Kuca K

General

Full name : Kuca Kamil

First name : Kamil

Mail : Faculty of Military Health Sciences\; Center of Advanced Studies\; Trebesska 1575\; Hradec Kralove\; 500

Zip Code :

City :

Country : Czech Republic

Email : kamil.kuca@uhk.cz

Phone : +420973253028

Fax :

Website : \/\/www.unob.cz\/en\/fmhs\/structure\/k311\/Pages\/Kuca.aspx

Directory :

References (354)

Title : Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators - Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735
Author(s) : Kapitanov IV , Spulak M , Pour M , Soukup O , Marek J , Jun D , Novak M , Diz de Almeida JSF , Costa Franca TC , Gathergood N , Kuca K , Karpichev Y
Ref : Chemico-Biological Interactions , :110735 , 2023
PubMedID: 37802409

Title : Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups - Bibi_2023_Sci.Total.Environ__163359
Author(s) : Bibi S , Habib R , Shafiq S , Abbas SS , Khan S , Eqani S , Nepovimova E , Khan MS , Kuca K , Nurulain SM
Ref : Sci Total Environ , :163359 , 2023
PubMedID: 37030382

Title : Pralidoxime-like reactivator with increased lipophilicity - Molecular modeling and in vitro study - Kuca_2023_Chem.Biol.Interact_14ChEPon_110734
Author(s) : Kuca K , Valle da Silva JA , Nepovimova E , Pham NL , Wu W , Valis M , Wu Q , Franca TCC
Ref : Chemico-Biological Interactions , :110734 , 2023
PubMedID: 37788753

Title : In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents' surrogates - Kitagawa_2023_Chem.Biol.Interact_14ChEPon_110678
Author(s) : Kitagawa DAS , Dos Santos MC , Kuca K , Franca TCC , Cavalcante SFA
Ref : Chemico-Biological Interactions , 383 :110678 , 2023
PubMedID: 37595776

Title : Applications of the Near Attack Conformation (NAC) approach in the search for Acetylcholinesterase reactivators - Franca_2023_Chem.Biol.Interact_14ChEPon_382_110619
Author(s) : Franca TCC , Valle da Silva JA , Dos Santos MC , Cavalcante SFA , Kuca K
Ref : Chemico-Biological Interactions , 382 :110619 , 2023
PubMedID: 37406983

Title : Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes - Jacevic_2023_Chem.Biol.Interact_14ChEPon_110658
Author(s) : Jacevic V , Dumanovic J , Grujic-Milanovic J , Milovanovic Z , Amidzic L , Vojinovic N , Nezic L , Markovic B , Dobricic V , Milosavljevic P , Nepovimova E , Kuca K
Ref : Chemico-Biological Interactions , :110658 , 2023
PubMedID: 37572873

Title : The measured CSF\/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24h after donepezil treatment in patients with Alzheimer's disease - Valis_2023_Biomed.Pharmacother_159_114223
Author(s) : Valis M , Dlabkova A , Hort J , Angelucci F , Pejchal J , Kuca K , Pavelek Z , Karasova JZ , Novotny M
Ref : Biomed Pharmacother , 159 :114223 , 2023
PubMedID: 36630846

Title : Assessing the therapeutic and toxicological profile of novel acetylcholinesterase reactivators: value of in silico and in vitro data - Ramalho_2022_Curr.Med.Chem__
Author(s) : Ramalho TC , de Castro AA , Leal DHS , Teixeira JP , de Cunha EFF , Kuca K
Ref : Curr Med Chem , : , 2022
PubMedID: 36239718

Title : Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities - Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605
Author(s) : Chrienova Z , Nepovimova E , Andrys R , Dolezal R , Janockova J , Muckova L , Fabova L , Soukup O , Oleksak P , Valis M , Korabecny J , Marco-Contelles J , Kuca K
Ref : J Enzyme Inhib Med Chem , 37 :2605 , 2022
PubMedID: 36131624

Title : N-substituted arylhydroxamic acids as acetylcholinesterase reactivators - Bondar_2022_Chem.Biol.Interact__110078
Author(s) : Bondar D , Kapitanov I , Pulkrabkova L , Soukup O , Jun D , Diniz FB , Franca TCC , Kuca K , Karpichev Y
Ref : Chemico-Biological Interactions , :110078 , 2022
PubMedID: 35940282

Title : Multiple Neurological Effects Associated with Exposure to Organophosphorus Pesticides in Man - Jokanovic_2022_Toxicology__153407
Author(s) : Jokanovic M , Oleksak P , Kuca K
Ref : Toxicology , :153407 , 2022
PubMedID: 36543276

Title : Are the current commercially available oximes capable of reactivating acetylcholinesterase inhibited by the nerve agents of the A-series? - Santos_2022_Arch.Toxicol__
Author(s) : Santos MC , Botelho FD , Goncalves AS , Kitagawa DAS , Borges CVN , Carvalho-Silva T , Bernardo LB , Ferreira CN , Rodrigues RB , Ferreira Neto DC , Nepovimova E , Kuca K , LaPlante SR , Lima ALS , Franca TCC , Cavalcante SFA
Ref : Archives of Toxicology , : , 2022
PubMedID: 35666269

Title : Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok) - Santos_2022_Food.Chem.Toxicol__113084
Author(s) : Santos MC , Botelho FD , Goncalves AS , Kuca K , Nepovimova E , Cavalcante SFA , Lima ALS , Franca TCC
Ref : Food & Chemical Toxicology , :113084 , 2022
PubMedID: 35489467

Title : Dysregulation of butyrylcholinesterase, BCHE gene SNP rs1803274, and pro-inflammatory cytokines in occupational workers - Khan_2022_Environ.Res__115195
Author(s) : Khan SA , Leonel Javeres MN , Abbas Shah ST , Bibi N , Muneer Z , Hussain S , Nepovimova E , Kuca K , Nurulain SM
Ref : Environ Research , :115195 , 2022
PubMedID: 36592809

Title : Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease - Hamulakova_2021_Future.Med.Chem__
Author(s) : Hamulakova S , Kudlickova Z , Janovec L , Mezencev R , Deckner ZJ , Chernoff YO , Janockova J , Ihnatova V , Bzonek P , Novakova N , Hepnarova V , Hrabinova M , Jun D , Korabecny J , Soukup O , Kuca K
Ref : Future Med Chem , : , 2021
PubMedID: 33829876

Title : Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators - Kitagawa_2021_J.Enzyme.Inhib.Med.Chem_36_1370
Author(s) : Kitagawa DAS , Rodrigues RB , Silva TN , Dos Santos WV , da Rocha VCV , de Almeida JSFD , Bernardo LB , Carvalho-Silva T , Ferreira CN , da Silva AAT , Simas ABC , Nepovimova E , Kuca K , Franca TCC , Cavalcante SFA
Ref : J Enzyme Inhib Med Chem , 36 :1370 , 2021
PubMedID: 34148470

Title : Experimental and Established Oximes as Pretreatment before Acute Exposure to Azinphos-Methyl - Lorke_2021_Int.J.Mol.Sci_22_
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 33802843

Title : Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells - Hudacova_2021_Int.J.Mol.Sci_22_
Author(s) : Hudacova M , Hamuakova S , Konkoova E , Jendzelovsky R , Vargova J , Sevc J , Fedorocko P , Soukup O , Janockova J , Ihnatova V , Kucera T , Bzonek P , Novakova N , Jun D , Junova L , Korabecny J , Kuca K , Kozurkova M
Ref : Int J Mol Sci , 22 : , 2021
PubMedID: 33917200

