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PhoPQ_related

Relationship

Family: PhoPQ_related

Block: X

Parent Family: No family

Comment

IPR009199 PIRSF014728 PhoPQ-activated pathogenicity-related protein, PqaA type. Proteins in this entry are believed to play a role in virulence/pathogenicity in Salmonella. Salmonella typhi PqaA has been shown to be activated by PhoP/Q two-component regulatory system, which regulates many virulence genes Baker et al 1997. It has been also shown to confer resistance to antimicrobial peptides (melittin). Autocrine proliferation repressor protein A (AprA, CfaD) is a protein secreted by Dictyostelium discoideum cells. AprA has DPPIV-like protease activity MEROPS ClanSC family S82

Database

Interpro : IPR009199 PhoPQ-activated pathogenicity-related protein, PqaA type

PIRSF : PIRSF014728 PhoPQ-activated pathogenicity-related protein, PqaA type

Pdoc : No Pdoc

Pfam : PF10142 PhoPQ_related

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Gene_locus Name Species
9bact-a3hwh7 Algoriphagus sp. PR1 Autocrine proliferation repressor Algoriphagus sp. PR1
9bact-b9xba2 Pedosphaera parvula Ellin514 Putative uncharacterized protein Pedosphaera parvula Ellin514
9burk-a2w736 Burkholderia dolosa AUO158 PhoPQ-activated pathogenicity-related protein Burkholderia dolosa AUO158
9burk-b1tgj2 Burkholderia ambifaria MEX-5 PqaA Burkholderia ambifaria MEX-5
9plan-a3zmp5 Blastopirellula marina DSM 3645 Putative uncharacterized protein Blastopirellula marina DSM 3645
9plan-a6ccm8 Planctomyces maris DSM 8797 Putative uncharacterized protein Planctomyces maris DSM 8797
brafl-c3yra8 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3zmp8 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
burps-a4lm41 Burkholderia pseudomallei (Pseudomonas pseudomallei) (strains 305\; MSHR346\; Pakistan 9\; 1106a\; S13\; 1710b\; 1106b\; 1710a\; Pasteur 52237\; 406e\; 1655\; 576\; 668) PqaA protein Burkholderia pseudomallei 305
burs3-q390h8 Burkholderia lata (strain ATCC 17760 \/ LMG 22485 \/ NCIMB 9086 \/ R18194 \/ 383) Putative uncharacterized protein Burkholderia sp.
burta-q2t934 Burkholderia thailandensis (strain E264 \/ ATCC 700388 \/ DSM 13276 CIP 106301) PqaA Burkholderia thailandensis
chrvo-q7nwm0 Chromobacterium violaceum Putative uncharacterized protein Chromobacterium violaceum
dicdi-apra Dictyostelium discoideum (Slime mold) PhoPQ-activated pathogenicity-related protein Dictyostelium discoideum
dicdi-q54li1 Dictyostelium discoideum (Slime mold) PhoPQ-activated pathogenicity-related protein Dictyostelium discoideum
dicdi-q54sz3 Dictyostelium discoideum (Slime mold) PhoPQ-activated pathogenicity-related protein Dictyostelium discoideum
dicdi-q86jb6 Dictyostelium discoideum (Slime mold) PhoPQ-activated pathogenicity-related protein Dictyostelium discoideum
dicdi-q550s3 Dictyostelium discoideum (Slime mold) PhoPQ-activated pathogenicity-related protein Dictyostelium discoideum
dyafd-c6w7f1 Dyadobacter fermentans (strain ATCC 700827 \/ DSM 18053 \/ NS114) Putative uncharacterized protein Dyadobacter fermentans
fernb-a7hnn4 Fervidobacterium nodosum (strain ATCC 35602 \/ DSM 5306 \/ Rt17-B1) PhoPQ-activated pathogenicity-related protein-like protein Fervidobacterium nodosum
kosot-c5ci03 Kosmotoga olearia (strain TBF 19.5.1) Putative uncharacterized protein Kosmotoga olearia
lawip-q1mnn9 Lawsonia intracellularis (strain PHE\/MN1-00) Putative uncharacterized protein LIC092 Lawsonia intracellularis
monbe-a9usu1 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
naegr-d2ux86 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2uzk6 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2v5p1 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2v6f6 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2vbq7 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2vh14 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2vj80 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2vu69 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2vxp2 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2w0v9 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
