| Title : Discovery of Enzyme Inhibitors from Mangrove Sediment Derived Fungus Trichoderma harzianum SCSIO 41051 - Huang_2024_Chem.Biodivers__e202400070 |
| Author(s) : Huang L , Chen C , Cai J , Chen Y , Zhu Y , Yang B , Zhou X , Liu Y , Tao H |
| Ref : Chem Biodivers , :e202400070 , 2024 |
|
Abstract :
One new fatty acid derivative, (2E,4E)-6,7-dihydroxy-2-methylocta-2,4-dienoic acid (1), and 16 known compounds (2-17) were isolated from the mangrove sediment derived fungus Trichoderma harzianum SCSIO 41051. Their structures were established by spectroscopic methods, computational ECD, and Mo2(OAc)4-induced ECD experiment. All the compounds were evaluated for their acetylcholinesterase (AChE) and pancreatic lipase (PL) inhibition. Compounds 9 and 14 exhibited moderate AChE inhibitory activities with IC50 values of 2.49 and 2.92 microM, respectively, which compounds 8 and 9 displayed moderate inhibition on PL with IC50 value of 2.30 and 2.34 microM, respectively. |
| PubMedSearch : Huang_2024_Chem.Biodivers__e202400070 |
| PubMedID: 38356321 |
Huang L, Chen C, Cai J, Chen Y, Zhu Y, Yang B, Zhou X, Liu Y, Tao H (2024)
Discovery of Enzyme Inhibitors from Mangrove Sediment Derived Fungus Trichoderma harzianum SCSIO 41051
Chem Biodivers
:e202400070
Huang L, Chen C, Cai J, Chen Y, Zhu Y, Yang B, Zhou X, Liu Y, Tao H (2024)
Chem Biodivers
:e202400070