| Title : Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor - Kapkova_2005_J.Med.Chem_48_7496 |
| Author(s) : Kapkova P , Heller E , Unger M , Folkers G , Holzgrabe U |
| Ref : Journal of Medicinal Chemistry , 48 :7496 , 2005 |
|
Abstract :
Random chemistry, the serendipitous generation of small compound libraries by gamma-irradiation of source compounds, presents a methodology providing reassembled and rearranged structures. The gamma-irradiation was applied to generate new acetylcholinesterase (AChE) inhibitors. The bioassay-guided fractionation as a deconvolution strategy was employed to analyze gained product mixture. The structure of the new highly potent AChE inhibitor, 9-amino-5,6,7,8-tetrahydroacridin-4yl)methanol (1), was elucidated by NMR spectroscopy and ESI (tandem) mass spectrometry. |
| PubMedSearch : Kapkova_2005_J.Med.Chem_48_7496 |
| PubMedID: 16279811 |
Kapkova P, Heller E, Unger M, Folkers G, Holzgrabe U (2005)
Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor
Journal of Medicinal Chemistry
48 :7496
Kapkova P, Heller E, Unger M, Folkers G, Holzgrabe U (2005)
Journal of Medicinal Chemistry
48 :7496