Inestrosa_1994_J.Neurol.Sci_122_1

Reference

Title : Blood markers in Alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes - Inestrosa_1994_J.Neurol.Sci_122_1
Author(s) : Inestrosa NC , Alarcon R , Arriagada J , Donoso A , Alvarez J , Campos EO
Ref : Journal of the Neurological Sciences , 122 :1 , 1994
Abstract :

In patients with the clinical diagnosis of Alzheimer disease (AD), we searched for systemic changes in components of the blood as a diagnostic tool. The acetylcholine-related enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BCHE) were measured in plasma, erythrocytes, platelets and lymphocytes. Results did not show a general effect; notwithstanding, specific cell types presented alterations either in AChE or BCHE but not in both enzymatic activities. In AD patients, AChE of lymphocytes was reduced by 60% compared with the age-matched controls. However, when patients were divided, the sporadic but not the familial subgroup exhibited a significant reduction. In erythrocytes the BCHE activity was reduced by 45% in sporadic AD. The molecular forms of the lymphocyte AChE were characterized by velocity sedimentation. Both globular forms were subnormal, more so the tetrameric G4 AChE form than the G2 form.

PubMedSearch : Inestrosa_1994_J.Neurol.Sci_122_1
PubMedID: 8195795

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Citations formats

Inestrosa NC, Alarcon R, Arriagada J, Donoso A, Alvarez J, Campos EO (1994)
Blood markers in Alzheimer disease: subnormal acetylcholinesterase and butyrylcholinesterase in lymphocytes and erythrocytes
Journal of the Neurological Sciences 122 :1

Inestrosa NC, Alarcon R, Arriagada J, Donoso A, Alvarez J, Campos EO (1994)
Journal of the Neurological Sciences 122 :1