Full name : Kuca Kamil
First name : Kamil
Mail : Faculty of Military Health Sciences\; Center of Advanced Studies\; Trebesska 1575\; Hradec Kralove\; 500
Zip Code :
City :
Country : Czech Republic
Email : kamil.kuca@uhk.cz
Phone : +420973253028
Fax :
Website : \/\/www.unob.cz\/en\/fmhs\/structure\/k311\/Pages\/Kuca.aspx
Directory :
| Title : The measured CSF\/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24h after donepezil treatment in patients with Alzheimer's disease - Valis_2023_Biomed.Pharmacother_159_114223 |
| Author(s) : Valis M , Dlabkova A , Hort J , Angelucci F , Pejchal J , Kuca K , Pavelek Z , Karasova JZ , Novotny M |
| Ref : Biomed Pharmacother , 159 :114223 , 2023 |
| Abstract : |
| PubMedSearch : Valis_2023_Biomed.Pharmacother_159_114223 |
| PubMedID: 36630846 |
| Title : In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents' surrogates - Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678 |
| Author(s) : Kitagawa DAS , Dos Santos MC , Kuca K , Franca TCC , Cavalcante SFA |
| Ref : Chemico-Biological Interactions , 383 :110678 , 2023 |
| Abstract : |
| PubMedSearch : Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678 |
| PubMedID: 37595776 |
| Title : Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators - Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735 |
| Author(s) : Kapitanov IV , Spulak M , Pour M , Soukup O , Marek J , Jun D , Novak M , Diz de Almeida JSF , Costa Franca TC , Gathergood N , Kuca K , Karpichev Y |
| Ref : Chemico-Biological Interactions , :110735 , 2023 |
| Abstract : |
| PubMedSearch : Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735 |
| PubMedID: 37802409 |
| Title : Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups - Bibi_2023_Sci.Total.Environ__163359 |
| Author(s) : Bibi S , Habib R , Shafiq S , Abbas SS , Khan S , Eqani S , Nepovimova E , Khan MS , Kuca K , Nurulain SM |
| Ref : Sci Total Environ , :163359 , 2023 |
| Abstract : |
| PubMedSearch : Bibi_2023_Sci.Total.Environ__163359 |
| PubMedID: 37030382 |
| Title : Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study - Kuca_2023_Chem.Biol.Interact_14ChEPon_110734 |
| Author(s) : Kuca K , Valle da Silva JA , Nepovimova E , Pham NL , Wu W , Valis M , Wu Q , Franca TCC |
| Ref : Chemico-Biological Interactions , :110734 , 2023 |
| Abstract : |
| PubMedSearch : Kuca_2023_Chem.Biol.Interact_14ChEPon_110734 |
| PubMedID: 37788753 |
| Title : Applications of the Near Attack Conformation (NAC) approach in the search for Acetylcholinesterase reactivators - Franca_2023_Chem.Biol.Interact_14ChEPon_382_110619 |
| Author(s) : Franca TCC , Valle da Silva JA , Dos Santos MC , Cavalcante SFA , Kuca K |
| Ref : Chemico-Biological Interactions , 382 :110619 , 2023 |
| Abstract : |
| PubMedSearch : Franca_2023_Chem.Biol.Interact_14ChEPon_382_110619 |
| PubMedID: 37406983 |
| Title : Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes - Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658 |
| Author(s) : Jacevic V , Dumanovic J , Grujic-Milanovic J , Milovanovic Z , Amidzic L , Vojinovic N , Nezic L , Markovic B , Dobricic V , Milosavljevic P , Nepovimova E , Kuca K |
| Ref : Chemico-Biological Interactions , :110658 , 2023 |
| Abstract : |
| PubMedSearch : Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658 |
| PubMedID: 37572873 |
| Title : Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series? - Santos_2022_Arch.Toxicol__ |
| Author(s) : Santos MC , Botelho FD , Goncalves AS , Kitagawa DAS , Borges CVN , Carvalho-Silva T , Bernardo LB , Ferreira CN , Rodrigues RB , Ferreira Neto DC , Nepovimova E , Kuca K , LaPlante SR , Lima ALS , Franca TCC , Cavalcante SFA |
| Ref : Archives of Toxicology , : , 2022 |
| Abstract : |
| PubMedSearch : Santos_2022_Arch.Toxicol__ |
| PubMedID: 35666269 |
| Title : Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities - Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| Author(s) : Chrienova Z , Nepovimova E , Andrys R , Dolezal R , Janockova J , Muckova L , Fabova L , Soukup O , Oleksak P , Valis M , Korabecny J , Marco-Contelles J , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 37 :2605 , 2022 |
| Abstract : |
| PubMedSearch : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| PubMedID: 36131624 |
| Title : N-substituted arylhydroxamic acids as acetylcholinesterase reactivators - Bondar_2022_Chem.Biol.Interact__110078 |
| Author(s) : Bondar D , Kapitanov I , Pulkrabkova L , Soukup O , Jun D , Diniz FB , Franca TCC , Kuca K , Karpichev Y |
| Ref : Chemico-Biological Interactions , :110078 , 2022 |
| Abstract : |
| PubMedSearch : Bondar_2022_Chem.Biol.Interact__110078 |
| PubMedID: 35940282 |
| Title : Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data - Ramalho_2022_Curr.Med.Chem__ |
| Author(s) : Ramalho TC , de Castro AA , Leal DHS , Teixeira JP , de Cunha EFF , Kuca K |
| Ref : Curr Med Chem , : , 2022 |
| Abstract : |
| PubMedSearch : Ramalho_2022_Curr.Med.Chem__ |
| PubMedID: 36239718 |
| Title : Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers - Khan_2022_Environ.Res__115195 |
| Author(s) : Khan SA , Leonel Javeres MN , Abbas Shah ST , Bibi N , Muneer Z , Hussain S , Nepovimova E , Kuca K , Nurulain SM |
| Ref : Environ Research , :115195 , 2022 |
| Abstract : |
| PubMedSearch : Khan_2022_Environ.Res__115195 |
| PubMedID: 36592809 |
| Title : Multiple Neurological Effects Associated with Exposure to Organophosphorus Pesticides in Man - Jokanovic_2022_Toxicology__153407 |
| Author(s) : Jokanovic M , Oleksak P , Kuca K |
| Ref : Toxicology , :153407 , 2022 |
| Abstract : |
| PubMedSearch : Jokanovic_2022_Toxicology__153407 |
| PubMedID: 36543276 |
| Title : Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok) - Santos_2022_Food.Chem.Toxicol__113084 |
| Author(s) : Santos MC , Botelho FD , Goncalves AS , Kuca K , Nepovimova E , Cavalcante SFA , Lima ALS , Franca TCC |
| Ref : Food & Chemical Toxicology , :113084 , 2022 |
| Abstract : |
| PubMedSearch : Santos_2022_Food.Chem.Toxicol__113084 |
| PubMedID: 35489467 |
| Title : Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators - Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370 |
| Author(s) : Kitagawa DAS , Rodrigues RB , Silva TN , Dos Santos WV , da Rocha VCV , de Almeida JSFD , Bernardo LB , Carvalho-Silva T , Ferreira CN , da Silva AAT , Simas ABC , Nepovimova E , Kuca K , Franca TCC , Cavalcante SFA |
| Ref : J Enzyme Inhib Med Chem , 36 :1370 , 2021 |
| Abstract : |
| PubMedSearch : Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370 |
| PubMedID: 34148470 |
| Title : Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl - Lorke_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : |
| PubMedSearch : Lorke_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 33802843 |
| Title : Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells - Hudacova_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Hudacova M , Hamuakova S , Konkoova E , Jendzelovsky R , Vargova J , Sevc J , Fedorocko P , Soukup O , Janockova J , Ihnatova V , Kucera T , Bzonek P , Novakova N , Jun D , Junova L , Korabecny J , Kuca K , Kozurkova M |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : |
| PubMedSearch : Hudacova_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 33917200 |
| Title : Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease - Hamulakova_2021_Future.Med.Chem__ |
| Author(s) : Hamulakova S , Kudlickova Z , Janovec L , Mezencev R , Deckner ZJ , Chernoff YO , Janockova J , Ihnatova V , Bzonek P , Novakova N , Hepnarova V , Hrabinova M , Jun D , Korabecny J , Soukup O , Kuca K |
| Ref : Future Med Chem , : , 2021 |
| Abstract : |
| PubMedSearch : Hamulakova_2021_Future.Med.Chem__ |
| PubMedID: 33829876 |
| Title : Combined Pre- and Posttreatment of Paraoxon Exposure - Lorke_2020_Molecules_25_ |
| Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : Lorke_2020_Molecules_25_ |
| PubMedID: 32230733 |
| Title : Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer's Drugs: Spectroscopic Insights - Sharma_2020_J.Biomol.Struct.Dyn_38_1822 |
| Author(s) : Sharma S , Singh N , Nepovimova E , Korabecny J , Kuca K , Satnami ML , Ghosh KK |
| Ref : J Biomol Struct Dyn , 38 :1822 , 2020 |
| Abstract : |
| PubMedSearch : Sharma_2020_J.Biomol.Struct.Dyn_38_1822 |
| PubMedID: 31096863 |
| Title : Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators - Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
| Author(s) : Malinak D , Dolezal R , Hepnarova V , Hozova M , Andrys R , Bzonek P , Racakova V , Korabecny J , Gorecki L , Mezeiova E , Psotka M , Jun D , Kuca K , Musilek K |
| Ref : J Enzyme Inhib Med Chem , 35 :478 , 2020 |
| Abstract : |
| PubMedSearch : Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
| PubMedID: 31910701 |
| Title : Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study - da Silva_2020_Biomolecules_10_ |
| Author(s) : da Silva JAV , Pereira AF , LaPlante SR , Kuca K , Ramalho TC , Franca TCC |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : |
| PubMedSearch : da Silva_2020_Biomolecules_10_ |
| PubMedID: 32012780 |
| Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596 |
| Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K |
| Ref : Bioorg Chem , 107 :104596 , 2020 |
| Abstract : |
| PubMedSearch : Nepovimova_2020_Bioorg.Chem_107_104596 |
| PubMedID: 33421953 |
| Title : Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects - de Castro_2020_Int.J.Mol.Sci_21_ |
| Author(s) : de Castro AA , Polisel DA , Pereira BTL , da Cunha EFF , Kuca K , Nepovimova E , Ramalho TC |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : de Castro_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32899591 |
| Title : Acetylcholinesterase: The Hub for Neurodegenerative Diseases and Chemical Weapons Convention - Cavalcante_2020_Biomolecules_10_ |
| Author(s) : Cavalcante SFA , Simas ABC , Barcellos MC , de Oliveira VGM , Sousa RB , Cabral PAM , Kuca K , Franca TCC |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : |
| PubMedSearch : Cavalcante_2020_Biomolecules_10_ |
| PubMedID: 32155996 |
| Title : Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602 - Furqan_2020_Biomolecules_10_ |
| Author(s) : Furqan T , Batool S , Habib R , Shah M , Kalasz H , Darvas F , Kuca K , Nepovimova E , Nurulain SM |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : |
| PubMedSearch : Furqan_2020_Biomolecules_10_ |
| PubMedID: 32414087 |
| Title : Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019) - de Castro_2020_Biomolecules_10_ |
| Author(s) : de Castro AA , Assis LC , Soares FV , Kuca K , Polisel DA , da Cunha EFF , Ramalho TC |
| Ref : Biomolecules , 10 : , 2020 |
| Abstract : |
| PubMedSearch : de Castro_2020_Biomolecules_10_ |
| PubMedID: 32178264 |
| Title : Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness - Karasova_2020_Toxicol.Lett_320_64 |
| Author(s) : Karasova JZ , Hepnarova V , Andrys R , Lisa M , Jost P , Muckova L , Pejchal J , Herman D , Jun D , Kassa J , Kuca K |
| Ref : Toxicol Lett , 320 :64 , 2020 |
| Abstract : |
| PubMedSearch : Karasova_2020_Toxicol.Lett_320_64 |
| PubMedID: 31794810 |
| Title : Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan - Mbah Ntepe_2020_Int.J.Mol.Sci_21_ |
| Author(s) : Mbah Ntepe LJ , Habib R , Judith Laure N , Raza S , Nepovimova E , Kuca K , Batool S , Muhammad Nurulain S |
| Ref : Int J Mol Sci , 21 : , 2020 |
| Abstract : |
| PubMedSearch : Mbah Ntepe_2020_Int.J.Mol.Sci_21_ |
| PubMedID: 32899431 |
| Title : Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations - Leonel_2020_Environ.Res__110210 |
| Author(s) : Leonel Javeres MN , Habib R , Judith N , Iqbal M , Nepovimova E , Kuca K , Batool S , Nurulain SM |
| Ref : Environ Research , :110210 , 2020 |
| Abstract : |
| PubMedSearch : Leonel_2020_Environ.Res__110210 |
| PubMedID: 32949615 |
| Title : Review about structure and evaluation of reactivators of Acetylcholinesterase inhibited with neurotoxic organophosphorus compounds - Figueroa-Villar_2020_Curr.Med.Chem__ |
| Author(s) : Figueroa-Villar JD , Petronilho EC , Kuca K , Franca TCC |
| Ref : Curr Med Chem , : , 2020 |
| Abstract : |
| PubMedSearch : Figueroa-Villar_2020_Curr.Med.Chem__ |
| PubMedID: 32334495 |
| Title : Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats - Karasova_2020_Iran.J.Pharm.Res_19_95 |
| Author(s) : Karasova JZ , Hrabinova M , Krejciova M , Jun D , Kuca K |
| Ref : Iran J Pharm Res , 19 :95 , 2020 |
| Abstract : |
| PubMedSearch : Karasova_2020_Iran.J.Pharm.Res_19_95 |
| PubMedID: 33680013 |
| Title : An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment - Wu_2020_Arch.Toxicol_94_3645 |
| Author(s) : Wu Q , Qin Z , Kuca K , You L , Zhao Y , Liu A , Musilek K , Chrienova Z , Nepovimova E , Oleksak P , Wu W , Wang X |
| Ref : Archives of Toxicology , 94 :3645 , 2020 |
| Abstract : |
| PubMedSearch : Wu_2020_Arch.Toxicol_94_3645 |
| PubMedID: 32910237 |
| Title : Glycosylated-Imidazole Aldoximes as Reactivators of Pesticides Inhibited AChE: Synthesis and In-vitro Reactivation Study - Sharma_2020_Environ.Toxicol.Pharmacol__103454 |
| Author(s) : Sharma R , Upadhyaya K , Gupta B , Ghosh KK , Tripathi RP , Musilek K , Kuca K |
| Ref : Environ Toxicol Pharmacol , :103454 , 2020 |
| Abstract : |
| PubMedSearch : Sharma_2020_Environ.Toxicol.Pharmacol__103454 |
| PubMedID: 32645360 |
| Title : Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors - Gorecki_2020_ACS.Med.Chem.Lett_11_65 |
| Author(s) : Gorecki L , Andrys R , Schmidt M , Kucera T , Psotka M , Svobodova B , Hrabcova V , Hepnarova V , Bzonek P , Jun D , Kuca K , Korabecny J , Musilek K |
| Ref : ACS Med Chem Lett , 11 :65 , 2020 |
| Abstract : |
| PubMedSearch : Gorecki_2020_ACS.Med.Chem.Lett_11_65 |
| PubMedID: 31938465 |
| Title : Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors - Botelho_2020_Toxins.(Basel)_12_ |
| Author(s) : Botelho FD , Dos Santos MC , Goncalves ADS , Kuca K , Valis M , LaPlante SR , Franca TCC , de Almeida J |
| Ref : Toxins (Basel) , 12 : , 2020 |
| Abstract : |
| PubMedSearch : Botelho_2020_Toxins.(Basel)_12_ |
| PubMedID: 33256167 |
| Title : N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy - Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| Author(s) : Nepovimova E , Korabecny J , Hepnarova V , Jun D , Dolezal R , Muckova L , Jost P , Soukup O , Janockova J , Pham NL , Nguyen TD , Valis M , Kuca K |
| Ref : Curr Alzheimer Res , 16 :333 , 2019 |
| Abstract : |
| PubMedSearch : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| PubMedID: 30873921 |
| Title : Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease - Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| Author(s) : Mezeiova E , Chalupova K , Nepovimova E , Gorecki L , Prchal L , Malinak D , Kuca K , Soukup O , Korabecny J |
| Ref : Curr Alzheimer Res , 16 :772 , 2019 |
| Abstract : |
| PubMedSearch : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| PubMedID: 30819078 |
| Title : Oxime K203: a drug candidate for the treatment of tabun intoxication - Gorecki_2019_Arch.Toxicol_93_673 |
| Author(s) : Gorecki L , Soukup O , Kucera T , Malinak D , Jun D , Kuca K , Musilek K , Korabecny J |
| Ref : Archives of Toxicology , 93 :673 , 2019 |
| Abstract : |
| PubMedSearch : Gorecki_2019_Arch.Toxicol_93_673 |
| PubMedID: 30564897 |
| Title : Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease - de Oliveira_2019_Int.J.Mol.Sci_20_ |
| Author(s) : de Oliveira CBJ , Neto DCF , de Almeida JSFD , Lima JA , Kuca K , Franca TCC , Figueroa-Villar JD |
| Ref : Int J Mol Sci , 20 : , 2019 |
| Abstract : |
| PubMedSearch : de Oliveira_2019_Int.J.Mol.Sci_20_ |
| PubMedID: 31416113 |