Title : Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations - Leonel_2020_Environ.Res__110210
Author(s) : Leonel Javeres MN , Habib R , Judith N , Iqbal M , Nepovimova E , Kuca K , Batool S , Nurulain SM
Ref : Environ Research , :110210 , 2020
PubMedID: 32949615

Title : Review about structure and evaluation of reactivators of Acetylcholinesterase inhibited with neurotoxic organophosphorus compounds - Figueroa-Villar_2020_Curr.Med.Chem__
Author(s) : Figueroa-Villar JD , Petronilho EC , Kuca K , Franca TCC
Ref : Curr Med Chem , : , 2020
PubMedID: 32334495

Title : Donepezil and Rivastigmine: Pharmacokinetic Profile and Brain-targeting After Intramuscular Administration in Rats - Karasova_2020_Iran.J.Pharm.Res_19_95
Author(s) : Karasova JZ , Hrabinova M , Krejciova M , Jun D , Kuca K
Ref : Iran J Pharm Res , 19 :95 , 2020
PubMedID: 33680013

Title : Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors - Gorecki_2020_ACS.Med.Chem.Lett_11_65
Author(s) : Gorecki L , Andrys R , Schmidt M , Kucera T , Psotka M , Svobodova B , Hrabcova V , Hepnarova V , Bzonek P , Jun D , Kuca K , Korabecny J , Musilek K
Ref : ACS Med Chem Lett , 11 :65 , 2020
PubMedID: 31938465

Title : Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects - de Castro_2020_Int.J.Mol.Sci_21_
Author(s) : de Castro AA , Polisel DA , Pereira BTL , da Cunha EFF , Kuca K , Nepovimova E , Ramalho TC
Ref : Int J Mol Sci , 21 : , 2020
PubMedID: 32899591

Title : Glycosylated-Imidazole Aldoximes as Reactivators of Pesticides Inhibited AChE: Synthesis and In-vitro Reactivation Study - Sharma_2020_Environ.Toxicol.Pharmacol__103454
Author(s) : Sharma R , Upadhyaya K , Gupta B , Ghosh KK , Tripathi RP , Musilek K , Kuca K
Ref : Environ Toxicol Pharmacol , :103454 , 2020
PubMedID: 32645360

Title : Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators - Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478
Author(s) : Malinak D , Dolezal R , Hepnarova V , Hozova M , Andrys R , Bzonek P , Racakova V , Korabecny J , Gorecki L , Mezeiova E , Psotka M , Jun D , Kuca K , Musilek K
Ref : J Enzyme Inhib Med Chem , 35 :478 , 2020
PubMedID: 31910701

Title : Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness - Karasova_2020_Toxicol.Lett_320_64
Author(s) : Karasova JZ , Hepnarova V , Andrys R , Lisa M , Jost P , Muckova L , Pejchal J , Herman D , Jun D , Kassa J , Kuca K
Ref : Toxicol Lett , 320 :64 , 2020
PubMedID: 31794810

Title : Interaction of Synthesized Nitrogen enriched Graphene Quantum Dots with Novel Anti-Alzheimer's Drugs: Spectroscopic Insights - Sharma_2020_J.Biomol.Struct.Dyn_38_1822
Author(s) : Sharma S , Singh N , Nepovimova E , Korabecny J , Kuca K , Satnami ML , Ghosh KK
Ref : J Biomol Struct Dyn , 38 :1822 , 2020
PubMedID: 31096863

Title : An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment - Wu_2020_Arch.Toxicol_94_3645
Author(s) : Wu Q , Qin Z , Kuca K , You L , Zhao Y , Liu A , Musilek K , Chrienova Z , Nepovimova E , Oleksak P , Wu W , Wang X
Ref : Archives of Toxicology , 94 :3645 , 2020
PubMedID: 32910237

Title : Combined Pre- and Posttreatment of Paraoxon Exposure - Lorke_2020_Molecules_25_
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA
Ref : Molecules , 25 : , 2020
PubMedID: 32230733

Title : Ligand-Based Virtual Screening, Molecular Docking, Molecular Dynamics, and MM-PBSA Calculations towards the Identification of Potential Novel Ricin Inhibitors - Botelho_2020_Toxins.(Basel)_12_
Author(s) : Botelho FD , Dos Santos MC , Goncalves ADS , Kuca K , Valis M , LaPlante SR , Franca TCC , de Almeida J
Ref : Toxins (Basel) , 12 : , 2020
PubMedID: 33256167

Title : Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study - da Silva_2020_Biomolecules_10_
Author(s) : da Silva JAV , Pereira AF , LaPlante SR , Kuca K , Ramalho TC , Franca TCC
Ref : Biomolecules , 10 : , 2020
PubMedID: 32012780

Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596
Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K
Ref : Bioorg Chem , 107 :104596 , 2020
PubMedID: 33421953

Title : Acetylcholinesterase: The Hub for Neurodegenerative Diseases and Chemical Weapons Convention - Cavalcante_2020_Biomolecules_10_
Author(s) : Cavalcante SFA , Simas ABC , Barcellos MC , de Oliveira VGM , Sousa RB , Cabral PAM , Kuca K , Franca TCC
Ref : Biomolecules , 10 : , 2020
PubMedID: 32155996

Title : Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602 - Furqan_2020_Biomolecules_10_
Author(s) : Furqan T , Batool S , Habib R , Shah M , Kalasz H , Darvas F , Kuca K , Nepovimova E , Nurulain SM
Ref : Biomolecules , 10 : , 2020
PubMedID: 32414087

Title : Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019) - de Castro_2020_Biomolecules_10_
Author(s) : de Castro AA , Assis LC , Soares FV , Kuca K , Polisel DA , da Cunha EFF , Ramalho TC
Ref : Biomolecules , 10 : , 2020
PubMedID: 32178264

Title : Oxidative Stress and Analysis of Selected SNPs of ACHE (rs 2571598), BCHE (rs 3495), CAT (rs 7943316), SIRT1 (rs 10823108), GSTP1 (rs 1695), and Gene GSTM1, GSTT1 in Chronic Organophosphates Exposed Groups from Cameroon and Pakistan - Mbah Ntepe_2020_Int.J.Mol.Sci_21_
Author(s) : Mbah Ntepe LJ , Habib R , Judith Laure N , Raza S , Nepovimova E , Kuca K , Batool S , Muhammad Nurulain S
Ref : Int J Mol Sci , 21 : , 2020
PubMedID: 32899431

Title : Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside - Sharma_2019_Expert.Rev.Neurother_19_359
Author(s) : Sharma R , Kuca K , Nepovimova E , Kabra A , Rao MM , Prajapati PK
Ref : Expert Rev Neurother , 19 :359 , 2019
PubMedID: 30884983

Title : Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models - Iqbal_2019_Chem.Biol.Interact_13ChEPon_310_108735
Author(s) : Iqbal A , Malik S , Nurulain SM , Musilek K , Kuca K , Kalasz H , Fatmi MQ
Ref : Chemico-Biological Interactions , 310 :108735 , 2019
PubMedID: 31276662

Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491
Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019
PubMedID: 30851693
Gene_locus related to this paper: torca-ACHE

Title : Orexin supplementation in narcolepsy treatment: A review - Nepovimova_2019_Med.Res.Rev_39_961
Author(s) : Nepovimova E , Janockova J , Misik J , Kubik S , Stuchlik A , Vales K , Korabecny J , Mezeiova E , Dolezal R , Soukup O , Kobrlova T , Pham NL , Nguyen TD , Konecny J , Kuca K
Ref : Med Res Rev , 39 :961 , 2019
PubMedID: 30426515

Title : Oximes as pretreatment before acute exposure to paraoxon - Lorke_2019_J.Appl.Toxicol_39_1506
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA
Ref : J Appl Toxicol , 39 :1506 , 2019
PubMedID: 31264735

