Neurotactin
Relationship
Comment
Only the C-terminal part of Neurotactin is a member of the alpha/beta hydrolase family. The N-terminal part of Neurotactin has low complexity is desordered and is intracellular. Neurotactin is found only in arthropods 
Neurotactin is only detected during cell proliferation and differentiation, and it is found mainly in neural tissue and also in mesoderm and imaginal discs. Neurotactin has a large cytoplasmic domain rich in charged residues and an extracellular domain similar to cholinesterase that lacks the active site serine required for esterase activity. Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila. Mutants of neurotactin revealed specific requirements for neurotactin during axon outgrowth, fasciculation, and guidance.
Database
Interpro : IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : No Pdoc
Pfam : PF00135 COesterase
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| 9arac-a0a087ti34 | Stegodyphus mimosarum. Neurotactin | Stegodyphus mimosarum |
| 9cest-a0a0r3udz5 | Mesocestoides corti. Uncharacterized protein | Mesocestoides corti |
| 9crus-a0a0p5ghz8 | Daphnia magna Uncharacterized protein | Daphnia magna |
| 9dipt-a0a084wk64 | Anopheles sinensis. AGAP005644-PA-like protein | Anopheles sinensis |
| 9hyme-a0a022t6n5 | Microplitis demolitor. Neurotactin-like protein | Microplitis demolitor |
| 9hyme-a0a0c9ru64 | Fopius arisanus. Nrt_2 protein | Fopius arisanus |
| 9hyme-a0a0l7r8y8 | Habropoda laboriosa Uncharacterized protein | Habropoda laboriosa |
| 9hyme-a0a0n0u7u2 | Melipona quadrifasciata Uncharacterized protein | Melipona quadrifasciata |
| 9hyme-a0a151im92 | Cyphomyrmex costatus. Neurotactin | Cyphomyrmex costatus |
| 9hyme-a0a151wvd4 | Trachymyrmex zeteki. Neurotactin | Trachymyrmex zeteki |
| 9hyme-a0a154pkj7 | Dufourea novaeangliae. Neurotactin | Dufourea novaeangliae |
| 9hyme-e2a8v4 | Camponotus floridanus (Florida carpenter ant) Neurotactin | Camponotus floridanus |
| 9hyme-e2bi28 | Harpegnathos saltator (Jerdon's jumping ant) Neurotactin | Harpegnathos saltator |
| 9neop-a0a0l7lds9 | Operophtera brumata (winter moth) Uncharacterized protein | Operophtera brumata |
| 9scar-a0a0t6ayl4 | Oryctes borbonicus. Hydrolase | Oryctes borbonicus |
| acrec-f4wng2 | Acromyrmex echinatior (Panamanian leafcutter ant) Atta cephalotes (Leafcutter ant)\; Atta colombica\; Trachymyrmex septentrionalis Neurotactin | Acromyrmex echinatior |
| aedae-q16wf1 | Aedes aegypti (Yellowfever mosquito)\; Aedes albopictus (Asian tiger mosquito) (Stegomyia albopicta) neurotactin | Aedes aegypti |
| anoal-a0a182fc87 | Anopheles albimanus (New world malaria mosquito). Uncharacterized protein | Anopheles albimanus |
| anoda-w5jih3 | Anopheles darlingi (Mosquito). Uncharacterized protein | Anopheles darlingi |
| anoga-nrtac | Anopheles gambiae\; Anopheles coluzzii\; Anopheles melas\; Anopheles merus\; Anopheles arabiensis\; Anopheles quadriannulatus\; CRA_x9P1GAV5CJS neurotactin | Anopheles gambiae |
| apime-h9ks30 | Apis mellifera (Honeybee) Uncharacterized protein | Apis mellifera |