naegr-d2w3g8 Naegleria gruberi (Amoeba) Predicted protein Naegleria gruberi
nitoc-q3jbe6 Nitrosococcus oceani (strains ATCC 19707 \/ NCIMB 11848\; AFC27) Putative uncharacterized protein Nitrosococcus oceani
phypa-a9tmr4 Physcomitrella patens subsp. patens (Moss) Predicted protein Physcomitrella patens subsp. patens
polpa-d3awt3 Polysphondylium pallidum (Cellular slime mold) Putative uncharacterized protein Polysphondylium pallidum
polpa-d3bi08.1 Polysphondylium pallidum (Cellular slime mold) Putative uncharacterized protein Polysphondylium pallidum
polpa-d3bi08.2 Polysphondylium pallidum (Cellular slime mold) Putative uncharacterized protein Polysphondylium pallidum
polpa-d3bsh8 Polysphondylium pallidum (Cellular slime mold) PhoPQ-activated pathogenicity-related protein Polysphondylium pallidum
psep1-a5wa77 Pseudomonas putida (strains F1 \/ ATCC 700007\; KT2440) PhoPQ-activated pathogenicity-related protein-like protein Pseudomonas putida
ralso-a3s0y6 Ralstonia solanacearum (Pseudomonas solanacearum) UW551 PhoP\/Q-regulated protein PqaA Ralstonia solanacearum
ralso-q8xtf1 Ralstonia solanacearum (Pseudomonas solanacearum) UW551 PhoP\/Q- Putative transmembrane protein Ralstonia solanacearum
rhoba-q7urv6 Rhodopirellula baltica Putative uncharacterized protein Rhodopirellula baltica
salar-a9mrr8 Salmonella arizonae (strain ATCC BAA-731 \/ CDC346-86 \/ RSK2980) Putative uncharacterized protein Salmonella arizonae
salti-q8z717 Salmonella typhi, S. typhimurium, S. agona, S. enterica, S. choleraesuis, S. heidelberg, S. dublin, S. schwarzengrund, Putative uncharacterized protein pqaA Salmonella typhi
shepa-a8h6h3 Shewanella pealeana (strain ATCC 700345 \/ ANG-SQ1) Shewanella woodyi (strain ATCC 51908 \/ MS32) Putative uncharacterized protein Shewanella pealeana
solue-q025c1 Solibacter usitatus (strain Ellin6076) PhoPQ-activated pathogenicity-related protein Solibacter usitatus
spild-d2qut9 Spirosoma linguale (strain ATCC 33905 \/ DSM 74 \/ LMG 10896) PhoPQ-activated pathogenicity-related protein PqaA type Spirosoma linguale
thelt-a8f5n9 Thermotoga lettingae (strain ATCC BAA-301 \/ DSM 14385 \/ TMO) Putative uncharacterized protein Thermotoga lettingae
thema-q9x042 Thermotoga maritima Thermotoga neapolitana (strains ATCC 49049 \/ DSM 4359 \/ NS-E\; ATCC BAA-489 \/ DSM 13996 \/ JCM 10882 \/ RKU-10) Putative uncharacterized protein Thermotoga maritima
thep1-a5inm4 Thermotoga petrophila (strain RKU-1 \/ ATCC BAA-488 \/ DSM 13995) PhoPQ-activated pathogenicity-related protein-like protein Thermotoga petrophila
thesq-b1l8n3 Thermotoga sp. (strain RQ2) PhoPQ-activated pathogenicity-related protein-like protein Thermotoga sp.
xanac-q8phx9 Xanthomonas axonopodis pv. citri (Citrus canker) Putative uncharacterized protein Xanthomonas axonopodis pv. citri
xanc5-q3bqi2 Xanthomonas campestris pv. vesicatoria, Xanthomonas fuscans subsp. aurantifolii, Xanthomonas perforans, Putative secreted protein Xanthomonas campestris pv. vesicatoria
xancb-b0rq23 Xanthomonas campestris pv. campestris (strains B100\; 8004) Putative uncharacterized protein Xanthomonas campestris pv. campestris
xanor-q5h236 Xanthomonas oryzae pv. oryzae (and strain MAFF 311018\; PXO99A) Putative uncharacterized protein Xanthomonas oryzae pv. oryzae
xylfa-q9pdj5 Xylella fastidiosa Putative uncharacterized protein Xylella fastidiosa
yeral-c4ud85 Yersinia aldovae ATCC 35236 Putative uncharacterized protein Yersinia aldovae ATCC 35236
yere8-a1jrp7 Yersinia enterocolitica serotype O:8 \/ biotype 1B (strain 8081) Putative exported protein Yersinia enterocolitica
yerfr-c4st09 Yersinia frederiksenii ATCC 33641 Putative uncharacterized protein Yersinia frederiksenii ATCC 33641
yerin-c4t634 Yersinia intermedia ATCC 29909 Putative uncharacterized protein Yersinia intermedia ATCC 29909
yerkr-c4tz78 Yersinia kristensenii ATCC 33638 Putative uncharacterized protein Yersinia kristensenii ATCC 33638
yerro-c4uxf3 Yersinia rohdei ATCC 43380 Putative uncharacterized protein Yersinia rohdei ATCC 43380

