| Title : Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu - Inestrosa_2005_Neurobiol.Aging_26_1023 |
| Author(s) : Inestrosa NC , Reyes AE , Chacon MA , Cerpa W , Villalon A , Montiel J , Merabachvili G , Aldunate R , Bozinovic F , Aboitiz F |
| Ref : Neurobiology of Aging , 26 :1023 , 2005 |
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Abstract :
It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains. We report here that an aged wild-type South American rodent, Octodon degu, expresses neuronal beta-amyloid precursor protein (beta-APP695) displaying both intracellular and extracellular deposits of amyloid-beta-peptide (Abeta), intracellular accumulations of tau-protein and ubiquitin, a strong astrocytic response and acetylcholinesterase (AChE)-rich pyramidal neurons. The high amino acid homology (97.5%) between deguAbeta and humanAbeta sequences is probably a major factor in the appearance of AD markers in this aged rodent. Our results indicate that aged O. degu constitutes the first wild-type rodent model for neurodegenerative processes associated to AD. |
| PubMedSearch : Inestrosa_2005_Neurobiol.Aging_26_1023 |
| PubMedID: 15748782 |
Inestrosa NC, Reyes AE, Chacon MA, Cerpa W, Villalon A, Montiel J, Merabachvili G, Aldunate R, Bozinovic F, Aboitiz F (2005)
Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu
Neurobiology of Aging
26 :1023
Inestrosa NC, Reyes AE, Chacon MA, Cerpa W, Villalon A, Montiel J, Merabachvili G, Aldunate R, Bozinovic F, Aboitiz F (2005)
Neurobiology of Aging
26 :1023