Holzgrabe U

General

Full name : Holzgrabe Ulrike

First name : Ulrike

Mail : Department of Pharmaceutical Chemistry, Institute of Pharmacy, Julius-Maximilians-University, Wurzburg

Zip Code :

City :

Country : Germany

Email : u.holzgrabe@pharmazie.uni-wuerzburg.de

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References (42)

Title : N-Substituted piperidine-3-carbohydrazide-hydrazones against Alzheimer's disease: Synthesis and evaluation of cholinesterase, beta-amyloid inhibitory activity, and antioxidant capacity - Parlar_2022_Arch.Pharm.(Weinheim)__e2200519
Author(s) : Parlar S , Sayar G , Tarikogullari AH , Karadagli SS , Alan E , Sevin G , Erciyas E , Holzgrabe U , Alptuzun V
Ref : Arch Pharm (Weinheim) , :e2200519 , 2022
Abstract :
PubMedSearch : Parlar_2022_Arch.Pharm.(Weinheim)__e2200519
PubMedID: 36461719

Title : Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors - Maspero_2020_Bioorg.Chem_96_103633
Author(s) : Maspero M , Volpato D , Cirillo D , Yuan Chen N , Messerer R , Sotriffer C , De Amici M , Holzgrabe U , Dallanoce C
Ref : Bioorg Chem , 96 :103633 , 2020
Abstract :
PubMedSearch : Maspero_2020_Bioorg.Chem_96_103633
PubMedID: 32032848

Title : Synthesis, bioactivity and molecular modeling studies on potential anti-Alzheimer piperidinehydrazide-hydrazones - Parlar_2019_Bioorg.Chem_87_888
Author(s) : Parlar S , Sayar G , Tarikogullari AH , Karadagli SS , Alptuzun V , Erciyas E , Holzgrabe U
Ref : Bioorg Chem , 87 :888 , 2019
Abstract :
PubMedSearch : Parlar_2019_Bioorg.Chem_87_888
PubMedID: 30538051

Title : Bitopic muscarinic agonists and antagonists and uses thereof: a patent evaluation of US20160136145A1 - Holzgrabe_2017_Expert.Opin.Ther.Pat_27_121
Author(s) : Holzgrabe U , Decker M
Ref : Expert Opin Ther Pat , 27 :121 , 2017
Abstract :
PubMedSearch : Holzgrabe_2017_Expert.Opin.Ther.Pat_27_121
PubMedID: 27967250

Title : Acetylcholinesterase inhibitors with photoswitchable inhibition of beta-amyloid aggregation - Chen_2014_ACS.Chem.Neurosci_5_377
Author(s) : Chen X , Wehle S , Kuzmanovic N , Merget B , Holzgrabe U , Konig B , Sotriffer CA , Decker M
Ref : ACS Chem Neurosci , 5 :377 , 2014
Abstract :
PubMedSearch : Chen_2014_ACS.Chem.Neurosci_5_377
PubMedID: 24628027

Title : Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity - Matera_2014_Eur.J.Med.Chem_75C_222
Author(s) : Matera C , Flammini L , Quadri M , Vivo V , Ballabeni V , Holzgrabe U , Mohr K , De Amici M , Barocelli E , Bertoni S , Dallanoce C
Ref : Eur Journal of Medicinal Chemistry , 75C :222 , 2014
Abstract :
PubMedSearch : Matera_2014_Eur.J.Med.Chem_75C_222
PubMedID: 24534538

Title : 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BCHE, and amyloid-beta aggregation crossing the blood-brain barrier - Prinz_2013_Eur.J.Pharm.Sci_49_603
Author(s) : Prinz M , Parlar S , Bayraktar G , Alptuzun V , Erciyas E , Fallarero A , Karlsson D , Vuorela P , Burek M , Forster C , Turunc E , Armagan G , Yalcin A , Schiller C , Leuner K , Krug M , Sotriffer CA , Holzgrabe U
Ref : Eur J Pharm Sci , 49 :603 , 2013
Abstract :
PubMedSearch : Prinz_2013_Eur.J.Pharm.Sci_49_603
PubMedID: 23643737

Title : Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor - Schrage_2013_Br.J.Pharmacol_169_357
Author(s) : Schrage R , Seemann WK , Klockner J , Dallanoce C , Racke K , Kostenis E , De Amici M , Holzgrabe U , Mohr K
Ref : British Journal of Pharmacology , 169 :357 , 2013
Abstract :
PubMedSearch : Schrage_2013_Br.J.Pharmacol_169_357
PubMedID: 23062057

Title : The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling - Bock_2012_Nat.Commun_3_1044
Author(s) : Bock A , Merten N , Schrage R , Dallanoce C , Batz J , Klockner J , Schmitz J , Matera C , Simon K , Kebig A , Peters L , Muller A , Schrobang-Ley J , Trankle C , Hoffmann C , De Amici M , Holzgrabe U , Kostenis E , Mohr K
Ref : Nat Commun , 3 :1044 , 2012
Abstract :
PubMedSearch : Bock_2012_Nat.Commun_3_1044
PubMedID: 22948826

Title : Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors - Ignasik_2012_Arch.Pharm.(Weinheim)_345_509
Author(s) : Ignasik M , Bajda M , Guzior N , Prinz M , Holzgrabe U , Malawska B
Ref : Arch Pharm (Weinheim) , 345 :509 , 2012
Abstract :
PubMedSearch : Ignasik_2012_Arch.Pharm.(Weinheim)_345_509
PubMedID: 22467516

Title : Identification and characterization of diarylimidazoles as hybrid inhibitors of butyrylcholinesterase and amyloid beta fibril formation - Karlsson_2012_Eur.J.Pharm.Sci_45_169
Author(s) : Karlsson D , Fallarero A , Brunhofer G , Guzik P , Prinz M , Holzgrabe U , Erker T , Vuorela P
Ref : Eur J Pharm Sci , 45 :169 , 2012
Abstract :
PubMedSearch : Karlsson_2012_Eur.J.Pharm.Sci_45_169
PubMedID: 22108346

Title : Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases - Alptuzun_2010_Bioorg.Med.Chem_18_2049
Author(s) : Alptuzun V , Prinz M , Horr V , Scheiber J , Radacki K , Fallarero A , Vuorela P , Engels B , Braunschweig H , Erciyas E , Holzgrabe U
Ref : Bioorganic & Medicinal Chemistry , 18 :2049 , 2010
Abstract :
PubMedSearch : Alptuzun_2010_Bioorg.Med.Chem_18_2049
PubMedID: 20149667

Title : Rational design of dualsteric GPCR ligands: quests and promise - Mohr_2010_Br.J.Pharmacol_159_997
Author(s) : Mohr K , Trankle C , Kostenis E , Barocelli E , De Amici M , Holzgrabe U
Ref : British Journal of Pharmacology , 159 :997 , 2010
Abstract :
PubMedSearch : Mohr_2010_Br.J.Pharmacol_159_997
PubMedID: 20136835

Title : Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity - Antony_2009_FASEB.J_23_442
Author(s) : Antony J , Kellershohn K , Mohr-Andra M , Kebig A , Prilla S , Muth M , Heller E , Disingrini T , Dallanoce C , Bertoni S , Schrobang J , Trankle C , Kostenis E , Christopoulos A , Holtje HD , Barocelli E , De Amici M , Holzgrabe U , Mohr K
Ref : FASEB Journal , 23 :442 , 2009
Abstract :
PubMedSearch : Antony_2009_FASEB.J_23_442
PubMedID: 18842964

Title : Targeting acetylcholinesterase to treat neurodegeneration - Holzgrabe_2007_Expert.Opin.Ther.Targets_11_161
Author(s) : Holzgrabe U , Kapkova P , Alptuzun V , Scheiber J , Kugelmann E
Ref : Expert Opin Ther Targets , 11 :161 , 2007
Abstract :
PubMedSearch : Holzgrabe_2007_Expert.Opin.Ther.Targets_11_161
PubMedID: 17227232

Title : Allosteric small molecules unveil a role of an extracellular E2\/transmembrane helix 7 junction for G protein-coupled receptor activation - Jager_2007_J.Biol.Chem_282_34968
Author(s) : Jager D , Schmalenbach C , Prilla S , Schrobang J , Kebig A , Sennwitz M , Heller E , Trankle C , Holzgrabe U , Holtje HD , Mohr K
Ref : Journal of Biological Chemistry , 282 :34968 , 2007
Abstract :
PubMedSearch : Jager_2007_J.Biol.Chem_282_34968
PubMedID: 17890226

Title : Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist - Grossmuller_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_372_267
Author(s) : Grossmuller M , Antony J , Trankle C , Holzgrabe U , Mohr K
Ref : Naunyn Schmiedebergs Arch Pharmacol , 372 :267 , 2006
Abstract :
PubMedSearch : Grossmuller_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_372_267
PubMedID: 16362429

Title : Allosteric modulators and selective agonists of muscarinic receptors - Holzgrabe_2006_J.Mol.Neurosci_30_165
Author(s) : Holzgrabe U , De Amici M , Mohr K
Ref : Journal of Molecular Neuroscience , 30 :165 , 2006
Abstract :
PubMedSearch : Holzgrabe_2006_J.Mol.Neurosci_30_165
PubMedID: 17192667

Title : Search for dual function inhibitors for Alzheimer's disease: synthesis and biological activity of acetylcholinesterase inhibitors of pyridinium-type and their Abeta fibril formation inhibition capacity - Kapkova_2006_Bioorg.Med.Chem_14_472
Author(s) : Kapkova P , Alptuzun V , Frey P , Erciyas E , Holzgrabe U
Ref : Bioorganic & Medicinal Chemistry , 14 :472 , 2006
Abstract :
PubMedSearch : Kapkova_2006_Bioorg.Med.Chem_14_472
PubMedID: 16198581

Title : Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2\/M5 chimeric receptors - Trankle_2005_Mol.Pharmacol_68_1597
Author(s) : Trankle C , Dittmann A , Schulz U , Weyand O , Buller S , Johren K , Heller E , Birdsall NJ , Holzgrabe U , Ellis J , Holtje HD , Mohr K
Ref : Molecular Pharmacology , 68 :1597 , 2005
Abstract :
PubMedSearch : Trankle_2005_Mol.Pharmacol_68_1597
PubMedID: 16157694

Title : Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor - Kapkova_2005_J.Med.Chem_48_7496
Author(s) : Kapkova P , Heller E , Unger M , Folkers G , Holzgrabe U
Ref : Journal of Medicinal Chemistry , 48 :7496 , 2005
Abstract :
PubMedSearch : Kapkova_2005_J.Med.Chem_48_7496
PubMedID: 16279811

Title : Synthesis, biological activity, and docking studies of new acetylcholinesterase inhibitors of the bispyridinium type - Kapkova_2003_Arch.Pharm.(Weinheim)_336_523
Author(s) : Kapkova P , Stiefl N , Surig U , Engels B , Baumann K , Holzgrabe U
Ref : Arch Pharm (Weinheim) , 336 :523 , 2003
Abstract :
PubMedSearch : Kapkova_2003_Arch.Pharm.(Weinheim)_336_523
PubMedID: 14639745

Title : Synthesis and biological activity of pyridinium-type acetylcholinesterase inhibitors - Alptuzun_2003_J.Pharm.Pharmacol_55_1397
Author(s) : Alptuzun V , Kapkova P , Baumann K , Erciyas E , Holzgrabe U
Ref : J Pharm Pharmacol , 55 :1397 , 2003
Abstract :
PubMedSearch : Alptuzun_2003_J.Pharm.Pharmacol_55_1397
PubMedID: 14607022

Title : Structure\/activity relationships of M2 muscarinic allosteric modulators - Mohr_2003_Receptors.Channels_9_229
Author(s) : Mohr K , Trankle C , Holzgrabe U
Ref : Receptors Channels , 9 :229 , 2003
Abstract :
PubMedSearch : Mohr_2003_Receptors.Channels_9_229
PubMedID: 12893536

Title : Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding - Muth_2003_J.Med.Chem_46_1031
Author(s) : Muth M , Bender W , Scharfenstein O , Holzgrabe U , Balatkova E , Trankle C , Mohr K
Ref : Journal of Medicinal Chemistry , 46 :1031 , 2003
Abstract :
PubMedSearch : Muth_2003_J.Med.Chem_46_1031
PubMedID: 12620079

Title : Cooperative interactions at M2 muscarinic acetylcholine receptors: structure\/activity relationships in stepwise shortened bispyridinium- and bis(ammonio)alkane-type allosteric modulators - Gilsbach_2003_Neurochem.Res_28_667
Author(s) : Gilsbach R , Grossmuller M , Alptuzun V , Erciyas E , Trankle C , Holzgrabe U , Mohr K
Ref : Neurochem Res , 28 :667 , 2003
Abstract :
PubMedSearch : Gilsbach_2003_Neurochem.Res_28_667
PubMedID: 12675159

Title : Elevation of ligand binding to muscarinic M(2) acetylcholine receptors by bis(ammonio)alkane-type allosteric modulators - Raasch_2002_J.Med.Chem_45_3809
Author(s) : Raasch A , Scharfenstein O , Trankle C , Holzgrabe U , Mohr K
Ref : Journal of Medicinal Chemistry , 45 :3809 , 2002
Abstract :
PubMedSearch : Raasch_2002_J.Med.Chem_45_3809
PubMedID: 12166953

Title : Poster: Ligand for the common allosteric site of M2-receptors of subnanomolar potency -
Author(s) : Holzgrabe U , Bender W , Balatkova E , Trankle C , Mohr K
Ref : Life Sciences , 68 :2620 , 2001
PubMedID:

Title : Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically - Botero Cid_2000_J.Med.Chem_43_2155
Author(s) : Botero Cid HM , Trankle C , Baumann K , Pick R , Mies-Klomfass E , Kostenis E , Mohr K , Holzgrabe U
Ref : Journal of Medicinal Chemistry , 43 :2155 , 2000
Abstract :
PubMedSearch : Botero Cid_2000_J.Med.Chem_43_2155
PubMedID: 10841794

Title : Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors - Bender_2000_Life.Sci_66_1675
Author(s) : Bender W , Staudt M , Trankle C , Mohr K , Holzgrabe U
Ref : Life Sciences , 66 :1675 , 2000
Abstract :
PubMedSearch : Bender_2000_Life.Sci_66_1675
PubMedID: 10809164

Title : Ligands for the common allosteric site of acetylcholine M2-receptors: development and application - Holzgrabe_2000_Pharm.Acta.Helv_74_149
Author(s) : Holzgrabe U , Bender W , Cid HM , Staudt M , Pick R , Pfletschinger C , Balatkova E , Trankle C , Mohr K
Ref : Pharm Acta Helv , 74 :149 , 2000
Abstract :
PubMedSearch : Holzgrabe_2000_Pharm.Acta.Helv_74_149
PubMedID: 10812952

Title : Poster: Probing the overlap of the selective antagonist AF-DX 384 with the allosteric site of muscarinic M2 receptors -
Author(s) : Mohr K , Ataie-Ghassemi A , Holzgrabe U
Ref : Life Sciences , 64 :560 , 1999
PubMedID:

Title : Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements - Nassif-Makki_1999_J.Med.Chem_42_849
Author(s) : Nassif-Makki T , Trankle C , Zlotos D , Bejeuhr G , Cambareri A , Pfletschinger C , Kostenis E , Mohr K , Holzgrabe U
Ref : Journal of Medicinal Chemistry , 42 :849 , 1999
Abstract :
PubMedSearch : Nassif-Makki_1999_J.Med.Chem_42_849
PubMedID: 10072682

Title : Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors - Trankle_1998_Mol.Pharmacol_54_139
Author(s) : Trankle C , Mies-Klomfass E , Botero Cid HM , Holzgrabe U , Mohr K
Ref : Molecular Pharmacology , 54 :139 , 1998
Abstract :
PubMedSearch : Trankle_1998_Mol.Pharmacol_54_139
PubMedID: 9658199

Title : Stability of mono- and bisbenzyloxime ethers of the acetylcholinesterase reactivator TMB-4(Trimedoxime) - Inkmann_1997_Pharmazie_52_764
Author(s) : Inkmann E , Holzgrabe U , Hesse KF
Ref : Pharmazie , 52 :764 , 1997
Abstract :
PubMedSearch : Inkmann_1997_Pharmazie_52_764
PubMedID: 9362091

Title : Poster: Influence of the lateral substituents of bispyridinium compounds on the mode of allosteric action on muscarinic M2-receptors -
Author(s) : Schulz U , Trankle C , Botero Cid HM , Holzgrabe U , Mohr K
Ref : Life Sciences , 60 :1172 , 1997
PubMedID:

Title : Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors - Kostenis_1996_Eur.J.Pharmacol_314_385
Author(s) : Kostenis E , Botero Cid HM , Holzgrabe U , Mohr K
Ref : European Journal of Pharmacology , 314 :385 , 1996
Abstract :
PubMedSearch : Kostenis_1996_Eur.J.Pharmacol_314_385
PubMedID: 8957263

Title : Poster: Potentiation of the action of N-methylscopolamine in guinea pig atria by the allosteric antagonists tetra-W84, W84, and alcuronium -
Author(s) : Maass A , Kostenis E , Holzgrabe U , Mohr K
Ref : Life Sciences , 56(11-12) :1008 , 1995
PubMedID:

Title : Poster: Side chain variations in bispyridinium-type allosteric modulators of M2-cholinoceptors -
Author(s) : Kostenis E , Botero Cid HM , Holzgrabe U , Mohr K
Ref : Life Sciences , 56(11-12) :1009 , 1995
PubMedID:

Title : A stable and highly potent hexamethonium derivative which modulates muscarinic receptors allosterically in guinea-pig hearts - Bejeuhr_1994_J.Pharm.Pharmacol_46_108
Author(s) : Bejeuhr G , Blaschke G , Holzgrabe U , Mohr K , Surig U , Terfloth G
Ref : J Pharm Pharmacol , 46 :108 , 1994
Abstract :
PubMedSearch : Bejeuhr_1994_J.Pharm.Pharmacol_46_108
PubMedID: 7912726

Title : Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors - Botero Cid_1994_J.Med.Chem_37_1439
Author(s) : Botero Cid HM , Holzgrabe U , Kostenis E , Mohr K , Trankle C
Ref : Journal of Medicinal Chemistry , 37 :1439 , 1994
Abstract :
PubMedSearch : Botero Cid_1994_J.Med.Chem_37_1439
PubMedID: 8182702

Title : Poster: On the over-additive antimuscarinic action with atropine of potent allosteric stabilizers of antagonist binding to M2-receptors -
Author(s) : Mohr K , Holzgrabe U , Luss H , Trankle C
Ref : Life Sciences , 52(5-6) :564 , 1993
PubMedID: