Herlihy_2017_Protein.Sci_26_578

Reference

Title : Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV - Herlihy_2017_Protein.Sci_26_578
Author(s) : Herlihy SE , Tang Y , Phillips JE , Gomer RH
Ref : Protein Science , 26 :578 , 2017
Abstract :

Autocrine proliferation repressor protein A (AprA) is a protein secreted by Dictyostelium discoideum cells. Although there is very little sequence similarity between AprA and any human protein, AprA has a predicted structural similarity to the human protein dipeptidyl peptidase IV (DPPIV). AprA is a chemorepellent for Dictyostelium cells, and DPPIV is a chemorepellent for neutrophils. This led us to investigate if AprA and DPPIV have additional functional similarities. We find that like AprA, DPPIV is a chemorepellent for, and inhibits the proliferation of, D. discoideum cells, and that AprA binds some DPPIV binding partners such as fibronectin. Conversely, rAprA has DPPIV-like protease activity. These results indicate a functional similarity between two eukaryotic chemorepellent proteins with very little sequence similarity, and emphasize the usefulness of using a predicted protein structure to search a protein structure database, in addition to searching for proteins with similar sequences.

PubMedSearch : Herlihy_2017_Protein.Sci_26_578
PubMedID: 28028841
Gene_locus related to this paper: dicdi-apra

Related information

Gene_locus dicdi-apra
Family dicdi-apra    PhoPQ_related

Citations formats

Herlihy SE, Tang Y, Phillips JE, Gomer RH (2017)
Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV
Protein Science 26 :578

Herlihy SE, Tang Y, Phillips JE, Gomer RH (2017)
Protein Science 26 :578