| Title : Genome of the bacterium Streptococcus pneumoniae strain R6 - Hoskins_2001_J.Bacteriol_183_5709 |
| Author(s) : Hoskins J , Alborn WE, Jr. , Arnold J , Blaszczak LC , Burgett S , DeHoff BS , Estrem ST , Fritz L , Fu DJ , Fuller W , Geringer C , Gilmour R , Glass JS , Khoja H , Kraft AR , Lagace RE , LeBlanc DJ , Lee LN , Lefkowitz EJ , Lu J , Matsushima P , McAhren SM , McHenney M , McLeaster K , Mundy CW , Nicas TI , Norris FH , O'Gara M , Peery RB , Robertson GT , Rockey P , Sun PM , Winkler ME , Yang Y , Young-Bellido M , Zhao G , Zook CA , Baltz RH , Jaskunas SR , Rosteck PR, Jr. , Skatrud PL , Glass JI |
| Ref : Journal of Bacteriology , 183 :5709 , 2001 |
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Abstract :
Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because the R6 strain is avirulent and, more importantly, because it is readily transformed with DNA from homologous species and many heterologous species, it is the principal platform for investigation of the biology of this important pathogen. It is also used as a primary vehicle for genomics-based development of antibiotics for gram-positive bacteria. In our analysis of the genome, we identified a large number of new uncharacterized genes predicted to encode proteins that either reside on the surface of the cell or are secreted. Among those proteins there may be new targets for vaccine and antibiotic development. |
| PubMedSearch : Hoskins_2001_J.Bacteriol_183_5709 |
| PubMedID: 11544234 |
| Gene_locus related to this paper: strp2-q04l35 , strpj-b8zns7 , strpn-AXE1 , strpn-b2dz20 , strpn-pepx , strpn-SP0614 , strpn-SP0777 , strpn-SP0902 , strpn-SP1343 |
| Gene_locus | strp2-q04l35 strpj-b8zns7 strpn-AXE1 strpn-b2dz20 strpn-pepx strpn-SP0614 strpn-SP0777 strpn-SP0902 strpn-SP1343 |
| Gene_locus_frgt | strpn-SP0883 |
Hoskins J, Alborn WE, Jr., Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR, Jr., Skatrud PL, Glass JI (2001)
Genome of the bacterium Streptococcus pneumoniae strain R6
Journal of Bacteriology
183 :5709
Hoskins J, Alborn WE, Jr., Arnold J, Blaszczak LC, Burgett S, DeHoff BS, Estrem ST, Fritz L, Fu DJ, Fuller W, Geringer C, Gilmour R, Glass JS, Khoja H, Kraft AR, Lagace RE, LeBlanc DJ, Lee LN, Lefkowitz EJ, Lu J, Matsushima P, McAhren SM, McHenney M, McLeaster K, Mundy CW, Nicas TI, Norris FH, O'Gara M, Peery RB, Robertson GT, Rockey P, Sun PM, Winkler ME, Yang Y, Young-Bellido M, Zhao G, Zook CA, Baltz RH, Jaskunas SR, Rosteck PR, Jr., Skatrud PL, Glass JI (2001)
Journal of Bacteriology
183 :5709