Full name : Kuca Kamil
First name : Kamil
Mail : Faculty of Military Health Sciences\; Center of Advanced Studies\; Trebesska 1575\; Hradec Kralove\; 500
Zip Code :
City :
Country : Czech Republic
Email : kamil.kuca@uhk.cz
Phone : +420973253028
Fax :
Website : \/\/www.unob.cz\/en\/fmhs\/structure\/k311\/Pages\/Kuca.aspx
Directory :
Comment
Title : Novel chlorinated oxime K870 protects rats against paraoxon poisoning better than obidoxime - Maksimovic_2025_Drug.Chem.Toxicol__1 |
Author(s) : Maksimovic z M , S TM , Dukanovic D , Mandic-Kovacevic N , Uletilovic S , Duran M , Kuca K , Musilek K , Loncar-Stojiljkovic D , Skrbic R , Stojiljkovic MP |
Ref : Drug & Chemical Toxicology , :1 , 2025 |
Abstract : |
PubMedSearch : Maksimovic_2025_Drug.Chem.Toxicol__1 |
PubMedID: 39871446 |
Title : Association of BCHE gene SNP rs1803274 (K-variant) and rs3495 with obesity in Pakistani population group - Amir_2025_Int.J.Obes.(Lond)__ |
Author(s) : Amir A , Hussain S , Shah STA , Habib R , Muneer Z , Nepovimova E , Kuca K , Nurulain SM |
Ref : Int J Obes (Lond) , : , 2025 |
Abstract : |
PubMedSearch : Amir_2025_Int.J.Obes.(Lond)__ |
PubMedID: 39875593 |
Gene_locus related to this paper: human-BCHE |
Title : Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats - Jacevic_2024_Chem.Biol.Interact_399_111138 |
Author(s) : Jacevic V , Grujic-Milanovic J , Milovanovic Z , Nezic L , Amidzic L , Vojinovic N , Markovic B , Dobricic V , Milosavljevic P , Nepovimova E , Kuca K |
Ref : Chemico-Biological Interactions , 399 :111138 , 2024 |
Abstract : |
PubMedSearch : Jacevic_2024_Chem.Biol.Interact_399_111138 |
PubMedID: 38992768 |
Title : Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate - Bernardo_2024_Arch.Toxicol__ |
Author(s) : Bernardo LB , Borges CVN , Buitrago PAG , Kuca K , Cavalcante SFA , Sousa RB , Lima ALS , Kitagawa DAS |
Ref : Archives of Toxicology , : , 2024 |
Abstract : |
PubMedSearch : Bernardo_2024_Arch.Toxicol__ |
PubMedID: 39004640 |
Title : Drosophila melanogaster as a model organism for screening acetylcholinesterase reactivators - Macedo_2024_J.Toxicol.Environ.Health.A__1 |
Author(s) : Macedo PE , Batista JES , Souza LR , Dafre AL , Farina M , Kuca K , Posser T , Pinto PM , Boldo JT , Franco JL |
Ref : J Toxicol Environ Health A , :1 , 2024 |
Abstract : |
PubMedSearch : Macedo_2024_J.Toxicol.Environ.Health.A__1 |
PubMedID: 39292449 |
Gene_locus related to this paper: drome-ACHE |
Title : In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents' surrogates - Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678 |
Author(s) : Kitagawa DAS , Dos Santos MC , Kuca K , Franca TCC , Cavalcante SFA |
Ref : Chemico-Biological Interactions , 383 :110678 , 2023 |
Abstract : |
PubMedSearch : Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678 |
PubMedID: 37595776 |
Title : Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators - Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735 |
Author(s) : Kapitanov IV , Spulak M , Pour M , Soukup O , Marek J , Jun D , Novak M , Diz de Almeida JSF , Franca TCC , Gathergood N , Kuca K , Karpichev Y |
Ref : Chemico-Biological Interactions , :110735 , 2023 |
Abstract : |
PubMedSearch : Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735 |
PubMedID: 37802409 |
Title : Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study - Kuca_2023_Chem.Biol.Interact_14ChEPon_110734 |
Author(s) : Kuca K , Valle da Silva JA , Nepovimova E , Pham NL , Wu W , Valis M , Wu Q , Franca TCC |
Ref : Chemico-Biological Interactions , :110734 , 2023 |
Abstract : |
PubMedSearch : Kuca_2023_Chem.Biol.Interact_14ChEPon_110734 |
PubMedID: 37788753 |
Title : The measured CSF\/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24h after donepezil treatment in patients with Alzheimer's disease - Valis_2023_Biomed.Pharmacother_159_114223 |
Author(s) : Valis M , Dlabkova A , Hort J , Angelucci F , Pejchal J , Kuca K , Pavelek Z , Karasova JZ , Novotny M |
Ref : Biomed Pharmacother , 159 :114223 , 2023 |
Abstract : |
PubMedSearch : Valis_2023_Biomed.Pharmacother_159_114223 |
PubMedID: 36630846 |
Title : Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups - Bibi_2023_Sci.Total.Environ__163359 |
Author(s) : Bibi S , Habib R , Shafiq S , Abbas SS , Khan S , Eqani S , Nepovimova E , Khan MS , Kuca K , Nurulain SM |
Ref : Sci Total Environ , :163359 , 2023 |
Abstract : |
PubMedSearch : Bibi_2023_Sci.Total.Environ__163359 |
PubMedID: 37030382 |
Title : Applications of the Near Attack Conformation (NAC) approach in the search for Acetylcholinesterase reactivators - Franca_2023_Chem.Biol.Interact_14ChEPon_382_110619 |
Author(s) : Franca TCC , Valle da Silva JA , Dos Santos MC , Cavalcante SFA , Kuca K |
Ref : Chemico-Biological Interactions , 382 :110619 , 2023 |
Abstract : |
PubMedSearch : Franca_2023_Chem.Biol.Interact_14ChEPon_382_110619 |
PubMedID: 37406983 |
Title : Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes - Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658 |
Author(s) : Jacevic V , Dumanovic J , Grujic-Milanovic J , Milovanovic Z , Amidzic L , Vojinovic N , Nezic L , Markovic B , Dobricic V , Milosavljevic P , Nepovimova E , Kuca K |
Ref : Chemico-Biological Interactions , :110658 , 2023 |
Abstract : |
PubMedSearch : Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658 |
PubMedID: 37572873 |
Title : N-substituted arylhydroxamic acids as acetylcholinesterase reactivators - Bondar_2022_Chem.Biol.Interact__110078 |
Author(s) : Bondar D , Kapitanov I , Pulkrabkova L , Soukup O , Jun D , Diniz FB , Franca TCC , Kuca K , Karpichev Y |
Ref : Chemico-Biological Interactions , :110078 , 2022 |
Abstract : |
PubMedSearch : Bondar_2022_Chem.Biol.Interact__110078 |
PubMedID: 35940282 |
Title : Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series? - Santos_2022_Arch.Toxicol__ |
Author(s) : Santos MC , Botelho FD , Goncalves AS , Kitagawa DAS , Borges CVN , Carvalho-Silva T , Bernardo LB , Ferreira CN , Rodrigues RB , Ferreira Neto DC , Nepovimova E , Kuca K , LaPlante SR , Lima ALS , Franca TCC , Cavalcante SFA |
Ref : Archives of Toxicology , : , 2022 |
Abstract : |
PubMedSearch : Santos_2022_Arch.Toxicol__ |
PubMedID: 35666269 |
Title : Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok) - Santos_2022_Food.Chem.Toxicol__113084 |
Author(s) : Santos MC , Botelho FD , Goncalves AS , Kuca K , Nepovimova E , Cavalcante SFA , Lima ALS , Franca TCC |
Ref : Food & Chemical Toxicology , :113084 , 2022 |
Abstract : |
PubMedSearch : Santos_2022_Food.Chem.Toxicol__113084 |
PubMedID: 35489467 |
Title : Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities - Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
Author(s) : Chrienova Z , Nepovimova E , Andrys R , Dolezal R , Janockova J , Muckova L , Fabova L , Soukup O , Oleksak P , Valis M , Korabecny J , Marco-Contelles J , Kuca K |
Ref : J Enzyme Inhib Med Chem , 37 :2605 , 2022 |
Abstract : |
PubMedSearch : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
PubMedID: 36131624 |
Title : Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data - Ramalho_2022_Curr.Med.Chem__ |
Author(s) : Ramalho TC , de Castro AA , Leal DHS , Teixeira JP , de Cunha EFF , Kuca K |
Ref : Curr Med Chem , : , 2022 |
Abstract : |
PubMedSearch : Ramalho_2022_Curr.Med.Chem__ |
PubMedID: 36239718 |
Title : Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers - Khan_2022_Environ.Res__115195 |
Author(s) : Khan SA , Ntepe LJM , Abbas Shah ST , Bibi N , Muneer Z , Hussain S , Nepovimova E , Kuca K , Nurulain SM |
Ref : Environ Research , :115195 , 2022 |
Abstract : |
PubMedSearch : Khan_2022_Environ.Res__115195 |
PubMedID: 36592809 |
Title : Multiple Neurological Effects Associated with Exposure to Organophosphorus Pesticides in Man - Jokanovic_2022_Toxicology__153407 |
Author(s) : Jokanovic M , Oleksak P , Kuca K |
Ref : Toxicology , :153407 , 2022 |
Abstract : |
PubMedSearch : Jokanovic_2022_Toxicology__153407 |
PubMedID: 36543276 |
Title : Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators - Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370 |
Author(s) : Kitagawa DAS , Rodrigues RB , Silva TN , Dos Santos WV , da Rocha VCV , de Almeida JSFD , Bernardo LB , Carvalho-Silva T , Ferreira CN , da Silva AAT , Simas ABC , Nepovimova E , Kuca K , Franca TCC , Cavalcante SFA |
Ref : J Enzyme Inhib Med Chem , 36 :1370 , 2021 |
Abstract : |
PubMedSearch : Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370 |
PubMedID: 34148470 |
Title : Chronic Exposure to Organophosphates Pesticides and Risk of Metabolic Disorder in Cohort from Pakistan and Cameroon - Ntepe_2021_Int.J.Environ.Res.Public.Health_18_ |
Author(s) : Ntepe LJM , Habib R , Ngondi JL , Abbas Shah ST , Valis M , Kuca K , Nurulain SM |
Ref : Int J Environ Research Public Health , 18 : , 2021 |
Abstract : |
PubMedSearch : Ntepe_2021_Int.J.Environ.Res.Public.Health_18_ |
PubMedID: 33652791 |
Title : Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease - Hamulakova_2021_Future.Med.Chem__ |
Author(s) : Hamulakova S , Kudlickova Z , Janovec L , Mezencev R , Deckner ZJ , Chernoff YO , Janockova J , Ihnatova V , Bzonek P , Novakova N , Hepnarova V , Hrabinova M , Jun D , Korabecny J , Soukup O , Kuca K |
Ref : Future Med Chem , : , 2021 |
Abstract : |
PubMedSearch : Hamulakova_2021_Future.Med.Chem__ |
PubMedID: 33829876 |
Title : Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl - Lorke_2021_Int.J.Mol.Sci_22_ |
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
Ref : Int J Mol Sci , 22 : , 2021 |
Abstract : |
PubMedSearch : Lorke_2021_Int.J.Mol.Sci_22_ |
PubMedID: 33802843 |
Title : Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells - Hudacova_2021_Int.J.Mol.Sci_22_ |
Author(s) : Hudacova M , Hamuakova S , Konkoova E , Jendzelovsky R , Vargova J , Sevc J , Fedorocko P , Soukup O , Janockova J , Ihnatova V , Kucera T , Bzonek P , Novakova N , Jun D , Junova L , Korabecny J , Kuca K , Kozurkova M |
Ref : Int J Mol Sci , 22 : , 2021 |
Abstract : |
PubMedSearch : Hudacova_2021_Int.J.Mol.Sci_22_ |
PubMedID: 33917200 |
Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596 |
Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K |
Ref : Bioorg Chem , 107 :104596 , 2020 |
Abstract : |
PubMedSearch : Nepovimova_2020_Bioorg.Chem_107_104596 |
PubMedID: 33421953 |
Title : Combined Pre- and Posttreatment of Paraoxon Exposure - Lorke_2020_Molecules_25_ |
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
Ref : Molecules , 25 : , 2020 |
Abstract : |
PubMedSearch : Lorke_2020_Molecules_25_ |
PubMedID: 32230733 |
Title : Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators - Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
Author(s) : Malinak D , Dolezal R , Hepnarova V , Hozova M , Andrys R , Bzonek P , Racakova V , Korabecny J , Gorecki L , Mezeiova E , Psotka M , Jun D , Kuca K , Musilek K |
Ref : J Enzyme Inhib Med Chem , 35 :478 , 2020 |
Abstract : |
PubMedSearch : Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
PubMedID: 31910701 |
Title : Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study - da Silva_2020_Biomolecules_10_ |
Author(s) : da Silva JAV , Pereira AF , LaPlante SR , Kuca K , Ramalho TC , Franca TCC |
Ref : Biomolecules , 10 : , 2020 |
Abstract : |
PubMedSearch : da Silva_2020_Biomolecules_10_ |
PubMedID: 32012780 |
Title : Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors - Botelho_2020_Toxins.(Basel)_12_ |
Author(s) : Botelho FD , Dos Santos MC , Goncalves ADS , Kuca K , Valis M , LaPlante SR , Franca TCC , de Almeida J |
Ref : Toxins (Basel) , 12 : , 2020 |
Abstract : |
PubMedSearch : Botelho_2020_Toxins.(Basel)_12_ |
PubMedID: 33256167 |
Title : Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer's Drugs: Spectroscopic Insights - Sharma_2020_J.Biomol.Struct.Dyn_38_1822 |
Author(s) : Sharma S , Singh N , Nepovimova E , Korabecny J , Kuca K , Satnami ML , Ghosh KK |
Ref : J Biomol Struct Dyn , 38 :1822 , 2020 |
Abstract : |
PubMedSearch : Sharma_2020_J.Biomol.Struct.Dyn_38_1822 |
PubMedID: 31096863 |
Title : Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602 - Furqan_2020_Biomolecules_10_ |
Author(s) : Furqan T , Batool S , Habib R , Shah M , Kalasz H , Darvas F , Kuca K , Nepovimova E , Nurulain SM |
Ref : Biomolecules , 10 : , 2020 |
Abstract : |
PubMedSearch : Furqan_2020_Biomolecules_10_ |
PubMedID: 32414087 |
Title : Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan - Ntepe_2020_Int.J.Mol.Sci_21_ |
Author(s) : Ntepe LJM , Habib R , Ngondi JL , Raza S , Nepovimova E , Kuca K , Batool S , Nurulain SM |
Ref : Int J Mol Sci , 21 : , 2020 |
Abstract : |
PubMedSearch : Ntepe_2020_Int.J.Mol.Sci_21_ |
PubMedID: 32899431 |
Title : Acetylcholinesterase: The Hub for Neurodegenerative Diseases and Chemical Weapons Convention - Cavalcante_2020_Biomolecules_10_ |
Author(s) : Cavalcante SFA , Simas ABC , Barcellos MC , de Oliveira VGM , Sousa RB , Cabral PAM , Kuca K , Franca TCC |
Ref : Biomolecules , 10 : , 2020 |
Abstract : |
PubMedSearch : Cavalcante_2020_Biomolecules_10_ |
PubMedID: 32155996 |
Title : Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects - de Castro_2020_Int.J.Mol.Sci_21_ |
Author(s) : de Castro AA , Polisel DA , Pereira BTL , da Cunha EFF , Kuca K , Nepovimova E , Ramalho TC |
Ref : Int J Mol Sci , 21 : , 2020 |
Abstract : |
PubMedSearch : de Castro_2020_Int.J.Mol.Sci_21_ |
PubMedID: 32899591 |
Title : Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations - Leonel_2020_Environ.Res__110210 |
Author(s) : Leonel Javeres MN , Habib R , Judith N , Iqbal M , Nepovimova E , Kuca K , Batool S , Nurulain SM |
Ref : Environ Research , :110210 , 2020 |
Abstract : |
PubMedSearch : Leonel_2020_Environ.Res__110210 |
PubMedID: 32949615 |
Title : Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019) - de Castro_2020_Biomolecules_10_ |
Author(s) : de Castro AA , Assis LC , Soares FV , Kuca K , Polisel DA , da Cunha EFF , Ramalho TC |
Ref : Biomolecules , 10 : , 2020 |
Abstract : |
PubMedSearch : de Castro_2020_Biomolecules_10_ |
PubMedID: 32178264 |
Title : Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats - Karasova_2020_Iran.J.Pharm.Res_19_95 |
Author(s) : Karasova JZ , Hrabinova M , Krejciova M , Jun D , Kuca K |
Ref : Iran J Pharm Res , 19 :95 , 2020 |
Abstract : |
PubMedSearch : Karasova_2020_Iran.J.Pharm.Res_19_95 |
PubMedID: 33680013 |
Title : Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness - Karasova_2020_Toxicol.Lett_320_64 |
Author(s) : Karasova JZ , Hepnarova V , Andrys R , Lisa M , Jost P , Muckova L , Pejchal J , Herman D , Jun D , Kassa J , Kuca K |
Ref : Toxicol Lett , 320 :64 , 2020 |
Abstract : |
PubMedSearch : Karasova_2020_Toxicol.Lett_320_64 |
PubMedID: 31794810 |
Title : Review about structure and evaluation of reactivators of Acetylcholinesterase inhibited with neurotoxic organophosphorus compounds - Figueroa-Villar_2020_Curr.Med.Chem__ |
Author(s) : Figueroa-Villar JD , Petronilho EC , Kuca K , Franca TCC |
Ref : Curr Med Chem , : , 2020 |
Abstract : |
PubMedSearch : Figueroa-Villar_2020_Curr.Med.Chem__ |
PubMedID: 32334495 |
Title : Glycosylated-Imidazole Aldoximes as Reactivators of Pesticides Inhibited AChE: Synthesis and In-vitro Reactivation Study - Sharma_2020_Environ.Toxicol.Pharmacol__103454 |
Author(s) : Sharma R , Upadhyaya K , Gupta B , Ghosh KK , Tripathi RP , Musilek K , Kuca K |
Ref : Environ Toxicol Pharmacol , :103454 , 2020 |
Abstract : |
PubMedSearch : Sharma_2020_Environ.Toxicol.Pharmacol__103454 |
PubMedID: 32645360 |
Title : Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors - Gorecki_2020_ACS.Med.Chem.Lett_11_65 |
Author(s) : Gorecki L , Andrys R , Schmidt M , Kucera T , Psotka M , Svobodova B , Hrabcova V , Hepnarova V , Bzonek P , Jun D , Kuca K , Korabecny J , Musilek K |
Ref : ACS Med Chem Lett , 11 :65 , 2020 |
Abstract : |
PubMedSearch : Gorecki_2020_ACS.Med.Chem.Lett_11_65 |
PubMedID: 31938465 |
Title : An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment - Wu_2020_Arch.Toxicol_94_3645 |
Author(s) : Wu Q , Qin Z , Kuca K , You L , Zhao Y , Liu A , Musilek K , Chrienova Z , Nepovimova E , Oleksak P , Wu W , Wang X |
Ref : Archives of Toxicology , 94 :3645 , 2020 |
Abstract : |
PubMedSearch : Wu_2020_Arch.Toxicol_94_3645 |
PubMedID: 32910237 |
Title : Oxime K203: a drug candidate for the treatment of tabun intoxication - Gorecki_2019_Arch.Toxicol_93_673 |
Author(s) : Gorecki L , Soukup O , Kucera T , Malinak D , Jun D , Kuca K , Musilek K , Korabecny J |
Ref : Archives of Toxicology , 93 :673 , 2019 |
Abstract : |
PubMedSearch : Gorecki_2019_Arch.Toxicol_93_673 |
PubMedID: 30564897 |
Title : N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy - Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
Author(s) : Nepovimova E , Korabecny J , Hepnarova V , Jun D , Dolezal R , Muckova L , Jost P , Soukup O , Janockova J , Pham NL , Nguyen TD , Valis M , Kuca K |
Ref : Curr Alzheimer Res , 16 :333 , 2019 |
Abstract : |
PubMedSearch : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
PubMedID: 30873921 |
Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
Abstract : |
PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
PubMedID: 30851693 |
Gene_locus related to this paper: torca-ACHE |
Title : Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13 - Cruz_2019_J.Biomol.Struct.Dyn_37_1616 |
Author(s) : Cruz JN , Costa JFS , Khayat AS , Kuca K , Barros CAL , Neto A |
Ref : J Biomol Struct Dyn , 37 :1616 , 2019 |
Abstract : |
PubMedSearch : Cruz_2019_J.Biomol.Struct.Dyn_37_1616 |
PubMedID: 29633908 |
Title : Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease - de Oliveira_2019_Int.J.Mol.Sci_20_ |
Author(s) : de Oliveira CBJ , Neto DCF , de Almeida JSFD , Lima JA , Kuca K , Franca TCC , Figueroa-Villar JD |
Ref : Int J Mol Sci , 20 : , 2019 |
Abstract : |
PubMedSearch : de Oliveira_2019_Int.J.Mol.Sci_20_ |
PubMedID: 31416113 |
Title : Biodegradation of Organophosphorus Compounds Predicted by Enzymatic Process Using Molecular Modelling and Observed in Soil Samples Through Analytical Techniques and Microbiological Analysis: A Comparison - Cardozo_2019_Molecules_25_ |
Author(s) : Cardozo M , de Almeida J , Cavalcante SFA , Salgado JRS , Goncalves AS , Franca TCC , Kuca K , Bizzo HR |
Ref : Molecules , 25 : , 2019 |
Abstract : |
PubMedSearch : Cardozo_2019_Molecules_25_ |
PubMedID: 31878010 |
Title : Non-conventional compounds with potential therapeutic effects against Alzheimer's disease - de Castro_2019_Expert.Rev.Neurother_19_375 |
Author(s) : de Castro AA , Soares FV , Pereira AF , Polisel DA , Caetano MS , Leal DHS , da Cunha EFF , Nepovimova E , Kuca K , Ramalho TC |
Ref : Expert Rev Neurother , 19 :375 , 2019 |
Abstract : |
PubMedSearch : de Castro_2019_Expert.Rev.Neurother_19_375 |
PubMedID: 30999771 |
Title : Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes - Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16 |
Author(s) : Zorbaz T , Malinak D , Kuca K , Musilek K , Kovarik Z |
Ref : Chemico-Biological Interactions , 307 :16 , 2019 |
Abstract : |
PubMedSearch : Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16 |
PubMedID: 31004594 |
Title : In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers - Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877 |
Author(s) : Janockova J , Korabecny J , Plsikova J , Babkova K , Konkolova E , Kucerova D , Vargova J , Koval J , Jendzelovsky R , Fedorocko P , Kasparkova J , Brabec V , Rosocha J , Soukup O , Hamulakova S , Kuca K , Kozurkova M |
Ref : J Enzyme Inhib Med Chem , 34 :877 , 2019 |
Abstract : |
PubMedSearch : Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877 |
PubMedID: 30938202 |
Title : Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models - Iqbal_2019_Chem.Biol.Interact_13ChEPon_310_108735 |
Author(s) : Iqbal A , Malik S , Nurulain SM , Musilek K , Kuca K , Kalasz H , Fatmi MQ |
Ref : Chemico-Biological Interactions , 310 :108735 , 2019 |
Abstract : |
PubMedSearch : Iqbal_2019_Chem.Biol.Interact_13ChEPon_310_108735 |
PubMedID: 31276662 |
Title : Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning - Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737 |
Author(s) : Tekes K , Karvaly G , Nurulain SM , Kuca K , Musilek K , Adeghate E , Jung YS , Kalasz H |
Ref : Chemico-Biological Interactions , 310 :108737 , 2019 |
Abstract : |
PubMedSearch : Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737 |
PubMedID: 31279792 |
Title : Tacrine and its 7-methoxy derivate\; time-change concentration in plasma and brain tissue and basic toxicological profile in rats - Karasova_2019_Drug.Chem.Toxicol__1 |
Author(s) : Karasova JZ , Soukup O , Korabecny J , Hroch M , Krejciova M , Hrabinova M , Misik J , Novotny L , Hepnarova V , Kuca K |
Ref : Drug & Chemical Toxicology , :1 , 2019 |
Abstract : |
PubMedSearch : Karasova_2019_Drug.Chem.Toxicol__1 |
PubMedID: 31257938 |
Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC |
Ref : J Enzyme Inhib Med Chem , 34 :1018 , 2019 |
Abstract : |
PubMedSearch : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
PubMedID: 31074292 |
Title : Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths - da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195 |
Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC |
Ref : Chemico-Biological Interactions , 307 :195 , 2019 |
Abstract : |
PubMedSearch : da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195 |
PubMedID: 31121152 |
Title : Interspecies and intergender differences in acute toxicity of K-oximes drug candidates - Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312 |
Author(s) : Jacevic V , Nepovimova E , Kuca K |
Ref : Chemico-Biological Interactions , 308 :312 , 2019 |
Abstract : |
PubMedSearch : Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312 |
PubMedID: 31153983 |
Title : Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation - Antonijevic_2019_Chem.Biol.Interact_13ChEPon_308_385 |
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Andjelkovic M , Djordjevic AB , Antonijevic B |
Ref : Chemico-Biological Interactions , 308 :385 , 2019 |
Abstract : |
PubMedSearch : Antonijevic_2019_Chem.Biol.Interact_13ChEPon_308_385 |
PubMedID: 31141677 |
Title : Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase - de Almeida_2019_Chem.Biol.Interact_13ChEPon_308_113 |
Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC |
Ref : Chemico-Biological Interactions , 308 :113 , 2019 |
Abstract : |
PubMedSearch : de Almeida_2019_Chem.Biol.Interact_13ChEPon_308_113 |
PubMedID: 31100275 |
Title : Some Possibilities to Study New Prophylactics against Nerve Agents - Bajgar_2019_Mini.Rev.Med.Chem_19_970 |
Author(s) : Bajgar J , Kassa J , Kucera T , Musilek K , Jun D , Kuca K |
Ref : Mini Rev Med Chem , 19 :970 , 2019 |
Abstract : |
PubMedSearch : Bajgar_2019_Mini.Rev.Med.Chem_19_970 |
PubMedID: 30827238 |
Title : Orexin supplementation in narcolepsy treatment: A review - Nepovimova_2019_Med.Res.Rev_39_961 |
Author(s) : Nepovimova E , Janockova J , Misik J , Kubik S , Stuchlik A , Vales K , Korabecny J , Mezeiova E , Dolezal R , Soukup O , Kobrlova T , Pham NL , Nguyen TD , Konecny J , Kuca K |
Ref : Med Res Rev , 39 :961 , 2019 |
Abstract : |
PubMedSearch : Nepovimova_2019_Med.Res.Rev_39_961 |
PubMedID: 30426515 |
Title : Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure - Jacevic_2019_Sci.Rep_9_1457 |
Author(s) : Jacevic V , Nepovimova E , Kuca K |
Ref : Sci Rep , 9 :1457 , 2019 |
Abstract : |
PubMedSearch : Jacevic_2019_Sci.Rep_9_1457 |
PubMedID: 30728420 |
Title : Oximes as pretreatment before acute exposure to paraoxon - Lorke_2019_J.Appl.Toxicol_39_1506 |
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
Ref : J Appl Toxicol , 39 :1506 , 2019 |
Abstract : |
PubMedSearch : Lorke_2019_J.Appl.Toxicol_39_1506 |
PubMedID: 31264735 |
Title : Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside - Sharma_2019_Expert.Rev.Neurother_19_359 |
Author(s) : Sharma R , Kuca K , Nepovimova E , Kabra A , Rao MM , Prajapati PK |
Ref : Expert Rev Neurother , 19 :359 , 2019 |
Abstract : |
PubMedSearch : Sharma_2019_Expert.Rev.Neurother_19_359 |
PubMedID: 30884983 |
Title : Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease - Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
Author(s) : Mezeiova E , Chalupova K , Nepovimova E , Gorecki L , Prchal L , Malinak D , Kuca K , Soukup O , Korabecny J |
Ref : Curr Alzheimer Res , 16 :772 , 2019 |
Abstract : |
PubMedSearch : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
PubMedID: 30819078 |
Title : Novichoks: The Dangerous Fourth Generation of Chemical Weapons - Franca_2019_Int.J.Mol.Sci_20_ |
Author(s) : Franca TCC , Kitagawa DAS , Cavalcante SFA , da Silva JAV , Nepovimova E , Kuca K |
Ref : Int J Mol Sci , 20 : , 2019 |
Abstract : |
PubMedSearch : Franca_2019_Int.J.Mol.Sci_20_ |
PubMedID: 30862059 |
Title : Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate - Cavalcante_2019_Chem.Biol.Interact_13ChEPon_309_108682 |
Author(s) : Cavalcante SFA , Kitagawa DAS , Rodrigues RB , Bernardo LB , da Silva TN , Dos Santos WV , Correa ABA , de Almeida JSFD , Franca TCC , Kuca K , Simas ABC |
Ref : Chemico-Biological Interactions , 309 :108682 , 2019 |
Abstract : |
PubMedSearch : Cavalcante_2019_Chem.Biol.Interact_13ChEPon_309_108682 |
PubMedID: 31163137 |
Title : Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects - Polisel_2019_Chem.Biol.Interact_13ChEPon_309_108671 |
Author(s) : Polisel DA , de Castro AA , Mancini DT , da Cunha EFF , Franca TCC , Ramalho TC , Kuca K |
Ref : Chemico-Biological Interactions , 309 :108671 , 2019 |
Abstract : |
PubMedSearch : Polisel_2019_Chem.Biol.Interact_13ChEPon_309_108671 |
PubMedID: 31207225 |
Title : In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon - Kitagawa_2019_Biomolecules_9_ |
Author(s) : Kitagawa DAS , Cavalcante SFA , de Paula RL , Rodrigues RB , Bernardo LB , da Silva MCJ , da Silva TN , Dos Santos WV , Granjeiro JM , de Almeida JSFD , Barcellos MC , de ACAB , Franca TCC , Kuca K , Simas ABC |
Ref : Biomolecules , 9 : , 2019 |
Abstract : |
PubMedSearch : Kitagawa_2019_Biomolecules_9_ |
PubMedID: 31597234 |
Title : The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats - Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373 |
Author(s) : Karasova JZ , Mzik M , Hroch M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K |
Ref : Basic Clin Pharmacol Toxicol , 122 :373 , 2018 |
Abstract : |
PubMedSearch : Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373 |
PubMedID: 29067789 |
Title : The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease - Hepnarova_2018_Eur.J.Med.Chem_150_292 |
Author(s) : Hepnarova V , Korabecny J , Matouskova L , Jost P , Muckova L , Hrabinova M , Vykoukalova N , Kerhartova M , Kucera T , Dolezal R , Nepovimova E , Spilovska K , Mezeiova E , Pham NL , Jun D , Staud F , Kaping D , Kuca K , Soukup O |
Ref : Eur Journal of Medicinal Chemistry , 150 :292 , 2018 |
Abstract : |
PubMedSearch : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
PubMedID: 29533874 |
Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281 |
Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K |
Ref : Med Chem , 14 :281 , 2018 |
Abstract : |
PubMedSearch : Soukup_2018_Med.Chem_14_281 |
PubMedID: 29332594 |
Title : Profiling donepezil template into multipotent hybrids with antioxidant properties - Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
Author(s) : Mezeiova E , Spilovska K , Nepovimova E , Gorecki L , Soukup O , Dolezal R , Malinak D , Janockova J , Jun D , Kuca K , Korabecny J |
Ref : J Enzyme Inhib Med Chem , 33 :583 , 2018 |
Abstract : |
PubMedSearch : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
PubMedID: 29529892 |
Title : Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier - Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Janockova J , Hrabinova M , Sepsova V , Kuca K |
Ref : Curr Alzheimer Res , 15 :1096 , 2018 |
Abstract : |
PubMedSearch : Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
PubMedID: 29992880 |
Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC |
Ref : BMC Pharmacol Toxicol , 19 :8 , 2018 |
Abstract : |
PubMedSearch : Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
PubMedID: 29467029 |
Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505 |
Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K |
Ref : Drug Des Devel Ther , 12 :505 , 2018 |
Abstract : |
PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
PubMedID: 29563775 |
Title : Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon - Kuca_2018_Molecules_23_ |
Author(s) : Kuca K , Jun D , Junova L , Musilek K , Hrabinova M , da Silva JAV , Ramalho TC , Valko M , Wu Q , Nepovimova E , Franca TCC |
Ref : Molecules , 23 : , 2018 |
Abstract : |
PubMedSearch : Kuca_2018_Molecules_23_ |
PubMedID: 29735900 |
Title : Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study - Malinak_2018_Molecules_23_ |
Author(s) : Malinak D , Nepovimova E , Jun D , Musilek K , Kuca K |
Ref : Molecules , 23 : , 2018 |
Abstract : |
PubMedSearch : Malinak_2018_Molecules_23_ |
PubMedID: 30205495 |
Title : Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents - Zorbaz_2018_J.Med.Chem_61_10753 |
Author(s) : Zorbaz T , Malinak D , Marakovic N , Macek Hrvat N , Zandona A , Novotny M , Skarka A , Andrys R , Benkova M , Soukup O , Katalinic M , Kuca K , Kovarik Z , Musilek K |
Ref : Journal of Medicinal Chemistry , 61 :10753 , 2018 |
Abstract : |
PubMedSearch : Zorbaz_2018_J.Med.Chem_61_10753 |
PubMedID: 30383374 |
Title : In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication - Arshad_2018_Toxicol.Mech.Methods_28_62 |
Author(s) : Arshad M , Fatmi MQ , Musilek K , Hussain A , Kuca K , Petroianu G , Kalasz H , Nurulain SM |
Ref : Toxicol Mech Methods , 28 :62 , 2018 |
Abstract : |
PubMedSearch : Arshad_2018_Toxicol.Mech.Methods_28_62 |
PubMedID: 28722512 |
Title : A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators - Tsai_2021_J.Food.Drug.Anal_29_153 |
Author(s) : Malinak D , Korabecny J , Soukup O , Gorecki L , Nepovimova E , Psotka M , Dolezal R , Nguyen TD , Mezeiova E , Musilek K , Kuca K |
Ref : Current Organic Chemistry , 22\ :1619 , 2018 |
Abstract : |
PubMedSearch : Tsai_2021_J.Food.Drug.Anal_29_153 |
PubMedID: |
Title : Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site (PAS) of human acetylcholinesterase - de Almeida_2018_J.Biomol.Struct.Dyn__1 |
Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC |
Ref : J Biomol Struct Dyn , :1 , 2018 |
Abstract : |
PubMedSearch : de Almeida_2018_J.Biomol.Struct.Dyn__1 |
PubMedID: 29749305 |
Title : Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods - Janockova_2018_Molecules_23_ |
Author(s) : Janockova J , Dolezal R , Nepovimova E , Kobrlova T , Benkova M , Kuca K , Konecny J , Mezeiova E , Melikova M , Hepnarova V , Ring A , Soukup O , Korabecny J |
Ref : Molecules , 23 : , 2018 |
Abstract : |
PubMedSearch : Janockova_2018_Molecules_23_ |
PubMedID: 30423961 |
Title : Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes - Antonijevic_2018_Food.Chem.Toxicol_121_224 |
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Curcic M , Miladinovic DC , Bulat Z , Antonijevic B |
Ref : Food & Chemical Toxicology , 121 :224 , 2018 |
Abstract : |
PubMedSearch : Antonijevic_2018_Food.Chem.Toxicol_121_224 |
PubMedID: 30176309 |
Title : Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon - de Paula_2018_Molecules_23_ |
Author(s) : de Paula RL , de Almeida JSFD , Cavalcante SFA , Goncalves AS , Simas ABC , Franca TCC , Valis M , Kuca K , Nepovimova E , Granjeiro JM |
Ref : Molecules , 23 : , 2018 |
Abstract : |
PubMedSearch : de Paula_2018_Molecules_23_ |
PubMedID: 30424582 |
Title : Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS) - de Almeida_2018_Toxins.(Basel)_10_ |
Author(s) : de Almeida JSFD , Dolezal R , Krejcar O , Kuca K , Musilek K , Jun D , Franca TCC |
Ref : Toxins (Basel) , 10 : , 2018 |
Abstract : |
PubMedSearch : de Almeida_2018_Toxins.(Basel)_10_ |
PubMedID: 30257474 |
Title : Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication - Soares_2018_Int.J.Mol.Sci_19_ |
Author(s) : Soares FV , de Castro AA , Pereira AF , Leal DHS , Mancini DT , Krejcar O , Ramalho TC , da Cunha EFF , Kuca K |
Ref : Int J Mol Sci , 19 : , 2018 |
Abstract : |
PubMedSearch : Soares_2018_Int.J.Mol.Sci_19_ |
PubMedID: 29690585 |
Title : Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves - Affonso_2018_Biomed.Chromatogr_32_ |
Author(s) : Affonso RS , Lima JA , Lessa BM , Caetano JVO , Obara MT , Nobrega AB , Nepovimova E , Musilek K , Kuca K , Slana G , Franca TCC |
Ref : Biomedical Chromatography , 32 : , 2018 |
Abstract : |
PubMedSearch : Affonso_2018_Biomed.Chromatogr_32_ |
PubMedID: 28913959 |
Title : Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission - Korabecny_2018_Neurosci_370_191 |
Author(s) : Korabecny J , Nepovimova E , Cikankova T , Spilovska K , Vaskova L , Mezeiova E , Kuca K , Hroudova J |
Ref : Neuroscience , 370 :191 , 2018 |
Abstract : |
PubMedSearch : Korabecny_2018_Neurosci_370_191 |
PubMedID: 28673719 |
Title : Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain - Antonijevic_2018_Arch.Toxicol_92_745 |
Author(s) : Antonijevic E , Kotur-Stevuljevic J , Musilek K , Kosvancova A , Kuca K , Djukic-Cosic D , Spasojevic-Kalimanovska V , Antonijevic B |
Ref : Archives of Toxicology , 92 :745 , 2018 |
Abstract : |
PubMedSearch : Antonijevic_2018_Arch.Toxicol_92_745 |
PubMedID: 29098328 |
Title : Chemical warfare agent NOVICHOK - mini-review of available data - Nepovimova_2018_Food.Chem.Toxicol_121_343 |
Author(s) : Nepovimova E , Kuca K |
Ref : Food & Chemical Toxicology , 121 :343 , 2018 |
Abstract : |
PubMedSearch : Nepovimova_2018_Food.Chem.Toxicol_121_343 |
PubMedID: 30213549 |
Title : The pharmacology of tacrine at N-methyl-d-aspartate receptors - Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
Author(s) : Horak M , Holubova K , Nepovimova E , Krusek J , Kaniakova M , Korabecny J , Vyklicky L , Kuca K , Stuchlik A , Ricny J , Vales K , Soukup O |
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 75 :54 , 2017 |
Abstract : |
PubMedSearch : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
PubMedID: 28089695 |
Title : Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-Tabun conjugate: A molecular modeling approach - de Souza_2017_J.Biomol.Struct.Dyn__1 |
Author(s) : de Souza FR , Garcia DR , Guizado TC , Kuca K , de Alencastro RB , Franca TCC |
Ref : J Biomol Struct Dyn , :1 , 2017 |
Abstract : |
PubMedSearch : de Souza_2017_J.Biomol.Struct.Dyn__1 |
PubMedID: 28446076 |
Title : Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment - Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
Author(s) : Gazova Z , Soukup O , Sepsova V , Siposova K , Drtinova L , Jost P , Spilovska K , Korabecny J , Nepovimova E , Fedunova D , Horak M , Kaniakova M , Wang ZJ , Hamouda AK , Kuca K |
Ref : Biochimica & Biophysica Acta Mol Basis Dis , 1863 :607 , 2017 |
Abstract : |
PubMedSearch : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
PubMedID: 27865910 |
Title : Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation - Spilovska_2017_Molecules_22_ |
Author(s) : Spilovska K , Korabecny J , Sepsova V , Jun D , Hrabinova M , Jost P , Muckova L , Soukup O , Janockova J , Kucera T , Dolezal R , Mezeiova E , Kaping D , Kuca K |
Ref : Molecules , 22 : , 2017 |
Abstract : |
PubMedSearch : Spilovska_2017_Molecules_22_ |
PubMedID: 28621747 |
Title : HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication - Psotka_2017_Mil.Med.Sci.Lett_86_70 |
Author(s) : Psotka M , Malinak D , Gorecki L , Nguyen TD , Soukup O , Jun D , Kuca K , Musilek K , Korabecny J |
Ref : Military Medical Science Letters , 86 :70 , 2017 |
Abstract : |
PubMedSearch : Psotka_2017_Mil.Med.Sci.Lett_86_70 |
PubMedID: |
Title : Optimal Pre-treatment for Acute Exposure to the Organophosphate Dicrotophos - Lorke_2017_Curr.Pharm.Des_23_3432 |
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
Ref : Curr Pharm Des , 23 :3432 , 2017 |
Abstract : |
PubMedSearch : Lorke_2017_Curr.Pharm.Des_23_3432 |
PubMedID: 27799040 |
Title : Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids - Hamulakova_2017_Int.J.Biol.Macromol_104_333 |
Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Kuca K |
Ref : Int J Biol Macromol , 104 :333 , 2017 |
Abstract : |
PubMedSearch : Hamulakova_2017_Int.J.Biol.Macromol_104_333 |
PubMedID: 28601645 |
Title : Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy - Mezeiova_2017_Molecules_22_ |
Author(s) : Mezeiova E , Korabecny J , Sepsova V , Hrabinova M , Jost P , Muckova L , Kucera T , Dolezal R , Misik J , Spilovska K , Pham NL , Pokrievkova L , Roh J , Jun D , Soukup O , Kaping D , Kuca K |
Ref : Molecules , 22 : , 2017 |
Abstract : |
PubMedSearch : Mezeiova_2017_Molecules_22_ |
PubMedID: 28788095 |
Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K |
Ref : Expert Opin Ther Pat , 27 :971 , 2017 |
Abstract : |
PubMedSearch : Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
PubMedID: 28569609 |
Title : Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis - Karasova_2017_Toxicol.Lett_277_24 |
Author(s) : Karasova JZ , Maderycova Z , Tumova M , Jun D , Rehacek V , Kuca K , Misik J |
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PubMedSearch : Karasova_2017_Toxicol.Lett_277_24 |
PubMedID: 28465191 |
Title : Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors - Babkova_2017_Future.Med.Chem_9_1015 |
Author(s) : Babkova K , Korabecny J , Soukup O , Nepovimova E , Jun D , Kuca K |
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PubMedSearch : Babkova_2017_Future.Med.Chem_9_1015 |
PubMedID: 28632451 |
Title : Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment - Soukup_2017_Curr.Neuropharmacol_15_637 |
Author(s) : Soukup O , Winder M , Killi UK , Wsol V , Jun D , Kuca K , Tobin G |
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PubMedSearch : Soukup_2017_Curr.Neuropharmacol_15_637 |
PubMedID: 27281175 |
Title : Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease - Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
Author(s) : Spilovska K , Korabecny J , Nepovimova E , Dolezal R , Mezeiova E , Soukup O , Kuca K |
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PubMedSearch : Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
PubMedID: 27697055 |
Title : The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: A computational study - Cuya_2017_J.Biomol.Struct.Dyn__1 |
Author(s) : Cuya T , Goncalves ADS , da Silva JAV , Ramalho TC , Kuca K , Franca TCC |
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PubMedSearch : Cuya_2017_J.Biomol.Struct.Dyn__1 |
PubMedID: 29019446 |
Title : Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs - Karasova_2017_Toxicol.Lett_273_20 |
Author(s) : Karasova JZ , Kvetina J , Tacheci I , Radochova V , Musilek K , Kuca K , Bures J |
Ref : Toxicol Lett , 273 :20 , 2017 |
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PubMedSearch : Karasova_2017_Toxicol.Lett_273_20 |
PubMedID: 28343895 |
Title : An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study - Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85 |
Author(s) : Mzik M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K , Karasova JZ |
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1020 :85 , 2016 |
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PubMedSearch : Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85 |
PubMedID: 27030895 |
Title : Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies - Dolezal_2016_Eur.J.Med.Chem_121_699 |
Author(s) : Dolezal R , Soukup O , Malinak D , Savedra RML , Marek J , Dolezalova M , Pasdiorova M , Salajkova S , Korabecny J , Honegr J , Ramalho TC , Kuca K |
Ref : Eur Journal of Medicinal Chemistry , 121 :699 , 2016 |
Abstract : |
PubMedSearch : Dolezal_2016_Eur.J.Med.Chem_121_699 |
PubMedID: 27341309 |
Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831 |
Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K |
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PubMedSearch : Gorecki_2016_Arch.Toxicol_90_2831 |
PubMedID: 27582056 |
Title : Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1 - Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
Author(s) : Kristofikova Z , Ricny J , Soukup O , Korabecny J , Nepovimova E , Kuca K , Ripova D |
Ref : Dementia & Geriatric Cognitive Disorders , 43 :45 , 2016 |
Abstract : |
PubMedSearch : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
PubMedID: 27988521 |
Title : Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase - Winter_2016_Toxicol.Lett_244_136 |
Author(s) : Winter M , Wille T , Musilek K , Kuca K , Thiermann H , Worek F |
Ref : Toxicol Lett , 244 :136 , 2016 |
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PubMedSearch : Winter_2016_Toxicol.Lett_244_136 |
PubMedID: 26210933 |
Title : Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease - Jerabek_2016_Eur.J.Med.Chem_127_250 |
Author(s) : Jerabek J , Uliassi E , Guidotti L , Korabecny J , Soukup O , Sepsova V , Hrabinova M , Kuca K , Bartolini M , Pena-Altamira LE , Petralla S , Monti B , Roberti M , Bolognesi ML |
Ref : Eur Journal of Medicinal Chemistry , 127 :250 , 2016 |
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PubMedSearch : Jerabek_2016_Eur.J.Med.Chem_127_250 |
PubMedID: 28064079 |
Title : Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity - Janockova_2016_Mol.Biosyst_12_2910 |
Author(s) : Janockova J , Zilecka E , Kasparkova J , Brabec V , Soukup O , Kuca K , Kozurkova M |
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PubMedSearch : Janockova_2016_Mol.Biosyst_12_2910 |
PubMedID: 27412811 |
Title : Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase - Musilek_2016_Med.Chem_12_362 |
Author(s) : Musilek K , Hambalek J , Holas O , Dohnal V , Kuca K |
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PubMedSearch : Musilek_2016_Med.Chem_12_362 |
PubMedID: 26427931 |
Title : Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor - Antonijevic_2016_Neurotoxicol_55_33 |
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Vucinic S , Antonijevic B |
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PubMedSearch : Antonijevic_2016_Neurotoxicol_55_33 |
PubMedID: 27177985 |
Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264 |
Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K |
Ref : ChemMedChem , 11 :1264 , 2016 |
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PubMedSearch : Benek_2016_ChemMedChem_11_1264 |
PubMedID: 26427608 |
Title : Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides - Ramalho_2016_Curr.Med.Chem_23_1041 |
Author(s) : Ramalho TC , de Castro AA , Silva DR , Silva MC , Franca TCC , Bennion BJ , Kuca K |
Ref : Curr Med Chem , 23 :1041 , 2016 |
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PubMedSearch : Ramalho_2016_Curr.Med.Chem_23_1041 |
PubMedID: 26898655 |
Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K |
Ref : Toxicol Res (Camb) , 5 :1012 , 2016 |
Abstract : |
PubMedSearch : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
PubMedID: 30090408 |
Title : Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules - Hamulakova_2016_J.Inorg.Biochem_161_52 |
Author(s) : Hamulakova S , Poprac P , Jomova K , Brezova V , Lauro P , Drostinova L , Jun D , Sepsova V , Hrabinova M , Soukup O , Kristian P , Gazova Z , Bednarikova Z , Kuca K , Valko M |
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PubMedSearch : Hamulakova_2016_J.Inorg.Biochem_161_52 |
PubMedID: 27230386 |
Title : Blood-fetus penetration of pralidoxime - Ojha_2016_Mil.Med.Sci.Lett_85_63 |
Author(s) : Ojha S , Nurulain SM , Dhanasekaran S , Shafiullah M , Adem A , Sharma C , Kuca K , Kalasz H |
Ref : Military Medical Science Letters , 85 :63 , 2016 |
Abstract : |
PubMedSearch : Ojha_2016_Mil.Med.Sci.Lett_85_63 |
PubMedID: |
Title : Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators - Spicakova_2016_Food.Chem.Toxicol_88_100 |
Author(s) : Spicakova A , Anzenbacher P , Liskova B , Kuca K , Fusek J , Anzenbacherova E |
Ref : Food & Chemical Toxicology , 88 :100 , 2016 |
Abstract : |
PubMedSearch : Spicakova_2016_Food.Chem.Toxicol_88_100 |
PubMedID: 26747974 |
Title : Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase - Sahu_2016_Toxicol.Mech.Methods__1 |
Author(s) : Sahu AK , Sharma R , Gupta B , Musilek K , Kuca K , Acharya J , Ghosh KK |
Ref : Toxicol Mech Methods , :1 , 2016 |
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PubMedSearch : Sahu_2016_Toxicol.Mech.Methods__1 |
PubMedID: 27101948 |
Title : Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity - Karasova_2016_Neurotox.Res_29_267 |
Author(s) : Karasova JZ , Hroch M , Musilek K , Kuca K |
Ref : Neurotox Res , 29 :267 , 2016 |
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PubMedSearch : Karasova_2016_Neurotox.Res_29_267 |
PubMedID: 26646154 |
Title : Development and validation of a FIA\/UV-vis method for pK determination of oxime based acetylcholinesterase reactivators - Musil_2015_J.Pharm.Biomed.Anal_117_240 |
Author(s) : Musil K , Florianova V , Bucek P , Dohnal V , Kuca K , Musilek K |
Ref : J Pharm Biomed Anal , 117 :240 , 2015 |
Abstract : |
PubMedSearch : Musil_2015_J.Pharm.Biomed.Anal_117_240 |
PubMedID: 26386953 |
Title : Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs - Bures_2015_Neuro.Endocrinol.Lett_36_ |
Author(s) : Bures J , Jun D , Hrabinova M , Tacheci I , Kvetina J , Pavlik M , Rejchrt S , Douda T , Kunes M , Kuca K , Kopacova M |
Ref : Neuro Endocrinol Lett , 36 : , 2015 |
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PubMedSearch : Bures_2015_Neuro.Endocrinol.Lett_36_ |
PubMedID: 26757120 |
Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985 |
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K |
Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015 |
Abstract : |
PubMedSearch : Nepovimova_2015_J.Med.Chem_58_8985 |
PubMedID: 26503905 |
Title : Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE - Kuca_2015_Med.Chem_11_683 |
Author(s) : Kuca K , Hrabinova M , Jun D , Musilek K , Penhaker M , Krejcar O , Soukup O |
Ref : Med Chem , 11 :683 , 2015 |
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PubMedSearch : Kuca_2015_Med.Chem_11_683 |
PubMedID: 25845909 |
Title : Cholinergic properties of new 7-methoxytacrine-donepezil derivatives - Sepsova_2015_Gen.Physiol.Biophys_34_189 |
Author(s) : Sepsova V , Karasova JZ , Tobin G , Jun D , Korabecny J , Cabelova P , Janska K , Krusek J , Skrenkova K , Kuca K , Soukup O |
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PubMedSearch : Sepsova_2015_Gen.Physiol.Biophys_34_189 |
PubMedID: 25504063 |
Title : Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase - Dolezal_2015_J.Mol.Graph.Model_56_113 |
Author(s) : Dolezal R , Korabecny J , Malinak D , Honegr J , Musilek K , Kuca K |
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PubMedSearch : Dolezal_2015_J.Mol.Graph.Model_56_113 |
PubMedID: 25588616 |
Title : Reversible cholinesterase inhibitors as pre-treatment for exposure to organophosphates: assessment using azinphos-methyl - Petroianu_2015_J.Appl.Toxicol_35_493 |
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Ref : J Appl Toxicol , 35 :493 , 2015 |
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PubMedSearch : Petroianu_2015_J.Appl.Toxicol_35_493 |
PubMedID: 25186309 |
Title : Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review - Sharma_2015_Mini.Rev.Med.Chem_15_58 |
Author(s) : Sharma R , Gupta B , Singh N , Acharya JR , Musilek K , Kuca K , Ghosh KK |
Ref : Mini Rev Med Chem , 15 :58 , 2015 |
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PubMedSearch : Sharma_2015_Mini.Rev.Med.Chem_15_58 |
PubMedID: 25441834 |
Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084 |
Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K |
Ref : Molecules , 20 :22084 , 2015 |
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PubMedSearch : Korabecny_2015_Molecules_20_22084 |
PubMedID: 26690394 |
Title : Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase - Horn_2015_Arch.Toxicol_89_405 |
Author(s) : Horn G , Wille T , Musilek K , Kuca K , Thiermann H , Worek F |
Ref : Archives of Toxicology , 89 :405 , 2015 |
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PubMedSearch : Horn_2015_Arch.Toxicol_89_405 |
PubMedID: 24912784 |
Title : Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents - Giacoppo_2015_J.Biomol.Struct.Dyn_33_2048 |
Author(s) : Giacoppo JO , Franca TCC , Kuca K , da Cunha EFF , Abagyan R , Mancini DT , Ramalho TC |
Ref : J Biomol Struct Dyn , 33 :2048 , 2015 |
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PubMedSearch : Giacoppo_2015_J.Biomol.Struct.Dyn_33_2048 |
PubMedID: 25407587 |
Title : HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs - Kunes_2014_Neuro.Endocrinol.Lett_35_186 |
Author(s) : Kunes M , Kvetina J , Bures J , Karasova JZ , Pavlik M , Tacheci I , Musilek K , Kuca K |
Ref : Neuro Endocrinol Lett , 35 :186 , 2014 |
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PubMedSearch : Kunes_2014_Neuro.Endocrinol.Lett_35_186 |
PubMedID: 25638385 |
Title : 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies - Korabecny_2014_Eur.J.Med.Chem_82C_426 |
Author(s) : Korabecny J , Dolezal R , Cabelova P , Horova A , Hruba E , Ricny J , Sedlacek L , Nepovimova E , Spilovska K , Andrs M , Musilek K , Opletalova V , Sepsova V , Ripova D , Kuca K |
Ref : Eur Journal of Medicinal Chemistry , 82C :426 , 2014 |
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PubMedSearch : Korabecny_2014_Eur.J.Med.Chem_82C_426 |
PubMedID: 24929293 |
Title : Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects - Nepovimova_2014_J.Med.Chem_57_8576 |
Author(s) : Nepovimova E , Uliassi E , Korabecny J , Pena-Altamira LE , Samez S , Pesaresi A , Garcia GE , Bartolini M , Andrisano V , Bergamini C , Fato R , Lamba D , Roberti M , Kuca K , Monti B , Bolognesi ML |
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PubMedSearch : Nepovimova_2014_J.Med.Chem_57_8576 |
PubMedID: 25259726 |
Gene_locus related to this paper: torca-ACHE |
Title : Novel tacrine\/acridine anticholinesterase inhibitors with piperazine and thiourea linkers - Hamulakova_2014_Int.J.Biol.Macromol_70C_435 |
Author(s) : Hamulakova S , Imrich J , Janovec L , Kristian P , Danihel I , Holas O , Pohanka M , Bohm S , Kozurkova M , Kuca K |
Ref : Int J Biol Macromol , 70C :435 , 2014 |
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PubMedSearch : Hamulakova_2014_Int.J.Biol.Macromol_70C_435 |
PubMedID: 25036600 |
Title : In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat - Killi_2014_Clin.Exp.Pharmacol.Physiol_41_139 |
Author(s) : Killi UK , Wsol V , Soukup O , Kuca K , Winder M , Tobin G |
Ref : Clinical & Experimental Pharmacology & Physiology , 41 :139 , 2014 |
Abstract : |
PubMedSearch : Killi_2014_Clin.Exp.Pharmacol.Physiol_41_139 |
PubMedID: 24341923 |
Title : Prophylactic administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using terbufos sulfone - Lorke_2014_J.Appl.Toxicol_34_1096 |
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
Ref : J Appl Toxicol , 34 :1096 , 2014 |
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PubMedSearch : Lorke_2014_J.Appl.Toxicol_34_1096 |
PubMedID: 24136594 |
Title : Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51 - Benek_2014_Med.Chem_11_21 |
Author(s) : Benek O , Musilek K , Horova A , Dohnal V , Dolezal R , Kuca K |
Ref : Med Chem , 11 :21 , 2014 |
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PubMedSearch : Benek_2014_Med.Chem_11_21 |
PubMedID: 24773345 |
Title : The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor - Sepsova_2014_Physiol.Res_63_771 |
Author(s) : Sepsova V , Krusek J , Karasova JZ , Zemek F , Musilek K , Kuca K , Soukup O |
Ref : Physiol Res , 63 :771 , 2014 |
Abstract : |
PubMedSearch : Sepsova_2014_Physiol.Res_63_771 |
PubMedID: 25157661 |
Title : From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators - Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
Author(s) : Korabecny J , Soukup O , Dolezal R , Spilovska K , Nepovimova E , Andrs M , Nguyen TD , Jun D , Musilek K , Kucerova-Chlupacova M , Kuca K |
Ref : Mini Rev Med Chem , 14 :215 , 2014 |
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PubMedSearch : Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
PubMedID: 24552265 |
Title : Structural modifications of dicationic acetylcholinesterase reactivators studied under ion-pairing mechanism in reversed-phase liquid chromatography - Radulescu_2014_J.Sep.Sci_37_3024 |
Author(s) : Radulescu M , Kuca K , Musilek K , David V |
Ref : J Sep Sci , 37 :3024 , 2014 |
Abstract : |
PubMedSearch : Radulescu_2014_J.Sep.Sci_37_3024 |
PubMedID: 25141798 |
Title : Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties - Gupta_2014_Bioorg.Med.Chem.Lett_24_4743 |
Author(s) : Gupta B , Singh N , Sharma R , Foretic B , Musilek K , Kuca K , Acharya J , Satnami ML , Ghosh KK |
Ref : Bioorganic & Medicinal Chemistry Lett , 24 :4743 , 2014 |
Abstract : |
PubMedSearch : Gupta_2014_Bioorg.Med.Chem.Lett_24_4743 |
PubMedID: 25190468 |
Title : Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors - Hamulakova_2014_J.Med.Chem_57_7073 |
Author(s) : Hamulakova S , Janovec L , Hrabinova M , Spilovska K , Korabecny J , Kristian P , Kuca K , Imrich J |
Ref : Journal of Medicinal Chemistry , 57 :7073 , 2014 |
Abstract : |
PubMedSearch : Hamulakova_2014_J.Med.Chem_57_7073 |
PubMedID: 25089370 |
Title : Chemical warfare: perspectives on reactivating the enzyme acetylcholinesterase inhibited by organophosphates - Giacoppo_2014_Mil.Med.Sci.Lett_83_165 |
Author(s) : Giacoppo JO , de Lima WE , Kuca K , da Cunha EFF , Franca TCC , Ramalho TC |
Ref : Military Medical Science Letters , 83 :165 , 2014 |
Abstract : |
PubMedSearch : Giacoppo_2014_Mil.Med.Sci.Lett_83_165 |
PubMedID: |
Title : In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes - Gupta_2014_Arch.Toxicol_88_381 |
Author(s) : Gupta B , Sharma R , Singh N , Kuca K , Acharya JR , Ghosh KK |
Ref : Archives of Toxicology , 88 :381 , 2014 |
Abstract : |
PubMedSearch : Gupta_2014_Arch.Toxicol_88_381 |
PubMedID: 24065055 |
Title : Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update - Wu_2014_Arch.Toxicol_88_1309 |
Author(s) : Wu QH , Wang X , Yang W , Nussler AK , Xiong LY , Kuca K , Dohnal V , Zhang XJ , Yuan ZH |
Ref : Archives of Toxicology , 88 :1309 , 2014 |
Abstract : |
PubMedSearch : Wu_2014_Arch.Toxicol_88_1309 |
PubMedID: 24894432 |
Title : In vivo evaluation of cholinesterase activity, oxidative stress markers, cyto- and genotoxicity of K048 oxime-a promising antidote against organophosphate poisoning - Zunec_2014_Basic.Clin.Pharmacol.Toxicol_114_344 |
Author(s) : Zunec S , Kopjar N , Zeljezic D , Kuca K , Musilek K , Lucic Vrdoljak A |
Ref : Basic Clin Pharmacol Toxicol , 114 :344 , 2014 |
Abstract : |
PubMedSearch : Zunec_2014_Basic.Clin.Pharmacol.Toxicol_114_344 |
PubMedID: 24741714 |
Title : Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine - Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
Author(s) : Zemek F , Drtinova L , Nepovimova E , Sepsova V , Korabecny J , Klimes J , Kuca K |
Ref : Expert Opin Drug Safety , 13 :759 , 2014 |
Abstract : |
PubMedSearch : Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
PubMedID: 24845946 |
Title : Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon - Petroianu_2013_J.Appl.Toxicol_33_894 |
Author(s) : Petroianu GA , Nurulain SM , Shafiullah M , Hasan MY , Kuca K , Lorke DE |
Ref : Journal of Applied Toxicology , 33 :894 , 2013 |
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PubMedSearch : Petroianu_2013_J.Appl.Toxicol_33_894 |
PubMedID: 22611016 |
Title : Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study - Sepsova_2013_Int.J.Mol.Sci_14_16882 |
Author(s) : Sepsova V , Karasova JZ , Korabecny J , Dolezal R , Zemek F , Bennion BJ , Kuca K |
Ref : Int J Mol Sci , 14 :16882 , 2013 |
Abstract : |
PubMedSearch : Sepsova_2013_Int.J.Mol.Sci_14_16882 |
PubMedID: 23959117 |
Title : Physicochemical properties and supernucleophilicity of oxime-functionalized surfactants: hydrolytic catalysts toward dephosphorylation of di- and triphosphate esters - Singh_2013_J.Phys.Chem.B_117_3806 |
Author(s) : Singh N , Karpichev Y , Gupta B , Satnami ML , Marek J , Kuca K , Ghosh KK |
Ref : J Phys Chem B , 117 :3806 , 2013 |
Abstract : |
PubMedSearch : Singh_2013_J.Phys.Chem.B_117_3806 |
PubMedID: 23480470 |
Title : Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs - Bures_2013_Neuro.Endocrinol.Lett_34_79 |
Author(s) : Bures J , Kvetina J , Pavlik M , Kunes M , Kopacova M , Rejchrt S , Jun D , Hrabinova M , Kuca K , Tacheci I |
Ref : Neuro Endocrinol Lett , 34 :79 , 2013 |
Abstract : |
PubMedSearch : Bures_2013_Neuro.Endocrinol.Lett_34_79 |
PubMedID: 24362097 |
Title : 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in alzheimer's disease treatment, synthesis, biological evaluation and molecular modeling studies - Spilovska_2013_Molecules_18_2397 |
Author(s) : Spilovska K , Korabecny J , Kral J , Horova A , Musilek K , Soukup O , Drtinova L , Gazova Z , Siposova K , Kuca K |
Ref : Molecules , 18 :2397 , 2013 |
Abstract : |
PubMedSearch : Spilovska_2013_Molecules_18_2397 |
PubMedID: 23429378 |
Title : Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium\/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors - Komloova_2013_Bioorg.Med.Chem.Lett_23_6663 |
Author(s) : Komloova M , Horova A , Hrabinova M , Jun D , Dolezal M , Vinsova J , Kuca K , Musilek K |
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6663 , 2013 |
Abstract : |
PubMedSearch : Komloova_2013_Bioorg.Med.Chem.Lett_23_6663 |
PubMedID: 24220173 |
Title : Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration - Karasova_2013_Neuro.Endocrinol.Lett_34_74 |
Author(s) : Karasova JZ , Zemek F , Kunes M , Kvetina J , Chladek J , Jun D , Bures J , Tacheci I , Kuca K |
Ref : Neuro Endocrinol Lett , 34 :74 , 2013 |
Abstract : |
PubMedSearch : Karasova_2013_Neuro.Endocrinol.Lett_34_74 |
PubMedID: 24362096 |
Title : Interaction of cholinesterase modulators with DNA and their cytotoxic activity - Janockova_2013_Int.J.Biol.Macromol_64C_53 |
Author(s) : Janockova J , Gulasova Z , Plsikova J , Musilek K , Kuca K , Mikes J , Culka L , Fedorocko P , Kozurkova M |
Ref : Int J Biol Macromol , 64C :53 , 2013 |
Abstract : |
PubMedSearch : Janockova_2013_Int.J.Biol.Macromol_64C_53 |
PubMedID: 24296409 |
Title : A Resurrection of 7-MEOTA: A Comparison with Tacrine - Soukup_2013_Curr.Alzheimer.Res_10_893 |
Author(s) : Soukup O , Jun D , Karasova JZ , Patocka J , Musilek K , Korabecny J , Krusek J , Kaniakova M , Sepsova V , Mandikova J , Trejtnar F , Pohanka M , Drtinova L , Pavlik M , Tobin G , Kuca K |
Ref : Curr Alzheimer Res , 10 :893 , 2013 |
Abstract : |
PubMedSearch : Soukup_2013_Curr.Alzheimer.Res_10_893 |
PubMedID: 24093535 |
Title : Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities - Cahlikova_2013_Nat.Prod.Commun_8_1541 |
Author(s) : Cahlikova L , Hrabinova M , Kulhankova A , Benesova N , Chlebek J , Jun D , Novak Z , Macakova K , Kunes J , Kuca K , Opletal L |
Ref : Nat Prod Commun , 8 :1541 , 2013 |
Abstract : |
PubMedSearch : Cahlikova_2013_Nat.Prod.Commun_8_1541 |
PubMedID: 24427936 |
Title : Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma - Karasova_2013_J.Appl.Toxicol_33_18 |
Author(s) : Karasova JZ , Chladek J , Hroch M , Josef F , Hnidkova D , Kuca K |
Ref : J Appl Toxicol , 33 :18 , 2013 |
Abstract : |
PubMedSearch : Karasova_2013_J.Appl.Toxicol_33_18 |
PubMedID: 21717485 |
Title : The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors - Soukup_2013_Arch.Toxicol_87_711 |
Author(s) : Soukup O , Jun D , Tobin G , Kuca K |
Ref : Archives of Toxicology , 87 :711 , 2013 |
Abstract : |
PubMedSearch : Soukup_2013_Arch.Toxicol_87_711 |
PubMedID: 23179755 |
Title : Novel cholinesterase modulators and their ability to interact with DNA - Janockova_2013_Spectrochim.Acta.A.Mol.Biomol.Spectrosc_115C_364 |
Author(s) : Janockova J , Gulasova Z , Musilek K , Kuca K , Kozurkova M |
Ref : Spectrochim Acta A Mol Biomol Spectrosc , 115C :364 , 2013 |
Abstract : |
PubMedSearch : Janockova_2013_Spectrochim.Acta.A.Mol.Biomol.Spectrosc_115C_364 |
PubMedID: 23851179 |
Title : In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators - Bhattacharjee_2013_Curr.Comput.Aided.Drug.Des_9_402 |
Author(s) : Bhattacharjee AK , Musilek K , Kuca K |
Ref : Curr Comput Aided Drug Des , 9 :402 , 2013 |
Abstract : |
PubMedSearch : Bhattacharjee_2013_Curr.Comput.Aided.Drug.Des_9_402 |
PubMedID: 23789829 |
Title : Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX - Kuca_2013_Med.Chem_9_689 |
Author(s) : Kuca K , Musilek K , Jun D , Karasova J , Soukup O , Pejchal J , Hrabinova M |
Ref : Med Chem , 9 :689 , 2013 |
Abstract : |
PubMedSearch : Kuca_2013_Med.Chem_9_689 |
PubMedID: 22779796 |
Title : selective monitoring of enzymatic activity of acetylcholinesterase by flow injection analysis with mass spectrometric detection - Dohnal_2013_Mil.Med.Sci.Lett_82_120 |
Author(s) : Dohnal V , Dohnalova L , Jun D , Kuca K |
Ref : Military Medical Science Letters , 82 :120 , 2013 |
Abstract : |
PubMedSearch : Dohnal_2013_Mil.Med.Sci.Lett_82_120 |
PubMedID: |
Title : Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides - Kuca_2013_Mini.Rev.Med.Chem_13_2102 |
Author(s) : Kuca K , Jun D , Musilek K , Pohanka M , Karasova JZ , Soukup O |
Ref : Mini Rev Med Chem , 13 :2102 , 2013 |
Abstract : |
PubMedSearch : Kuca_2013_Mini.Rev.Med.Chem_13_2102 |
PubMedID: 24195661 |
Title : Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase - Worek_2012_Arch.Toxicol_86_1379 |
Author(s) : Worek F , von der Wellen J , Musilek K , Kuca K , Thiermann H |
Ref : Archives of Toxicology , 86 :1379 , 2012 |
Abstract : |
PubMedSearch : Worek_2012_Arch.Toxicol_86_1379 |
PubMedID: 22437842 |
Title : Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease - Hamulakova_2012_Eur.J.Med.Chem_55_23 |
Author(s) : Hamulakova S , Janovec L , Hrabinova M , Kristian P , Kuca K , Banasova M , Imrich J |
Ref : Eur Journal of Medicinal Chemistry , 55 :23 , 2012 |
Abstract : |
PubMedSearch : Hamulakova_2012_Eur.J.Med.Chem_55_23 |
PubMedID: 22818849 |
Title : Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings - Kassa_2012_Mini.Rev.Med.Chem_12_24 |
Author(s) : Kassa J , Musilek K , Karasova JZ , Kuca K , Bajgar J |
Ref : Mini Rev Med Chem , 12 :24 , 2012 |
Abstract : |
PubMedSearch : Kassa_2012_Mini.Rev.Med.Chem_12_24 |
PubMedID: 22360668 |
Title : First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans? - Matos_2012_J.Biomol.Struct.Dyn_30_546 |
Author(s) : Matos KS , da Cunha EFF , da Silva Goncalves A , Wilter A , Kuca K , Franca TCC , Ramalho TC |
Ref : J Biomol Struct Dyn , 30 :546 , 2012 |
Abstract : |
PubMedSearch : Matos_2012_J.Biomol.Struct.Dyn_30_546 |
PubMedID: 22731788 |
Title : The progress in the cholinesterase quantification methods - Holas_2012_Expert.Opin.Drug.Discov_7_1207 |
Author(s) : Holas O , Musilek K , Pohanka M , Kuca K |
Ref : Expert Opin Drug Discov , 7 :1207 , 2012 |
Abstract : |
PubMedSearch : Holas_2012_Expert.Opin.Drug.Discov_7_1207 |
PubMedID: 23013366 |
Title : Acetylcholinesterase Inhibitors as Pretreatment before Acute Exposure to Organophosphates: Assessment Using Methyl-paraoxon - Lorke_2012_CNS.Neurol.Disord.Drug.Targets_11_1052 |
Author(s) : Lorke DE , Hasan MY , Nurulain SM , Shafiullah MS , Kuca K , Petroianu GA |
Ref : CNS Neurol Disord Drug Targets , 11 :1052 , 2012 |
Abstract : |
PubMedSearch : Lorke_2012_CNS.Neurol.Disord.Drug.Targets_11_1052 |
PubMedID: 23244429 |
Title : [Tacrine and its derivatives in the therapy of Alzheimers disease] - Korabecny_2012_Ceska.Slov.Farm_61_210 |
Author(s) : Korabecny J , Spilovska K , Benek O , Musilek K , Soukup O , Kuca K |
Ref : Ceska a Slovenska Farmacie , 61 :210 , 2012 |
Abstract : |
PubMedSearch : Korabecny_2012_Ceska.Slov.Farm_61_210 |
PubMedID: 23256654 |
Title : The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers - Soukup_2012_Toxicol.Lett_212_315 |
Author(s) : Soukup O , Kristofikova Z , Jun D , Tambor V , Ripova D , Kuca K |
Ref : Toxicol Lett , 212 :315 , 2012 |
Abstract : |
PubMedSearch : Soukup_2012_Toxicol.Lett_212_315 |
PubMedID: 22683831 |
Title : In vivo decontamination of the nerve agent VX using the domestic swine model - Misik_2012_Clin.Toxicol.(Phila)_50_807 |
Author(s) : Misik J , Pavlik M , Novotny L , Pavlikova R , Chilcott RP , Cabal J , Kuca K |
Ref : Clinical Toxicology (Phila) , 50 :807 , 2012 |
Abstract : |
PubMedSearch : Misik_2012_Clin.Toxicol.(Phila)_50_807 |
PubMedID: 22963275 |
Title : An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning - Bhattacharjee_2012_Med.Chem_8_230 |
Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK |
Ref : Med Chem , 8 :230 , 2012 |
Abstract : |
PubMedSearch : Bhattacharjee_2012_Med.Chem_8_230 |
PubMedID: 22385173 |
Title : Method optimization for acetylcholinesterase modulators-albumin interactions - Zemek_2011_Mil.Med.Sci.Lett_80_58 |
Author(s) : Zemek F , Karasova JZ , Musilek K , Kuca K |
Ref : Military Medical Science Letters , 80 :58 , 2011 |
Abstract : |
PubMedSearch : Zemek_2011_Mil.Med.Sci.Lett_80_58 |
PubMedID: |
Title : Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model - Pohanka_2011_Bratisl.Lek.Listy_112_539 |
Author(s) : Pohanka M , Pikula J , Kuca K , Kassa J |
Ref : Bratislavske Lekarske Listy , 112 :539 , 2011 |
Abstract : |
PubMedSearch : Pohanka_2011_Bratisl.Lek.Listy_112_539 |
PubMedID: 21954536 |
Title : Human serum butyrylcholinesterase as a prophylaxis against russian VX - Karasova_2011_Mil.Med.Sci.Lett_80_97 |
Author(s) : Karasova JZ , Kuca K , Jun D , Bajgar J |
Ref : Military Medical Science Letters , 80 :97 , 2011 |
Abstract : |
PubMedSearch : Karasova_2011_Mil.Med.Sci.Lett_80_97 |
PubMedID: |
Title : Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128 - Musilek_2011_Bioorg.Med.Chem.Lett_21_150 |
Author(s) : Musilek K , Roder J , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Opletalova V , Kuca K , Jung YS |
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :150 , 2011 |
Abstract : |
PubMedSearch : Musilek_2011_Bioorg.Med.Chem.Lett_21_150 |
PubMedID: 21144749 |
Title : Anatoxin-a(s): natural organophosphorus anticholinesterase agent - Patocka_2011_Mil.Med.Sci.Lett_80_129 |
Author(s) : Patocka J , Gupta RC , Kuca K |
Ref : Military Medical Science Letters , 80 :129 , 2011 |
Abstract : |
PubMedSearch : Patocka_2011_Mil.Med.Sci.Lett_80_129 |
PubMedID: |
Title : Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors - Lorke_2011_J.Appl.Toxicol_31_515 |
Author(s) : Lorke DE , Hasan MY , Nurulain SM , Shafiullah M , Kuca K , Petroianu GA |
Ref : Journal of Applied Toxicology , 31 :515 , 2011 |
Abstract : |
PubMedSearch : Lorke_2011_J.Appl.Toxicol_31_515 |
PubMedID: 20981864 |
Title : On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning - Kuca_2011_Mil.Med.Sci.Lett_80_80 |
Author(s) : Kuca K , Musilek K , Karasova J , Jun D , Soukup O , Pohanka M , Ghosh KK , Hrabinova M |
Ref : Military Medical Science Letters , 80 :80 , 2011 |
Abstract : |
PubMedSearch : Kuca_2011_Mil.Med.Sci.Lett_80_80 |
PubMedID: |
Title : Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice - dos Santos_2011_Neurotoxicol_32_888 |
Author(s) : Dos Santos AA , dos Santos DB , Ribeiro RP , Colle D , Peres KC , Hermes J , Barbosa AM , Dafre AL , de Bem AF , Kuca K , Farina M |
Ref : Neurotoxicology , 32 :888 , 2011 |
Abstract : |
PubMedSearch : dos Santos_2011_Neurotoxicol_32_888 |
PubMedID: 21723318 |
Title : Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain - Karasova_2011_J.Pharm.Biomed.Anal_54_1082 |
Author(s) : Karasova JZ , Zemek F , Bajgar J , Vasatova M , Prochazka P , Novotny L , Kuca K |
Ref : J Pharm Biomed Anal , 54 :1082 , 2011 |
Abstract : |
PubMedSearch : Karasova_2011_J.Pharm.Biomed.Anal_54_1082 |
PubMedID: 21146949 |
Title : In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase - Jun_2011_Int.J.Mol.Sci_12_2077 |
Author(s) : Jun D , Musilova L , Musilek K , Kuca K |
Ref : Int J Mol Sci , 12 :2077 , 2011 |
Abstract : |
PubMedSearch : Jun_2011_Int.J.Mol.Sci_12_2077 |
PubMedID: 21673941 |
Title : Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment - Komloova_2011_Bioorg.Med.Chem.Lett_21_2505 |
Author(s) : Komloova M , Musilek K , Horova A , Holas O , Dohnal V , Gunn-Moore F , Kuca K |
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2505 , 2011 |
Abstract : |
PubMedSearch : Komloova_2011_Bioorg.Med.Chem.Lett_21_2505 |
PubMedID: 21397501 |
Title : Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking - Musilek_2011_Bioorg.Med.Chem_19_754 |
Author(s) : Musilek K , Komloova M , Holas O , Horova A , Pohanka M , Gunn-Moore F , Dohnal V , Dolezal M , Kuca K |
Ref : Bioorganic & Medicinal Chemistry , 19 :754 , 2011 |
Abstract : |
PubMedSearch : Musilek_2011_Bioorg.Med.Chem_19_754 |
PubMedID: 21215642 |
Title : Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment - Musilek_2011_Eur.J.Med.Chem_46_811 |
Author(s) : Musilek K , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Nachon F , Dolezal M , Kuca K |
Ref : Eur Journal of Medicinal Chemistry , 46 :811 , 2011 |
Abstract : |
PubMedSearch : Musilek_2011_Eur.J.Med.Chem_46_811 |
PubMedID: 21236521 |
Title : The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage - Musilek_2011_J.Enzyme.Inhib.Med.Chem_26_245 |
Author(s) : Musilek K , Pavlikova R , Marek J , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Dolezal M , Gunn-Moore F , Kuca K |
Ref : J Enzyme Inhib Med Chem , 26 :245 , 2011 |
Abstract : |
PubMedSearch : Musilek_2011_J.Enzyme.Inhib.Med.Chem_26_245 |
PubMedID: 21406034 |
Title : Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method - Pohanka_2011_Int.J.Mol.Sci_12_2631 |
Author(s) : Pohanka M , Hrabinova M , Kuca K , Simonato JP |
Ref : Int J Mol Sci , 12 :2631 , 2011 |
Abstract : |
PubMedSearch : Pohanka_2011_Int.J.Mol.Sci_12_2631 |
PubMedID: 21731462 |
Title : Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides - Musilek_2011_Med.Res.Rev_31_548 |
Author(s) : Musilek K , Dolezal M , Gunn-Moore F , Kuca K |
Ref : Med Res Rev , 31 :548 , 2011 |
Abstract : |
PubMedSearch : Musilek_2011_Med.Res.Rev_31_548 |
PubMedID: 20027669 |
Title : The effect of oxime reactivators on muscarinic receptors: functional and binding examinations - Soukup_2011_Environ.Toxicol.Pharmacol_31_364 |
Author(s) : Soukup O , Kumar UK , Proska J , Bratova L , Adem A , Jun D , Fusek J , Kuca K , Tobin G |
Ref : Environ Toxicol Pharmacol , 31 :364 , 2011 |
Abstract : |
PubMedSearch : Soukup_2011_Environ.Toxicol.Pharmacol_31_364 |
PubMedID: 21787706 |
Title : Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors - Soukup_2011_Physiol.Res_60_679 |
Author(s) : Soukup O , Krusek J , Kaniakova M , Kumar UK , Oz M , Jun D , Fusek J , Kuca K , Tobin G |
Ref : Physiol Res , 60 :679 , 2011 |
Abstract : |
PubMedSearch : Soukup_2011_Physiol.Res_60_679 |
PubMedID: 21574759 |
Title : Oximes as inhibitors of acetylholinesterase - a structure-activity relationship (SAR) study - Sepsova_2011_Mil.Med.Sci.Lett_80_178 |
Author(s) : Sepsova V , Karasova JZ , Zemek F , Bennion BJ , Kuca K |
Ref : Military Medical Science Letters , 80 :178 , 2011 |
Abstract : |
PubMedSearch : Sepsova_2011_Mil.Med.Sci.Lett_80_178 |
PubMedID: |
Title : Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties - Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563 |
Author(s) : Korabecny J , Musilek K , Zemek F , Horova A , Holas O , Nepovimova E , Opletalova V , Hroudova J , Fisar Z , Jung YS , Kuca K |
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :6563 , 2011 |
Abstract : |
PubMedSearch : Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563 |
PubMedID: 21920739 |
Title : Why acetylcholinesterase reactivators do not work in butyrylcholinesterase - Wiesner_2010_J.Enzyme.Inhib.Med.Chem_25_318 |
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J |
Ref : J Enzyme Inhib Med Chem , 25 :318 , 2010 |
Abstract : |
PubMedSearch : Wiesner_2010_J.Enzyme.Inhib.Med.Chem_25_318 |
PubMedID: 19874115 |
Title : A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats - Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861 |
Author(s) : Kassa J , Karasova JZ , Tesarova S , Musilek K , Kuca K , Jung YS |
Ref : Basic Clin Pharmacol Toxicol , 107 :861 , 2010 |
Abstract : |
PubMedSearch : Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861 |
PubMedID: 22545968 |
Title : A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice - Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480 |
Author(s) : Kassa J , Karasova JZ , Caisberger F , Musilek K , Kuca K , Jung YS |
Ref : J Enzyme Inhib Med Chem , 25 :480 , 2010 |
Abstract : |
PubMedSearch : Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480 |
PubMedID: 20233085 |
Title : Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration - Karasova_2010_Anal.Sci_26_63 |
Author(s) : Karasova JZ , Novotny L , Antos K , Zivna H , Kuca K |
Ref : Anal Sci , 26 :63 , 2010 |
Abstract : |
PubMedSearch : Karasova_2010_Anal.Sci_26_63 |
PubMedID: 20065589 |
Title : Characterization of the anticholinergic properties of obidoxime\; functional examinations of the rat atria and the urinary bladder - Soukup_2010_Toxicol.Mech.Methods_20_428 |
Author(s) : Soukup O , Tobin G , Kumar UK , Jun D , Fusek J , Kuca K |
Ref : Toxicol Mech Methods , 20 :428 , 2010 |
Abstract : |
PubMedSearch : Soukup_2010_Toxicol.Mech.Methods_20_428 |
PubMedID: 20602545 |
Title : Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies - Musilek_2010_ChemMedChem_5_247 |
Author(s) : Musilek K , Holas O , Misik J , Pohanka M , Novotny L , Dohnal V , Opletalova V , Kuca K |
Ref : ChemMedChem , 5 :247 , 2010 |
Abstract : |
PubMedSearch : Musilek_2010_ChemMedChem_5_247 |
PubMedID: 20058292 |
Title : High-performance liquid chromatography analysis of by-products and intermediates arising during the synthesis of the acetylcholinesterase reactivator HI-6 - Jun_2010_J.Chromatogr.Sci_48_694 |
Author(s) : Jun D , Stodulka P , Kuca K , Dolezal B |
Ref : Journal of Chromatography Sci , 48 :694 , 2010 |
Abstract : |
PubMedSearch : Jun_2010_J.Chromatogr.Sci_48_694 |
PubMedID: 20819302 |
Title : Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX - Pohanka_2010_Talanta_81_621 |
Author(s) : Pohanka M , Karasova JZ , Kuca K , Pikula J , Holas O , Korabecny J , Cabal J |
Ref : Talanta , 81 :621 , 2010 |
Abstract : |
PubMedSearch : Pohanka_2010_Talanta_81_621 |
PubMedID: 20188972 |
Title : Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications - Musilek_2010_Bioorg.Med.Chem.Lett_20_1763 |
Author(s) : Musilek K , Komloova M , Zavadova V , Holas O , Hrabinova M , Pohanka M , Dohnal V , Nachon F , Dolezal M , Kuca K , Jung YS |
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1763 , 2010 |
Abstract : |
PubMedSearch : Musilek_2010_Bioorg.Med.Chem.Lett_20_1763 |
PubMedID: 20138518 |
Title : Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure - Karasova_2010_Toxicol.In.Vitro_24_1838 |
Author(s) : Karasova JZ , Pohanka M , Musilek K , Zemek F , Kuca K |
Ref : Toxicol In Vitro , 24 :1838 , 2010 |
Abstract : |
PubMedSearch : Karasova_2010_Toxicol.In.Vitro_24_1838 |
PubMedID: 20546883 |
Title : Chemical warfare agents - Kuca_2010_Exs_100_543 |
Author(s) : Kuca K , Pohanka M |
Ref : Exs , 100 :543 , 2010 |
Abstract : |
PubMedSearch : Kuca_2010_Exs_100_543 |
PubMedID: 20358695 |
Title : In vivo experimental approach to treatment against tabun poisoning - Berend_2010_J.Enzyme.Inhib.Med.Chem_25_531 |
Author(s) : Zunec S , Katalinic M , Vrdoljak AL , Kovarik Z , Kuca K , Radic B |
Ref : J Enzyme Inhib Med Chem , 25 :531 , 2010 |
Abstract : |
PubMedSearch : Berend_2010_J.Enzyme.Inhib.Med.Chem_25_531 |
PubMedID: 20235800 |
Title : In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase - dos Santos_2010_Basic.Clin.Pharmacol.Toxicol_107_768 |
Author(s) : Dos Santos AA , dos Santos DB , Dafre AL , de Bem AF , Souza DO , da Rocha JB , Kuca K , Farina M |
Ref : Basic Clin Pharmacol Toxicol , 107 :768 , 2010 |
Abstract : |
PubMedSearch : dos Santos_2010_Basic.Clin.Pharmacol.Toxicol_107_768 |
PubMedID: 20406208 |
Title : Influence of the acetylcholinesterase active site protonation on omega loop and active site dynamics - Wiesner_2010_J.Biomol.Struct.Dyn_28_393 |
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J |
Ref : J Biomol Struct Dyn , 28 :393 , 2010 |
Abstract : |
PubMedSearch : Wiesner_2010_J.Biomol.Struct.Dyn_28_393 |
PubMedID: 20919754 |
Title : Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment - Korabecny_2010_Molecules_15_8804 |
Author(s) : Korabecny J , Musilek K , Holas O , Nepovimova E , Jun D , Zemek F , Opletalova V , Patocka J , Dohnal V , Nachon F , Hroudova J , Fisar Z , Kuca K |
Ref : Molecules , 15 :8804 , 2010 |
Abstract : |
PubMedSearch : Korabecny_2010_Molecules_15_8804 |
PubMedID: 21127466 |
Title : Structure-activity relationship of quaternary acetylcholinesterase inhibitors - outlook for early myasthenia gravis treatment - Komloova_2010_Curr.Med.Chem_17_1810 |
Author(s) : Komloova M , Musilek K , Dolezal M , Gunn-Moore F , Kuca K |
Ref : Curr Med Chem , 17 :1810 , 2010 |
Abstract : |
PubMedSearch : Komloova_2010_Curr.Med.Chem_17_1810 |
PubMedID: 20345342 |
Title : Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease - Korabecny_2010_Bioorg.Med.Chem.Lett_20_6093 |
Author(s) : Korabecny J , Musilek K , Holas O , Binder J , Zemek F , Marek J , Pohanka M , Opletalova V , Dohnal V , Kuca K |
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6093 , 2010 |
Abstract : |
PubMedSearch : Korabecny_2010_Bioorg.Med.Chem.Lett_20_6093 |
PubMedID: 20817518 |
Title : The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice - Berend_2010_Chem.Biol.Interact_187_291 |
Author(s) : Zunec S , Radic B , Kuca K , Lucic Vrdoljak A |
Ref : Chemico-Biological Interactions , 187 :291 , 2010 |
Abstract : |
PubMedSearch : Berend_2010_Chem.Biol.Interact_187_291 |
PubMedID: 20138854 |
Title : Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase - Kuca_2010_J.Enzyme.Inhib.Med.Chem_25_509 |
Author(s) : Kuca K , Musilek K , Jun D , Pohanka M , Ghosh KK , Hrabinova M |
Ref : J Enzyme Inhib Med Chem , 25 :509 , 2010 |
Abstract : |
PubMedSearch : Kuca_2010_J.Enzyme.Inhib.Med.Chem_25_509 |
PubMedID: 20192902 |
Title : A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice - Kassa_2010_Drug.Chem.Toxicol_33_227 |
Author(s) : Kassa J , Karasova JZ , Kuca K , Musilek K |
Ref : Drug & Chemical Toxicology , 33 :227 , 2010 |
Abstract : |
PubMedSearch : Kassa_2010_Drug.Chem.Toxicol_33_227 |
PubMedID: 20429807 |
Title : Colorimetric Detectors Based on Acetylcholinesterase and Its Construction - Pohanka_2010_Mil.Med.Sci.Lett_79_9 |
Author(s) : Pohanka M , Vlcek V , Karasova JZ , Kuca K , Cabal J |
Ref : Military Medical Science Letters , 79 :9 , 2010 |
Abstract : |
PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_9 |
PubMedID: |
Title : Immobilization of Acetylcholinesterase and a Construction of Biochemical Biosensor for Identification of Toxic Organophosphates. - Pohanka_2010_Mil.Med.Sci.Lett_79_105 |
Author(s) : Pohanka M , Drobik O , Krenkova Z , Karasova JZ , Cabal J , Kuca K |
Ref : Military Medical Science Letters , 79 :105 , 2010 |
Abstract : |
PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_105 |
PubMedID: |
Title : Testing of a Referential Method Based on Indoxylacetate as a Acetylcholinesterase Substrate for Identification of Reactivation Efficacy. - Pohanka_2010_Mil.Med.Sci.Lett_79_111 |
Author(s) : Pohanka M , Hrabinova M , Karasova JZ , Holas O , Kuca K , Cabal J |
Ref : Military Medical Science Letters , 79 :111 , 2010 |
Abstract : |
PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_111 |
PubMedID: |
Title : Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy - Kuca_2010_Bratisl.Lek.Listy_111_502 |
Author(s) : Kuca K , Hrabinova M , Soukup O , Tobin G , Karasova J , Pohanka M |
Ref : Bratislavske Lekarske Listy , 111 :502 , 2010 |
Abstract : |
PubMedSearch : Kuca_2010_Bratisl.Lek.Listy_111_502 |
PubMedID: 21180265 |
Title : New Bisquaternary Inhibitors of Acetylcholinesterase Used as a Prophylactics in Organophosphorus Poisoning - Pavlikova_2010_Mil.Med.Sci.Lett_79_46 |
Author(s) : Pavlikova R , Marek J , Musilek K , Fusek J , Kuca K , Karasova JZ |
Ref : Military Medical Science Letters , 79 :46 , 2010 |
Abstract : |
PubMedSearch : Pavlikova_2010_Mil.Med.Sci.Lett_79_46 |
PubMedID: |
Title : Novel acetylcholinesterase reactivator K112 and its cholinergic properties - Soukup_2010_Biomed.Pharmacother_64_541 |
Author(s) : Soukup O , Kristofikova Z , Proska J , Tobin G , Patocka J , Marek J , Jun D , Fusek J , Ripova D , Kuca K |
Ref : Biomed Pharmacother , 64 :541 , 2010 |
Abstract : |
PubMedSearch : Soukup_2010_Biomed.Pharmacother_64_541 |
PubMedID: 20634031 |
Title : Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase - Kovarik_2010_Chem.Biol.Interact_187_167 |
Author(s) : Kovarik Z , Katalinic M , Sinko G , Binder J , Holas O , Jung YS , Musilova L , Jun D , Kuca K |
Ref : Chemico-Biological Interactions , 187 :167 , 2010 |
Abstract : |
PubMedSearch : Kovarik_2010_Chem.Biol.Interact_187_167 |
PubMedID: 20206154 |
Title : Interaction of nerve agent antidotes with cholinergic systems - Soukup_2010_Curr.Med.Chem_17_1708 |
Author(s) : Soukup O , Tobin G , Kumar UK , Binder J , Proska J , Jun D , Fusek J , Kuca K |
Ref : Curr Med Chem , 17 :1708 , 2010 |
Abstract : |
PubMedSearch : Soukup_2010_Curr.Med.Chem_17_1708 |
PubMedID: 20345348 |
Title : Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model - Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62 |
Author(s) : Pohanka M , Pejchal J , Horackova S , Kuca K , Bandouchova H , Damkova V , Pikula J |
Ref : Neuro Endocrinol Lett , 31 Suppl 2 :62 , 2010 |
Abstract : |
PubMedSearch : Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62 |
PubMedID: 21187825 |
Title : In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties - Bhattacharjee_2010_Chem.Res.Toxicol_23_26 |
Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK |
Ref : Chemical Research in Toxicology , 23 :26 , 2010 |
Abstract : |
PubMedSearch : Bhattacharjee_2010_Chem.Res.Toxicol_23_26 |
PubMedID: 20028185 |
Title : Evaluation of aflatoxin B1--acetylcholinesterase dissociation kinetic using the amperometric biosensor technology: prospect for toxicity mechanism - Pohanka_2010_Protein.Pept.Lett_17_340 |
Author(s) : Pohanka M , Musilek K , Kuca K |
Ref : Protein Pept Lett , 17 :340 , 2010 |
Abstract : |
PubMedSearch : Pohanka_2010_Protein.Pept.Lett_17_340 |
PubMedID: 19508188 |
Title : A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques - Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790 |
Author(s) : Bajgar J , Hajek P , Karasova JZ , Kassa J , Paseka A , Slizova D , Krs O , Kuca K , Jun D , Fusek J , Capek L |
Ref : J Enzyme Inhib Med Chem , 25 :790 , 2010 |
Abstract : |
PubMedSearch : Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790 |
PubMedID: 21054236 |
Title : Development of new acetylcholinesterase reactivators: molecular modeling versus in vitro data - Ramalho_2010_Chem.Biol.Interact_185_73 |
Author(s) : Ramalho TC , Franca TCC , Renno MN , Guimaraes AP , da Cunha EFF , Kuca K |
Ref : Chemico-Biological Interactions , 185 :73 , 2010 |
Abstract : |
PubMedSearch : Ramalho_2010_Chem.Biol.Interact_185_73 |
PubMedID: 20188081 |
Title : Is Oxime Fluorination the Proper Way to Increase Penetration of These Compounds in the Central Nervous System? - Karasova_2010_Mil.Med.Sci.Lett_79_23 |
Author(s) : Karasova JZ , Kassa J , Musilek K , Jung Y , Kuca K |
Ref : Military Medical Science Letters , 79 :23 , 2010 |
Abstract : |
PubMedSearch : Karasova_2010_Mil.Med.Sci.Lett_79_23 |
PubMedID: |
Title : Irinotecan side effects relieved by the use of HI-6 oxime: in vivo experimental approach - Vrdoljak_2009_Basic.Clin.Pharmacol.Toxicol_105_401 |
Author(s) : Vrdoljak AL , Zunec S , Zeljezic D , Piljac-Zegarac J , Plestina S , Kuca K , Radic B , Mladinic M , Kopjar N |
Ref : Basic Clin Pharmacol Toxicol , 105 :401 , 2009 |
Abstract : |
PubMedSearch : Vrdoljak_2009_Basic.Clin.Pharmacol.Toxicol_105_401 |
PubMedID: 19663821 |
Title : A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Toxicol.Mech.Methods_19_346 |
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K |
Ref : Toxicol Mech Methods , 19 :346 , 2009 |
Abstract : |
PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_346 |
PubMedID: 19778210 |
Title : Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent - Jeong_2009_Bioorg.Med.Chem_17_6213 |
Author(s) : Jeong HC , Park NJ , Chae CH , Musilek K , Kassa J , Kuca K , Jung YS |
Ref : Bioorganic & Medicinal Chemistry , 17 :6213 , 2009 |
Abstract : |
PubMedSearch : Jeong_2009_Bioorg.Med.Chem_17_6213 |
PubMedID: 19665386 |
Title : Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats - Karasova_2009_Int.J.Mol.Sci_10_3065 |
Author(s) : Karasova JZ , Kassa J , Musilek K , Pohanka M , Novotny L , Kuca K |
Ref : Int J Mol Sci , 10 :3065 , 2009 |
Abstract : |
PubMedSearch : Karasova_2009_Int.J.Mol.Sci_10_3065 |
PubMedID: 19742125 |
Title : Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy - Pohanka_2009_J.Appl.Toxicol_29_483 |
Author(s) : Pohanka M , Karasova JZ , Musilek K , Kuca K , Kassa J |
Ref : J Appl Toxicol , 29 :483 , 2009 |
Abstract : |
PubMedSearch : Pohanka_2009_J.Appl.Toxicol_29_483 |
PubMedID: 19338015 |
Title : Progress of biosensors based on cholinesterase inhibition - Pohanka_2009_Curr.Med.Chem_16_1790 |
Author(s) : Pohanka M , Musilek K , Kuca K |
Ref : Curr Med Chem , 16 :1790 , 2009 |
Abstract : |
PubMedSearch : Pohanka_2009_Curr.Med.Chem_16_1790 |
PubMedID: 19442145 |
Title : A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats - Kassa_2009_Toxicol.Mech.Methods_19_232 |
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K , Jung AY |
Ref : Toxicol Mech Methods , 19 :232 , 2009 |
Abstract : |
PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_232 |
PubMedID: 19730756 |
Title : Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127 - Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
Author(s) : Kuca K , Cabal J , Jung YS , Musilek K , Soukup O , Jun D , Pohanka M , Musilova L , Karasova J , Novotny L , Hrabinova M |
Ref : Basic Clin Pharmacol Toxicol , 105 :207 , 2009 |
Abstract : |
PubMedSearch : Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
PubMedID: 19473310 |
Title : Chemical aspects of pharmacological prophylaxis against nerve agent poisoning - Bajgar_2009_Curr.Med.Chem_16_2977 |
Author(s) : Bajgar J , Fusek J , Kassa J , Kuca K , Jun D |
Ref : Curr Med Chem , 16 :2977 , 2009 |
Abstract : |
PubMedSearch : Bajgar_2009_Curr.Med.Chem_16_2977 |
PubMedID: 19689278 |
Title : Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6 - Lorke_2009_Toxicol.Mech.Methods_19_327 |
Author(s) : Lorke DE , Hasan MY , Nurulain SM , Kuca K , Schmitt A , Petroianu GA |
Ref : Toxicol Mech Methods , 19 :327 , 2009 |
Abstract : |
PubMedSearch : Lorke_2009_Toxicol.Mech.Methods_19_327 |
PubMedID: 19778224 |
Title : An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Clin.Toxicol.(Phila)_47_72 |
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Bajgar J |
Ref : Clinical Toxicology (Phila) , 47 :72 , 2009 |
Abstract : |
PubMedSearch : Kassa_2009_Clin.Toxicol.(Phila)_47_72 |
PubMedID: 18686075 |
Title : In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048 - Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680 |
Author(s) : Pohanka M , Jun D , Kuca K |
Ref : J Enzyme Inhib Med Chem , 24 :680 , 2009 |
Abstract : |