Title : Novichoks: The Dangerous Fourth Generation of Chemical Weapons - Franca_2019_Int.J.Mol.Sci_20_
Author(s) : Franca TCC , Kitagawa DAS , Cavalcante SFA , da Silva JAV , Nepovimova E , Kuca K
Ref : Int J Mol Sci , 20 : , 2019
PubMedID: 30862059

Title : In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon - Kitagawa_2019_Biomolecules_9_
Author(s) : Kitagawa DAS , Cavalcante SFA , de Paula RL , Rodrigues RB , Bernardo LB , da Silva MCJ , da Silva TN , Dos Santos WV , Granjeiro JM , de Almeida JSFD , Barcellos MC , de ACAB , Franca TCC , Kuca K , Simas ABC
Ref : Biomolecules , 9 : , 2019
PubMedID: 31597234

Title : Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning - Tekes_2019_Chem.Biol.Interact_13ChEPon_310_108737
Author(s) : Tekes K , Karvaly G , Nurulain S , Kuca K , Musilek K , Adeghate E , Jung YS , Kalasz H
Ref : Chemico-Biological Interactions , 310 :108737 , 2019
PubMedID: 31279792

Title : N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy - Nepovimova_2019_Curr.Alzheimer.Res_16_333
Author(s) : Nepovimova E , Korabecny J , Hepnarova V , Jun D , Dolezal R , Muckova L , Jost P , Soukup O , Janockova J , Pham NL , Nguyen TD , Valis M , Kuca K
Ref : Curr Alzheimer Res , 16 :333 , 2019
PubMedID: 30873921

Title : Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease - de Oliveira_2019_Int.J.Mol.Sci_20_
Author(s) : de Oliveira CBJ , Neto DCF , de Almeida JSFD , Lima JA , Kuca K , Franca TCC , Figueroa-Villar JD
Ref : Int J Mol Sci , 20 : , 2019
PubMedID: 31416113

Title : Synthesis and in vitro evaluation of neutral aryloximes as reactivators of Electrophorus eel acetylcholinesterase inhibited by NEMP, a VX surrogate - Cavalcante_2019_Chem.Biol.Interact_13ChEPon_309_108682
Author(s) : Cavalcante SFA , Kitagawa DAS , Rodrigues RB , Bernardo LB , da Silva TN , Dos Santos WV , Correa ABA , de Almeida JSFD , Franca TCC , Kuca K , Simas ABC
Ref : Chemico-Biological Interactions , 309 :108682 , 2019
PubMedID: 31163137

Title : Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease - Mezeiova_2019_Curr.Alzheimer.Res_16_772
Author(s) : Mezeiova E , Chalupova K , Nepovimova E , Gorecki L , Prchal L , Malinak D , Kuca K , Soukup O , Korabecny J
Ref : Curr Alzheimer Res , 16 :772 , 2019
PubMedID: 30819078

Title : Interspecies and intergender differences in acute toxicity of K-oximes drug candidates - Jacevic_2019_Chem.Biol.Interact_13ChEPon_308_312
Author(s) : Jacevic V , Nepovimova E , Kuca K
Ref : Chemico-Biological Interactions , 308 :312 , 2019
PubMedID: 31153983

Title : Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation - Antonijevic_2019_Chem.Biol.Interact_13ChEPon_308_385
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Andjelkovic M , Djordjevic AB , Antonijevic B
Ref : Chemico-Biological Interactions , 308 :385 , 2019
PubMedID: 31141677

Title : Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes - Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16
Author(s) : Zorbaz T , Malinak D , Kuca K , Musilek K , Kovarik Z
Ref : Chemico-Biological Interactions , 307 :16 , 2019
PubMedID: 31004594

Title : Non-conventional compounds with potential therapeutic effects against Alzheimer's disease - de Castro_2019_Expert.Rev.Neurother_19_375
Author(s) : de Castro AA , Soares FV , Pereira AF , Polisel DA , Caetano MS , Leal DHS , da Cunha EFF , Nepovimova E , Kuca K , Ramalho TC
Ref : Expert Rev Neurother , 19 :375 , 2019
PubMedID: 30999771

Title : Biodegradation of Organophosphorus Compounds Predicted by Enzymatic Process Using Molecular Modelling and Observed in Soil Samples Through Analytical Techniques and Microbiological Analysis: A Comparison - Cardozo_2019_Molecules_25_
Author(s) : Cardozo M , de Almeida J , Cavalcante SFA , Salgado JRS , Goncalves AS , Franca TCC , Kuca K , Bizzo HR
Ref : Molecules , 25 : , 2019
PubMedID: 31878010

Title : In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers - Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877
Author(s) : Janockova J , Korabecny J , Plsikova J , Babkova K , Konkolova E , Kucerova D , Vargova J , Koval J , Jendzelovsky R , Fedorocko P , Kasparkova J , Brabec V , Rosocha J , Soukup O , Hamulakova S , Kuca K , Kozurkova M
Ref : J Enzyme Inhib Med Chem , 34 :877 , 2019
PubMedID: 30938202

Title : Tacrine and its 7-methoxy derivate\; time-change concentration in plasma and brain tissue and basic toxicological profile in rats - Karasova_2019_Drug.Chem.Toxicol__1
Author(s) : Karasova JZ , Soukup O , Korabecny J , Hroch M , Krejciova M , Hrabinova M , Misik J , Novotny L , Hepnarova V , Kuca K
Ref : Drug & Chemical Toxicology , :1 , 2019
PubMedID: 31257938

Title : Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach - da Silva_2019_J.Enzyme.Inhib.Med.Chem_34_1018
Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC
Ref : J Enzyme Inhib Med Chem , 34 :1018 , 2019
PubMedID: 31074292

Title : Molecular modelling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime with VX-inhibited human acetylcholinesterase. A near attack approach to assess different spacer-lengths - da Silva_2019_Chem.Biol.Interact_13ChEPon_307_195
Author(s) : da Silva JAV , Nepovimova E , Ramalho TC , Kuca K , Franca TCC
Ref : Chemico-Biological Interactions , 307 :195 , 2019
PubMedID: 31121152

Title : Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects - Polisel_2019_Chem.Biol.Interact_13ChEPon_309_108671
Author(s) : Polisel DA , de Castro AA , Mancini DT , da Cunha EFF , Franca TCC , Ramalho TC , Kuca K
Ref : Chemico-Biological Interactions , 309 :108671 , 2019
PubMedID: 31207225

Title : Oxime K203: a drug candidate for the treatment of tabun intoxication - Gorecki_2019_Arch.Toxicol_93_673
Author(s) : Gorecki L , Soukup O , Kucera T , Malinak D , Jun D , Kuca K , Musilek K , Korabecny J
Ref : Archives of Toxicology , 93 :673 , 2019
PubMedID: 30564897

Title : Some Possibilities to Study New Prophylactics against Nerve Agents - Bajgar_2019_Mini.Rev.Med.Chem_19_970
Author(s) : Bajgar J , Kassa J , Kucera T , Musilek K , Jun D , Kuca K
Ref : Mini Rev Med Chem , 19 :970 , 2019
PubMedID: 30827238

Title : Molecular dynamics simulation and binding free energy studies of novel leads belonging to the benzofuran class inhibitors of Mycobacterium tuberculosis Polyketide Synthase 13 - Cruz_2019_J.Biomol.Struct.Dyn_37_1616
Author(s) : Cruz JN , Costa JFS , Khayat AS , Kuca K , Barros CAL , Neto A
Ref : J Biomol Struct Dyn , 37 :1616 , 2019
PubMedID: 29633908

Title : Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase - de Almeida_2019_Chem.Biol.Interact_13ChEPon_308_113
Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC
Ref : Chemico-Biological Interactions , 308 :113 , 2019
PubMedID: 31100275

