Title : Studies on linkage and association of atopy with the chromosomal region 12q13-24 - Heinzmann_2000_Clin.Exp.Allergy_30_1555 |
Author(s) : Heinzmann A , Grotherr P , Jerkic SP , Lichtenberg A , Braun S , Kruse S , Forster J , Kuehr J , Deichmann KA |
Ref : Clin Exp Allergy , 30 :1555 , 2000 |
Abstract :
BACKGROUND: Several studies have shown linkage of bronchial asthma, allergic rhinitis and total serum IgE concentration to the chromosomal region 12q13-24 in ethnical diverse populations. This region harbours a number of candidate genes for asthma and atopy, including stem cell factor (SCF), leukotriene A4 hydrolase (LTA4H), thyroid receptor 2 (TR2), and signal transducer and activator of transcription 6 (STAT6). However, the same region was shown as well to be linked to other diseases with inflammatory character. So far no variants in any of these genes have been published which would allow association studies and confirm the pathogenicity of any of these genes. OBJECTIVE: We wanted to test for linkage of the chromosomal region 12q13-24 with the atopic phenotype without regard to clinical manifestations. Furthermore we screened for common nucleotide polymorphisms in candidate genes to enable association studies. |
PubMedSearch : Heinzmann_2000_Clin.Exp.Allergy_30_1555 |
PubMedID: 11069563 |
Heinzmann A, Grotherr P, Jerkic SP, Lichtenberg A, Braun S, Kruse S, Forster J, Kuehr J, Deichmann KA (2000)
Studies on linkage and association of atopy with the chromosomal region 12q13-24
Clin Exp Allergy
30 :1555
Heinzmann A, Grotherr P, Jerkic SP, Lichtenberg A, Braun S, Kruse S, Forster J, Kuehr J, Deichmann KA (2000)
Clin Exp Allergy
30 :1555