| attce-w4vya2 | Atta cephalotes (Leafcutter ant). Uncharacterized protein | Atta cephalotes |
| baccu-a0a0a1xrb1 | Bactrocera cucurbitae (Melon fruit fly) (Dacus cucurbitae). Neurotactin | Bactrocera cucurbitae |
| bacdo-a0a034vjg4 | Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis). Neurotactin | Bactrocera dorsalis |
| bommo-h9ivg2 | Bombyx mori (Silk moth) Uncharacterized protein | Bombyx mori |
| calsg-a0a068f7v0 | Calliphora stygia (Common brown blowfly). Esterase | Calliphora stygia |
| cerbi-a0a026wla0 | Cerapachys biroi (Ant). Neurotactin | Cerapachys biroi |
| cerca-w8c4d2 | Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata). Neurotactin | Ceratitis capitata |
| closi-g7y5y3 | Clonorchis sinensis (Chinese liver fluke) Neurotactin | Clonorchis sinensis |
| culqu-b0wnn8 | Culex quinquefasciatus (Southern house mosquito) Neurotactin | Culex quinquefasciatus |
| danpl-g6cnf9 | Danaus plexippus (Monarch butterfly) Neurotactin | Danaus plexippus |
| dappu-e9h8r4 | Daphnia pulex (Water flea) Putative uncharacterized protein | Daphnia pulex |
| droan-b3m4e3 | Drosophila ananassae (Fruit fly) GF23930 | Drosophila ananassae |
| drobs-a0a0m4efv3 | Drosophila busckii Uncharacterized protein | Drosophila busckii |
| droer-b3ndh9 | Drosophila erecta (Fruit fly) GG13576 | Drosophila erecta |
| drogr-b4ixf7 | Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) GH16222 | Drosophila grimshawi |
| drome-nrtac | Drosophila melanogaster (Fruit fly) mRNA for neurotactin | Drosophila melanogaster |
| dromo-b4kxz6 | Drosophila mojavensis (Fruit fly) GI13369 | Drosophila mojavensis |
| drops-nrtac | Drosophila pseudoobscura (Fruit fly) ga21977-pa (fragment) | Drosophila pseudoobscura |
| drose-b4hk63 | Drosophila sechellia (Fruit fly) GM25656 | Drosophila sechellia |
| drosi-a0a0j9rwn7 | Drosophila simulans (Fruit fly). Uncharacterized protein | Drosophila simulans |
| drovi-b4lg54 | Drosophila virilis (Fruit fly) GJ13198 | Drosophila virilis |
| drowi-b4n3x7 | Drosophila willistoni (Fruit fly) GK25299 | Drosophila willistoni |
| droya-b4pka2 | Drosophila yakuba (Fruit fly) GE19873 | Drosophila yakuba |
| echgr-a0a068wgw1 | Echinococcus granulosus (Hydatid tapeworm), Echinococcus multilocularis (Fox tapeworm). Family S9 non peptidase ue S09 family | Echinococcus granulosus |
| fashe-a0a2h1cvt6 | Fasciola hepatica (Liver fluke) COesterase domain-containing protein | Fasciola hepatica |
| fashe-a0a4e0rjz9 | Fasciola hepatica (Liver fluke) Neurotactin | Fasciola hepatica |
| hymdi-a0a158qem1 | Hymenolepis diminuta (Rat tapeworm). Uncharacterized protein | Hymenolepis diminuta |
| hymmi-a0a068xge7 | Hymenolepis microstoma (Rodent tapeworm) (Rodentolepis microstoma). Family S9 non peptidase ue (S09 family) | Hymenolepis microstoma |
| ixosc-b7qa70 | Ixodes scapularis (Black-legged tick) (Deer tick)\; Ixodes ricinus , putative | Ixodes scapularis |
| luccu-a0a0l0bps0 | Lucilia cuprina (Green bottle fly) (Australian sheep blowfly) Uncharacterized protein | Lucilia cuprina |
| nasvi-k7iz24 | Nasonia vitripennis (Parasitic wasp) Neurotactin | Nasonia vitripennis |
