity of acetylcholinesterase in cerebral homogenate and blood serum of rats]
Zhongguo Zhong Yao Za Zhi
33 :813
He L, Li HT, Guo SW, Liu LF, Qiu JB, Li F, Cai BC (2008)
Zhongguo Zhong Yao Za Zhi
33 :813