Title : Toxic Injury to Muscle Tissue of Rats Following Acute Oximes Exposure - Jacevic_2019_Sci.Rep_9_1457
Author(s) : Jacevic V , Nepovimova E , Kuca K
Ref : Sci Rep , 9 :1457 , 2019
PubMedID: 30728420

Title : Newly Developed Drugs for Alzheimer's Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission - Korabecny_2018_Neurosci_370_191
Author(s) : Korabecny J , Nepovimova E , Cikankova T , Spilovska K , Vaskova L , Mezeiova E , Kuca K , Hroudova J
Ref : Neuroscience , 370 :191 , 2018
PubMedID: 28673719

Title : Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain - Antonijevic_2018_Arch.Toxicol_92_745
Author(s) : Antonijevic E , Kotur-Stevuljevic J , Musilek K , Kosvancova A , Kuca K , Djukic-Cosic D , Spasojevic-Kalimanovska V , Antonijevic B
Ref : Archives of Toxicology , 92 :745 , 2018
PubMedID: 29098328

Title : The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats - Zdarova Karasova_2018_Basic.Clin.Pharmacol.Toxicol_122_373
Author(s) : Karasova JZ , Mzik M , Hroch M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K
Ref : Basic Clin Pharmacol Toxicol , 122 :373 , 2018
PubMedID: 29067789

Title : The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease - Hepnarova_2018_Eur.J.Med.Chem_150_292
Author(s) : Hepnarova V , Korabecny J , Matouskova L , Jost P , Muckova L , Hrabinova M , Vykoukalova N , Kerhartova M , Kucera T , Dolezal R , Nepovimova E , Spilovska K , Mezeiova E , Pham NL , Jun D , Staud F , Kaping D , Kuca K , Soukup O
Ref : Eur Journal of Medicinal Chemistry , 150 :292 , 2018
PubMedID: 29533874

Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8
Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC
Ref : BMC Pharmacol Toxicol , 19 :8 , 2018
PubMedID: 29467029

Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505
Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K
Ref : Drug Des Devel Ther , 12 :505 , 2018
PubMedID: 29563775

Title : Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods - Janockova_2018_Molecules_23_
Author(s) : Janockova J , Dolezal R , Nepovimova E , Kobrlova T , Benkova M , Kuca K , Konecny J , Mezeiova E , Melikova M , Hepnarova V , Ring A , Soukup O , Korabecny J
Ref : Molecules , 23 : , 2018
PubMedID: 30423961

Title : Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon - Kuca_2018_Molecules_23_
Author(s) : Kuca K , Jun D , Junova L , Musilek K , Hrabinova M , da Silva JAV , Ramalho TC , Valko M , Wu Q , Nepovimova E , Franca TCC
Ref : Molecules , 23 : , 2018
PubMedID: 29735900

Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281
Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K
Ref : Med Chem , 14 :281 , 2018
PubMedID: 29332594

Title : Profiling donepezil template into multipotent hybrids with antioxidant properties - Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583
Author(s) : Mezeiova E , Spilovska K , Nepovimova E , Gorecki L , Soukup O , Dolezal R , Malinak D , Janockova J , Jun D , Kuca K , Korabecny J
Ref : J Enzyme Inhib Med Chem , 33 :583 , 2018
PubMedID: 29529892

Title : Chemical warfare agent NOVICHOK - mini-review of available data - Nepovimova_2018_Food.Chem.Toxicol_121_343
Author(s) : Nepovimova E , Kuca K
Ref : Food & Chemical Toxicology , 121 :343 , 2018
PubMedID: 30213549

Title : Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study - Malinak_2018_Molecules_23_
Author(s) : Malinak D , Nepovimova E , Jun D , Musilek K , Kuca K
Ref : Molecules , 23 : , 2018
PubMedID: 30205495

Title : Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents - Zorbaz_2018_J.Med.Chem_61_10753
Author(s) : Zorbaz T , Malinak D , Marakovic N , Macek Hrvat N , Zandona A , Novotny M , Skarka A , Andrys R , Benkova M , Soukup O , Katalinic M , Kuca K , Kovarik Z , Musilek K
Ref : Journal of Medicinal Chemistry , 61 :10753 , 2018
PubMedID: 30383374

Title : Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier - Hamulakova_2018_Curr.Alzheimer.Res_15_1096
Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Janockova J , Hrabinova M , Sepsova V , Kuca K
Ref : Curr Alzheimer Res , 15 :1096 , 2018
PubMedID: 29992880

Title : A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators - Tsai_2021_J.Food.Drug.Anal_29_153
Author(s) : Malinak D , Korabecny J , Soukup O , Gorecki L , Nepovimova E , Psotka M , Dolezal R , Nguyen TD , Mezeiova E , Musilek K , Kuca K
Ref : Current Organic Chemistry , 22\ :1619 , 2018
PubMedID:

Title : In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication - Arshad_2018_Toxicol.Mech.Methods_28_62
Author(s) : Arshad M , Fatmi MQ , Musilek K , Hussain A , Kuca K , Petroianu G , Kalasz H , Nurulain SM
Ref : Toxicol Mech Methods , 28 :62 , 2018
PubMedID: 28722512

Title : Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes - Antonijevic_2018_Food.Chem.Toxicol_121_224
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Curcic M , Miladinovic DC , Bulat Z , Antonijevic B
Ref : Food & Chemical Toxicology , 121 :224 , 2018
PubMedID: 30176309

Title : Theoretical Studies Applied to the Evaluation of the DFPase Bioremediation Potential against Chemical Warfare Agents Intoxication - Soares_2018_Int.J.Mol.Sci_19_
Author(s) : Soares FV , de Castro AA , Pereira AF , Leal DHS , Mancini DT , Krejcar O , Ramalho TC , da Cunha EFF , Kuca K
Ref : Int J Mol Sci , 19 : , 2018
PubMedID: 29690585

Title : Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon - de Paula_2018_Molecules_23_
Author(s) : de Paula RL , de Almeida JSFD , Cavalcante SFA , Goncalves AS , Simas ABC , Franca TCC , Valis M , Kuca K , Nepovimova E , Granjeiro JM
Ref : Molecules , 23 : , 2018
PubMedID: 30424582

Title : Molecular modeling studies on the interactions of aflatoxin B1 and its metabolites with the peripheral anionic site (PAS) of human acetylcholinesterase - de Almeida_2018_J.Biomol.Struct.Dyn__1
Author(s) : de Almeida JSFD , Cavalcante SFA , Dolezal R , Kuca K , Musilek K , Jun D , Franca TCC
Ref : J Biomol Struct Dyn , :1 , 2018
PubMedID: 29749305

Title : Molecular Modeling Studies on the Interactions of Aflatoxin B1 and Its Metabolites with Human Acetylcholinesterase. Part II: Interactions with the Catalytic Anionic Site (CAS) - de Almeida_2018_Toxins.(Basel)_10_
Author(s) : de Almeida JSFD , Dolezal R , Krejcar O , Kuca K , Musilek K , Jun D , Franca TCC
Ref : Toxins (Basel) , 10 : , 2018
PubMedID: 30257474

Title : Quantification through TLC-densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves - Affonso_2018_Biomed.Chromatogr_32_
Author(s) : Affonso RS , Lima JA , Lessa BM , Caetano JVO , Obara MT , Nobrega AB , Nepovimova E , Musilek K , Kuca K , Slana G , Franca TCC
Ref : Biomedical Chromatography , 32 : , 2018
PubMedID: 28913959

