| Title : Molecular interactions of acetylcholinesterase with senile plaques - Inestrosa_1998_J.Physiol.Paris_92_341 |
| Author(s) : Inestrosa NC , Alarcon R |
| Ref : Journal de Physiologie (Paris) , 92 :341 , 1998 |
|
Abstract :
Acetylcholinesterase (AChE) present in Alzheimer plaques is resistant to low pH, anti-ChE inhibitors and high substrate concentrations in comparison with the free enzyme. Kinetic and pharmacological studies of AChE-amyloid complexes indicate that steric hindrance by the amyloid over the gorge and the peripheral site of AChE is responsible for these effects. |
| PubMedSearch : Inestrosa_1998_J.Physiol.Paris_92_341 |
| PubMedID: 9789834 |
Inestrosa NC, Alarcon R (1998)
Molecular interactions of acetylcholinesterase with senile plaques
Journal de Physiologie (Paris)
92 :341
Inestrosa NC, Alarcon R (1998)
Journal de Physiologie (Paris)
92 :341