Jamain_2008_Proc.Natl.Acad.Sci.U.S.A_105_1710

Reference

Title : Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism - Jamain_2008_Proc.Natl.Acad.Sci.U.S.A_105_1710
Author(s) : Jamain S , Radyushkin K , Hammerschmidt K , Granon S , Boretius S , Varoqueaux F , Ramanantsoa N , Gallego J , Ronnenberg A , Winter D , Frahm J , Fischer J , Bourgeron T , Ehrenreich H , Brose N
Ref : Proc Natl Acad Sci U S A , 105 :1710 , 2008
Abstract :

Autism spectrum conditions (ASCs) are heritable conditions characterized by impaired reciprocal social interactions, deficits in language acquisition, and repetitive and restricted behaviors and interests. In addition to more complex genetic susceptibilities, even mutation of a single gene can lead to ASC. Several such monogenic heritable ASC forms are caused by loss-of-function mutations in genes encoding regulators of synapse function in neurons, including NLGN4. We report that mice with a loss-of-function mutation in the murine NLGN4 ortholog Nlgn4, which encodes the synaptic cell adhesion protein Neuroligin-4, exhibit highly selective deficits in reciprocal social interactions and communication that are reminiscent of ASCs in humans. Our findings indicate that a protein network that regulates the maturation and function of synapses in the brain is at the core of a major ASC susceptibility pathway, and establish Neuroligin-4-deficient mice as genetic models for the exploration of the complex neurobiological disorders in ASCs.

PubMedSearch : Jamain_2008_Proc.Natl.Acad.Sci.U.S.A_105_1710
PubMedID: 18227507
Gene_locus related to this paper: mouse-4neur

Related information

Gene_locus mouse-4neur

Citations formats

Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N (2008)
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism
Proc Natl Acad Sci U S A 105 :1710

Jamain S, Radyushkin K, Hammerschmidt K, Granon S, Boretius S, Varoqueaux F, Ramanantsoa N, Gallego J, Ronnenberg A, Winter D, Frahm J, Fischer J, Bourgeron T, Ehrenreich H, Brose N (2008)
Proc Natl Acad Sci U S A 105 :1710