Title : Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment - Soukup_2017_Curr.Neuropharmacol_15_637
Author(s) : Soukup O , Winder M , Killi UK , Wsol V , Jun D , Kuca K , Tobin G
Ref : Curr Neuropharmacol , 15 :637 , 2017
PubMedID: 27281175

Title : Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease - Spilovska_2017_Curr.Top.Med.Chem_17_1006
Author(s) : Spilovska K , Korabecny J , Nepovimova E , Dolezal R , Mezeiova E , Soukup O , Kuca K
Ref : Curr Top Med Chem , 17 :1006 , 2017
PubMedID: 27697055

Title : The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: A computational study - Cuya_2017_J.Biomol.Struct.Dyn__1
Author(s) : Cuya T , Goncalves ADS , da Silva JAV , Ramalho TC , Kuca K , Franca TCC
Ref : J Biomol Struct Dyn , :1 , 2017
PubMedID: 29019446

Title : HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication - Psotka_2017_Mil.Med.Sci.Lett_86_70
Author(s) : Psotka M , Malinak D , Gorecki L , Nguyen TD , Soukup O , Jun D , Kuca K , Musilek K , Korabecny J
Ref : Military Medical Science Letters , 86 :70 , 2017
PubMedID:

Title : Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors - Babkova_2017_Future.Med.Chem_9_1015
Author(s) : Babkova K , Korabecny J , Soukup O , Nepovimova E , Jun D , Kuca K
Ref : Future Med Chem , 9 :1015 , 2017
PubMedID: 28632451

Title : Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment - Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607
Author(s) : Gazova Z , Soukup O , Sepsova V , Siposova K , Drtinova L , Jost P , Spilovska K , Korabecny J , Nepovimova E , Fedunova D , Horak M , Kaniakova M , Wang ZJ , Hamouda AK , Kuca K
Ref : Biochimica & Biophysica Acta Mol Basis Dis , 1863 :607 , 2017
PubMedID: 27865910

Title : The pharmacology of tacrine at N-methyl-d-aspartate receptors - Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54
Author(s) : Horak M , Holubova K , Nepovimova E , Krusek J , Kaniakova M , Korabecny J , Vyklicky L , Kuca K , Stuchlik A , Ricny J , Vales K , Soukup O
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 75 :54 , 2017
PubMedID: 28089695

Title : Optimal Pre-treatment for Acute Exposure to the Organophosphate Dicrotophos - Lorke_2017_Curr.Pharm.Des_23_3432
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Petroianu GA
Ref : Curr Pharm Des , 23 :3432 , 2017
PubMedID: 27799040

Title : Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-Tabun conjugate: A molecular modeling approach - de Souza_2017_J.Biomol.Struct.Dyn__1
Author(s) : de Souza FR , Garcia DR , Guizado TC , Kuca K , de Alencastro RB , Franca TCC
Ref : J Biomol Struct Dyn , :1 , 2017
PubMedID: 28446076

Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971
Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K
Ref : Expert Opin Ther Pat , 27 :971 , 2017
PubMedID: 28569609

Title : Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation - Spilovska_2017_Molecules_22_
Author(s) : Spilovska K , Korabecny J , Sepsova V , Jun D , Hrabinova M , Jost P , Muckova L , Soukup O , Janockova J , Kucera T , Dolezal R , Mezeiova E , Kaping D , Kuca K
Ref : Molecules , 22 : , 2017
PubMedID: 28621747

Title : Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs - Karasova_2017_Toxicol.Lett_273_20
Author(s) : Karasova JZ , Kvetina J , Tacheci I , Radochova V , Musilek K , Kuca K , Bures J
Ref : Toxicol Lett , 273 :20 , 2017
PubMedID: 28343895

Title : Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids - Hamulakova_2017_Int.J.Biol.Macromol_104_333
Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Kuca K
Ref : Int J Biol Macromol , 104 :333 , 2017
PubMedID: 28601645

Title : Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy - Mezeiova_2017_Molecules_22_
Author(s) : Mezeiova E , Korabecny J , Sepsova V , Hrabinova M , Jost P , Muckova L , Kucera T , Dolezal R , Misik J , Spilovska K , Pham NL , Pokrievkova L , Roh J , Jun D , Soukup O , Kaping D , Kuca K
Ref : Molecules , 22 : , 2017
PubMedID: 28788095

Title : Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis - Karasova_2017_Toxicol.Lett_277_24
Author(s) : Karasova JZ , Maderycova Z , Tumova M , Jun D , Rehacek V , Kuca K , Misik J
Ref : Toxicol Lett , 277 :24 , 2017
PubMedID: 28465191

Title : Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules - Hamulakova_2016_J.Inorg.Biochem_161_52
Author(s) : Hamulakova S , Poprac P , Jomova K , Brezova V , Lauro P , Drostinova L , Jun D , Sepsova V , Hrabinova M , Soukup O , Kristian P , Gazova Z , Bednarikova Z , Kuca K , Valko M
Ref : J Inorg Biochem , 161 :52 , 2016
PubMedID: 27230386

Title : Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity - Karasova_2016_Neurotox.Res_29_267
Author(s) : Karasova JZ , Hroch M , Musilek K , Kuca K
Ref : Neurotox Res , 29 :267 , 2016
PubMedID: 26646154

Title : Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase - Sahu_2016_Toxicol.Mech.Methods__1
Author(s) : Sahu AK , Sharma R , Gupta B , Musilek K , Kuca K , Acharya J , Ghosh KK
Ref : Toxicol Mech Methods , :1 , 2016
PubMedID: 27101948

Title : Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies - Dolezal_2016_Eur.J.Med.Chem_121_699
Author(s) : Dolezal R , Soukup O , Malinak D , Savedra RML , Marek J , Dolezalova M , Pasdiorova M , Salajkova S , Korabecny J , Honegr J , Ramalho TC , Kuca K
Ref : Eur Journal of Medicinal Chemistry , 121 :699 , 2016
PubMedID: 27341309

Title : Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase - Winter_2016_Toxicol.Lett_244_136
Author(s) : Winter M , Wille T , Musilek K , Kuca K , Thiermann H , Worek F
Ref : Toxicol Lett , 244 :136 , 2016
PubMedID: 26210933

Title : An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study - Mzik_2016_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1020_85
Author(s) : Mzik M , Korabecny J , Nepovimova E , Vorisek V , Palicka V , Kuca K , Karasova JZ
Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1020 :85 , 2016
PubMedID: 27030895

Title : Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease - Jerabek_2016_Eur.J.Med.Chem_127_250
Author(s) : Jerabek J , Uliassi E , Guidotti L , Korabecny J , Soukup O , Sepsova V , Hrabinova M , Kuca K , Bartolini M , Pena-Altamira LE , Petralla S , Monti B , Roberti M , Bolognesi ML
Ref : Eur Journal of Medicinal Chemistry , 127 :250 , 2016
PubMedID: 28064079

Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831
Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K
Ref : Archives of Toxicology , 90 :2831 , 2016
PubMedID: 27582056

Title : Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1 - Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45
Author(s) : Kristofikova Z , Ricny J , Soukup O , Korabecny J , Nepovimova E , Kuca K , Ripova D
Ref : Dementia & Geriatric Cognitive Disorders , 43 :45 , 2016
PubMedID: 27988521

Title : Computational Enzymology and Organophosphorus Degrading Enzymes: Promising Approaches Toward Remediation Technologies of Warfare Agents and Pesticides - Ramalho_2016_Curr.Med.Chem_23_1041
Author(s) : Ramalho TC , de Castro AA , Silva DR , Silva MC , Franca TCC , Bennion BJ , Kuca K
Ref : Curr Med Chem , 23 :1041 , 2016
PubMedID: 26898655

Title : Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase - Musilek_2016_Med.Chem_12_362
Author(s) : Musilek K , Hambalek J , Holas O , Dohnal V , Kuca K
Ref : Med Chem , 12 :362 , 2016
PubMedID: 26427931

