Corydaline
General
Type : Alkaloid, Natural, Quinoline
Chemical_Nomenclature : (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline
Canonical SMILES : C[C@@H]1[C@@H]2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
InChI : InChI=1S\/C22H27NO4\/c1-13-15-6-7-18(24-2)22(27-5)17(15)12-23-9-8-14-10-19(25-3)20(26-4)11-16(14)21(13)23\/h6-7,10-11,13,21H,8-9,12H2,1-5H3\/t13-,21+\/m0\/s1
InChIKey : VRSRXLJTYQVOHC-YEJXKQKISA-N
Other name(s) : (+)-Corydaline || (+\/-)-Corydaline || d-Corydaline || CHEBI:14027 || SCHEMBL230676 || CHEMBL2165401
MW : 369.5
Formula : C22H27NO4
CAS_number : 518-69-4
PubChem : 101301
UniChem : VRSRXLJTYQVOHC-YEJXKQKISA-N
Target
Families : Corydaline ligand of proteins in family
ACHE
Protein :
human-ACHE
References (8)
| Title : Corydaline Alleviates 1-Methyl-4-Phenylpyridium (MPP(+))-Induced Human Neuroblastoma Cell Injury by BAP1-NRF2\/HO-1\/GPX4 Pathway - Song_2025_Neurochem.Res_50_107 |
| Author(s) : Song Y , Yu C , Wang Y , Bai X , Zhou D |
| Ref : Neurochem Res , 50 :107 , 2025 |
| Abstract : |
| PubMedSearch : Song_2025_Neurochem.Res_50_107 |
| PubMedID: 40014251 |
| Title : Identification of bioactive natural products using yeastApplication to monoacylglycerol lipase inhibitor extraction from Corydalis Rhizoma - Mei_2022_Biomed.Pharmacother_149_112798 |
| Author(s) : Mei J , Guo R , Zhang F , Zhang H , Yang X , Yu B , Liu J , Liu X |
| Ref : Biomed Pharmacother , 149 :112798 , 2022 |
| Abstract : |
| PubMedSearch : Mei_2022_Biomed.Pharmacother_149_112798 |
| PubMedID: 35286964 |
| Title : Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry - Wang_2018_J.Chromatogr.A_1563_135 |
| Author(s) : Wang L , Zhao Y , Zhang Y , Zhang T , Kool J , Somsen GW , Wang Q , Jiang Z |
| Ref : Journal of Chromatography A , 1563 :135 , 2018 |
| Abstract : |
| PubMedSearch : Wang_2018_J.Chromatogr.A_1563_135 |
| PubMedID: 29866504 |
| Title : Anti-Metastatic Effect of Dehydrocorydaline on H1299 Non-Small Cell Lung Carcinoma Cells via Inhibition of Matrix Metalloproteinases and B Cell Lymphoma 2 - Lee_2017_Phytother.Res_31_441 |
| Author(s) : Lee J , Sohn EJ , Yoon SW , Kim CG , Lee S , Kim JY , Baek N , Kim SH |
| Ref : Phytother Res , 31 :441 , 2017 |
| Abstract : |
| PubMedSearch : Lee_2017_Phytother.Res_31_441 |
| PubMedID: 28144994 |
| Title : Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry - Chai_2017_Xenobiotica__1 |
| Author(s) : Chai L , Donkor PO , Wang K , Sun Y , Oppong MB , Ding L , Qiu F |
| Ref : Xenobiotica , :1 , 2017 |
| Abstract : |
| PubMedSearch : Chai_2017_Xenobiotica__1 |
| PubMedID: 29235899 |
| Title : Rapid TLC\/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts - Berkov_2008_Phytochem.Anal_19_411 |
| Author(s) : Berkov S , Bastida J , Nikolova M , Viladomat F , Codina C |
| Ref : Phytochem Anal , 19 :411 , 2008 |
| Abstract : |
| PubMedSearch : Berkov_2008_Phytochem.Anal_19_411 |
| PubMedID: 18446766 |
| Title : Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii - Hung_2008_J.Ethnopharmacol_119_74 |
| Author(s) : Hung TM , Na M , Dat NT , Ngoc TM , Youn U , Kim HJ , Min BS , Lee J , Bae K |
| Ref : J Ethnopharmacol , 119 :74 , 2008 |
| Abstract : |
| PubMedSearch : Hung_2008_J.Ethnopharmacol_119_74 |
| PubMedID: 18601993 |