Title : Cresylbenzodioxaphosphorin oxide pretreatment alters soman-induced toxicity and inhibition of tissue cholinesterase activity of the rat - Jimmerson_1989_Toxicol.Lett_48_93 |
Author(s) : Jimmerson VR , Shih TM , Maxwell DM , Mailman RB |
Ref : Toxicol Lett , 48 :93 , 1989 |
Abstract :
The toxicity of soman was investigated in the rat with and without pretreatment with cresylbenzodioxaphosphorin oxide (CBDP). Without pretreatment, the 24-h LD50 for soman was 118.2 micrograms/kg s.c., and soman inhibited carboxylesterase (CaE) activity in plasma (ED50 of 55 micrograms/kg) and cholinesterase (ChE) activity in brain regions (ED50 values of 65-105 micrograms/kg) in a dose-related manner. With pretreatment, the 24-h LD50 for soman was reduced by approximately 6-fold and 8-fold (by 1.0 mg/kg and 16.0 mg/kg of CBDP, respectively), and the ED50 values for soman-induced inhibition of ChE activity in brain regions were reduced by approximately 10-fold (by 1.0 mg/kg of CBDP). The dose-dependent severity of soman intoxication varied widely in rats treated with soman alone but not in CBDP-pretreated rats, and the ED50 for the occurrence of signs of soman intoxication was reduced approximately 7-fold following CBDP (1.0 mg/kg) pretreatment. These data support the hypothesis that CBDP pretreatment effectively blocks tissue CaE sites which serve to detoxify soman, thus potentiating both the soman-induced inhibition of ChE in the CNS and the lethality of soman. |
PubMedSearch : Jimmerson_1989_Toxicol.Lett_48_93 |
PubMedID: 2749782 |
Inhibitor | CBDP |
Jimmerson VR, Shih TM, Maxwell DM, Mailman RB (1989)
Cresylbenzodioxaphosphorin oxide pretreatment alters soman-induced toxicity and inhibition of tissue cholinesterase activity of the rat
Toxicol Lett
48 :93
Jimmerson VR, Shih TM, Maxwell DM, Mailman RB (1989)
Toxicol Lett
48 :93