Title : Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii - Hung_2008_J.Ethnopharmacol_119_74 |
Author(s) : Hung TM , Na M , Dat NT , Ngoc TM , Youn U , Kim HJ , Min BS , Lee J , Bae K |
Ref : J Ethnopharmacol , 119 :74 , 2008 |
Abstract :
In the course of screening plants used in Korean folk medicine as memory enhancers, a 70% ethanol extract of tuber from Corydalis turtschaninovii Besser (Papaveraceae) showed significant acetylcholinesterase (AChE) inhibitory activity. Repeated column chromatography led to the isolation of a new aporphine alkaloid, oxoglaucidaline (9), and a new protoberberine, pseudodehydrocorydaline (13) together with 14 known compounds (1-8, 10-12, and 14-16). The chemical structures of isolated compounds were elucidated base on extensive 1D and 2D NMR spectroscopic data. Compounds 1-16 were investigated in vitro for their anti-cholinesterase activity using the mice cortex AChE enzyme. In further study, the anti-amnesic activities of pseudoberberine (16) in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) were examined. This alkaloid (5.0 mg/kg, p.o.) administration significantly reversed cognitive impairments in mice by passive avoidance test (P<0.05). It also reduced escape latencies in training trials and prolonged swimming times in the target quadrant during the probe trial in the water maze task (P<0.05). These results indicated that Corydalis turtschaninovii due to its alkaloids have anti-cholinesterase activity and pseudoberberine and other alkaloids have anti-amnesic activities that may be useful for cognitive impairment treatment. |
PubMedSearch : Hung_2008_J.Ethnopharmacol_119_74 |
PubMedID: 18601993 |
Hung TM, Na M, Dat NT, Ngoc TM, Youn U, Kim HJ, Min BS, Lee J, Bae K (2008)
Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii
J Ethnopharmacol
119 :74
Hung TM, Na M, Dat NT, Ngoc TM, Youn U, Kim HJ, Min BS, Lee J, Bae K (2008)
J Ethnopharmacol
119 :74