| pedhc-e0vcd0 | Pediculus humanus corporis (Body louse) Neurotactin, putative | Pediculus humanus corporis |
| rhopr-t1h9l8 | Rhodnius prolixus (Triatomid bug) Uncharacterized protein | Rhodnius prolixus |
| solin-e9j7j5 | Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri) Putative uncharacterized protein | Solenopsis invicta |
| spoli-a0a0u2lcp7 | Spodoptera littoralis (Egyptian cotton leafworm). Neurotactin | Spodoptera littoralis |
| strmm-t1iuk3 | Strigamia maritima (European centipede) (Geophilus maritimus) Uncharacterized protein | Strigamia maritima |
| taeas-a0a0r3vsc2 | Taenia asiatica (Asian tapeworm). Uncharacterized protein | Taenia asiatica |
| trica-d2a2b8 | Tribolium castaneum (Red flour beetle) Putative uncharacterized protein GLEAN_07674 | Tribolium castaneum |
| zoone-a0a067rh81 | Zootermopsis nevadensis (Dampwood termite). Neurotactin | Zootermopsis nevadensis |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| 9bact-a0a060bsh8 | environmental samples uncultured bacterium Uncharacterized protein | uncultured bacterium |
| 9crus-a0a0n8eqn7 | Daphnia magna Uncharacterized protein | Daphnia magna |
| 9euca-a0a0p4vz69 | Scylla olivacea (orange mud crab) Uncharacterized protein | Scylla olivacea |
| 9neop-s4p6t6 | Pararge aegeria (specked wood butterfly) Neurotactin | Pararge aegeria |
| bacdo-g9bhz4 | Bactrocera dorsalis (Oriental fruit fly) (Dacus dorsalis) Juvenile hormone esterase | Bactrocera dorsalis |
| denpd-n6t9u4 | Dendroctonus ponderosae (Mountain pine beetle) Uncharacterized protein | Dendroctonus ponderosae |
| drope-b4h4f4 | Drosophila persimilis (Fruit fly) GL20689 | Drosophila persimilis |
| drosi-b4qmy2 | Drosophila simulans (Fruit fly) GD14662 | Drosophila simulans |
| drosi-b4qmy3 | Drosophila simulans (Fruit fly) GD14663 | Drosophila simulans |
| hydta-a0a0r3x9a0 | Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis). Uncharacterized protein | Hydatigera taeniaeformis taeniaeformis |
| hymnn-a0a0r3ta79 | Hymenolepis nana (Dwarf tapeworm) (Rodentolepis nana). Uncharacterized protein | Hymenolepis nana |
| lasni-a0a0j7kaz7 | Lasius niger Uncharacterized protein | Lasius niger |
| lepde-a0a0a7eq81 | Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora decemlineata). Putative neurotactin | Leptinotarsa decemlineata |
| lepsm-a0a0k2vhe0 | Lepeophtheirus salmonis (Salmon louse) Uncharacterized protein | Lepeophtheirus salmonis |
| lyghe-a0a0a9yam0 | Lygus hesperus (Western plant bug). Neurotactin | Lygus hesperus |
| schso-a0a0x3pjz9 | Schistocephalus solidus (Tapeworm). Neurotactin | Schistocephalus solidus |
References (10)
| Title : The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties - Zeev-Ben-Mordehai_2009_Biophys.J_97_2316 |
| Author(s) : Zeev-Ben-Mordehai T , Mylonas E , Paz A , Peleg Y , Toker L , Silman I , Svergun DI , Sussman JL |
| Ref : Biophysical Journal , 97 :2316 , 2009 |
| Abstract : |
| PubMedSearch : Zeev-Ben-Mordehai_2009_Biophys.J_97_2316 |
| PubMedID: 19843464 |
| Title : Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization - Zeev-Ben-Mordehai_2009_Protein.Expr.Purif_63_147 |