Title : Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor - Antonijevic_2016_Neurotoxicol_55_33
Author(s) : Antonijevic E , Musilek K , Kuca K , Djukic-Cosic D , Vucinic S , Antonijevic B
Ref : Neurotoxicology , 55 :33 , 2016
PubMedID: 27177985

Title : Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity - Janockova_2016_Mol.Biosyst_12_2910
Author(s) : Janockova J , Zilecka E , Kasparkova J , Brabec V , Soukup O , Kuca K , Kozurkova M
Ref : Mol Biosyst , 12 :2910 , 2016
PubMedID: 27412811

Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264
Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K
Ref : ChemMedChem , 11 :1264 , 2016
PubMedID: 26427608

Title : Blood-fetus penetration of pralidoxime - Ojha_2016_Mil.Med.Sci.Lett_85_63
Author(s) : Ojha S , Nurulain SM , Dhanasekaran S , Shafiullah M , Adem A , Sharma C , Kuca K , Kalasz H
Ref : Military Medical Science Letters , 85 :63 , 2016
PubMedID:

Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K
Ref : Toxicol Res (Camb) , 5 :1012 , 2016
PubMedID: 30090408

Title : Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators - Spicakova_2016_Food.Chem.Toxicol_88_100
Author(s) : Spicakova A , Anzenbacher P , Liskova B , Kuca K , Fusek J , Anzenbacherova E
Ref : Food & Chemical Toxicology , 88 :100 , 2016
PubMedID: 26747974

Title : Development and validation of a FIA\/UV-vis method for pK determination of oxime based acetylcholinesterase reactivators - Musil_2015_J.Pharm.Biomed.Anal_117_240
Author(s) : Musil K , Florianova V , Bucek P , Dohnal V , Kuca K , Musilek K
Ref : J Pharm Biomed Anal , 117 :240 , 2015
PubMedID: 26386953

Title : Impact of tacrine and 7-methoxytacrine on gastric myoelectrical activity assessed using electrogastrography in experimental pigs - Bures_2015_Neuro.Endocrinol.Lett_36_
Author(s) : Bures J , Jun D , Hrabinova M , Tacheci I , Kvetina J , Pavlik M , Rejchrt S , Douda T , Kunes M , Kuca K , Kopacova M
Ref : Neuro Endocrinol Lett , 36 : , 2015
PubMedID: 26757120

Title : Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE - Kuca_2015_Med.Chem_11_683
Author(s) : Kuca K , Hrabinova M , Jun D , Musilek K , Penhaker M , Krejcar O , Soukup O
Ref : Med Chem , 11 :683 , 2015
PubMedID: 25845909

Title : Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase - Dolezal_2015_J.Mol.Graph.Model_56_113
Author(s) : Dolezal R , Korabecny J , Malinak D , Honegr J , Musilek K , Kuca K
Ref : J Mol Graph Model , 56 :113 , 2015
PubMedID: 25588616

Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985
Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K
Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015
PubMedID: 26503905

Title : Cholinergic properties of new 7-methoxytacrine-donepezil derivatives - Sepsova_2015_Gen.Physiol.Biophys_34_189
Author(s) : Sepsova V , Karasova JZ , Tobin G , Jun D , Korabecny J , Cabelova P , Janska K , Krusek J , Skrenkova K , Kuca K , Soukup O
Ref : Gen Physiol Biophys , 34 :189 , 2015
PubMedID: 25504063

Title : Reversible cholinesterase inhibitors as pre-treatment for exposure to organophosphates: assessment using azinphos-methyl - Petroianu_2015_J.Appl.Toxicol_35_493
Author(s) : Petroianu GA , Nurulain SM , Hasan MY , Kuca K , Lorke DE
Ref : J Appl Toxicol , 35 :493 , 2015
PubMedID: 25186309

Title : Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review - Sharma_2015_Mini.Rev.Med.Chem_15_58
Author(s) : Sharma R , Gupta B , Singh N , Acharya JR , Musilek K , Kuca K , Ghosh KK
Ref : Mini Rev Med Chem , 15 :58 , 2015
PubMedID: 25441834

Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084
Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K
Ref : Molecules , 20 :22084 , 2015
PubMedID: 26690394

Title : Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents - Giacoppo_2015_J.Biomol.Struct.Dyn_33_2048
Author(s) : Giacoppo JO , Franca TCC , Kuca K , da Cunha EFF , Abagyan R , Mancini DT , Ramalho TC
Ref : J Biomol Struct Dyn , 33 :2048 , 2015
PubMedID: 25407587

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Author(s) : Nepovimova E , Uliassi E , Korabecny J , Pena-Altamira LE , Samez S , Pesaresi A , Garcia GE , Bartolini M , Andrisano V , Bergamini C , Fato R , Lamba D , Roberti M , Kuca K , Monti B , Bolognesi ML
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Author(s) : Kunes M , Kvetina J , Bures J , Karasova JZ , Pavlik M , Tacheci I , Musilek K , Kuca K
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Title : Chemical warfare: perspectives on reactivating the enzyme acetylcholinesterase inhibited by organophosphates - Giacoppo_2014_Mil.Med.Sci.Lett_83_165
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Title : Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX - Kuca_2013_Med.Chem_9_689
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Title : In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators - Bhattacharjee_2013_Curr.Comput.Aided.Drug.Des_9_402
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Title : Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium\/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors - Komloova_2013_Bioorg.Med.Chem.Lett_23_6663
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Title : Interaction of cholinesterase modulators with DNA and their cytotoxic activity - Janockova_2013_Int.J.Biol.Macromol_64C_53
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Author(s) : Kuca K , Jun D , Musilek K , Pohanka M , Karasova JZ , Soukup O
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Title : Intravenous application of HI-6 salts (dichloride and dimethansulphonate) in pigs: comparison with pharmacokinetics profile after intramuscular administration - Karasova_2013_Neuro.Endocrinol.Lett_34_74
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Title : A Resurrection of 7-MEOTA: A Comparison with Tacrine - Soukup_2013_Curr.Alzheimer.Res_10_893
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Title : selective monitoring of enzymatic activity of acetylcholinesterase by flow injection analysis with mass spectrometric detection - Dohnal_2013_Mil.Med.Sci.Lett_82_120
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Title : Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase - Worek_2012_Arch.Toxicol_86_1379
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Title : Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease - Hamulakova_2012_Eur.J.Med.Chem_55_23
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Title : The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers - Soukup_2012_Toxicol.Lett_212_315
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Title : First principles calculations of thermodynamics and kinetic parameters and molecular dynamics simulations of acetylcholinesterase reactivators: can mouse data provide new insights into humans? - Matos_2012_J.Biomol.Struct.Dyn_30_546
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Title : Acetylcholinesterase Inhibitors as Pretreatment before Acute Exposure to Organophosphates: Assessment Using Methyl-paraoxon - Lorke_2012_CNS.Neurol.Disord.Drug.Targets_11_1052
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Title : Method optimization for acetylcholinesterase modulators-albumin interactions - Zemek_2011_Mil.Med.Sci.Lett_80_58
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Title : On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning - Kuca_2011_Mil.Med.Sci.Lett_80_80
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Title : Effects of K074 and pralidoxime on antioxidant and acetylcholinesterase response in malathion-poisoned mice - dos Santos_2011_Neurotoxicol_32_888
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Title : Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment - Komloova_2011_Bioorg.Med.Chem.Lett_21_2505
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Title : Human serum butyrylcholinesterase as a prophylaxis against russian VX - Karasova_2011_Mil.Med.Sci.Lett_80_97
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Title : In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase - Jun_2011_Int.J.Mol.Sci_12_2077
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Title : Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking - Musilek_2011_Bioorg.Med.Chem_19_754
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Title : Assessment of acetylcholinesterase activity using indoxylacetate and comparison with the standard Ellman's method - Pohanka_2011_Int.J.Mol.Sci_12_2631
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Title : Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment - Musilek_2011_Eur.J.Med.Chem_46_811
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Title : The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage - Musilek_2011_J.Enzyme.Inhib.Med.Chem_26_245
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Title : Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides - Musilek_2011_Med.Res.Rev_31_548
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Title : Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies - Musilek_2010_ChemMedChem_5_247
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Title : Colorimetric dipstick for assay of organophosphate pesticides and nerve agents represented by paraoxon, sarin and VX - Pohanka_2010_Talanta_81_621
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Title : Is Oxime Fluorination the Proper Way to Increase Penetration of These Compounds in the Central Nervous System? - Karasova_2010_Mil.Med.Sci.Lett_79_23
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PubMedID: 20138518

