| Title : Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides - Hu_2020_Chem.Commun.(Camb)__ |
| Author(s) : Hu D , Zong XC , Xue F , Li C , Hu BC , Wu MC |
| Ref : Chem Commun (Camb) , : , 2020 |
|
Abstract :
Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were remarkably improved via reshaping two substrate tunnels based on rational design. The elegant one-step enantioconvergent hydrolysis of seven rac-epoxides was achieved by single mutants, allowing green and efficient access to valuable (R)-1,2 diols with high eep (90.1-98.3%) and yields. |
| PubMedSearch : Hu_2020_Chem.Commun.(Camb)__ |
| PubMedID: 32030396 |
Hu D, Zong XC, Xue F, Li C, Hu BC, Wu MC (2020)
Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides
Chem Commun (Camb)
:
Hu D, Zong XC, Xue F, Li C, Hu BC, Wu MC (2020)
Chem Commun (Camb)
: