| Title : Monitoring the pharmacokinetics of pyridinium aldoximes in the body - Kalasz_2009_Mini.Rev.Med.Chem_9_596 |
| Author(s) : Kalasz H , Furesz J , Tekes K |
| Ref : Mini Rev Med Chem , 9 :596 , 2009 |
|
Abstract :
A huge number of organophosphate poisonings occurring in agriculture, and a constant threat of misapplication of organophosphates as warfare agents require antidotes that efficiently improve the health-condition of intoxicated subjects. Pyridinium aldoximes are medically used to reactivate the cholinesterase enzymes inhibited by organophosphates. This paper outlines pharmacokinetics, metabolic disposition and blood-brain-barrier penetration of pyridinium aldoximes into the human and animal body, and the methods of their pharmacological analysis. |
| PubMedSearch : Kalasz_2009_Mini.Rev.Med.Chem_9_596 |
| PubMedID: 19456290 |
Kalasz H, Furesz J, Tekes K (2009)
Monitoring the pharmacokinetics of pyridinium aldoximes in the body
Mini Rev Med Chem
9 :596
Kalasz H, Furesz J, Tekes K (2009)
Mini Rev Med Chem
9 :596