Title : In vivo experimental approach to treatment against tabun poisoning - Berend_2010_J.Enzyme.Inhib.Med.Chem_25_531
Author(s) : Zunec S , Katalinic M , Vrdoljak AL , Kovarik Z , Kuca K , Radic B
Ref : J Enzyme Inhib Med Chem , 25 :531 , 2010
PubMedID: 20235800

Title : Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure - Karasova_2010_Toxicol.In.Vitro_24_1838
Author(s) : Karasova JZ , Pohanka M , Musilek K , Zemek F , Kuca K
Ref : Toxicol In Vitro , 24 :1838 , 2010
PubMedID: 20546883

Title : In vitro reactivating effects of standard and newly developed oximes on malaoxon-inhibited mouse brain acetylcholinesterase - dos Santos_2010_Basic.Clin.Pharmacol.Toxicol_107_768
Author(s) : Dos Santos AA , dos Santos DB , Dafre AL , de Bem AF , Souza DO , da Rocha JB , Kuca K , Farina M
Ref : Basic Clin Pharmacol Toxicol , 107 :768 , 2010
PubMedID: 20406208

Title : Influence of the acetylcholinesterase active site protonation on omega loop and active site dynamics - Wiesner_2010_J.Biomol.Struct.Dyn_28_393
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J
Ref : J Biomol Struct Dyn , 28 :393 , 2010
PubMedID: 20919754

Title : Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment - Korabecny_2010_Molecules_15_8804
Author(s) : Korabecny J , Musilek K , Holas O , Nepovimova E , Jun D , Zemek F , Opletalova V , Patocka J , Dohnal V , Nachon F , Hroudova J , Fisar Z , Kuca K
Ref : Molecules , 15 :8804 , 2010
PubMedID: 21127466

Title : Pseudo-catalytic scavenging: searching for a suitable reactivator of phosphorylated butyrylcholinesterase - Kovarik_2010_Chem.Biol.Interact_187_167
Author(s) : Kovarik Z , Katalinic M , Sinko G , Binder J , Holas O , Jung YS , Musilova L , Jun D , Kuca K
Ref : Chemico-Biological Interactions , 187 :167 , 2010
PubMedID: 20206154

Title : A comparison of the reactivating and therapeutic efficacy of newly developed oximes (K347, K628) with commonly used oximes (obidoxime, HI-6) against tabun in rats and mice - Kassa_2010_Drug.Chem.Toxicol_33_227
Author(s) : Kassa J , Karasova JZ , Kuca K , Musilek K
Ref : Drug & Chemical Toxicology , 33 :227 , 2010
PubMedID: 20429807

Title : Structure-activity relationship of quaternary acetylcholinesterase inhibitors - outlook for early myasthenia gravis treatment - Komloova_2010_Curr.Med.Chem_17_1810
Author(s) : Komloova M , Musilek K , Dolezal M , Gunn-Moore F , Kuca K
Ref : Curr Med Chem , 17 :1810 , 2010
PubMedID: 20345342

Title : In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties - Bhattacharjee_2010_Chem.Res.Toxicol_23_26
Author(s) : Bhattacharjee AK , Kuca K , Musilek K , Gordon RK
Ref : Chemical Research in Toxicology , 23 :26 , 2010
PubMedID: 20028185

Title : Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease - Korabecny_2010_Bioorg.Med.Chem.Lett_20_6093
Author(s) : Korabecny J , Musilek K , Holas O , Binder J , Zemek F , Marek J , Pohanka M , Opletalova V , Dohnal V , Kuca K
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6093 , 2010
PubMedID: 20817518

Title : The antidotal efficacy of the bispyridinium oximes K027 and TMB-4 against tabun poisoning in mice - Berend_2010_Chem.Biol.Interact_187_291
Author(s) : Zunec S , Radic B , Kuca K , Lucic Vrdoljak A
Ref : Chemico-Biological Interactions , 187 :291 , 2010
PubMedID: 20138854

Title : Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase - Kuca_2010_J.Enzyme.Inhib.Med.Chem_25_509
Author(s) : Kuca K , Musilek K , Jun D , Pohanka M , Ghosh KK , Hrabinova M
Ref : J Enzyme Inhib Med Chem , 25 :509 , 2010
PubMedID: 20192902

Title : Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy - Kuca_2010_Bratisl.Lek.Listy_111_502
Author(s) : Kuca K , Hrabinova M , Soukup O , Tobin G , Karasova J , Pohanka M
Ref : Bratislavske Lekarske Listy , 111 :502 , 2010
PubMedID: 21180265

Title : Evaluation of aflatoxin B1--acetylcholinesterase dissociation kinetic using the amperometric biosensor technology: prospect for toxicity mechanism - Pohanka_2010_Protein.Pept.Lett_17_340
Author(s) : Pohanka M , Musilek K , Kuca K
Ref : Protein Pept Lett , 17 :340 , 2010
PubMedID: 19508188

Title : Novel acetylcholinesterase reactivator K112 and its cholinergic properties - Soukup_2010_Biomed.Pharmacother_64_541
Author(s) : Soukup O , Kristofikova Z , Proska J , Tobin G , Patocka J , Marek J , Jun D , Fusek J , Ripova D , Kuca K
Ref : Biomed Pharmacother , 64 :541 , 2010
PubMedID: 20634031

Title : Interaction of nerve agent antidotes with cholinergic systems - Soukup_2010_Curr.Med.Chem_17_1708
Author(s) : Soukup O , Tobin G , Kumar UK , Binder J , Proska J , Jun D , Fusek J , Kuca K
Ref : Curr Med Chem , 17 :1708 , 2010
PubMedID: 20345348

Title : A comparison of tabun-inhibited rat brain acetylcholinesterase reactivation by three oximes (HI-6, obidoxime, and K048) in vivo detected by biochemical and histochemical techniques - Bajgar_2010_J.Enzyme.Inhib.Med.Chem_25_790
Author(s) : Bajgar J , Hajek P , Karasova JZ , Kassa J , Paseka A , Slizova D , Krs O , Kuca K , Jun D , Fusek J , Capek L
Ref : J Enzyme Inhib Med Chem , 25 :790 , 2010
PubMedID: 21054236

Title : Modulation of ionising radiation generated oxidative stress by HI-6 (asoxime) in a laboratory rat model - Pohanka_2010_Neuro.Endocrinol.Lett_31 Suppl 2_62
Author(s) : Pohanka M , Pejchal J , Horackova S , Kuca K , Bandouchova H , Damkova V , Pikula J
Ref : Neuro Endocrinol Lett , 31 Suppl 2 :62 , 2010
PubMedID: 21187825

