| Title : Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors - Jia_2009_Eur.J.Med.Chem_44_772 |
| Author(s) : Jia P , Sheng R , Zhang J , Fang L , He Q , Yang B , Hu Y |
| Ref : Eur Journal of Medicinal Chemistry , 44 :772 , 2009 |
|
Abstract :
A new series of galanthamine derivatives have been designed, synthesized and evaluated as acetylcholinesterase inhibitors. All of the new compounds prepared showed high AChE inhibitory activities, with compound 3e that has an N-hexyl-benzyl piperidine substituent on the nitrogen atom reaching the best inhibitory activity for AChE (IC(50)=5.62 nM). The docking study performed with AutoDock demonstrated that 3e was nicely accommodated by AChE. |
| PubMedSearch : Jia_2009_Eur.J.Med.Chem_44_772 |
| PubMedID: 18550228 |
Jia P, Sheng R, Zhang J, Fang L, He Q, Yang B, Hu Y (2009)
Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors
Eur Journal of Medicinal Chemistry
44 :772
Jia P, Sheng R, Zhang J, Fang L, He Q, Yang B, Hu Y (2009)
Eur Journal of Medicinal Chemistry
44 :772