Kassa_2004_Mil.Med.Sci.Lett_73_107

Male NMRI mice were used to test the influence of orally administered prophylactic mean PANPAL on acute toxic effects of tabun and to compare its efficacy with the commonly used pyridostigmine by means of protective ratio evaluation. The effect of antidotal treatment of acute tabun poisoning which depends on the choice of anticholinergic drug or the addition of anticonvulsive drug was compared in the same way. Then the reactivating efficacy of selected oximes was tested on Wistar rats using evaluation of the percentage of tabun-inhibited acetylchollinesterase reactivation in blood, the diaphragm and in the brain of poisoned rats 30 minutes after poisoning and antidotal treatment. We also used the rats to test the influence of pharmacological prophylaxis and the choice of a suitable reactivator for tabun-induced neurotoxic symptoms with the help of functional observatory battery.The results confirm that obidoxime seems to be the most suitable acetylcholinesterase reactivator while the oxime HI-6, which is very effective against soman, is practically ineffective against tabun. Trimedoxim also appears to be a prospective acetylcholinesterase reactivator for the antidotal treatment of tabun poisoning. In order to achieve the sufficient effectiveness of antidotal treatment of acute tabun poisonings, the commonly used anticholinergic drug atropine should be replaced by a cholinolytic drug with pronounced central effects (biperiden, benactyzine, scopolamine). If atropine is used for the antidotal treatment of tabun poisoning, the addition of an anticonvulsive drug such as diazepam is suitable. If PANPAL is administered in case of tabun exposure threat, the resistance of the exposed organism as well as the efficacy of postexposure antidotal treatment are significantly increased. Unlike PANPAL, pyridostigmine is not practically effective against acute toxic effects of tabun.