| Title : Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden - Hurst-Hess_2023_Antimicrob.Agents.Chemother_67_e0016223 |
| Author(s) : Hurst-Hess K , Walz A , Yang Y , McGuirk H , Gonzalez-Juarrero M , Hatfull GF , Ghosh P , Ojha AK |
| Ref : Antimicrobial Agents & Chemotherapy , 67 :e0016223 , 2023 |
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Abstract :
Intrinsic and acquired antibiotic resistance in Mycobacterium abscessus presents challenges in infection control, and new therapeutic strategies are needed. Bacteriophage therapy shows promise, but variabilities in M. abscessus phage susceptibility limits its broader utility. We show here that a mycobacteriophage-encoded lysin B (LysB) efficiently and rapidly kills both smooth- and rough-colony morphotype M. abscessus strains and reduces the pulmonary bacterial load in mice. LysB aerosolization presents a plausible treatment for pulmonary M. abscessus infections. |
| PubMedSearch : Hurst-Hess_2023_Antimicrob.Agents.Chemother_67_e0016223 |
| PubMedID: 37154689 |
| Family | Lysin_B_C_ter |
Hurst-Hess K, Walz A, Yang Y, McGuirk H, Gonzalez-Juarrero M, Hatfull GF, Ghosh P, Ojha AK (2023)
Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden
Antimicrobial Agents & Chemotherapy
67 :e0016223
Hurst-Hess K, Walz A, Yang Y, McGuirk H, Gonzalez-Juarrero M, Hatfull GF, Ghosh P, Ojha AK (2023)
Antimicrobial Agents & Chemotherapy
67 :e0016223