| Title : Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13 - Cruz_2019_J.Biomol.Struct.Dyn_37_1616 |
| Author(s) : Cruz JN , Costa JFS , Khayat AS , Kuca K , Barros CAL , Neto A |
| Ref : J Biomol Struct Dyn , 37 :1616 , 2019 |
| Abstract : |
| PubMedSearch : Cruz_2019_J.Biomol.Struct.Dyn_37_1616 |
| PubMedID: 29633908 |
| Title : Non-conventional compounds with potential therapeutic effects against Alzheimer's disease - de Castro_2019_Expert.Rev.Neurother_19_375 |
| Author(s) : de Castro AA , Soares FV , Pereira AF , Polisel DA , Caetano MS , Leal DHS , da Cunha EFF , Nepovimova E , Kuca K , Ramalho TC |
| Ref : Expert Rev Neurother , 19 :375 , 2019 |
| Abstract : |
| PubMedSearch : de Castro_2019_Expert.Rev.Neurother_19_375 |
| PubMedID: 30999771 |
| Title : Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate - Cavalcante_2019_Chem.Biol.Interact_13ChEPon_309_108682 |
| Author(s) : Cavalcante SFA , Kitagawa DAS , Rodrigues RB , Bernardo LB , da Silva TN , Dos Santos WV , Correa ABA , de Almeida JSFD , Franca TCC , Kuca K , Simas ABC |
| Ref : Chemico-Biological Interactions , 309 :108682 , 2019 |
| Abstract : |
| PubMedSearch : Cavalcante_2019_Chem.Biol.Interact_13ChEPon_309_108682 |
| PubMedID: 31163137 |
| Title : Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes - Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16 |
| Author(s) : Zorbaz T , Malinak D , Kuca K , Musilek K , Kovarik Z |
| Ref : Chemico-Biological Interactions , 307 :16 , 2019 |
| Abstract : |
| PubMedSearch : Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16 |
| PubMedID: 31004594 |
| Title : In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers - Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877 |
| Author(s) : Janockova J , Korabecny J , Plsikova J , Babkova K , Konkolova E , Kucerova D , Vargova J , Koval J , Jendzelovsky R , Fedorocko P , Kasparkova J , Brabec V , Rosocha J , Soukup O , Hamulakova S , Kuca K , Kozurkova M |
| Ref : J Enzyme Inhib Med Chem , 34 :877 , 2019 |
| Abstract : |
| PubMedSearch : Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877 |
| PubMedID: 30938202 |
| Title : Tacrine and its 7-methoxy derivate\; time-change concentration in plasma and brain tissue and basic toxicological profile in rats - Karasova_2019_Drug.Chem.Toxicol__1 |
| Author(s) : Karasova JZ , Soukup O , Korabecny J , Hroch M , Krejciova M , Hrabinova M , Misik J , Novotny L , Hepnarova V , Kuca K |
| Ref : Drug & Chemical Toxicology , :1 , 2019 |
| Abstract : |
| PubMedSearch : Karasova_2019_Drug.Chem.Toxicol__1 |
| PubMedID: 31257938 |
| Title : Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models - Iqbal_2019_Chem.Biol.Interact_13ChEPon_310_108735 |
| Author(s) : Iqbal A , Malik S , Nurulain SM , Musilek K , Kuca K , Kalasz H , Fatmi MQ |
| Ref : Chemico-Biological Interactions , 310 :108735 , 2019 |
| Abstract : |
| PubMedSearch : Iqbal_2019_Chem.Biol.Interact_13ChEPon_310_108735 |
| PubMedID: 31276662 |
| Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
| Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC |
| Ref : J Enzyme Inhib Med Chem , 34 :1018 , 2019 |
| Abstract : |
| PubMedSearch : da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018 |
| PubMedID: 31074292 |
| Title : Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning - Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737 |
| Author(s) : Tekes K , Karvaly G , Nurulain S , Kuca K , Musilek K , Adeghate E , Jung YS , Kalasz H |
| Ref : Chemico-Biological Interactions , 310 :108737 , 2019 |
| Abstract : |
| PubMedSearch : Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737 |
| PubMedID: 31279792 |
| Title : Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths - da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195 |
| Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC |
| Ref : Chemico-Biological Interactions , 307 :195 , 2019 |
| Abstract : |
| PubMedSearch : da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195 |
| PubMedID: 31121152 |
| Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
| Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
| Abstract : |
| PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedID: 30851693 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Some Possibilities to Study New Prophylactics against Nerve Agents - Bajgar_2019_Mini.Rev.Med.Chem_19_970 |
| Author(s) : Bajgar J , Kassa J , Kucera T , Musilek K , Jun D , Kuca K |
| Ref : Mini Rev Med Chem , 19 :970 , 2019 |
| Abstract : |
| PubMedSearch : Bajgar_2019_Mini.Rev.Med.Chem_19_970 |
| PubMedID: 30827238 |
| Title : Interspecies and intergender differences in acute toxicity of K-oximes drug candidates - Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312 |
| Author(s) : Jacevic V , Nepovimova E , Kuca K |
| Ref : Chemico-Biological Interactions , 308 :312 , 2019 |
| Abstract : |
| PubMedSearch : Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312 |
| PubMedID: 31153983 |
| Title : Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation - Antonijevic_2019_Chem.Biol.Interact_13ChEPon_308_385 |
| Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Andjelkovic M , Djordjevic AB , Antonijevic B |
| Ref : Chemico-Biological Interactions , 308 :385 , 2019 |
| Abstract : |
| PubMedSearch : Antonijevic_2019_Chem.Biol.Interact_13ChEPon_308_385 |
| PubMedID: 31141677 |
| Title : Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase - de Almeida_2019_Chem.Biol.Interact_13ChEPon_308_113 |
| Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC |
| Ref : Chemico-Biological Interactions , 308 :113 , 2019 |
| Abstract : |
| PubMedSearch : de Almeida_2019_Chem.Biol.Interact_13ChEPon_308_113 |
| PubMedID: 31100275 |
| Title : Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure - Jacevic_2019_Sci.Rep_9_1457 |
| Author(s) : Jacevic V , Nepovimova E , Kuca K |
| Ref : Sci Rep , 9 :1457 , 2019 |
| Abstract : |
| PubMedSearch : Jacevic_2019_Sci.Rep_9_1457 |
| PubMedID: 30728420 |
| Title : Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside - Sharma_2019_Expert.Rev.Neurother_19_359 |
| Author(s) : Sharma R , Kuca K , Nepovimova E , Kabra A , Rao MM , Prajapati PK |
| Ref : Expert Rev Neurother , 19 :359 , 2019 |
| Abstract : |
| PubMedSearch : Sharma_2019_Expert.Rev.Neurother_19_359 |
| PubMedID: 30884983 |
| Title : Orexin supplementation in narcolepsy treatment: A review - Nepovimova_2019_Med.Res.Rev_39_961 |
| Author(s) : Nepovimova E , Janockova J , Misik J , Kubik S , Stuchlik A , Vales K , Korabecny J , Mezeiova E , Dolezal R , Soukup O , Kobrlova T , Pham NL , Nguyen TD , Konecny J , Kuca K |
| Ref : Med Res Rev , 39 :961 , 2019 |
| Abstract : |
| PubMedSearch : Nepovimova_2019_Med.Res.Rev_39_961 |
| PubMedID: 30426515 |
| Title : Oximes as pretreatment before acute exposure to paraoxon - Lorke_2019_J.Appl.Toxicol_39_1506 |
| Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
| Ref : J Appl Toxicol , 39 :1506 , 2019 |
| Abstract : |
| PubMedSearch : Lorke_2019_J.Appl.Toxicol_39_1506 |
| PubMedID: 31264735 |
| Title : In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon - Kitagawa_2019_Biomolecules_9_ |
| Author(s) : Kitagawa DAS , Cavalcante SFA , de Paula RL , Rodrigues RB , Bernardo LB , da Silva MCJ , da Silva TN , Dos Santos WV , Granjeiro JM , de Almeida JSFD , Barcellos MC , de ACAB , Franca TCC , Kuca K , Simas ABC |
| Ref : Biomolecules , 9 : , 2019 |
| Abstract : |
| PubMedSearch : Kitagawa_2019_Biomolecules_9_ |
| PubMedID: 31597234 |
| Title : Biodegradation of Organophosphorus Compounds Predicted by Enzymatic Process Using Molecular Modelling and Observed in Soil Samples Through Analytical Techniques and Microbiological Analysis: A Comparison - Cardozo_2019_Molecules_25_ |
| Author(s) : Cardozo M , de Almeida J , Cavalcante SFA , Salgado JRS , Goncalves AS , Franca TCC , Kuca K , Bizzo HR |
| Ref : Molecules , 25 : , 2019 |
| Abstract : |
| PubMedSearch : Cardozo_2019_Molecules_25_ |
| PubMedID: 31878010 |
| Title : Novichoks: The Dangerous Fourth Generation of Chemical Weapons - Franca_2019_Int.J.Mol.Sci_20_ |
| Author(s) : Franca TCC , Kitagawa DAS , Cavalcante SFA , da Silva JAV , Nepovimova E , Kuca K |
| Ref : Int J Mol Sci , 20 : , 2019 |
| Abstract : |
| PubMedSearch : Franca_2019_Int.J.Mol.Sci_20_ |
| PubMedID: 30862059 |
| Title : Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects - Polisel_2019_Chem.Biol.Interact_13ChEPon_309_108671 |
| Author(s) : Polisel DA , de Castro AA , Mancini DT , da Cunha EFF , Franca TCC , Ramalho TC , Kuca K |
| Ref : Chemico-Biological Interactions , 309 :108671 , 2019 |
| Abstract : |
| PubMedSearch : Polisel_2019_Chem.Biol.Interact_13ChEPon_309_108671 |
| PubMedID: 31207225 |
| Title : Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier - Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Janockova J , Hrabinova M , Sepsova V , Kuca K |
| Ref : Curr Alzheimer Res , 15 :1096 , 2018 |
| Abstract : |
| PubMedSearch : Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| PubMedID: 29992880 |
| Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
| Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC |
| Ref : BMC Pharmacol Toxicol , 19 :8 , 2018 |
| Abstract : |
| PubMedSearch : Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
| PubMedID: 29467029 |
| Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K |
| Ref : Drug Des Devel Ther , 12 :505 , 2018 |
| Abstract : |
| PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedID: 29563775 |
| Title : Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon - Kuca_2018_Molecules_23_ |
| Author(s) : Kuca K , Jun D , Junova L , Musilek K , Hrabinova M , da Silva JAV , Ramalho TC , Valko M , Wu Q , Nepovimova E , Franca TCC |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Kuca_2018_Molecules_23_ |
| PubMedID: 29735900 |
| Title : Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes - Antonijevic_2018_Food.Chem.Toxicol_121_224 |
| Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Curcic M , Miladinovic DC , Bulat Z , Antonijevic B |
| Ref : Food & Chemical Toxicology , 121 :224 , 2018 |
| Abstract : |
| PubMedSearch : Antonijevic_2018_Food.Chem.Toxicol_121_224 |
| PubMedID: 30176309 |
| Title : Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study - Malinak_2018_Molecules_23_ |
| Author(s) : Malinak D , Nepovimova E , Jun D , Musilek K , Kuca K |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Malinak_2018_Molecules_23_ |
| PubMedID: 30205495 |
| Title : Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents - Zorbaz_2018_J.Med.Chem_61_10753 |
| Author(s) : Zorbaz T , Malinak D , Marakovic N , Macek Hrvat N , Zandona A , Novotny M , Skarka A , Andrys R , Benkova M , Soukup O , Katalinic M , Kuca K , Kovarik Z , Musilek K |
| Ref : Journal of Medicinal Chemistry , 61 :10753 , 2018 |
| Abstract : |
| PubMedSearch : Zorbaz_2018_J.Med.Chem_61_10753 |
| PubMedID: 30383374 |
| Title : In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication - Arshad_2018_Toxicol.Mech.Methods_28_62 |
| Author(s) : Arshad M , Fatmi MQ , Musilek K , Hussain A , Kuca K , Petroianu G , Kalasz H , Nurulain SM |
| Ref : Toxicol Mech Methods , 28 :62 , 2018 |
| Abstract : |
| PubMedSearch : Arshad_2018_Toxicol.Mech.Methods_28_62 |
| PubMedID: 28722512 |
| Title : Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication - Soares_2018_Int.J.Mol.Sci_19_ |
| Author(s) : Soares FV , de Castro AA , Pereira AF , Leal DHS , Mancini DT , Krejcar O , Ramalho TC , da Cunha EFF , Kuca K |
| Ref : Int J Mol Sci , 19 : , 2018 |
| Abstract : |
| PubMedSearch : Soares_2018_Int.J.Mol.Sci_19_ |
| PubMedID: 29690585 |
| Title : Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon - de Paula_2018_Molecules_23_ |
| Author(s) : de Paula RL , de Almeida JSFD , Cavalcante SFA , Goncalves AS , Simas ABC , Franca TCC , Valis M , Kuca K , Nepovimova E , Granjeiro JM |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : de Paula_2018_Molecules_23_ |
| PubMedID: 30424582 |
| Title : Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site (PAS) of human acetylcholinesterase - de Almeida_2018_J.Biomol.Struct.Dyn__1 |
| Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC |
| Ref : J Biomol Struct Dyn , :1 , 2018 |
| Abstract : |
| PubMedSearch : de Almeida_2018_J.Biomol.Struct.Dyn__1 |
| PubMedID: 29749305 |
| Title : Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS) - de Almeida_2018_Toxins.(Basel)_10_ |
| Author(s) : de Almeida JSFD , Dolezal R , Krejcar O , Kuca K , Musilek K , Jun D , Franca TCC |
| Ref : Toxins (Basel) , 10 : , 2018 |
| Abstract : |
| PubMedSearch : de Almeida_2018_Toxins.(Basel)_10_ |
| PubMedID: 30257474 |
| Title : A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators - Tsai_2021_J.Food.Drug.Anal_29_153 |
| Author(s) : Malinak D , Korabecny J , Soukup O , Gorecki L , Nepovimova E , Psotka M , Dolezal R , Nguyen TD , Mezeiova E , Musilek K , Kuca K |
| Ref : Current Organic Chemistry , 22\ :1619 , 2018 |
| Abstract : |
| PubMedSearch : Tsai_2021_J.Food.Drug.Anal_29_153 |
| PubMedID: |
| Title : Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves - Affonso_2018_Biomed.Chromatogr_32_ |
| Author(s) : Affonso RS , Lima JA , Lessa BM , Caetano JVO , Obara MT , Nobrega AB , Nepovimova E , Musilek K , Kuca K , Slana G , Franca TCC |
| Ref : Biomedical Chromatography , 32 : , 2018 |
| Abstract : |
| PubMedSearch : Affonso_2018_Biomed.Chromatogr_32_ |
| PubMedID: 28913959 |
| Title : Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission - Korabecny_2018_Neurosci_370_191 |
| Author(s) : Korabecny J , Nepovimova E , Cikankova T , Spilovska K , Vaskova L , Mezeiova E , Kuca K , Hroudova J |
| Ref : Neuroscience , 370 :191 , 2018 |
| Abstract : |
| PubMedSearch : Korabecny_2018_Neurosci_370_191 |
| PubMedID: 28673719 |
| Title : Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain - Antonijevic_2018_Arch.Toxicol_92_745 |
| Author(s) : Antonijevic E , Kotur-Stevuljevic J , Musilek K , Kosvancova A , Kuca K , Djukic-Cosic D , Spasojevic-Kalimanovska V , Antonijevic B |
| Ref : Archives of Toxicology , 92 :745 , 2018 |
| Abstract : |
| PubMedSearch : Antonijevic_2018_Arch.Toxicol_92_745 |
| PubMedID: 29098328 |
| Title : The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats - Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373 |
| Author(s) : Karasova JZ , Mzik M , Hroch M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K |
| Ref : Basic Clin Pharmacol Toxicol , 122 :373 , 2018 |
| Abstract : |
| PubMedSearch : Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373 |
| PubMedID: 29067789 |
| Title : The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease - Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| Author(s) : Hepnarova V , Korabecny J , Matouskova L , Jost P , Muckova L , Hrabinova M , Vykoukalova N , Kerhartova M , Kucera T , Dolezal R , Nepovimova E , Spilovska K , Mezeiova E , Pham NL , Jun D , Staud F , Kaping D , Kuca K , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 150 :292 , 2018 |
| Abstract : |
| PubMedSearch : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| PubMedID: 29533874 |
| Title : Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods - Janockova_2018_Molecules_23_ |
| Author(s) : Janockova J , Dolezal R , Nepovimova E , Kobrlova T , Benkova M , Kuca K , Konecny J , Mezeiova E , Melikova M , Hepnarova V , Ring A , Soukup O , Korabecny J |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Janockova_2018_Molecules_23_ |
| PubMedID: 30423961 |
| Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281 |
| Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K |
| Ref : Med Chem , 14 :281 , 2018 |
| Abstract : |
| PubMedSearch : Soukup_2018_Med.Chem_14_281 |
| PubMedID: 29332594 |
| Title : Profiling donepezil template into multipotent hybrids with antioxidant properties - Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| Author(s) : Mezeiova E , Spilovska K , Nepovimova E , Gorecki L , Soukup O , Dolezal R , Malinak D , Janockova J , Jun D , Kuca K , Korabecny J |
| Ref : J Enzyme Inhib Med Chem , 33 :583 , 2018 |
| Abstract : |
| PubMedSearch : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| PubMedID: 29529892 |
| Title : Chemical warfare agent NOVICHOK - mini-review of available data - Nepovimova_2018_Food.Chem.Toxicol_121_343 |
| Author(s) : Nepovimova E , Kuca K |
| Ref : Food & Chemical Toxicology , 121 :343 , 2018 |
| Abstract : |
| PubMedSearch : Nepovimova_2018_Food.Chem.Toxicol_121_343 |
| PubMedID: 30213549 |
| Title : The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: A computational study - Cuya_2017_J.Biomol.Struct.Dyn__1 |
| Author(s) : Cuya T , Goncalves ADS , da Silva JAV , Ramalho TC , Kuca K , Franca TCC |
| Ref : J Biomol Struct Dyn , :1 , 2017 |
| Abstract : |
| PubMedSearch : Cuya_2017_J.Biomol.Struct.Dyn__1 |
| PubMedID: 29019446 |
| Title : Optimal Pre-treatment for Acute Exposure to the Organophosphate Dicrotophos - Lorke_2017_Curr.Pharm.Des_23_3432 |
| Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
| Ref : Curr Pharm Des , 23 :3432 , 2017 |
| Abstract : |
| PubMedSearch : Lorke_2017_Curr.Pharm.Des_23_3432 |
| PubMedID: 27799040 |
| Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K |
| Ref : Expert Opin Ther Pat , 27 :971 , 2017 |
| Abstract : |
| PubMedSearch : Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| PubMedID: 28569609 |
| Title : HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication - Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| Author(s) : Psotka M , Malinak D , Gorecki L , Nguyen TD , Soukup O , Jun D , Kuca K , Musilek K , Korabecny J |
| Ref : Military Medical Science Letters , 86 :70 , 2017 |
| Abstract : |
| PubMedSearch : Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| PubMedID: |
| Title : The pharmacology of tacrine at N-methyl-d-aspartate receptors - Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
| Author(s) : Horak M , Holubova K , Nepovimova E , Krusek J , Kaniakova M , Korabecny J , Vyklicky L , Kuca K , Stuchlik A , Ricny J , Vales K , Soukup O |
| Ref : Prog Neuropsychopharmacol Biological Psychiatry , 75 :54 , 2017 |
| Abstract : |
| PubMedSearch : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
| PubMedID: 28089695 |
| Title : Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-Tabun conjugate: A molecular modeling approach - de Souza_2017_J.Biomol.Struct.Dyn__1 |
| Author(s) : de Souza FR , Garcia DR , Guizado TC , Kuca K , de Alencastro RB , Franca TCC |
| Ref : J Biomol Struct Dyn , :1 , 2017 |
| Abstract : |
| PubMedSearch : de Souza_2017_J.Biomol.Struct.Dyn__1 |
| PubMedID: 28446076 |
| Title : Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy - Mezeiova_2017_Molecules_22_ |
| Author(s) : Mezeiova E , Korabecny J , Sepsova V , Hrabinova M , Jost P , Muckova L , Kucera T , Dolezal R , Misik J , Spilovska K , Pham NL , Pokrievkova L , Roh J , Jun D , Soukup O , Kaping D , Kuca K |
| Ref : Molecules , 22 : , 2017 |
| Abstract : |
| PubMedSearch : Mezeiova_2017_Molecules_22_ |
| PubMedID: 28788095 |
| Title : Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation - Spilovska_2017_Molecules_22_ |
| Author(s) : Spilovska K , Korabecny J , Sepsova V , Jun D , Hrabinova M , Jost P , Muckova L , Soukup O , Janockova J , Kucera T , Dolezal R , Mezeiova E , Kaping D , Kuca K |
| Ref : Molecules , 22 : , 2017 |
| Abstract : |
| PubMedSearch : Spilovska_2017_Molecules_22_ |
| PubMedID: 28621747 |
| Title : Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment - Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| Author(s) : Gazova Z , Soukup O , Sepsova V , Siposova K , Drtinova L , Jost P , Spilovska K , Korabecny J , Nepovimova E , Fedunova D , Horak M , Kaniakova M , Wang ZJ , Hamouda AK , Kuca K |
| Ref : Biochimica & Biophysica Acta Mol Basis Dis , 1863 :607 , 2017 |
| Abstract : |
| PubMedSearch : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| PubMedID: 27865910 |
| Title : Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids - Hamulakova_2017_Int.J.Biol.Macromol_104_333 |
| Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Kuca K |
| Ref : Int J Biol Macromol , 104 :333 , 2017 |
| Abstract : |
| PubMedSearch : Hamulakova_2017_Int.J.Biol.Macromol_104_333 |
| PubMedID: 28601645 |
| Title : Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs - Karasova_2017_Toxicol.Lett_273_20 |
| Author(s) : Karasova JZ , Kvetina J , Tacheci I , Radochova V , Musilek K , Kuca K , Bures J |
| Ref : Toxicol Lett , 273 :20 , 2017 |
| Abstract : |
| PubMedSearch : Karasova_2017_Toxicol.Lett_273_20 |
| PubMedID: 28343895 |
| Title : Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors - Babkova_2017_Future.Med.Chem_9_1015 |
| Author(s) : Babkova K , Korabecny J , Soukup O , Nepovimova E , Jun D , Kuca K |
| Ref : Future Med Chem , 9 :1015 , 2017 |
| Abstract : |
| PubMedSearch : Babkova_2017_Future.Med.Chem_9_1015 |
| PubMedID: 28632451 |
| Title : Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis - Karasova_2017_Toxicol.Lett_277_24 |
| Author(s) : Karasova JZ , Maderycova Z , Tumova M , Jun D , Rehacek V , Kuca K , Misik J |
| Ref : Toxicol Lett , 277 :24 , 2017 |
| Abstract : |
| PubMedSearch : Karasova_2017_Toxicol.Lett_277_24 |
| PubMedID: 28465191 |
| Title : Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment - Soukup_2017_Curr.Neuropharmacol_15_637 |
| Author(s) : Soukup O , Winder M , Killi UK , Wsol V , Jun D , Kuca K , Tobin G |
| Ref : Curr Neuropharmacol , 15 :637 , 2017 |
| Abstract : |
| PubMedSearch : Soukup_2017_Curr.Neuropharmacol_15_637 |
| PubMedID: 27281175 |
| Title : Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease - Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
| Author(s) : Spilovska K , Korabecny J , Nepovimova E , Dolezal R , Mezeiova E , Soukup O , Kuca K |
| Ref : Curr Top Med Chem , 17 :1006 , 2017 |
| Abstract : |
| PubMedSearch : Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
| PubMedID: 27697055 |
| Title : Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides - Ramalho_2016_Curr.Med.Chem_23_1041 |
| Author(s) : Ramalho TC , de Castro AA , Silva DR , Silva MC , Franca TCC , Bennion BJ , Kuca K |
| Ref : Curr Med Chem , 23 :1041 , 2016 |
| Abstract : |
| PubMedSearch : Ramalho_2016_Curr.Med.Chem_23_1041 |
| PubMedID: 26898655 |
| Title : An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study - Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85 |
| Author(s) : Mzik M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K , Karasova JZ |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1020 :85 , 2016 |
| Abstract : |
| PubMedSearch : Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85 |
| PubMedID: 27030895 |
| Title : Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase - Winter_2016_Toxicol.Lett_244_136 |
| Author(s) : Winter M , Wille T , Musilek K , Kuca K , Thiermann H , Worek F |
| Ref : Toxicol Lett , 244 :136 , 2016 |
| Abstract : |
| PubMedSearch : Winter_2016_Toxicol.Lett_244_136 |
| PubMedID: 26210933 |
| Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831 |
| Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K |
| Ref : Archives of Toxicology , 90 :2831 , 2016 |
| Abstract : |
| PubMedSearch : Gorecki_2016_Arch.Toxicol_90_2831 |
| PubMedID: 27582056 |
| Title : Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1 - Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
| Author(s) : Kristofikova Z , Ricny J , Soukup O , Korabecny J , Nepovimova E , Kuca K , Ripova D |
| Ref : Dementia & Geriatric Cognitive Disorders , 43 :45 , 2016 |
| Abstract : |
| PubMedSearch : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
| PubMedID: 27988521 |
| Title : Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase - Musilek_2016_Med.Chem_12_362 |
| Author(s) : Musilek K , Hambalek J , Holas O , Dohnal V , Kuca K |
| Ref : Med Chem , 12 :362 , 2016 |
| Abstract : |
| PubMedSearch : Musilek_2016_Med.Chem_12_362 |
| PubMedID: 26427931 |
| Title : Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor - Antonijevic_2016_Neurotoxicol_55_33 |
| Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Vucinic S , Antonijevic B |
| Ref : Neurotoxicology , 55 :33 , 2016 |
| Abstract : |
| PubMedSearch : Antonijevic_2016_Neurotoxicol_55_33 |
| PubMedID: 27177985 |
| Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K |
| Ref : Toxicol Res (Camb) , 5 :1012 , 2016 |
| Abstract : |
| PubMedSearch : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| PubMedID: 30090408 |
| Title : Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity - Janockova_2016_Mol.Biosyst_12_2910 |
| Author(s) : Janockova J , Zilecka E , Kasparkova J , Brabec V , Soukup O , Kuca K , Kozurkova M |
| Ref : Mol Biosyst , 12 :2910 , 2016 |
| Abstract : |
| PubMedSearch : Janockova_2016_Mol.Biosyst_12_2910 |
| PubMedID: 27412811 |
| Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264 |
| Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K |
| Ref : ChemMedChem , 11 :1264 , 2016 |
| Abstract : |
| PubMedSearch : Benek_2016_ChemMedChem_11_1264 |
| PubMedID: 26427608 |
| Title : Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease - Jerabek_2016_Eur.J.Med.Chem_127_250 |
| Author(s) : Jerabek J , Uliassi E , Guidotti L , Korabecny J , Soukup O , Sepsova V , Hrabinova M , Kuca K , Bartolini M , Pena-Altamira LE , Petralla S , Monti B , Roberti M , Bolognesi ML |
| Ref : Eur Journal of Medicinal Chemistry , 127 :250 , 2016 |
| Abstract : |
| PubMedSearch : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| PubMedID: 28064079 |
| Title : Blood-fetus penetration of pralidoxime - Ojha_2016_Mil.Med.Sci.Lett_85_63 |
| Author(s) : Ojha S , Nurulain SM , Dhanasekaran S , Shafiullah M , Adem A , Sharma C , Kuca K , Kalasz H |
| Ref : Military Medical Science Letters , 85 :63 , 2016 |
| Abstract : |
| PubMedSearch : Ojha_2016_Mil.Med.Sci.Lett_85_63 |
| PubMedID: |
| Title : Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies - Dolezal_2016_Eur.J.Med.Chem_121_699 |
| Author(s) : Dolezal R , Soukup O , Malinak D , Savedra RML , Marek J , Dolezalova M , Pasdiorova M , Salajkova S , Korabecny J , Honegr J , Ramalho TC , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 121 :699 , 2016 |
| Abstract : |
| PubMedSearch : Dolezal_2016_Eur.J.Med.Chem_121_699 |
| PubMedID: 27341309 |
| Title : Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators - Spicakova_2016_Food.Chem.Toxicol_88_100 |
| Author(s) : Spicakova A , Anzenbacher P , Liskova B , Kuca K , Fusek J , Anzenbacherova E |
| Ref : Food & Chemical Toxicology , 88 :100 , 2016 |
| Abstract : |
| PubMedSearch : Spicakova_2016_Food.Chem.Toxicol_88_100 |
| PubMedID: 26747974 |
| Title : Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules - Hamulakova_2016_J.Inorg.Biochem_161_52 |
| Author(s) : Hamulakova S , Poprac P , Jomova K , Brezova V , Lauro P , Drostinova L , Jun D , Sepsova V , Hrabinova M , Soukup O , Kristian P , Gazova Z , Bednarikova Z , Kuca K , Valko M |
| Ref : J Inorg Biochem , 161 :52 , 2016 |
| Abstract : |
| PubMedSearch : Hamulakova_2016_J.Inorg.Biochem_161_52 |
| PubMedID: 27230386 |
| Title : Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase - Sahu_2016_Toxicol.Mech.Methods__1 |
| Author(s) : Sahu AK , Sharma R , Gupta B , Musilek K , Kuca K , Acharya J , Ghosh KK |
| Ref : Toxicol Mech Methods , :1 , 2016 |
| Abstract : |
| PubMedSearch : Sahu_2016_Toxicol.Mech.Methods__1 |
| PubMedID: 27101948 |
| Title : Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity - Karasova_2016_Neurotox.Res_29_267 |
| Author(s) : Karasova JZ , Hroch M , Musilek K , Kuca K |
| Ref : Neurotox Res , 29 :267 , 2016 |
| Abstract : |
| PubMedSearch : Karasova_2016_Neurotox.Res_29_267 |
| PubMedID: 26646154 |
| Title : Development and validation of a FIA\/UV-vis method for pK determination of oxime based acetylcholinesterase reactivators - Musil_2015_J.Pharm.Biomed.Anal_117_240 |
| Author(s) : Musil K , Florianova V , Bucek P , Dohnal V , Kuca K , Musilek K |
| Ref : J Pharm Biomed Anal , 117 :240 , 2015 |
| Abstract : |
| PubMedSearch : Musil_2015_J.Pharm.Biomed.Anal_117_240 |
| PubMedID: 26386953 |
| Title : Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs - Bures_2015_Neuro.Endocrinol.Lett_36_ |
| Author(s) : Bures J , Jun D , Hrabinova M , Tacheci I , Kvetina J , Pavlik M , Rejchrt S , Douda T , Kunes M , Kuca K , Kopacova M |
| Ref : Neuro Endocrinol Lett , 36 : , 2015 |
| Abstract : |
| PubMedSearch : Bures_2015_Neuro.Endocrinol.Lett_36_ |
| PubMedID: 26757120 |
| Title : Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE - Kuca_2015_Med.Chem_11_683 |
| Author(s) : Kuca K , Hrabinova M , Jun D , Musilek K , Penhaker M , Krejcar O , Soukup O |
| Ref : Med Chem , 11 :683 , 2015 |
| Abstract : |
| PubMedSearch : Kuca_2015_Med.Chem_11_683 |
| PubMedID: 25845909 |
| Title : Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase - Dolezal_2015_J.Mol.Graph.Model_56_113 |
| Author(s) : Dolezal R , Korabecny J , Malinak D , Honegr J , Musilek K , Kuca K |
| Ref : J Mol Graph Model , 56 :113 , 2015 |
| Abstract : |
| PubMedSearch : Dolezal_2015_J.Mol.Graph.Model_56_113 |
| PubMedID: 25588616 |
| Title : Cholinergic properties of new 7-methoxytacrine-donepezil derivatives - Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| Author(s) : Sepsova V , Karasova JZ , Tobin G , Jun D , Korabecny J , Cabelova P , Janska K , Krusek J , Skrenkova K , Kuca K , Soukup O |
| Ref : Gen Physiol Biophys , 34 :189 , 2015 |
| Abstract : |
| PubMedSearch : Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| PubMedID: 25504063 |
| Title : Reversible cholinesterase inhibitors as pre-treatment for exposure to organophosphates: assessment using azinphos-methyl - Petroianu_2015_J.Appl.Toxicol_35_493 |
| Author(s) : Petroianu GA , Nurulain SM , Hasan MY , Kuca K , Lorke DE |
| Ref : J Appl Toxicol , 35 :493 , 2015 |
| Abstract : |
| PubMedSearch : Petroianu_2015_J.Appl.Toxicol_35_493 |
| PubMedID: 25186309 |
| Title : Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review - Sharma_2015_Mini.Rev.Med.Chem_15_58 |
| Author(s) : Sharma R , Gupta B , Singh N , Acharya JR , Musilek K , Kuca K , Ghosh KK |
| Ref : Mini Rev Med Chem , 15 :58 , 2015 |
| Abstract : |
| PubMedSearch : Sharma_2015_Mini.Rev.Med.Chem_15_58 |
| PubMedID: 25441834 |
| Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K |
| Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015 |
| Abstract : |
| PubMedSearch : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedID: 26503905 |
| Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084 |
| Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K |
| Ref : Molecules , 20 :22084 , 2015 |
| Abstract : |
| PubMedSearch : Korabecny_2015_Molecules_20_22084 |
| PubMedID: 26690394 |
| Title : Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase - Horn_2015_Arch.Toxicol_89_405 |
| Author(s) : Horn G , Wille T , Musilek K , Kuca K , Thiermann H , Worek F |
| Ref : Archives of Toxicology , 89 :405 , 2015 |
| Abstract : |
| PubMedSearch : Horn_2015_Arch.Toxicol_89_405 |
| PubMedID: 24912784 |
| Title : Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents - Giacoppo_2015_J.Biomol.Struct.Dyn_33_2048 |
| Author(s) : Giacoppo JO , Franca TCC , Kuca K , da Cunha EFF , Abagyan R , Mancini DT , Ramalho TC |
| Ref : J Biomol Struct Dyn , 33 :2048 , 2015 |
| Abstract : |
| PubMedSearch : Giacoppo_2015_J.Biomol.Struct.Dyn_33_2048 |
| PubMedID: 25407587 |
| Title : Novel tacrine\/acridine anticholinesterase inhibitors with piperazine and thiourea linkers - Hamulakova_2014_Int.J.Biol.Macromol_70C_435 |
| Author(s) : Hamulakova S , Imrich J , Janovec L , Kristian P , Danihel I , Holas O , Pohanka M , Bohm S , Kozurkova M , Kuca K |
| Ref : Int J Biol Macromol , 70C :435 , 2014 |
| Abstract : |
| PubMedSearch : Hamulakova_2014_Int.J.Biol.Macromol_70C_435 |
| PubMedID: 25036600 |
| Title : HI-6 oxime (an acetylcholinesterase reactivator): blood plasma pharmacokinetics and organ distribution in experimental pigs - Kunes_2014_Neuro.Endocrinol.Lett_35_186 |
| Author(s) : Kunes M , Kvetina J , Bures J , Karasova JZ , Pavlik M , Tacheci I , Musilek K , Kuca K |
| Ref : Neuro Endocrinol Lett , 35 :186 , 2014 |
| Abstract : |
| PubMedSearch : Kunes_2014_Neuro.Endocrinol.Lett_35_186 |
| PubMedID: 25638385 |
| Title : Preparation, in vitro screening and molecular modelling of monoquaternary compounds related to the selective acetylcholinesterase inhibitor BW284c51 - Benek_2014_Med.Chem_11_21 |
| Author(s) : Benek O , Musilek K , Horova A , Dohnal V , Dolezal R , Kuca K |
| Ref : Med Chem , 11 :21 , 2014 |
| Abstract : |
| PubMedSearch : Benek_2014_Med.Chem_11_21 |
| PubMedID: 24773345 |
| Title : From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators - Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
| Author(s) : Korabecny J , Soukup O , Dolezal R , Spilovska K , Nepovimova E , Andrs M , Nguyen TD , Jun D , Musilek K , Kucerova-Chlupacova M , Kuca K |
| Ref : Mini Rev Med Chem , 14 :215 , 2014 |
| Abstract : |
| PubMedSearch : Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
| PubMedID: 24552265 |
| Title : The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor - Sepsova_2014_Physiol.Res_63_771 |
| Author(s) : Sepsova V , Krusek J , Karasova JZ , Zemek F , Musilek K , Kuca K , Soukup O |
| Ref : Physiol Res , 63 :771 , 2014 |
| Abstract : |
| PubMedSearch : Sepsova_2014_Physiol.Res_63_771 |
| PubMedID: 25157661 |
| Title : Prophylactic administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using terbufos sulfone - Lorke_2014_J.Appl.Toxicol_34_1096 |
| Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA |
| Ref : J Appl Toxicol , 34 :1096 , 2014 |
| Abstract : |
| PubMedSearch : Lorke_2014_J.Appl.Toxicol_34_1096 |
| PubMedID: 24136594 |
| Title : Structural modifications of dicationic acetylcholinesterase reactivators studied under ion-pairing mechanism in reversed-phase liquid chromatography - Radulescu_2014_J.Sep.Sci_37_3024 |
| Author(s) : Radulescu M , Kuca K , Musilek K , David V |
| Ref : J Sep Sci , 37 :3024 , 2014 |
| Abstract : |
| PubMedSearch : Radulescu_2014_J.Sep.Sci_37_3024 |
| PubMedID: 25141798 |
| Title : Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects - Nepovimova_2014_J.Med.Chem_57_8576 |
| Author(s) : Nepovimova E , Uliassi E , Korabecny J , Pena-Altamira LE , Samez S , Pesaresi A , Garcia GE , Bartolini M , Andrisano V , Bergamini C , Fato R , Lamba D , Roberti M , Kuca K , Monti B , Bolognesi ML |
| Ref : Journal of Medicinal Chemistry , 57 :8576 , 2014 |
| Abstract : |
| PubMedSearch : Nepovimova_2014_J.Med.Chem_57_8576 |
| PubMedID: 25259726 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties - Gupta_2014_Bioorg.Med.Chem.Lett_24_4743 |
| Author(s) : Gupta B , Singh N , Sharma R , Foretic B , Musilek K , Kuca K , Acharya J , Satnami ML , Ghosh KK |
| Ref : Bioorganic & Medicinal Chemistry Lett , 24 :4743 , 2014 |
| Abstract : |
| PubMedSearch : Gupta_2014_Bioorg.Med.Chem.Lett_24_4743 |
| PubMedID: 25190468 |
| Title : Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors - Hamulakova_2014_J.Med.Chem_57_7073 |
| Author(s) : Hamulakova S , Janovec L , Hrabinova M , Spilovska K , Korabecny J , Kristian P , Kuca K , Imrich J |
| Ref : Journal of Medicinal Chemistry , 57 :7073 , 2014 |
| Abstract : |
| PubMedSearch : Hamulakova_2014_J.Med.Chem_57_7073 |
| PubMedID: 25089370 |
| Title : Chemical warfare: perspectives on reactivating the enzyme acetylcholinesterase inhibited by organophosphates - Giacoppo_2014_Mil.Med.Sci.Lett_83_165 |
| Author(s) : Giacoppo JO , de Lima WE , Kuca K , da Cunha EFF , Franca TCC , Ramalho TC |
| Ref : Military Medical Science Letters , 83 :165 , 2014 |
| Abstract : |
| PubMedSearch : Giacoppo_2014_Mil.Med.Sci.Lett_83_165 |
| PubMedID: |
| Title : Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine - Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
| Author(s) : Zemek F , Drtinova L , Nepovimova E , Sepsova V , Korabecny J , Klimes J , Kuca K |
| Ref : Expert Opin Drug Safety , 13 :759 , 2014 |
| Abstract : |
| PubMedSearch : Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
| PubMedID: 24845946 |
| Title : Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update - Wu_2014_Arch.Toxicol_88_1309 |
| Author(s) : Wu QH , Wang X , Yang W , Nussler AK , Xiong LY , Kuca K , Dohnal V , Zhang XJ , Yuan ZH |
| Ref : Archives of Toxicology , 88 :1309 , 2014 |
| Abstract : |
| PubMedSearch : Wu_2014_Arch.Toxicol_88_1309 |
| PubMedID: 24894432 |
| Title : In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat - Killi_2014_Clin.Exp.Pharmacol.Physiol_41_139 |
| Author(s) : Killi UK , Wsol V , Soukup O , Kuca K , Winder M , Tobin G |
| Ref : Clinical & Experimental Pharmacology & Physiology , 41 :139 , 2014 |
| Abstract : |
| PubMedSearch : Killi_2014_Clin.Exp.Pharmacol.Physiol_41_139 |
| PubMedID: 24341923 |
| Title : In vitro reactivation kinetics of paraoxon- and DFP-inhibited electric eel AChE using mono- and bis-pyridinium oximes - Gupta_2014_Arch.Toxicol_88_381 |
| Author(s) : Gupta B , Sharma R , Singh N , Kuca K , Acharya JR , Ghosh KK |
| Ref : Archives of Toxicology , 88 :381 , 2014 |
| Abstract : |
| PubMedSearch : Gupta_2014_Arch.Toxicol_88_381 |
| PubMedID: 24065055 |
| Title : 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies - Korabecny_2014_Eur.J.Med.Chem_82C_426 |
| Author(s) : Korabecny J , Dolezal R , Cabelova P , Horova A , Hruba E , Ricny J , Sedlacek L , Nepovimova E , Spilovska K , Andrs M , Musilek K , Opletalova V , Sepsova V , Ripova D , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 82C :426 , 2014 |
| Abstract : |
| PubMedSearch : Korabecny_2014_Eur.J.Med.Chem_82C_426 |
| PubMedID: 24929293 |
| Title : In vivo evaluation of cholinesterase activity, oxidative stress markers, cyto- and genotoxicity of K048 oxime-a promising antidote against organophosphate poisoning - Zunec_2014_Basic.Clin.Pharmacol.Toxicol_114_344 |
| Author(s) : Zunec S , Kopjar N , Zeljezic D , Kuca K , Musilek K , Lucic Vrdoljak A |
| Ref : Basic Clin Pharmacol Toxicol , 114 :344 , 2014 |
| Abstract : |
| PubMedSearch : Zunec_2014_Basic.Clin.Pharmacol.Toxicol_114_344 |
| PubMedID: 24741714 |
| Title : Physicochemical properties and supernucleophilicity of oxime-functionalized surfactants: hydrolytic catalysts toward dephosphorylation of di- and triphosphate esters - Singh_2013_J.Phys.Chem.B_117_3806 |
| Author(s) : Singh N , Karpichev Y , Gupta B , Satnami ML , Marek J , Kuca K , Ghosh KK |
| Ref : J Phys Chem B , 117 :3806 , 2013 |
| Abstract : |
| PubMedSearch : Singh_2013_J.Phys.Chem.B_117_3806 |
| PubMedID: 23480470 |
| Title : Novel cholinesterase modulators and their ability to interact with DNA - Janockova_2013_Spectrochim.Acta.A.Mol.Biomol.Spectrosc_115C_364 |
| Author(s) : Janockova J , Gulasova Z , Musilek K , Kuca K , Kozurkova M |
| Ref : Spectrochim Acta A Mol Biomol Spectrosc , 115C :364 , 2013 |
| Abstract : |
| PubMedSearch : Janockova_2013_Spectrochim.Acta.A.Mol.Biomol.Spectrosc_115C_364 |
| PubMedID: 23851179 |
| Title : Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX - Kuca_2013_Med.Chem_9_689 |
| Author(s) : Kuca K , Musilek K , Jun D , Karasova J , Soukup O , Pejchal J , Hrabinova M |
| Ref : Med Chem , 9 :689 , 2013 |
| Abstract : |
| PubMedSearch : Kuca_2013_Med.Chem_9_689 |
| PubMedID: 22779796 |
| Title : In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators - Bhattacharjee_2013_Curr.Comput.Aided.Drug.Des_9_402 |
| Author(s) : Bhattacharjee AK , Musilek K , Kuca K |
| Ref : Curr Comput Aided Drug Des , 9 :402 , 2013 |
| Abstract : |
| PubMedSearch : Bhattacharjee_2013_Curr.Comput.Aided.Drug.Des_9_402 |
| PubMedID: 23789829 |
| Title : Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium\/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors - Komloova_2013_Bioorg.Med.Chem.Lett_23_6663 |
| Author(s) : Komloova M , Horova A , Hrabinova M , Jun D , Dolezal M , Vinsova J , Kuca K , Musilek K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6663 , 2013 |
| Abstract : |
| PubMedSearch : Komloova_2013_Bioorg.Med.Chem.Lett_23_6663 |
| PubMedID: 24220173 |
| Title : Interaction of cholinesterase modulators with DNA and their cytotoxic activity - Janockova_2013_Int.J.Biol.Macromol_64C_53 |
| Author(s) : Janockova J , Gulasova Z , Plsikova J , Musilek K , Kuca K , Mikes J , Culka L , Fedorocko P , Kozurkova M |
| Ref : Int J Biol Macromol , 64C :53 , 2013 |
| Abstract : |
| PubMedSearch : Janockova_2013_Int.J.Biol.Macromol_64C_53 |
| PubMedID: 24296409 |
| Title : A Resurrection of 7-MEOTA: A Comparison with Tacrine - Soukup_2013_Curr.Alzheimer.Res_10_893 |
| Author(s) : Soukup O , Jun D , Karasova JZ , Patocka J , Musilek K , Korabecny J , Krusek J , Kaniakova M , Sepsova V , Mandikova J , Trejtnar F , Pohanka M , Drtinova L , Pavlik M , Tobin G , Kuca K |
| Ref : Curr Alzheimer Res , 10 :893 , 2013 |
| Abstract : |
| PubMedSearch : Soukup_2013_Curr.Alzheimer.Res_10_893 |
| PubMedID: 24093535 |
| Title : selective monitoring of enzymatic activity of acetylcholinesterase by flow injection analysis with mass spectrometric detection - Dohnal_2013_Mil.Med.Sci.Lett_82_120 |
| Author(s) : Dohnal V , Dohnalova L , Jun D , Kuca K |
| Ref : Military Medical Science Letters , 82 :120 , 2013 |
| Abstract : |
| PubMedSearch : Dohnal_2013_Mil.Med.Sci.Lett_82_120 |
| PubMedID: |
| Title : Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma - Karasova_2013_J.Appl.Toxicol_33_18 |
| Author(s) : Karasova JZ , Chladek J , Hroch M , Josef F , Hnidkova D , Kuca K |
| Ref : J Appl Toxicol , 33 :18 , 2013 |
| Abstract : |
| PubMedSearch : Karasova_2013_J.Appl.Toxicol_33_18 |
| PubMedID: 21717485 |
| Title : Usefulness of administration of non-organophosphate cholinesterase inhibitors before acute exposure to organophosphates: assessment using paraoxon - Petroianu_2013_J.Appl.Toxicol_33_894 |
| Author(s) : Petroianu GA , Nurulain SM , Shafiullah M , Hasan MY , Kuca K , Lorke DE |
| Ref : Journal of Applied Toxicology , 33 :894 , 2013 |
| Abstract : |
| PubMedSearch : Petroianu_2013_J.Appl.Toxicol_33_894 |
| PubMedID: 22611016 |
| Title : 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in alzheimer's disease treatment, synthesis, biological evaluation and molecular modeling studies - Spilovska_2013_Molecules_18_2397 |
| Author(s) : Spilovska K , Korabecny J , Kral J , Horova A , Musilek K , Soukup O , Drtinova L , Gazova Z , Siposova K , Kuca K |
| Ref : Molecules , 18 :2397 , 2013 |
| Abstract : |
| PubMedSearch : Spilovska_2013_Molecules_18_2397 |
| PubMedID: 23429378 |
| Title : Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides - Kuca_2013_Mini.Rev.Med.Chem_13_2102 |
| Author(s) : Kuca K , Jun D , Musilek K , Pohanka M , Karasova JZ , Soukup O |
| Ref : Mini Rev Med Chem , 13 :2102 , 2013 |
| Abstract : |
| PubMedSearch : Kuca_2013_Mini.Rev.Med.Chem_13_2102 |
| PubMedID: 24195661 |
| Title : Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study - Sepsova_2013_Int.J.Mol.Sci_14_16882 |
| Author(s) : Sepsova V , Karasova JZ , Korabecny J , Dolezal R , Zemek F , Bennion BJ , Kuca K |
| Ref : Int J Mol Sci , 14 :16882 , 2013 |
| Abstract : |
| PubMedSearch : Sepsova_2013_Int.J.Mol.Sci_14_16882 |
| PubMedID: 23959117 |
| Title : Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs - Bures_2013_Neuro.Endocrinol.Lett_34_79 |
| Author(s) : Bures J , Kvetina J , Pavlik M , Kunes M , Kopacova M , Rejchrt S , Jun D , Hrabinova M , Kuca K , Tacheci I |
| Ref : Neuro Endocrinol Lett , 34 :79 , 2013 |
| Abstract : |
| PubMedSearch : Bures_2013_Neuro.Endocrinol.Lett_34_79 |
| PubMedID: 24362097 |
| Title : Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration - Karasova_2013_Neuro.Endocrinol.Lett_34_74 |
| Author(s) : Karasova JZ , Zemek F , Kunes M , Kvetina J , Chladek J , Jun D , Bures J , Tacheci I , Kuca K |
| Ref : Neuro Endocrinol Lett , 34 :74 , 2013 |
| Abstract : |
| PubMedSearch : Karasova_2013_Neuro.Endocrinol.Lett_34_74 |
| PubMedID: 24362096 |
| Title : Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities - Cahlikova_2013_Nat.Prod.Commun_8_1541 |
| Author(s) : Cahlikova L , Hrabinova M , Kulhankova A , Benesova N , Chlebek J , Jun D , Novak Z , Macakova K , Kunes J , Kuca K , Opletal L |
| Ref : Nat Prod Commun , 8 :1541 , 2013 |
| Abstract : |
| PubMedSearch : Cahlikova_2013_Nat.Prod.Commun_8_1541 |
| PubMedID: 24427936 |
| Title : The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors - Soukup_2013_Arch.Toxicol_87_711 |
| Author(s) : Soukup O , Jun D , Tobin G , Kuca K |
| Ref : Archives of Toxicology , 87 :711 , 2013 |
| Abstract : |
| PubMedSearch : Soukup_2013_Arch.Toxicol_87_711 |
| PubMedID: 23179755 |
| Title : Two possibilities how to increase the efficacy of antidotal treatment of nerve agent poisonings - Kassa_2012_Mini.Rev.Med.Chem_12_24 |
| Author(s) : Kassa J , Musilek K , Karasova JZ , Kuca K , Bajgar J |
| Ref : Mini Rev Med Chem , 12 :24 , 2012 |
| Abstract : |
| PubMedSearch : Kassa_2012_Mini.Rev.Med.Chem_12_24 |
| PubMedID: 22360668 |
| Title : An in silico stereo-electronic comparison of conventional pyridinium oximes and K-oximes for organophosphate (OP) poisoning - Bhattacharjee_2012_Med.Chem_8_230 |
| Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK |
| Ref : Med Chem , 8 :230 , 2012 |
| Abstract : |
| PubMedSearch : Bhattacharjee_2012_Med.Chem_8_230 |
| PubMedID: 22385173 |
| Title : The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers - Soukup_2012_Toxicol.Lett_212_315 |
| Author(s) : Soukup O , Kristofikova Z , Jun D , Tambor V , Ripova D , Kuca K |
| Ref : Toxicol Lett , 212 :315 , 2012 |
| Abstract : |
| PubMedSearch : Soukup_2012_Toxicol.Lett_212_315 |
| PubMedID: 22683831 |
| Title : Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase - Worek_2012_Arch.Toxicol_86_1379 |
| Author(s) : Worek F , von der Wellen J , Musilek K , Kuca K , Thiermann H |
| Ref : Archives of Toxicology , 86 :1379 , 2012 |
| Abstract : |
| PubMedSearch : Worek_2012_Arch.Toxicol_86_1379 |
| PubMedID: 22437842 |
| Title : Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease - Hamulakova_2012_Eur.J.Med.Chem_55_23 |
| Author(s) : Hamulakova S , Janovec L , Hrabinova M , Kristian P , Kuca K , Banasova M , Imrich J |
| Ref : Eur Journal of Medicinal Chemistry , 55 :23 , 2012 |
| Abstract : |
| PubMedSearch : Hamulakova_2012_Eur.J.Med.Chem_55_23 |
| PubMedID: 22818849 |
| Title : First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans? - Matos_2012_J.Biomol.Struct.Dyn_30_546 |
| Author(s) : Matos KS , da Cunha EFF , da Silva Goncalves A , Wilter A , Kuca K , Franca TCC , Ramalho TC |
| Ref : J Biomol Struct Dyn , 30 :546 , 2012 |
| Abstract : |
| PubMedSearch : Matos_2012_J.Biomol.Struct.Dyn_30_546 |
| PubMedID: 22731788 |
| Title : The progress in the cholinesterase quantification methods - Holas_2012_Expert.Opin.Drug.Discov_7_1207 |
| Author(s) : Holas O , Musilek K , Pohanka M , Kuca K |
| Ref : Expert Opin Drug Discov , 7 :1207 , 2012 |
| Abstract : |
| PubMedSearch : Holas_2012_Expert.Opin.Drug.Discov_7_1207 |
| PubMedID: 23013366 |
| Title : Acetylcholinesterase Inhibitors as Pretreatment before Acute Exposure to Organophosphates: Assessment Using Methyl-paraoxon - Lorke_2012_CNS.Neurol.Disord.Drug.Targets_11_1052 |
| Author(s) : Lorke DE , Hasan MY , Nurulain SM , Shafiullah MS , Kuca K , Petroianu GA |
| Ref : CNS Neurol Disord Drug Targets , 11 :1052 , 2012 |
| Abstract : |
| PubMedSearch : Lorke_2012_CNS.Neurol.Disord.Drug.Targets_11_1052 |
| PubMedID: 23244429 |
| Title : [Tacrine and its derivatives in the therapy of Alzheimers disease] - Korabecny_2012_Ceska.Slov.Farm_61_210 |
| Author(s) : Korabecny J , Spilovska K , Benek O , Musilek K , Soukup O , Kuca K |
| Ref : Ceska a Slovenska Farmacie , 61 :210 , 2012 |
| Abstract : |
| PubMedSearch : Korabecny_2012_Ceska.Slov.Farm_61_210 |
| PubMedID: 23256654 |
| Title : In vivo decontamination of the nerve agent VX using the domestic swine model - Misik_2012_Clin.Toxicol.(Phila)_50_807 |
| Author(s) : Misik J , Pavlik M , Novotny L , Pavlikova R , Chilcott RP , Cabal J , Kuca K |
| Ref : Clinical Toxicology (Phila) , 50 :807 , 2012 |
| Abstract : |
| PubMedSearch : Misik_2012_Clin.Toxicol.(Phila)_50_807 |
| PubMedID: 22963275 |
| Title : Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model - Pohanka_2011_Bratisl.Lek.Listy_112_539 |
| Author(s) : Pohanka M , Pikula J , Kuca K , Kassa J |
| Ref : Bratislavske Lekarske Listy , 112 :539 , 2011 |
| Abstract : |
| PubMedSearch : Pohanka_2011_Bratisl.Lek.Listy_112_539 |
| PubMedID: 21954536 |
| Title : Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method - Pohanka_2011_Int.J.Mol.Sci_12_2631 |
| Author(s) : Pohanka M , Hrabinova M , Kuca K , Simonato JP |
| Ref : Int J Mol Sci , 12 :2631 , 2011 |
| Abstract : |
| PubMedSearch : Pohanka_2011_Int.J.Mol.Sci_12_2631 |
| PubMedID: 21731462 |
| Title : Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128 - Musilek_2011_Bioorg.Med.Chem.Lett_21_150 |
| Author(s) : Musilek K , Roder J , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Opletalova V , Kuca K , Jung YS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :150 , 2011 |
| Abstract : |
| PubMedSearch : Musilek_2011_Bioorg.Med.Chem.Lett_21_150 |
| PubMedID: 21144749 |
| Title : Anatoxin-a(s): natural organophosphorus anticholinesterase agent - Patocka_2011_Mil.Med.Sci.Lett_80_129 |
| Author(s) : Patocka J , Gupta RC , Kuca K |
| Ref : Military Medical Science Letters , 80 :129 , 2011 |
| Abstract : |
| PubMedSearch : Patocka_2011_Mil.Med.Sci.Lett_80_129 |
| PubMedID: |
| Title : Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment - Musilek_2011_Eur.J.Med.Chem_46_811 |
| Author(s) : Musilek K , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Nachon F , Dolezal M , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 46 :811 , 2011 |
| Abstract : |
| PubMedSearch : Musilek_2011_Eur.J.Med.Chem_46_811 |
| PubMedID: 21236521 |
| Title : The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage - Musilek_2011_J.Enzyme.Inhib.Med.Chem_26_245 |
| Author(s) : Musilek K , Pavlikova R , Marek J , Komloova M , Holas O , Hrabinova M , Pohanka M , Dohnal V , Dolezal M , Gunn-Moore F , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 26 :245 , 2011 |
| Abstract : |
| PubMedSearch : Musilek_2011_J.Enzyme.Inhib.Med.Chem_26_245 |
| PubMedID: 21406034 |
| Title : Human serum butyrylcholinesterase as a prophylaxis against russian VX - Karasova_2011_Mil.Med.Sci.Lett_80_97 |
| Author(s) : Karasova JZ , Kuca K , Jun D , Bajgar J |
| Ref : Military Medical Science Letters , 80 :97 , 2011 |
| Abstract : |
| PubMedSearch : Karasova_2011_Mil.Med.Sci.Lett_80_97 |
| PubMedID: |
| Title : On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning - Kuca_2011_Mil.Med.Sci.Lett_80_80 |
| Author(s) : Kuca K , Musilek K , Karasova J , Jun D , Soukup O , Pohanka M , Ghosh KK , Hrabinova M |
| Ref : Military Medical Science Letters , 80 :80 , 2011 |
| Abstract : |
| PubMedSearch : Kuca_2011_Mil.Med.Sci.Lett_80_80 |
| PubMedID: |
| Title : Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides - Musilek_2011_Med.Res.Rev_31_548 |
| Author(s) : Musilek K , Dolezal M , Gunn-Moore F , Kuca K |
| Ref : Med Res Rev , 31 :548 , 2011 |
| Abstract : |
| PubMedSearch : Musilek_2011_Med.Res.Rev_31_548 |
| PubMedID: 20027669 |
| Title : Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice - dos Santos_2011_Neurotoxicol_32_888 |
| Author(s) : Dos Santos AA , dos Santos DB , Ribeiro RP , Colle D , Peres KC , Hermes J , Barbosa AM , Dafre AL , de Bem AF , Kuca K , Farina M |
| Ref : Neurotoxicology , 32 :888 , 2011 |
| Abstract : |
| PubMedSearch : dos Santos_2011_Neurotoxicol_32_888 |
| PubMedID: 21723318 |
| Title : Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain - Karasova_2011_J.Pharm.Biomed.Anal_54_1082 |
| Author(s) : Karasova JZ , Zemek F , Bajgar J , Vasatova M , Prochazka P , Novotny L , Kuca K |
| Ref : J Pharm Biomed Anal , 54 :1082 , 2011 |
| Abstract : |
| PubMedSearch : Karasova_2011_J.Pharm.Biomed.Anal_54_1082 |
| PubMedID: 21146949 |
| Title : Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment - Komloova_2011_Bioorg.Med.Chem.Lett_21_2505 |
| Author(s) : Komloova M , Musilek K , Horova A , Holas O , Dohnal V , Gunn-Moore F , Kuca K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2505 , 2011 |
| Abstract : |
| PubMedSearch : Komloova_2011_Bioorg.Med.Chem.Lett_21_2505 |
| PubMedID: 21397501 |
| Title : Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking - Musilek_2011_Bioorg.Med.Chem_19_754 |
| Author(s) : Musilek K , Komloova M , Holas O , Horova A , Pohanka M , Gunn-Moore F , Dohnal V , Dolezal M , Kuca K |
| Ref : Bioorganic & Medicinal Chemistry , 19 :754 , 2011 |
| Abstract : |
| PubMedSearch : Musilek_2011_Bioorg.Med.Chem_19_754 |
| PubMedID: 21215642 |
| Title : Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties - Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563 |
| Author(s) : Korabecny J , Musilek K , Zemek F , Horova A , Holas O , Nepovimova E , Opletalova V , Hroudova J , Fisar Z , Jung YS , Kuca K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :6563 , 2011 |
| Abstract : |
| PubMedSearch : Korabecny_2011_Bioorg.Med.Chem.Lett_21_6563 |
| PubMedID: 21920739 |
| Title : Pretreatment for acute exposure to diisopropylfluorophosphate: in vivo efficacy of various acetylcholinesterase inhibitors - Lorke_2011_J.Appl.Toxicol_31_515 |
| Author(s) : Lorke DE , Hasan MY , Nurulain SM , Shafiullah M , Kuca K , Petroianu GA |
| Ref : Journal of Applied Toxicology , 31 :515 , 2011 |
| Abstract : |
| PubMedSearch : Lorke_2011_J.Appl.Toxicol_31_515 |
| PubMedID: 20981864 |
| Title : Oximes as inhibitors of acetylholinesterase - a structure-activity relationship (SAR) study - Sepsova_2011_Mil.Med.Sci.Lett_80_178 |
| Author(s) : Sepsova V , Karasova JZ , Zemek F , Bennion BJ , Kuca K |
| Ref : Military Medical Science Letters , 80 :178 , 2011 |
| Abstract : |
| PubMedSearch : Sepsova_2011_Mil.Med.Sci.Lett_80_178 |
| PubMedID: |
| Title : The effect of oxime reactivators on muscarinic receptors: functional and binding examinations - Soukup_2011_Environ.Toxicol.Pharmacol_31_364 |
| Author(s) : Soukup O , Kumar UK , Proska J , Bratova L , Adem A , Jun D , Fusek J , Kuca K , Tobin G |
| Ref : Environ Toxicol Pharmacol , 31 :364 , 2011 |
| Abstract : |
| PubMedSearch : Soukup_2011_Environ.Toxicol.Pharmacol_31_364 |
| PubMedID: 21787706 |
| Title : Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors - Soukup_2011_Physiol.Res_60_679 |
| Author(s) : Soukup O , Krusek J , Kaniakova M , Kumar UK , Oz M , Jun D , Fusek J , Kuca K , Tobin G |
| Ref : Physiol Res , 60 :679 , 2011 |
| Abstract : |
| PubMedSearch : Soukup_2011_Physiol.Res_60_679 |
| PubMedID: 21574759 |
| Title : Method optimization for acetylcholinesterase modulators-albumin interactions - Zemek_2011_Mil.Med.Sci.Lett_80_58 |
| Author(s) : Zemek F , Karasova JZ , Musilek K , Kuca K |
| Ref : Military Medical Science Letters , 80 :58 , 2011 |
| Abstract : |
| PubMedSearch : Zemek_2011_Mil.Med.Sci.Lett_80_58 |
| PubMedID: |
| Title : In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase - Jun_2011_Int.J.Mol.Sci_12_2077 |
| Author(s) : Jun D , Musilova L , Musilek K , Kuca K |
| Ref : Int J Mol Sci , 12 :2077 , 2011 |
| Abstract : |
| PubMedSearch : Jun_2011_Int.J.Mol.Sci_12_2077 |
| PubMedID: 21673941 |
| Title : Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration - Karasova_2010_Anal.Sci_26_63 |
| Author(s) : Karasova JZ , Novotny L , Antos K , Zivna H , Kuca K |
| Ref : Anal Sci , 26 :63 , 2010 |
| Abstract : |
| PubMedSearch : Karasova_2010_Anal.Sci_26_63 |
| PubMedID: 20065589 |
| Title : A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats - Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861 |
| Author(s) : Kassa J , Karasova JZ , Tesarova S , Musilek K , Kuca K , Jung YS |
| Ref : Basic Clin Pharmacol Toxicol , 107 :861 , 2010 |
| Abstract : |
| PubMedSearch : Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861 |
| PubMedID: 22545968 |
| Title : A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice - Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480 |
| Author(s) : Kassa J , Karasova JZ , Caisberger F , Musilek K , Kuca K , Jung YS |
| Ref : J Enzyme Inhib Med Chem , 25 :480 , 2010 |
| Abstract : |
| PubMedSearch : Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480 |
| PubMedID: 20233085 |
| Title : Characterization of the anticholinergic properties of obidoxime\; functional examinations of the rat atria and the urinary bladder - Soukup_2010_Toxicol.Mech.Methods_20_428 |
| Author(s) : Soukup O , Tobin G , Kumar UK , Jun D , Fusek J , Kuca K |
| Ref : Toxicol Mech Methods , 20 :428 , 2010 |
| Abstract : |
| PubMedSearch : Soukup_2010_Toxicol.Mech.Methods_20_428 |
| PubMedID: 20602545 |
| Title : Influence of the acetylcholinesterase active site protonation on omega loop and active site dynamics - Wiesner_2010_J.Biomol.Struct.Dyn_28_393 |
| Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J |
| Ref : J Biomol Struct Dyn , 28 :393 , 2010 |
| Abstract : |
| PubMedSearch : Wiesner_2010_J.Biomol.Struct.Dyn_28_393 |
| PubMedID: 20919754 |
| Title : Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies - Musilek_2010_ChemMedChem_5_247 |
| Author(s) : Musilek K , Holas O , Misik J , Pohanka M , Novotny L , Dohnal V , Opletalova V , Kuca K |
| Ref : ChemMedChem , 5 :247 , 2010 |
| Abstract : |
| PubMedSearch : Musilek_2010_ChemMedChem_5_247 |
| PubMedID: 20058292 |
| Title : Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment - Korabecny_2010_Molecules_15_8804 |
| Author(s) : Korabecny J , Musilek K , Holas O , Nepovimova E , Jun D , Zemek F , Opletalova V , Patocka J , Dohnal V , Nachon F , Hroudova J , Fisar Z , Kuca K |
| Ref : Molecules , 15 :8804 , 2010 |
| Abstract : |
| PubMedSearch : Korabecny_2010_Molecules_15_8804 |
| PubMedID: 21127466 |
| Title : Why acetylcholinesterase reactivators do not work in butyrylcholinesterase - Wiesner_2010_J.Enzyme.Inhib.Med.Chem_25_318 |
| Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J |
| Ref : J Enzyme Inhib Med Chem , 25 :318 , 2010 |
| Abstract : |
| PubMedSearch : Wiesner_2010_J.Enzyme.Inhib.Med.Chem_25_318 |
| PubMedID: 19874115 |
| Title : Structure-activity relationship of quaternary acetylcholinesterase inhibitors - outlook for early myasthenia gravis treatment - Komloova_2010_Curr.Med.Chem_17_1810 |
| Author(s) : Komloova M , Musilek K , Dolezal M , Gunn-Moore F , Kuca K |
| Ref : Curr Med Chem , 17 :1810 , 2010 |
| Abstract : |
| PubMedSearch : Komloova_2010_Curr.Med.Chem_17_1810 |
| PubMedID: 20345342 |
| Title : Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease - Korabecny_2010_Bioorg.Med.Chem.Lett_20_6093 |
| Author(s) : Korabecny J , Musilek K , Holas O , Binder J , Zemek F , Marek J , Pohanka M , Opletalova V , Dohnal V , Kuca K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6093 , 2010 |
| Abstract : |
| PubMedSearch : Korabecny_2010_Bioorg.Med.Chem.Lett_20_6093 |
| PubMedID: 20817518 |
| Title : Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications - Musilek_2010_Bioorg.Med.Chem.Lett_20_1763 |
| Author(s) : Musilek K , Komloova M , Zavadova V , Holas O , Hrabinova M , Pohanka M , Dohnal V , Nachon F , Dolezal M , Kuca K , Jung YS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 20 :1763 , 2010 |
| Abstract : |
| PubMedSearch : Musilek_2010_Bioorg.Med.Chem.Lett_20_1763 |
| PubMedID: 20138518 |
| Title : Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase - Kovarik_2010_Chem.Biol.Interact_187_167 |
| Author(s) : Kovarik Z , Katalinic M , Sinko G , Binder J , Holas O , Jung YS , Musilova L , Jun D , Kuca K |
| Ref : Chemico-Biological Interactions , 187 :167 , 2010 |
| Abstract : |
| PubMedSearch : Kovarik_2010_Chem.Biol.Interact_187_167 |
| PubMedID: 20206154 |
| Title : In vivo experimental approach to treatment against tabun poisoning - Berend_2010_J.Enzyme.Inhib.Med.Chem_25_531 |
| Author(s) : Zunec S , Katalinic M , Vrdoljak AL , Kovarik Z , Kuca K , Radic B |
| Ref : J Enzyme Inhib Med Chem , 25 :531 , 2010 |
| Abstract : |
| PubMedSearch : Berend_2010_J.Enzyme.Inhib.Med.Chem_25_531 |
| PubMedID: 20235800 |
| Title : In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties - Bhattacharjee_2010_Chem.Res.Toxicol_23_26 |
| Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK |
| Ref : Chemical Research in Toxicology , 23 :26 , 2010 |
| Abstract : |
| PubMedSearch : Bhattacharjee_2010_Chem.Res.Toxicol_23_26 |
| PubMedID: 20028185 |
| Title : In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase - dos Santos_2010_Basic.Clin.Pharmacol.Toxicol_107_768 |
| Author(s) : Dos Santos AA , dos Santos DB , Dafre AL , de Bem AF , Souza DO , da Rocha JB , Kuca K , Farina M |
| Ref : Basic Clin Pharmacol Toxicol , 107 :768 , 2010 |
| Abstract : |
| PubMedSearch : dos Santos_2010_Basic.Clin.Pharmacol.Toxicol_107_768 |
| PubMedID: 20406208 |
| Title : Evaluation of aflatoxin B1--acetylcholinesterase dissociation kinetic using the amperometric biosensor technology: prospect for toxicity mechanism - Pohanka_2010_Protein.Pept.Lett_17_340 |
| Author(s) : Pohanka M , Musilek K , Kuca K |
| Ref : Protein Pept Lett , 17 :340 , 2010 |
| Abstract : |
| PubMedSearch : Pohanka_2010_Protein.Pept.Lett_17_340 |
| PubMedID: 19508188 |
| Title : Novel acetylcholinesterase reactivator K112 and its cholinergic properties - Soukup_2010_Biomed.Pharmacother_64_541 |
| Author(s) : Soukup O , Kristofikova Z , Proska J , Tobin G , Patocka J , Marek J , Jun D , Fusek J , Ripova D , Kuca K |
| Ref : Biomed Pharmacother , 64 :541 , 2010 |
| Abstract : |
| PubMedSearch : Soukup_2010_Biomed.Pharmacother_64_541 |
| PubMedID: 20634031 |
| Title : Interaction of nerve agent antidotes with cholinergic systems - Soukup_2010_Curr.Med.Chem_17_1708 |
| Author(s) : Soukup O , Tobin G , Kumar UK , Binder J , Proska J , Jun D , Fusek J , Kuca K |
| Ref : Curr Med Chem , 17 :1708 , 2010 |
| Abstract : |
| PubMedSearch : Soukup_2010_Curr.Med.Chem_17_1708 |
| PubMedID: 20345348 |
| Title : Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model - Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62 |
| Author(s) : Pohanka M , Pejchal J , Horackova S , Kuca K , Bandouchova H , Damkova V , Pikula J |
| Ref : Neuro Endocrinol Lett , 31 Suppl 2 :62 , 2010 |
| Abstract : |
| PubMedSearch : Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62 |
| PubMedID: 21187825 |
| Title : Development of new acetylcholinesterase reactivators: molecular modeling versus in vitro data - Ramalho_2010_Chem.Biol.Interact_185_73 |
| Author(s) : Ramalho TC , Franca TCC , Renno MN , Guimaraes AP , da Cunha EFF , Kuca K |
| Ref : Chemico-Biological Interactions , 185 :73 , 2010 |
| Abstract : |
| PubMedSearch : Ramalho_2010_Chem.Biol.Interact_185_73 |
| PubMedID: 20188081 |
| Title : Colorimetric Detectors Based on Acetylcholinesterase and Its Construction - Pohanka_2010_Mil.Med.Sci.Lett_79_9 |
| Author(s) : Pohanka M , Vlcek V , Karasova JZ , Kuca K , Cabal J |
| Ref : Military Medical Science Letters , 79 :9 , 2010 |
| Abstract : |
| PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_9 |
| PubMedID: |
| Title : Immobilization of Acetylcholinesterase and a Construction of Biochemical Biosensor for Identification of Toxic Organophosphates. - Pohanka_2010_Mil.Med.Sci.Lett_79_105 |
| Author(s) : Pohanka M , Drobik O , Krenkova Z , Karasova JZ , Cabal J , Kuca K |
| Ref : Military Medical Science Letters , 79 :105 , 2010 |
| Abstract : |
| PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_105 |
| PubMedID: |
| Title : Testing of a Referential Method Based on Indoxylacetate as a Acetylcholinesterase Substrate for Identification of Reactivation Efficacy. - Pohanka_2010_Mil.Med.Sci.Lett_79_111 |
| Author(s) : Pohanka M , Hrabinova M , Karasova JZ , Holas O , Kuca K , Cabal J |
| Ref : Military Medical Science Letters , 79 :111 , 2010 |
| Abstract : |
| PubMedSearch : Pohanka_2010_Mil.Med.Sci.Lett_79_111 |
| PubMedID: |
| Title : New Bisquaternary Inhibitors of Acetylcholinesterase Used as a Prophylactics in Organophosphorus Poisoning - Pavlikova_2010_Mil.Med.Sci.Lett_79_46 |
| Author(s) : Pavlikova R , Marek J , Musilek K , Fusek J , Kuca K , Karasova JZ |
| Ref : Military Medical Science Letters , 79 :46 , 2010 |
| Abstract : |
| PubMedSearch : Pavlikova_2010_Mil.Med.Sci.Lett_79_46 |
| PubMedID: |
| Title : A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice - Kassa_2010_Drug.Chem.Toxicol_33_227 |
| Author(s) : Kassa J , Karasova JZ , Kuca K , Musilek K |
| Ref : Drug & Chemical Toxicology , 33 :227 , 2010 |
| Abstract : |
| PubMedSearch : Kassa_2010_Drug.Chem.Toxicol_33_227 |
| PubMedID: 20429807 |
| Title : Is Oxime Fluorination the Proper Way to Increase Penetration of These Compounds in the Central Nervous System? - Karasova_2010_Mil.Med.Sci.Lett_79_23 |
| Author(s) : Karasova JZ , Kassa J , Musilek K , Jung Y , Kuca K |
| Ref : Military Medical Science Letters , 79 :23 , 2010 |
| Abstract : |
| PubMedSearch : Karasova_2010_Mil.Med.Sci.Lett_79_23 |
| PubMedID: |
| Title : The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice - Berend_2010_Chem.Biol.Interact_187_291 |
| Author(s) : Zunec S , Radic B , Kuca K , Lucic Vrdoljak A |
| Ref : Chemico-Biological Interactions , 187 :291 , 2010 |
| Abstract : |
| PubMedSearch : Berend_2010_Chem.Biol.Interact_187_291 |
| PubMedID: 20138854 |
| Title : Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase - Kuca_2010_J.Enzyme.Inhib.Med.Chem_25_509 |
| Author(s) : Kuca K , Musilek K , Jun D , Pohanka M , Ghosh KK , Hrabinova M |
| Ref : J Enzyme Inhib Med Chem , 25 :509 , 2010 |
| Abstract : |
| PubMedSearch : Kuca_2010_J.Enzyme.Inhib.Med.Chem_25_509 |
| PubMedID: 20192902 |
| Title : Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX - Pohanka_2010_Talanta_81_621 |
| Author(s) : Pohanka M , Karasova JZ , Kuca K , Pikula J , Holas O , Korabecny J , Cabal J |
| Ref : Talanta , 81 :621 , 2010 |
| Abstract : |
| PubMedSearch : Pohanka_2010_Talanta_81_621 |
| PubMedID: 20188972 |
| Title : Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy - Kuca_2010_Bratisl.Lek.Listy_111_502 |
| Author(s) : Kuca K , Hrabinova M , Soukup O , Tobin G , Karasova J , Pohanka M |
| Ref : Bratislavske Lekarske Listy , 111 :502 , 2010 |
| Abstract : |
| PubMedSearch : Kuca_2010_Bratisl.Lek.Listy_111_502 |
| PubMedID: 21180265 |
| Title : High-performance liquid chromatography analysis of by-products and intermediates arising during the synthesis of the acetylcholinesterase reactivator HI-6 - Jun_2010_J.Chromatogr.Sci_48_694 |
| Author(s) : Jun D , Stodulka P , Kuca K , Dolezal B |
| Ref : Journal of Chromatography Sci , 48 :694 , 2010 |
| Abstract : |
| PubMedSearch : Jun_2010_J.Chromatogr.Sci_48_694 |
| PubMedID: 20819302 |
| Title : A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques - Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790 |
| Author(s) : Bajgar J , Hajek P , Karasova JZ , Kassa J , Paseka A , Slizova D , Krs O , Kuca K , Jun D , Fusek J , Capek L |
| Ref : J Enzyme Inhib Med Chem , 25 :790 , 2010 |
| Abstract : |
| PubMedSearch : Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790 |
| PubMedID: 21054236 |
| Title : Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure - Karasova_2010_Toxicol.In.Vitro_24_1838 |
| Author(s) : Karasova JZ , Pohanka M , Musilek K , Zemek F , Kuca K |
| Ref : Toxicol In Vitro , 24 :1838 , 2010 |
| Abstract : |
| PubMedSearch : Karasova_2010_Toxicol.In.Vitro_24_1838 |
| PubMedID: 20546883 |
| Title : A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Toxicol.Mech.Methods_19_346 |
| Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K |
| Ref : Toxicol Mech Methods , 19 :346 , 2009 |
| Abstract : |
| PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_346 |
| PubMedID: 19778210 |
| Title : Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX - Hajek_2009_Drug.Chem.Toxicol_32_1 |
| Author(s) : Hajek P , Bajgar J , Slizova D , Krs O , Kuca K , Capek L , Fusek J |
| Ref : Drug & Chemical Toxicology , 32 :1 , 2009 |
| Abstract : |
| PubMedSearch : Hajek_2009_Drug.Chem.Toxicol_32_1 |
| PubMedID: 19514933 |
| Title : Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX - Karasova_2009_Neurotox.Res_16_356 |
| Author(s) : Karasova JZ , Bajgar J , Jun D , Pavlikova R , Kuca K |
| Ref : Neurotox Res , 16 :356 , 2009 |
| Abstract : |
| PubMedSearch : Karasova_2009_Neurotox.Res_16_356 |
| PubMedID: 19728005 |
| Title : Chemical aspects of pharmacological prophylaxis against nerve agent poisoning - Bajgar_2009_Curr.Med.Chem_16_2977 |
| Author(s) : Bajgar J , Fusek J , Kassa J , Kuca K , Jun D |
| Ref : Curr Med Chem , 16 :2977 , 2009 |
| Abstract : |
| PubMedSearch : Bajgar_2009_Curr.Med.Chem_16_2977 |
| PubMedID: 19689278 |
| Title : Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats - Karasova_2009_Int.J.Mol.Sci_10_3065 |
| Author(s) : Karasova JZ , Kassa J , Musilek K , Pohanka M , Novotny L , Kuca K |
| Ref : Int J Mol Sci , 10 :3065 , 2009 |
| Abstract : |
| PubMedSearch : Karasova_2009_Int.J.Mol.Sci_10_3065 |
| PubMedID: 19742125 |
| Title : A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats - Kassa_2009_Toxicol.Mech.Methods_19_232 |
| Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K , Jung AY |
| Ref : Toxicol Mech Methods , 19 :232 , 2009 |
| Abstract : |
| PubMedSearch : Kassa_2009_Toxicol.Mech.Methods_19_232 |
| PubMedID: 19730756 |
| Title : Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon - Kuca_2009_Molecules_14_4915 |
| Author(s) : Kuca K , Musilova L , Palecek J , Cirkva V , Paar M , Musilek K , Hrabinova M , Pohanka M , Karasova JZ , Jun D |
| Ref : Molecules , 14 :4915 , 2009 |
| Abstract : |
| PubMedSearch : Kuca_2009_Molecules_14_4915 |
| PubMedID: 20032868 |
| Title : Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127 - Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| Author(s) : Kuca K , Cabal J , Jung YS , Musilek K , Soukup O , Jun D , Pohanka M , Musilova L , Karasova J , Novotny L , Hrabinova M |
| Ref : Basic Clin Pharmacol Toxicol , 105 :207 , 2009 |
| Abstract : |
| PubMedSearch : Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| PubMedID: 19473310 |
| Title : Irinotecan side effects relieved by the use of HI-6 oxime: in vivo experimental approach - Vrdoljak_2009_Basic.Clin.Pharmacol.Toxicol_105_401 |
| Author(s) : Vrdoljak AL , Zunec S , Zeljezic D , Piljac-Zegarac J , Plestina S , Kuca K , Radic B , Mladinic M , Kopjar N |
| Ref : Basic Clin Pharmacol Toxicol , 105 :401 , 2009 |
| Abstract : |
| PubMedSearch : Vrdoljak_2009_Basic.Clin.Pharmacol.Toxicol_105_401 |
| PubMedID: 19663821 |
| Title : Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent - Jeong_2009_Bioorg.Med.Chem_17_6213 |
| Author(s) : Jeong HC , Park NJ , Chae CH , Musilek K , Kassa J , Kuca K , Jung YS |
| Ref : Bioorganic & Medicinal Chemistry , 17 :6213 , 2009 |
| Abstract : |
| PubMedSearch : Jeong_2009_Bioorg.Med.Chem_17_6213 |
| PubMedID: 19665386 |
| Title : Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6 - Lorke_2009_Toxicol.Mech.Methods_19_327 |
| Author(s) : Lorke DE , Hasan MY , Nurulain SM , Kuca K , Schmitt A , Petroianu GA |
| Ref : Toxicol Mech Methods , 19 :327 , 2009 |
| Abstract : |
| PubMedSearch : Lorke_2009_Toxicol.Mech.Methods_19_327 |
| PubMedID: 19778224 |
| Title : An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Clin.Toxicol.(Phila)_47_72 |
| Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Bajgar J |
| Ref : Clinical Toxicology (Phila) , 47 :72 , 2009 |
| Abstract : |
| PubMedSearch : Kassa_2009_Clin.Toxicol.(Phila)_47_72 |
| PubMedID: 18686075 |
| Title : Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy - Pohanka_2009_J.Appl.Toxicol_29_483 |
| Author(s) : Pohanka M , Karasova JZ , Musilek K , Kuca K , Kassa J |
| Ref : J Appl Toxicol , 29 :483 , 2009 |
| Abstract : |
| PubMedSearch : Pohanka_2009_J.Appl.Toxicol_29_483 |
| PubMedID: 19338015 |
| Title : Progress of biosensors based on cholinesterase inhibition - Pohanka_2009_Curr.Med.Chem_16_1790 |
| Author(s) : Pohanka M , Musilek K , Kuca K |
| Ref : Curr Med Chem , 16 :1790 , 2009 |
| Abstract : |
| PubMedSearch : Pohanka_2009_Curr.Med.Chem_16_1790 |
| PubMedID: 19442145 |
| Title : In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048 - Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680 |
| Author(s) : Pohanka M , Jun D , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 24 :680 , 2009 |
| Abstract : |
| PubMedSearch : Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680 |
| PubMedID: 18825528 |
| Title : Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime - Nurulain_2009_Neurotox.Res_16_60 |
| Author(s) : Nurulain SM , Lorke DE , Hasan MY , Shafiullah M , Kuca K , Musilek K , Petroianu GA |
| Ref : Neurotox Res , 16 :60 , 2009 |
| Abstract : |
| PubMedSearch : Nurulain_2009_Neurotox.Res_16_60 |
| PubMedID: 19526299 |
| Title : Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro - Veinlichova_2009_Chem.Biol.Interact_180_449 |
| Author(s) : Veinlichova A , Jancova P , Siller M , Anzenbacher P , Kuca K , Jun D , Fusek J , Anzenbacherova E |
| Ref : Chemico-Biological Interactions , 180 :449 , 2009 |
| Abstract : |
| PubMedSearch : Veinlichova_2009_Chem.Biol.Interact_180_449 |
| PubMedID: 19539805 |
| Title : An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Toxicology_243_311 |
| Author(s) : Kassa J , Karasova J , Musilek K , Kuca K |
| Ref : Toxicology , 243 :311 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Toxicology_243_311 |
| PubMedID: 18054821 |
| Title : Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman s Photometric Method - Pohanka_2008_Sensors.(Basel)_8_5229 |
| Author(s) : Pohanka M , Hrabinova M , Kuca K |
| Ref : Sensors (Basel) , 8 :5229 , 2008 |
| Abstract : |
| PubMedSearch : Pohanka_2008_Sensors.(Basel)_8_5229 |
| PubMedID: 27873811 |
| Title : Amperometric Biosensors for Real Time Assays of Organophosphates - Pohanka_2008_Sensors.(Basel)_8_5303 |
| Author(s) : Pohanka M , Jun D , Kuca K |
| Ref : Sensors (Basel) , 8 :5303 , 2008 |
| Abstract : |
| PubMedSearch : Pohanka_2008_Sensors.(Basel)_8_5303 |
| PubMedID: 27873815 |
| Title : Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation - Pohanka_2008_J.Enzyme.Inhib.Med.Chem_23_781 |
| Author(s) : Pohanka M , Jun D , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 23 :781 , 2008 |
| Abstract : |
| PubMedSearch : Pohanka_2008_J.Enzyme.Inhib.Med.Chem_23_781 |
| PubMedID: 18615283 |
| Title : In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate - Lorke_2008_J.Appl.Toxicol_28_422 |
| Author(s) : Lorke DE , Hasan MY , Arafat K , Kuca K , Musilek K , Schmitt A , Petroianu GA |
| Ref : J Appl Toxicol , 28 :422 , 2008 |
| Abstract : |
| PubMedSearch : Lorke_2008_J.Appl.Toxicol_28_422 |
| PubMedID: 18344198 |
| Title : Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro - Jun_2008_Chem.Biol.Interact_175_421 |
| Author(s) : Jun D , Musilova L , Kuca K , Kassa J , Bajgar J |
| Ref : Chemico-Biological Interactions , 175 :421 , 2008 |
| Abstract : |
| PubMedSearch : Jun_2008_Chem.Biol.Interact_175_421 |
| PubMedID: 18617161 |
| Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats - Kassa_2008_Chem.Biol.Interact_175_425 |
| Author(s) : Kassa J , Jun D , Karasova J , Bajgar J , Kuca K |
| Ref : Chemico-Biological Interactions , 175 :425 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Chem.Biol.Interact_175_425 |
| PubMedID: 18547554 |
| Title : New bispyridinium oximes: in vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning - Berend_2008_Chem.Biol.Interact_175_413 |
| Author(s) : Zunec S , Vrdoljak AL , Radic B , Kuca K |
| Ref : Chemico-Biological Interactions , 175 :413 , 2008 |
| Abstract : |
| PubMedSearch : Berend_2008_Chem.Biol.Interact_175_413 |
| PubMedID: 18547553 |
| Title : The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun - Kassa_2008_Mini.Rev.Med.Chem_8_1134 |
| Author(s) : Kassa J , Kuca K , Karasova J , Musilek K |
| Ref : Mini Rev Med Chem , 8 :1134 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Mini.Rev.Med.Chem_8_1134 |
| PubMedID: 18855728 |
| Title : RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker - Musilek_2008_Anal.Bioanal.Chem_391_367 |
| Author(s) : Musilek K , Jampilek J , Dohnal J , Jun D , Gunn-Moore F , Dolezal M , Kuca K |
| Ref : Anal Bioanal Chem , 391 :367 , 2008 |
| Abstract : |
| PubMedSearch : Musilek_2008_Anal.Bioanal.Chem_391_367 |
| PubMedID: 18369602 |
| Title : Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_Bioorg.Med.Chem_16_8218 |
| Author(s) : Musilek K , Kucera J , Jun D , Dohnal V , Opletalova V , Kuca K |
| Ref : Bioorganic & Medicinal Chemistry , 16 :8218 , 2008 |
| Abstract : |
| PubMedSearch : Musilek_2008_Bioorg.Med.Chem_16_8218 |
| PubMedID: 18676153 |
| Title : Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases - Calic_2008_Chem.Biol.Interact_175_305 |
| Author(s) : Calic M , Bosak A , Kuca K , Kovarik Z |
| Ref : Chemico-Biological Interactions , 175 :305 , 2008 |
| Abstract : |
| PubMedSearch : Calic_2008_Chem.Biol.Interact_175_305 |
| PubMedID: 18501885 |
| Title : Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats - Karasova_2008_Int.J.Mol.Sci_9_2243 |
| Author(s) : Karasova JZ , Kassa J , Jung YS , Musilek K , Pohanka M , Kuca K |
| Ref : Int J Mol Sci , 9 :2243 , 2008 |
| Abstract : |
| PubMedSearch : Karasova_2008_Int.J.Mol.Sci_9_2243 |
| PubMedID: 19330072 |
| Title : A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice - Kassa_2008_J.Enzyme.Inhib.Med.Chem_23_776 |
| Author(s) : Kassa J , Karasova J , Bajgar J , Kuca K , Musilek K |
| Ref : J Enzyme Inhib Med Chem , 23 :776 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_J.Enzyme.Inhib.Med.Chem_23_776 |
| PubMedID: 18608751 |
| Title : A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Drug.Chem.Toxicol_31_371 |
| Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Jung YS |
| Ref : Drug & Chemical Toxicology , 31 :371 , 2008 |
| Abstract : |
| PubMedSearch : Kassa_2008_Drug.Chem.Toxicol_31_371 |
| PubMedID: 18622871 |
| Title : The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder - Soukup_2008_Neuro.Endocrinol.Lett_29_759 |
| Author(s) : Soukup O , Pohanka M , Tobin G , Jun D , Fusek J , Musilek K , Marek J , Kassa J , Kuca K |
| Ref : Neuro Endocrinol Lett , 29 :759 , 2008 |
| Abstract : |
| PubMedSearch : Soukup_2008_Neuro.Endocrinol.Lett_29_759 |
| PubMedID: 18987577 |
| Title : Potency of novel oximes to reactivate sarin inhibited human cholinesterases - Jun_2008_Drug.Chem.Toxicol_31_1 |
| Author(s) : Jun D , Kuca K , Picha J , Koleckar V , Marek J |
| Ref : Drug & Chemical Toxicology , 31 :1 , 2008 |
| Abstract : |
| PubMedSearch : Jun_2008_Drug.Chem.Toxicol_31_1 |
| PubMedID: 18161504 |
| Title : TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate - Jun_2008_J.Chromatogr.Sci_46_316 |
| Author(s) : Jun D , Stodulka P , Kuca K , Koleckar V , Dolezal B , Simon P , Veverka M |
| Ref : Journal of Chromatography Sci , 46 :316 , 2008 |
| Abstract : |
| PubMedSearch : Jun_2008_J.Chromatogr.Sci_46_316 |
| PubMedID: 18402722 |
| Title : Analysis of pyridinium aldoximes - a chromatographic approach - Csermely_2008_Curr.Med.Chem_15_2401 |
| Author(s) : Csermely T , Kalasz H , Petroianu GA , Kuca K , Darvas F , Ludanyi K , Mudhafar AA , Tekes K |
| Ref : Curr Med Chem , 15 :2401 , 2008 |
| Abstract : |
| PubMedSearch : Csermely_2008_Curr.Med.Chem_15_2401 |
| PubMedID: 18855669 |
| Title : An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents - Bajgar_2008_Chem.Biol.Interact_175_281 |
| Author(s) : Bajgar J , Fusek J , Kassa J , Jun D , Kuca K , Hajek P |
| Ref : Chemico-Biological Interactions , 175 :281 , 2008 |
| Abstract : |
| PubMedSearch : Bajgar_2008_Chem.Biol.Interact_175_281 |
| PubMedID: 18579126 |
| Title : Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity - Lorke_2008_J.Appl.Toxicol_28_920 |
| Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Musilek K , Petroianu GA |
| Ref : J Appl Toxicol , 28 :920 , 2008 |
| Abstract : |
| PubMedSearch : Lorke_2008_J.Appl.Toxicol_28_920 |
| PubMedID: 18548743 |
| Title : Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex - da Silva_2008_Neurotoxicol_29_184 |
| Author(s) : da Silva AP , Farina M , Franco JL , Dafre AL , Kassa J , Kuca K |
| Ref : Neurotoxicology , 29 :184 , 2008 |
| Abstract : |
| PubMedSearch : da Silva_2008_Neurotoxicol_29_184 |
| PubMedID: 18035420 |
| Title : Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes - Oh_2008_Chem.Biol.Interact_175_365 |
| Author(s) : Oh KA , Park NJ , Park NS , Kuca K , Jun D , Jung YS |
| Ref : Chemico-Biological Interactions , 175 :365 , 2008 |
| Abstract : |
| PubMedSearch : Oh_2008_Chem.Biol.Interact_175_365 |
| PubMedID: 18565503 |
| Title : Cholinesterase biosensor construction - a review - Pohanka_2008_Protein.Pept.Lett_15_795 |
| Author(s) : Pohanka M , Jun D , Kalasz H , Kuca K |
| Ref : Protein Pept Lett , 15 :795 , 2008 |
| Abstract : |
| PubMedSearch : Pohanka_2008_Protein.Pept.Lett_15_795 |
| PubMedID: 18855751 |
| Title : New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine - Pohanka_2008_Neuro.Endocrinol.Lett_29_755 |
| Author(s) : Pohanka M , Kuca K , Kassa J |
| Ref : Neuro Endocrinol Lett , 29 :755 , 2008 |
| Abstract : |
| PubMedSearch : Pohanka_2008_Neuro.Endocrinol.Lett_29_755 |
| PubMedID: 18987590 |
| Title : Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease - Patocka_2008_Curr.Drug.Metab_9_332 |
| Author(s) : Patocka J , Jun D , Kuca K |
| Ref : Curr Drug Metab , 9 :332 , 2008 |
| Abstract : |
| PubMedSearch : Patocka_2008_Curr.Drug.Metab_9_332 |
| PubMedID: 18473751 |
| Title : Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70 |
| Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M |
| Ref : J Enzyme Inhib Med Chem , 23 :70 , 2008 |
| Abstract : |
| PubMedSearch : Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70 |
| PubMedID: 18341256 |
| Title : Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction - Bajgar_2007_Mini.Rev.Med.Chem_7_461 |
| Author(s) : Bajgar J , Fusek J , Kuca K , Bartosova L , Jun D |
| Ref : Mini Rev Med Chem , 7 :461 , 2007 |
| Abstract : |
| PubMedSearch : Bajgar_2007_Mini.Rev.Med.Chem_7_461 |
| PubMedID: 17504181 |
| Title : Inhibition of blood cholinesterases following intoxication with VX and its derivatives - Bajgar_2007_J.Appl.Toxicol_27_458 |
| Author(s) : Bajgar J , Kuca K , Fusek J , Karasova J , Kassa J , Cabal J , Jun D , Blaha V |
| Ref : J Appl Toxicol , 27 :458 , 2007 |
| Abstract : |
| PubMedSearch : Bajgar_2007_J.Appl.Toxicol_27_458 |
| PubMedID: 17299830 |
| Title : Acetylcholinesterases--the structural similarities and differences - Wiesner_2007_J.Enzyme.Inhib.Med.Chem_22_417 |
| Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J |
| Ref : J Enzyme Inhib Med Chem , 22 :417 , 2007 |
| Abstract : |
| PubMedSearch : Wiesner_2007_J.Enzyme.Inhib.Med.Chem_22_417 |
| PubMedID: 17847707 |
| Title : Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX) - Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203 |
| Author(s) : Musilek K , Kuca K , Jun D |
| Ref : Acta Medica (Hradec Kralove) , 50 :203 , 2007 |
| Abstract : |
| PubMedSearch : Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203 |
| PubMedID: 18254274 |
| Title : Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203) - Musilek_2007_J.Med.Chem_50_5514 |
| Author(s) : Musilek K , Jun D , Cabal J , Kassa J , Gunn-Moore F , Kuca K |
| Ref : Journal of Medicinal Chemistry , 50 :5514 , 2007 |
| Abstract : |
| PubMedSearch : Musilek_2007_J.Med.Chem_50_5514 |
| PubMedID: 17924614 |
| Title : Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2007_Bioorg.Med.Chem_15_6733 |
| Author(s) : Musilek K , Holas O , Jun D , Dohnal V , Gunn-Moore F , Opletalova V , Dolezal M , Kuca K |
| Ref : Bioorganic & Medicinal Chemistry , 15 :6733 , 2007 |
| Abstract : |
| PubMedSearch : Musilek_2007_Bioorg.Med.Chem_15_6733 |
| PubMedID: 17764957 |
| Title : Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon - Petroianu_2007_J.Appl.Toxicol_27_453 |
| Author(s) : Petroianu GA , Nurulain SM , Nagelkerke N , Shafiullah M , Kassa J , Kuca K |
| Ref : J Appl Toxicol , 27 :453 , 2007 |
| Abstract : |
| PubMedSearch : Petroianu_2007_J.Appl.Toxicol_27_453 |
| PubMedID: 17304644 |
| Title : Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin - Kuca_2007_Clin.Toxicol.(Phila)_45_512 |
| Author(s) : Kuca K , Cabal J , Jun D , Hrabinova M |
| Ref : Clinical Toxicology (Phila) , 45 :512 , 2007 |
| Abstract : |
| PubMedSearch : Kuca_2007_Clin.Toxicol.(Phila)_45_512 |
| PubMedID: 17503257 |
| Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats - Kassa_2007_J.Enzyme.Inhib.Med.Chem_22_297 |
| Author(s) : Kassa J , Jun D , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 22 :297 , 2007 |
| Abstract : |
| PubMedSearch : Kassa_2007_J.Enzyme.Inhib.Med.Chem_22_297 |
| PubMedID: 17674811 |
| Title : In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases - Kuca_2007_Neurotox.Res_11_101 |
| Author(s) : Kuca K , Cabal J , Jun D , Musilek K |
| Ref : Neurotox Res , 11 :101 , 2007 |
| Abstract : |
| PubMedSearch : Kuca_2007_Neurotox.Res_11_101 |
| PubMedID: 17449453 |
| Title : Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2007_Bioorg.Med.Chem.Lett_17_3172 |
| Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3172 , 2007 |
| Abstract : |
| PubMedSearch : Musilek_2007_Bioorg.Med.Chem.Lett_17_3172 |
| PubMedID: 17383875 |
| Title : Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats - Kassa_2007_Basic.Clin.Pharmacol.Toxicol_101_328 |
| Author(s) : Kassa J , Jun D , Kuca K , Bajgar J |
| Ref : Basic Clin Pharmacol Toxicol , 101 :328 , 2007 |
| Abstract : |
| PubMedSearch : Kassa_2007_Basic.Clin.Pharmacol.Toxicol_101_328 |
| PubMedID: 17910616 |
| Title : Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase - Bajgar_2007_Drug.Chem.Toxicol_30_351 |
| Author(s) : Bajgar J , Bartosova L , Kuca K , Jun D , Fusek J |
| Ref : Drug & Chemical Toxicology , 30 :351 , 2007 |
| Abstract : |
| PubMedSearch : Bajgar_2007_Drug.Chem.Toxicol_30_351 |
| PubMedID: 17934924 |
| Title : Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro - Kuca_2007_Drug.Chem.Toxicol_30_31 |
| Author(s) : Kuca K , Jun D , Bajgar J |
| Ref : Drug & Chemical Toxicology , 30 :31 , 2007 |
| Abstract : |
| PubMedSearch : Kuca_2007_Drug.Chem.Toxicol_30_31 |
| PubMedID: 17364862 |
| Title : Measurement of K-27, an oxime-type cholinesterase reactivator by high-performance liquid chromatography with electrochemical detection from different biological samples - Gyenge_2007_J.Chromatogr.A_1161_146 |
| Author(s) : Gyenge M , Kalasz H , Petroianu GA , Laufer R , Kuca K , Tekes K |
| Ref : Journal of Chromatography A , 1161 :146 , 2007 |
| Abstract : |
| PubMedSearch : Gyenge_2007_J.Chromatogr.A_1161_146 |
| PubMedID: 17603065 |
| Title : In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon - Petroianu_2007_J.Appl.Toxicol_27_168 |
| Author(s) : Petroianu GA , Arafat K , Nurulain SM , Kuca K , Kassa J |
| Ref : J Appl Toxicol , 27 :168 , 2007 |
| Abstract : |
| PubMedSearch : Petroianu_2007_J.Appl.Toxicol_27_168 |
| PubMedID: 17265452 |
| Title : Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study - Bajgar_2007_Chem.Biol.Interact_165_14 |
| Author(s) : Bajgar J , Hajek P , Slizova D , Krs O , Fusek J , Kuca K , Jun D , Bartosova L , Blaha V |
| Ref : Chemico-Biological Interactions , 165 :14 , 2007 |
| Abstract : |
| PubMedSearch : Bajgar_2007_Chem.Biol.Interact_165_14 |
| PubMedID: 17145052 |
| Title : Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2007_J.Enzyme.Inhib.Med.Chem_22_425 |
| Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Dolezal M |
| Ref : J Enzyme Inhib Med Chem , 22 :425 , 2007 |
| Abstract : |
| PubMedSearch : Musilek_2007_J.Enzyme.Inhib.Med.Chem_22_425 |
| PubMedID: 17847708 |
| Title : Two step synthesis of a non-symmetric acetylcholinesterase reactivator - Musilek_2007_Molecules_12_1755 |
| Author(s) : Musilek K , Kuca K , Dohnal V , Jun D , Marek J , Koleckar V |
| Ref : Molecules , 12 :1755 , 2007 |
| Abstract : |
| PubMedSearch : Musilek_2007_Molecules_12_1755 |
| PubMedID: 17960085 |
| Title : Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications - Kuca_2007_Curr.Pharm.Des_13_3445 |
| Author(s) : Kuca K , Jun D , Bajgar J |
| Ref : Curr Pharm Des , 13 :3445 , 2007 |
| Abstract : |
| PubMedSearch : Kuca_2007_Curr.Pharm.Des_13_3445 |
| PubMedID: 18045198 |
| Title : Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator - Kuca_2007_Molecules_12_1964 |
| Author(s) : Kuca K , Musilek K , Paar M , Jun D , Stodulka P , Hrabinova M , Marek J |
| Ref : Molecules , 12 :1964 , 2007 |
| Abstract : |
| PubMedSearch : Kuca_2007_Molecules_12_1964 |
| PubMedID: 17960099 |
| Title : Amperometric biosensor for pesticide methamidophos assay - Pohanka_2007_Acta.Medica.(Hradec.Kralove)_50_239 |
| Author(s) : Pohanka M , Kuca K , Jun D |
| Ref : Acta Medica (Hradec Kralove) , 50 :239 , 2007 |
| Abstract : |
| PubMedSearch : Pohanka_2007_Acta.Medica.(Hradec.Kralove)_50_239 |
| PubMedID: 18290547 |
| Title : Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates\/nerve agents - Bajgar_2007_Curr.Drug.Metab_8_803 |
| Author(s) : Bajgar J , Kuca K , Jun D , Bartosova L , Fusek J |
| Ref : Curr Drug Metab , 8 :803 , 2007 |
| Abstract : |
| PubMedSearch : Bajgar_2007_Curr.Drug.Metab_8_803 |
| PubMedID: 18220560 |
| Title : Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents - Bajgar_2006_J.Appl.Toxicol_26_439 |
| Author(s) : Bajgar J , Fusek J , Bartosova L , Jun D , Kuca K |
| Ref : J Appl Toxicol , 26 :439 , 2006 |
| Abstract : |
| PubMedSearch : Bajgar_2006_J.Appl.Toxicol_26_439 |
| PubMedID: 16915560 |
| Title : High-performance liquid chromatographic determination of the plasma concentration of K-27, a novel oxime-type cholinesterase reactivator - Tekes_2006_J.Chromatogr.A_1122_84 |
| Author(s) : Tekes K , Hasan MY , Sheen R , Kuca K , Petroianu GA , Ludanyi K , Kalasz H |
| Ref : Journal of Chromatography A , 1122 :84 , 2006 |
| Abstract : |
| PubMedSearch : Tekes_2006_J.Chromatogr.A_1122_84 |
| PubMedID: 16690067 |
| Title : Equine butyrylcholinesterase protects rats against inhalation exposure to sublethal sarin concentrations - Bajgar_2006_Arh.Hig.Rada.Toksikol_57_391 |
| Author(s) : Bajgar J , Bartosova L , Fusek J , Jun D , Kuca K |
| Ref : Arh Hig Rada Toksikol , 57 :391 , 2006 |
| Abstract : |
| PubMedSearch : Bajgar_2006_Arh.Hig.Rada.Toksikol_57_391 |
| PubMedID: 17265678 |
| Title : The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings - Kassa_2006_Int.J.Toxicol_25_397 |
| Author(s) : Kassa J , Jun D , Kuca K |
| Ref : Int J Toxicol , 25 :397 , 2006 |
| Abstract : |
| PubMedSearch : Kassa_2006_Int.J.Toxicol_25_397 |
| PubMedID: 16940011 |
| Title : Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent - Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389 |
| Author(s) : Kuca K , Jun D , Cabal J , Hrabinova M , Bartosova L , Opletalova V |
| Ref : Basic Clin Pharmacol Toxicol , 98 :389 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389 |
| PubMedID: 16623863 |
| Title : [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos] - Musilek_2006_Ceska.Slov.Farm_55_115 |
| Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Kim TH , Jung YS , Dolezal M |
| Ref : Ceska a Slovenska Farmacie , 55 :115 , 2006 |
| Abstract : |
| PubMedSearch : Musilek_2006_Ceska.Slov.Farm_55_115 |
| PubMedID: 16838488 |
| Title : Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase - Musilek_2006_Bioorg.Med.Chem.Lett_16_622 |
| Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Dolezal M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :622 , 2006 |
| Abstract : |
| PubMedSearch : Musilek_2006_Bioorg.Med.Chem.Lett_16_622 |
| PubMedID: 16288867 |
| Title : Influence of Length and Shape of the Connecting Chain of Bisquaternary Acetylcholinesterase Reactivators on Their Potency to Reactivate Enzyme Inhibited by Sarin - Kuca_2006_Mil.Med.Sci.Lett_75_37 |
| Author(s) : Kuca K , Jun D , Musilek K |
| Ref : Military Medical Science Letters , 75 :37 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_Mil.Med.Sci.Lett_75_37 |
| PubMedID: |
| Title : Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro - Jun_2006_J.Appl.Toxicol_26_258 |
| Author(s) : Jun D , Kuca K , Hronek M , Opletal L |
| Ref : J Appl Toxicol , 26 :258 , 2006 |
| Abstract : |
| PubMedSearch : Jun_2006_J.Appl.Toxicol_26_258 |
| PubMedID: 16307468 |
| Title : Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase - Racakova_2006_Arh.Hig.Rada.Toksikol_57_387 |
| Author(s) : Racakova V , Hrabinova M , Jun D , Kuca K |
| Ref : Arh Hig Rada Toksikol , 57 :387 , 2006 |
| Abstract : |
| PubMedSearch : Racakova_2006_Arh.Hig.Rada.Toksikol_57_387 |
| PubMedID: 17265677 |
| Title : In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity - Calic_2006_Toxicology_219_85 |
| Author(s) : Calic M , Vrdoljak AL , Radic B , Jelic D , Jun D , Kuca K , Kovarik Z |
| Ref : Toxicology , 219 :85 , 2006 |
| Abstract : |
| PubMedSearch : Calic_2006_Toxicology_219_85 |
| PubMedID: 16332406 |
| Title : Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes - Kuca_2006_Acta.Medica.(Hradec.Kralove)_49_233 |
| Author(s) : Kuca K , Picha J , Jun D |
| Ref : Acta Medica (Hradec Kralove) , 49 :233 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_Acta.Medica.(Hradec.Kralove)_49_233 |
| PubMedID: 17438836 |
| Title : Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon - Petroianu_2006_J.Appl.Toxicol_26_64 |
| Author(s) : Petroianu GA , Arafat K , Kuca K , Kassa J |
| Ref : J Appl Toxicol , 26 :64 , 2006 |
| Abstract : |
| PubMedSearch : Petroianu_2006_J.Appl.Toxicol_26_64 |
| PubMedID: 16193529 |
| Title : Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon - Petroianu_2006_J.Appl.Toxicol_26_262 |
| Author(s) : Petroianu GA , Nurulain SM , Nagelkerke N , Al-Sultan MA , Kuca K , Kassa J |
| Ref : J Appl Toxicol , 26 :262 , 2006 |
| Abstract : |
| PubMedSearch : Petroianu_2006_J.Appl.Toxicol_26_262 |
| PubMedID: 16583462 |
| Title : In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings - Kuca_2006_Drug.Chem.Toxicol_29_443 |
| Author(s) : Kuca K , Cabal J , Jun D , Hrabinova M |
| Ref : Drug & Chemical Toxicology , 29 :443 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_Drug.Chem.Toxicol_29_443 |
| PubMedID: 16931445 |
| Title : The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure - Bartosova_2006_Neurotox.Res_9_291 |
| Author(s) : Bartosova L , Kuca K , Kunesova G , Jun D |
| Ref : Neurotox Res , 9 :291 , 2006 |
| Abstract : |
| PubMedSearch : Bartosova_2006_Neurotox.Res_9_291 |
| PubMedID: 16782588 |
| Title : Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases - Kuca_2006_J.Enzyme.Inhib.Med.Chem_21_663 |
| Author(s) : Kuca K , Cabal J , Jun D , Bajgar J , Hrabinova M |
| Ref : J Enzyme Inhib Med Chem , 21 :663 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_J.Enzyme.Inhib.Med.Chem_21_663 |
| PubMedID: 17252938 |
| Title : Tests with Daphnia magna: a new approach to prescreen toxicity of newly synthesized acetylcholinesterase reactivators - Vesela_2006_J.Enzyme.Inhib.Med.Chem_21_427 |
| Author(s) : Vesela S , Ondruska V , Kuca K , Patocka J |
| Ref : J Enzyme Inhib Med Chem , 21 :427 , 2006 |
| Abstract : |
| PubMedSearch : Vesela_2006_J.Enzyme.Inhib.Med.Chem_21_427 |
| PubMedID: 17059176 |
| Gene_locus related to this paper: dapul-ACHE1 |
| Title : Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes - Kuca_2006_J.Med.Toxicol_2_141 |
| Author(s) : Kuca K , Jun D |
| Ref : J Med Toxicol , 2 :141 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_J.Med.Toxicol_2_141 |
| PubMedID: 18072133 |
| Title : Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning - Lucic_2006_Toxicology_228_41 |
| Author(s) : Lucic Vrdoljak A , Calic M , Radic B , Zunec S , Jun D , Kuca K , Kovarik Z |
| Ref : Toxicology , 228 :41 , 2006 |
| Abstract : |
| PubMedSearch : Lucic_2006_Toxicology_228_41 |
| PubMedID: 16982122 |
| Title : New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin - Hrabinova_2006_J.Enzyme.Inhib.Med.Chem_21_515 |
| Author(s) : Hrabinova M , Musilek K , Jun D , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 21 :515 , 2006 |
| Abstract : |
| PubMedSearch : Hrabinova_2006_J.Enzyme.Inhib.Med.Chem_21_515 |
| PubMedID: 17194020 |
| Title : Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2006_Bioorg.Med.Chem.Lett_16_5673 |
| Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Dolezal M |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5673 , 2006 |
| Abstract : |
| PubMedSearch : Musilek_2006_Bioorg.Med.Chem.Lett_16_5673 |
| PubMedID: 16934462 |
| Title : Structural requirements of acetylcholinesterase reactivators - Kuca_2006_Mini.Rev.Med.Chem_6_269 |
| Author(s) : Kuca K , Jun D , Musilek K |
| Ref : Mini Rev Med Chem , 6 :269 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_Mini.Rev.Med.Chem_6_269 |
| PubMedID: 16515465 |
| Title : A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vivo methods - Kassa_2006_J.Toxicol.Environ.Health.A_69_1875 |
| Author(s) : Kassa J , Kuca K , Cabal J , Paar M |
| Ref : J Toxicol Environ Health A , 69 :1875 , 2006 |
| Abstract : |
| PubMedSearch : Kassa_2006_J.Toxicol.Environ.Health.A_69_1875 |
| PubMedID: 16952906 |
| Title : In vitro potency of H oximes (HI-6, HLo-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase - Kuca_2006_J.Toxicol.Environ.Health.A_69_1431 |
| Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M |
| Ref : J Toxicol Environ Health A , 69 :1431 , 2006 |
| Abstract : |
| PubMedSearch : Kuca_2006_J.Toxicol.Environ.Health.A_69_1431 |
| PubMedID: 16766478 |
| Title : A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents - Picha_2005_J.Enzyme.Inhib.Med.Chem_20_233 |
| Author(s) : Picha J , Kuca K , Kivala M , Kohout M , Cabal J , Liska F |
| Ref : J Enzyme Inhib Med Chem , 20 :233 , 2005 |
| Abstract : |
| PubMedSearch : Picha_2005_J.Enzyme.Inhib.Med.Chem_20_233 |
| PubMedID: 16119193 |
| Title : In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions - Kuca_2005_J.Appl.Toxicol_25_296 |
| Author(s) : Kuca K , Cabal J , Jun D , Kassa J , Bartosova L , Kunesova G |
| Ref : J Appl Toxicol , 25 :296 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_J.Appl.Toxicol_25_296 |
| PubMedID: 16025528 |
| Title : A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_Acta.Medica.(Hradec.Kralove)_48_81 |
| Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M |
| Ref : Acta Medica (Hradec Kralove) , 48 :81 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_Acta.Medica.(Hradec.Kralove)_48_81 |
| PubMedID: 16259317 |
| Title : In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine) - Patocka_2005_Acta.Medica.(Hradec.Kralove)_48_145 |
| Author(s) : Patocka J , Jun D , Kuca K |
| Ref : Acta Medica (Hradec Kralove) , 48 :145 , 2005 |
| Abstract : |
| PubMedSearch : Patocka_2005_Acta.Medica.(Hradec.Kralove)_48_145 |
| PubMedID: 16640027 |
| Title : A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_J.Toxicol.Environ.Health.A_68_677 |
| Author(s) : Kuca K , Cabal J , Kassa J |
| Ref : J Toxicol Environ Health A , 68 :677 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_J.Toxicol.Environ.Health.A_68_677 |
| PubMedID: 15901095 |
| Title : New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications - Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_75 |
| Author(s) : Kuca K , Bartosova L , Jun D , Patocka J , Cabal J , Kassa J , Kunesova G |
| Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :75 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_75 |
| PubMedID: 16170392 |
| Title : Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo - Kuca_2005_Chem.Biol.Interact_157-158_367 |
| Author(s) : Kuca K , Bartosova L , Kassa J , Cabal J , Bajgar J , Kunesova G , Jun D |
| Ref : Chemico-Biological Interactions , 157-158 :367 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_Chem.Biol.Interact_157-158_367 |
| PubMedID: 16429489 |
| Title : Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings - Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_429 |
| Author(s) : Kuca K , Cabal J , Jun D , Kassa J , Bartosova L , Kunesova G , Dohnal V |
| Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :429 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_429 |
| PubMedID: 16601804 |
| Title : Effective bisquaternary reactivators of tabun-inhibited AChE - Kuca_2005_J.Appl.Toxicol_25_491 |
| Author(s) : Kuca K , Cabal J , Musilek K , Jun D , Bajgar J |
| Ref : J Appl Toxicol , 25 :491 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_J.Appl.Toxicol_25_491 |
| PubMedID: 16092078 |
| Title : Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin nerve agent - Kuca_2005_Toxicol.Mech.Methods_15_247 |
| Author(s) : Kuca K , Cabal J |
| Ref : Toxicol Mech Methods , 15 :247 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_Toxicol.Mech.Methods_15_247 |
| PubMedID: 20021089 |
| Title : A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun - Kassa_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_419 |
| Author(s) : Kassa J , Kuca K , Cabal J |
| Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :419 , 2005 |
| Abstract : |
| PubMedSearch : Kassa_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_419 |
| PubMedID: 16601802 |
| Title : Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents - Kim_2005_Bioorg.Med.Chem.Lett_15_2914 |
| Author(s) : Kim TH , Kuca K , Jun D , Jung YS |
| Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2914 , 2005 |
| Abstract : |
| PubMedSearch : Kim_2005_Bioorg.Med.Chem.Lett_15_2914 |
| PubMedID: 15911280 |
| Title : Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats - Bartosova_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_425 |
| Author(s) : Bartosova L , Kuca K , Kunesova G |
| Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :425 , 2005 |
| Abstract : |
| PubMedSearch : Bartosova_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_425 |
| PubMedID: 16601803 |
| Title : [A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun] - Cabal_2005_Ceska.Slov.Farm_54_192 |
| Author(s) : Cabal J , Kuca K , Jun D , Bajgar J , Hrabinova M |
| Ref : Ceska a Slovenska Farmacie , 54 :192 , 2005 |
| Abstract : |
| PubMedSearch : Cabal_2005_Ceska.Slov.Farm_54_192 |
| PubMedID: 16124202 |
| Title : Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain - Kuca_2005_J.Appl.Toxicol_25_271 |
| Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M |
| Ref : J Appl Toxicol , 25 :271 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_J.Appl.Toxicol_25_271 |
| PubMedID: 16021679 |
| Title : Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators - Krejcova-Kunesova_2005_Toxicology_216_32 |
| Author(s) : Krejcova-Kunesova G , Bartosova L , Kuca K |
| Ref : Toxicology , 216 :32 , 2005 |
| Abstract : |
| PubMedSearch : Krejcova-Kunesova_2005_Toxicology_216_32 |
| PubMedID: 16126317 |
| Title : Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase - Musilek_2005_J.Enzyme.Inhib.Med.Chem_20_409 |
| Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Dolezal M |
| Ref : J Enzyme Inhib Med Chem , 20 :409 , 2005 |
| Abstract : |
| PubMedSearch : Musilek_2005_J.Enzyme.Inhib.Med.Chem_20_409 |
| PubMedID: 16335048 |
| Title : In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes - Kuca_2005_J.Enzyme.Inhib.Med.Chem_20_227 |
| Author(s) : Kuca K , Cabal J , Kassa J |
| Ref : J Enzyme Inhib Med Chem , 20 :227 , 2005 |
| Abstract : |
| PubMedSearch : Kuca_2005_J.Enzyme.Inhib.Med.Chem_20_227 |
| PubMedID: 16119192 |
| Title : Computer Modeling and Simulation - New Technologies in Development of Means against Combat Chemical Substances - Wiesner_2005_Mil.Med.Sci.Lett_74_165 |
| Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J |
| Ref : Military Medical Science Letters , 74 :165 , 2005 |
| Abstract : |
| PubMedSearch : Wiesner_2005_Mil.Med.Sci.Lett_74_165 |
| PubMedID: |
| Title : Antidotal treatment of GF-agent intoxication in mice with bispyridinium oximes - Sevelova_2005_Toxicology_207_1 |
| Author(s) : Sevelova L , Kuca K , Krejcova-Kunesova G |
| Ref : Toxicology , 207 :1 , 2005 |
| Abstract : |
| PubMedSearch : Sevelova_2005_Toxicology_207_1 |
| PubMedID: 15590116 |
| Title : Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species - Jun_2005_Chem.Biol.Interact_157-158_385 |
| Author(s) : Jun D , Kuca K , Cabal J , Bartosova L , Kunesova G , Kassa J |
| Ref : Chemico-Biological Interactions , 157-158 :385 , 2005 |
| Abstract : |
| PubMedSearch : Jun_2005_Chem.Biol.Interact_157-158_385 |
| PubMedID: 16429518 |
| Title : Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing - Bartosova_2005_Int.J.Toxicol_24_399 |
| Author(s) : Bartosova L , Kuca K , Jun D , Kunesova G |
| Ref : Int J Toxicol , 24 :399 , 2005 |
| Abstract : |
| PubMedSearch : Bartosova_2005_Int.J.Toxicol_24_399 |
| PubMedID: 16393932 |
| Title : In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 AND K048 - Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_107 |
| Author(s) : Kuca K , Sevelova-Bartosova L , Krejcova-Kunesova G |
| Ref : Acta Medica (Hradec Kralove) , 47 :107 , 2004 |
| Abstract : |
| PubMedSearch : Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_107 |
| PubMedID: 15446359 |
| Title : 1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents - Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_167 |
| Author(s) : Kuca K , Dohnal V |
| Ref : Acta Medica (Hradec Kralove) , 47 :167 , 2004 |
| Abstract : |
| PubMedSearch : Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_167 |
| PubMedID: 15568733 |
| Title : In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes--K027, K005, K033 and K048 - Kuca_2004_Cent.Eur.J.Public.Health_12 Suppl_S59 |
| Author(s) : Kuca K , Cabal J |
| Ref : Central European Journal of Public Health , 12 Suppl :S59 , 2004 |
| Abstract : |
| PubMedSearch : Kuca_2004_Cent.Eur.J.Public.Health_12 Suppl_S59 |
| PubMedID: 15141981 |
| Title : In vitro reactivation of acetylcholinesterase using the oxime K027 - Kuca_2004_Vet.Hum.Toxicol_46_15 |
| Author(s) : Kuca K , Kassa J |
| Ref : Vet Hum Toxicol , 46 :15 , 2004 |
| Abstract : |
| PubMedSearch : Kuca_2004_Vet.Hum.Toxicol_46_15 |
| PubMedID: 14748409 |
| Title : Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent - Kuca_2004_Hum.Exp.Toxicol_23_167 |
| Author(s) : Kuca K , Kassa J |
| Ref : Hum Exp Toxicol , 23 :167 , 2004 |
| Abstract : |
| PubMedSearch : Kuca_2004_Hum.Exp.Toxicol_23_167 |
| PubMedID: 15171567 |
| Title : Pharmacological Prophylaxis and Antidotal Treatment of Acute Tabun Poisoning - Kassa_2004_Mil.Med.Sci.Lett_73_107 |
| Author(s) : Kassa J , Kunesova G , Vachek J , Kuca K , Cabal J |
| Ref : Military Medical Science Letters , 73 :107 , 2004 |
| Abstract : |
| PubMedSearch : Kassa_2004_Mil.Med.Sci.Lett_73_107 |
| PubMedID: |
| Title : Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes - Kuca_2004_Neurotox.Res_6_565 |
| Author(s) : Kuca K , Patocka J , Cabal J , Jun D |
| Ref : Neurotox Res , 6 :565 , 2004 |
| Abstract : |
| PubMedSearch : Kuca_2004_Neurotox.Res_6_565 |
| PubMedID: 15639788 |
| Title : Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase - Cabal_2004_Basic.Clin.Pharmacol.Toxicol_95_81 |
| Author(s) : Cabal J , Kuca K , Kassa J |
| Ref : Basic Clin Pharmacol Toxicol , 95 :81 , 2004 |
| Abstract : |
| PubMedSearch : Cabal_2004_Basic.Clin.Pharmacol.Toxicol_95_81 |
| PubMedID: 15379785 |
| Title : Cyclodextrines as functional agents for decontamination of the skin contaminated by nerve agents - Cabal_2004_Acta.Medica.(Hradec.Kralove)_47_115 |
| Author(s) : Cabal J , Kuca K , Sevelova-Bartosova L , Dohnal V |
| Ref : Acta Medica (Hradec Kralove) , 47 :115 , 2004 |
| Abstract : |
| PubMedSearch : Cabal_2004_Acta.Medica.(Hradec.Kralove)_47_115 |
| PubMedID: 15446361 |
| Title : A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods - Kuca_2004_Pharmazie_59_795 |
| Author(s) : Kuca K , Cabal J , Kassa J |
| Ref : Pharmazie , 59 :795 , 2004 |
| Abstract : |
| PubMedSearch : Kuca_2004_Pharmazie_59_795 |
| PubMedID: 15544060 |
| Title : Therapeutic efficacy of different antidotal mixtures against poisoning with GF-agent in mice - Bartosova_2004_Acta.Medica.(Hradec.Kralove)_47_249 |
| Author(s) : Bartosova L , Kunesova G , Kuca K , Vachek J |
| Ref : Acta Medica (Hradec Kralove) , 47 :249 , 2004 |
| Abstract : |
| PubMedSearch : Bartosova_2004_Acta.Medica.(Hradec.Kralove)_47_249 |
| PubMedID: 15841904 |
| Title : Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body - Patocka_2004_Acta.Medica.(Hradec.Kralove)_47_215 |
| Author(s) : Patocka J , Kuca K , Jun D |
| Ref : Acta Medica (Hradec Kralove) , 47 :215 , 2004 |
| Abstract : |
| PubMedSearch : Patocka_2004_Acta.Medica.(Hradec.Kralove)_47_215 |
| PubMedID: 15841900 |
| Title : Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes - Kuca_2004_J.Enzyme.Inhib.Med.Chem_19_39 |
| Author(s) : Kuca K , Patocka J |
| Ref : J Enzyme Inhib Med Chem , 19 :39 , 2004 |
| Abstract : |
| PubMedSearch : Kuca_2004_J.Enzyme.Inhib.Med.Chem_19_39 |
| PubMedID: 15202491 |
| Title : A comparison of the ability of a new bispyridinium oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2003_J.Enzyme.Inhib.Med.Chem_18_529 |
| Author(s) : Kuca K , Kassa J |
| Ref : J Enzyme Inhib Med Chem , 18 :529 , 2003 |
| Abstract : |
| PubMedSearch : Kuca_2003_J.Enzyme.Inhib.Med.Chem_18_529 |
| PubMedID: 15008517 |
| Title : Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase - Kuca_2003_Bioorg.Med.Chem.Lett_13_3545 |
| Author(s) : Kuca K , Bielavsky J , Cabal J , Kassa J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 13 :3545 , 2003 |
| Abstract : |
| PubMedSearch : Kuca_2003_Bioorg.Med.Chem.Lett_13_3545 |
| PubMedID: 14505667 |