Hogg_2003_Drug.News.Perspect_16_261

Reference

Title : Regulating the regulators: the role of nicotinic acetylcholine receptors in human epilepsy - Hogg_2003_Drug.News.Perspect_16_261
Author(s) : Hogg RC , Bertrand D
Ref : Drug News Perspect , 16 :261 , 2003
Abstract :

Recent advances in genetic mapping have linked several epilepsies to mutations in genes coding for ion channel proteins. Mutations in genes coding for the alpha(4) and beta(2) subunits of the nicotinic acetylcholine receptor have been found in some families suffering from autosomal dominant nocturnal frontal lobe epilepsy. Expression of mutant alleles in the Xenopus oocyte expression system has allowed functional characterization of these mutant receptors at the cellular level. The challenge is now to design therapeutic strategies based on this knowledge of how receptor function is altered in certain epilepsies.

PubMedSearch : Hogg_2003_Drug.News.Perspect_16_261
PubMedID: 12942156

Related information

Citations formats

Hogg RC, Bertrand D (2003)
Regulating the regulators: the role of nicotinic acetylcholine receptors in human epilepsy
Drug News Perspect 16 :261

Hogg RC, Bertrand D (2003)
Drug News Perspect 16 :261