Hortsch_1990_Development_1100_1327

Reference

Title : Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis - Hortsch_1990_Development_1100_1327
Author(s) : Hortsch M , Patel NH , Bieber AJ , Traquina ZR , Goodman CS
Ref : Development , 110 (4) :1327 , 1990
Abstract :

Drosophila neurotactin is a transmembrane glycoprotein with an apparent molecular mass of 135 x 10(3). Neurotactin is regionally expressed at the cellular blastoderm stage; later in embryogenesis the expression of the protein becomes restricted to cells of the peripheral and central nervous system. Immunocytochemical localization shows neurotactin protein at points of cell-cell contact. Using the anti-neurotactin monoclonal antibody BP-106, a neurotactin cDNA was isolated that encodes a 846 residue polypeptide. The chromosomal location of the neurotactin gene is 73C. The extracellular domain at the carboxyterminal end of the neurotactin protein shows a strong structural and sequence homology to serine esterases without retaining the amino acids forming the active center. Neurotactin therefore belongs to a growing group of proteins including Drosophila glutactin and thyroglobulins that are known to share this serine esterase protein domain motif without retaining the active center of the enzyme.

PubMedSearch : Hortsch_1990_Development_1100_1327
PubMedID: 2100266
Gene_locus related to this paper: drome-nrtac

Related information

Gene_locus drome-nrtac
Family drome-nrtac    Neurotactin    Non-catalytic_C

Citations formats

Hortsch M, Patel NH, Bieber AJ, Traquina ZR, Goodman CS (1990)
Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis
Development 110 (4) :1327

Hortsch M, Patel NH, Bieber AJ, Traquina ZR, Goodman CS (1990)
Development 110 (4) :1327