| Author(s) : Zeev-Ben-Mordehai T , Paz A , Peleg Y , Toker L , Wolf SG , Rydberg EH , Sussman JL , Silman I |
| Ref : Protein Expr Purif , 63 :147 , 2009 |
| Abstract : |
| PubMedSearch : Zeev-Ben-Mordehai_2009_Protein.Expr.Purif_63_147 |
| PubMedID: 18938249 |
| Title : Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila - Truman_2004_Development_131_5167 |
| Author(s) : Truman JW , Schuppe H , Shepherd D , Williams DW |
| Ref : Development , 131 :5167 , 2004 |
| Abstract : |
| PubMedSearch : Truman_2004_Development_131_5167 |
| PubMedID: 15459108 |
| Title : Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding - Liebl_2003_Development_130_3217 |
| Author(s) : Liebl EC , Rowe RG , Forsthoefel DJ , Stammler AL , Schmidt ER , Turski M , Seeger MA |
| Ref : Development , 130 :3217 , 2003 |
| Abstract : |
| PubMedSearch : Liebl_2003_Development_130_3217 |
| PubMedID: 12783792 |
| Title : Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila - Fremion_2000_EMBO.J_19_4463 |
| Author(s) : Fremion F , Darboux I , Diano M , Hipeau-Jacquotte R , Seeger MA , Piovant M |
| Ref : EMBO Journal , 19 :4463 , 2000 |
| Abstract : |
| PubMedSearch : Fremion_2000_EMBO.J_19_4463 |
| PubMedID: 10970840 |
| Gene_locus related to this paper: drome-nrtac |
| Title : Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila - Speicher_1998_Neuron_20_221 |
| Author(s) : Speicher S , Garci-Alonso L , Carmena A , Martin-Bermudo MD , de la Escalera S , Jimenez F |
| Ref : Neuron , 20 :221 , 1998 |
| Abstract : |
| PubMedSearch : Speicher_1998_Neuron_20_221 |
| PubMedID: 9491984 |
| Title : The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties - Darboux_1996_EMBO.J_15_4835 |
| Author(s) : Darboux I , Barthalay Y , Piovant M , Hipeau-Jacquotte R |
| Ref : EMBO Journal , 15 :4835 , 1996 |
| Abstract : |
| PubMedSearch : Darboux_1996_EMBO.J_15_4835 |
| PubMedID: 8890157 |
| Title : Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases - de la Escalera_1990_EMBO.J_9_3593 |
| Author(s) : de la Escalera S , Bockamp EO , Moya F , Piovant M , Jimenez F |
| Ref : EMBO Journal , 9 :3593 , 1990 |
| Abstract : |
| PubMedSearch : de la Escalera_1990_EMBO.J_9_3593 |
| PubMedID: 2120047 |
| Gene_locus related to this paper: drome-nrtac |
| Title : Drosophila neurotactin mediates heterophilic cell adhesion - Barthalay_1990_EMBO.J_9_3603 |
| Author(s) : Barthalay Y , Hipeau-Jacquotte R , de la Escalera S , Jimenez F , Piovant M |
| Ref : EMBO Journal , 9 :3603 , 1990 |
| Abstract : |
| PubMedSearch : Barthalay_1990_EMBO.J_9_3603 |
| PubMedID: 2120048 |
| Gene_locus related to this paper: drome-nrtac |
| Title : Drosophila neurotactin, a surface glycoprotein with homology to serine esterases, is dynamically expressed during embryogenesis - Hortsch_1990_Development_1100_1327 |
| Author(s) : Hortsch M , Patel NH , Bieber AJ , Traquina ZR , Goodman CS |
| Ref : Development , 110 (4) :1327 , 1990 |
| Abstract : |
| PubMedSearch : Hortsch_1990_Development_1100_1327 |
| PubMedID: 2100266 |
| Gene_locus related to this paper: drome-nrtac |