Hiramatsu_2004_Biol.Chem_385_561

Reference

Title : The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A - Hiramatsu_2004_Biol.Chem_385_561
Author(s) : Hiramatsu H , Yamamoto A , Kyono K , Higashiyama Y , Fukushima C , Shima H , Sugiyama S , Inaka K , Shimizu R
Ref : Biol Chem , 385 :561 , 2004
Abstract : Dipeptidyl peptidase IV (DPPIV) is a serine protease, a member of the prolyl oligopeptidase (POP) family, and has been implicated in several diseases. Therefore, it seems important to develop selective inhibitors for human DPPIV (hDPPIV) that are able to control the biological function of hDPPIV. In order to elucidate the binding mode and substrate specificity, we determined the crystal structure complex of hDPPIV and diprotin A (IIe-Pro-IIe), a slowly hydrolyzed substrate of hDPPIV, at 2.2 A resolution. In this paper, we discuss the molecular interaction mechanism of diprotin A with hDPPIV based on the X-ray crystal structure.
ESTHER : Hiramatsu_2004_Biol.Chem_385_561
PubMedSearch : Hiramatsu_2004_Biol.Chem_385_561
PubMedID: 15255191
Gene_locus related to this paper: human-DPP4

Related information

Gene_locus related to this paper: human-DPP4

Citations formats

Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R (2004)
The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A
Biol Chem 385 :561

Hiramatsu H, Yamamoto A, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Shimizu R (2004)
Biol Chem 385 :561