| Title : Synthesis of 2,8-Dioxabicyclo[3.3.1]nonane Derivatives and Their Neuroprotective Activities - Kamauchi_2024_Chem.Pharm.Bull.(Tokyo)_72_56 |
| Author(s) : Kamauchi H , Takanashi A , Suzuki M , Izumi K , Takao K , Sugita Y |
| Ref : Chem Pharm Bull (Tokyo) , 72 :56 , 2024 |
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Abstract :
Twenty natural-product-like 2,8-dioxabicyclo[3.3.1]nonane derivatives were synthesized and their neuroprotective activities were tested using human monoamine oxidases (MAO) A and B and acetyl and butyryl cholinesterases (ChE). Compound 1s showed inhibitory activity for MAO-A, MAO-B and acetylcholinesterase (AChE) (IC(50) values 34.0, 2.3 and 11.0 microM, respectively). The inhibition mode of (-)-1s for MAO-B was investigated. Chiral HPLC of (+/-)-1s separated the enantiomers and (-)-1s showed MAO-B inhibitory activity. Molecular docking simulation of (-)-1s and MAO-B revealed the binding mode. |
| PubMedSearch : Kamauchi_2024_Chem.Pharm.Bull.(Tokyo)_72_56 |
| PubMedID: 38171905 |
Kamauchi H, Takanashi A, Suzuki M, Izumi K, Takao K, Sugita Y (2024)
Synthesis of 2,8-Dioxabicyclo[3.3.1]nonane Derivatives and Their Neuroprotective Activities
Chem Pharm Bull (Tokyo)
72 :56
Kamauchi H, Takanashi A, Suzuki M, Izumi K, Takao K, Sugita Y (2024)
Chem Pharm Bull (Tokyo)
72 :56