Gene_locus_frgt Name Species
9entr-d2tzg5 Arsenophonus nasoniae (son-killer infecting Nasonia vitripennis) Putative uncharacterized protein Arsenophonus nasoniae
brafl-c3zmp6 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae
brafl-c3zmp7 Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein Branchiostoma floridae

References (6)

Title : Functional similarities between the dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV - Herlihy_2017_Protein.Sci_26_578
Author(s) : Herlihy SE , Tang Y , Phillips JE , Gomer RH
Ref : Protein Science , 26 :578 , 2017
Abstract :
PubMedSearch : Herlihy_2017_Protein.Sci_26_578
PubMedID: 28028841
Gene_locus related to this paper: dicdi-apra

Title : Dictyostelium cells bind a secreted autocrine factor that represses cell proliferation - Choe_2009_BMC.Biochem_10_4
Author(s) : Choe JM , Bakthavatsalam D , Phillips JE , Gomer RH
Ref : BMC Biochem , 10 :4 , 2009
Abstract :
PubMedSearch : Choe_2009_BMC.Biochem_10_4
PubMedID: 19187549
Gene_locus related to this paper: dicdi-apra

Title : The secreted Dictyostelium protein CfaD is a chalone - Bakthavatsalam_2008_J.Cell.Sci_121_2473
Author(s) : Bakthavatsalam D , Brock DA , Nikravan NN , Houston KD , Hatton RD , Gomer RH
Ref : Journal of Cell Science , 121 :2473 , 2008
Abstract :
PubMedSearch : Bakthavatsalam_2008_J.Cell.Sci_121_2473
PubMedID: 18611962
Gene_locus related to this paper: dicdi-apra

Title : Rcs and PhoPQ regulatory overlap in the control of Salmonella enterica virulence. - Garcia-Calderon_2007_J.Bacteriol_189_6635
Author(s) : Garcia-Calderon CB , Casadesus J , Ramos-Morales F
Ref : Journal of Bacteriology , 189 :6635 , 2007
Abstract :
PubMedSearch : Garcia-Calderon_2007_J.Bacteriol_189_6635
PubMedID: 17616593

Title : A secreted factor represses cell proliferation in Dictyostelium - Brock_2005_Development_132_4553
Author(s) : Brock DA , Gomer RH
Ref : Development , 132 :4553 , 2005
Abstract :
PubMedSearch : Brock_2005_Development_132_4553
PubMedID: 16176950
Gene_locus related to this paper: dicdi-apra

Title : PhoP\/Q regulated genes in Salmonella typhi identification of melittin sensitive mutants - Baker_1997_Microb.Pathog_22_165
Author(s) : Baker SJ , Daniels C , Morona R
Ref : Microb Pathog , 22 :165 , 1997
Abstract :
PubMedSearch : Baker_1997_Microb.Pathog_22_165
PubMedID: 9075219