Horn_2004_Science_304_728

Reference

Title : Illuminating the evolutionary history of chlamydiae - Horn_2004_Science_304_728
Author(s) : Horn M , Collingro A , Schmitz-Esser S , Beier CL , Purkhold U , Fartmann B , Brandt P , Nyakatura GJ , Droege M , Frishman D , Rattei T , Mewes HW , Wagner M
Ref : Science , 304 :728 , 2004
Abstract :

Chlamydiae are the major cause of preventable blindness and sexually transmitted disease. Genome analysis of a chlamydia-related symbiont of free-living amoebae revealed that it is twice as large as any of the pathogenic chlamydiae and had few signs of recent lateral gene acquisition. We showed that about 700 million years ago the last common ancestor of pathogenic and symbiotic chlamydiae was already adapted to intracellular survival in early eukaryotes and contained many virulence factors found in modern pathogenic chlamydiae, including a type III secretion system. Ancient chlamydiae appear to be the originators of mechanisms for the exploitation of eukaryotic cells.

PubMedSearch : Horn_2004_Science_304_728
PubMedID: 15073324
Gene_locus related to this paper: paruw-q6m9q5 , paruw-q6m9q7 , paruw-q6mcu6 , paruw-q6mev0

Related information

Gene_locus paruw-q6m9q5    paruw-q6m9q7    paruw-q6mcu6    paruw-q6mev0

Citations formats

Horn M, Collingro A, Schmitz-Esser S, Beier CL, Purkhold U, Fartmann B, Brandt P, Nyakatura GJ, Droege M, Frishman D, Rattei T, Mewes HW, Wagner M (2004)
Illuminating the evolutionary history of chlamydiae
Science 304 :728

Horn M, Collingro A, Schmitz-Esser S, Beier CL, Purkhold U, Fartmann B, Brandt P, Nyakatura GJ, Droege M, Frishman D, Rattei T, Mewes HW, Wagner M (2004)
Science 304 :728