Inestrosa_1998_J.Physiol.Paris_92_341

Reference

Title : Molecular interactions of acetylcholinesterase with senile plaques - Inestrosa_1998_J.Physiol.Paris_92_341
Author(s) : Inestrosa NC , Alarcon R
Ref : Journal de Physiologie (Paris) , 92 :341 , 1998
Abstract :

Acetylcholinesterase (AChE) present in Alzheimer plaques is resistant to low pH, anti-ChE inhibitors and high substrate concentrations in comparison with the free enzyme. Kinetic and pharmacological studies of AChE-amyloid complexes indicate that steric hindrance by the amyloid over the gorge and the peripheral site of AChE is responsible for these effects.

PubMedSearch : Inestrosa_1998_J.Physiol.Paris_92_341
PubMedID: 9789834

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Citations formats

Inestrosa NC, Alarcon R (1998)
Molecular interactions of acetylcholinesterase with senile plaques
Journal de Physiologie (Paris) 92 :341

Inestrosa NC, Alarcon R (1998)
Journal de Physiologie (Paris) 92 :341