Title : Development of new acetylcholinesterase reactivators: molecular modeling versus in vitro data - Ramalho_2010_Chem.Biol.Interact_185_73
Author(s) : Ramalho TC , Franca TCC , Renno MN , Guimaraes AP , da Cunha EFF , Kuca K
Ref : Chemico-Biological Interactions , 185 :73 , 2010
PubMedID: 20188081

Title : Colorimetric Detectors Based on Acetylcholinesterase and Its Construction - Pohanka_2010_Mil.Med.Sci.Lett_79_9
Author(s) : Pohanka M , Vlcek V , Karasova JZ , Kuca K , Cabal J
Ref : Military Medical Science Letters , 79 :9 , 2010
PubMedID:

Title : Immobilization of Acetylcholinesterase and a Construction of Biochemical Biosensor for Identification of Toxic Organophosphates. - Pohanka_2010_Mil.Med.Sci.Lett_79_105
Author(s) : Pohanka M , Drobik O , Krenkova Z , Karasova JZ , Cabal J , Kuca K
Ref : Military Medical Science Letters , 79 :105 , 2010
PubMedID:

Title : Testing of a Referential Method Based on Indoxylacetate as a Acetylcholinesterase Substrate for Identification of Reactivation Efficacy. - Pohanka_2010_Mil.Med.Sci.Lett_79_111
Author(s) : Pohanka M , Hrabinova M , Karasova JZ , Holas O , Kuca K , Cabal J
Ref : Military Medical Science Letters , 79 :111 , 2010
PubMedID:

Title : Time-dependent changes in concentration of two clinically used acetylcholinesterase reactivators (HI-6 and obidoxime) in rat plasma determined by HPLC techniques after in vivo administration - Karasova_2010_Anal.Sci_26_63
Author(s) : Karasova JZ , Novotny L , Antos K , Zivna H , Kuca K
Ref : Anal Sci , 26 :63 , 2010
PubMedID: 20065589

Title : New Bisquaternary Inhibitors of Acetylcholinesterase Used as a Prophylactics in Organophosphorus Poisoning - Pavlikova_2010_Mil.Med.Sci.Lett_79_46
Author(s) : Pavlikova R , Marek J , Musilek K , Fusek J , Kuca K , Karasova JZ
Ref : Military Medical Science Letters , 79 :46 , 2010
PubMedID:

Title : A Comparison of Neuroprotective Efficacy of the Oxime K203 and its Fluorinated Analogue (KR-22836) with Obidoxime in Tabun-Poisoned Rats - Kassa_2010_Basic.Clin.Pharmacol.Toxicol_107_861
Author(s) : Kassa J , Karasova JZ , Tesarova S , Musilek K , Kuca K , Jung YS
Ref : Basic Clin Pharmacol Toxicol , 107 :861 , 2010
PubMedID: 22545968

Title : A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice - Kassa_2010_J.Enzyme.Inhib.Med.Chem_25_480
Author(s) : Kassa J , Karasova JZ , Caisberger F , Musilek K , Kuca K , Jung YS
Ref : J Enzyme Inhib Med Chem , 25 :480 , 2010
PubMedID: 20233085

Title : Characterization of the anticholinergic properties of obidoxime\; functional examinations of the rat atria and the urinary bladder - Soukup_2010_Toxicol.Mech.Methods_20_428
Author(s) : Soukup O , Tobin G , Kumar UK , Jun D , Fusek J , Kuca K
Ref : Toxicol Mech Methods , 20 :428 , 2010
PubMedID: 20602545

Title : Effect of five acetylcholinesterase reactivators on tabun-intoxicated rats: induction of oxidative stress versus reactivation efficacy - Pohanka_2009_J.Appl.Toxicol_29_483
Author(s) : Pohanka M , Karasova JZ , Musilek K , Kuca K , Kassa J
Ref : J Appl Toxicol , 29 :483 , 2009
PubMedID: 19338015

Title : Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats - Karasova_2009_Int.J.Mol.Sci_10_3065
Author(s) : Karasova JZ , Kassa J , Musilek K , Pohanka M , Novotny L , Kuca K
Ref : Int J Mol Sci , 10 :3065 , 2009
PubMedID: 19742125

Title : Progress of biosensors based on cholinesterase inhibition - Pohanka_2009_Curr.Med.Chem_16_1790
Author(s) : Pohanka M , Musilek K , Kuca K
Ref : Curr Med Chem , 16 :1790 , 2009
PubMedID: 19442145

Title : Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX - Hajek_2009_Drug.Chem.Toxicol_32_1
Author(s) : Hajek P , Bajgar J , Slizova D , Krs O , Kuca K , Capek L , Fusek J
Ref : Drug & Chemical Toxicology , 32 :1 , 2009
PubMedID: 19514933

Title : Time-course changes of acetylcholinesterase activity in blood and some tissues in rats after intoxication by Russian VX - Karasova_2009_Neurotox.Res_16_356
Author(s) : Karasova JZ , Bajgar J , Jun D , Pavlikova R , Kuca K
Ref : Neurotox Res , 16 :356 , 2009
PubMedID: 19728005

Title : Chemical aspects of pharmacological prophylaxis against nerve agent poisoning - Bajgar_2009_Curr.Med.Chem_16_2977
Author(s) : Bajgar J , Fusek J , Kassa J , Kuca K , Jun D
Ref : Curr Med Chem , 16 :2977 , 2009
PubMedID: 19689278

Title : A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats - Kassa_2009_Toxicol.Mech.Methods_19_232
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K , Jung AY
Ref : Toxicol Mech Methods , 19 :232 , 2009
PubMedID: 19730756

Title : Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127 - Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207
Author(s) : Kuca K , Cabal J , Jung YS , Musilek K , Soukup O , Jun D , Pohanka M , Musilova L , Karasova J , Novotny L , Hrabinova M
Ref : Basic Clin Pharmacol Toxicol , 105 :207 , 2009
PubMedID: 19473310

Title : An evaluation of reactivating and therapeutic efficacy of newly developed oximes (K206, K269) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Clin.Toxicol.(Phila)_47_72
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Bajgar J
Ref : Clinical Toxicology (Phila) , 47 :72 , 2009
PubMedID: 18686075

Title : Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6 - Lorke_2009_Toxicol.Mech.Methods_19_327
Author(s) : Lorke DE , Hasan MY , Nurulain SM , Kuca K , Schmitt A , Petroianu GA
Ref : Toxicol Mech Methods , 19 :327 , 2009
PubMedID: 19778224

Title : Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon - Kuca_2009_Molecules_14_4915
Author(s) : Kuca K , Musilova L , Palecek J , Cirkva V , Paar M , Musilek K , Hrabinova M , Pohanka M , Karasova JZ , Jun D
Ref : Molecules , 14 :4915 , 2009
PubMedID: 20032868

Title : Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime - Nurulain_2009_Neurotox.Res_16_60
Author(s) : Nurulain SM , Lorke DE , Hasan MY , Shafiullah M , Kuca K , Musilek K , Petroianu GA
Ref : Neurotox Res , 16 :60 , 2009
PubMedID: 19526299

Title : In vitro reactivation of trichlorfon-inhibited butyrylcholinesterase using HI-6, obidoxime, pralidoxime and K048 - Pohanka_2009_J.Enzyme.Inhib.Med.Chem_24_680
Author(s) : Pohanka M , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 24 :680 , 2009
PubMedID: 18825528

Title : Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent - Jeong_2009_Bioorg.Med.Chem_17_6213
Author(s) : Jeong HC , Park NJ , Chae CH , Musilek K , Kassa J , Kuca K , Jung YS
Ref : Bioorganic & Medicinal Chemistry , 17 :6213 , 2009
PubMedID: 19665386

Title : Effect of acetylcholinesterase oxime-type reactivators K-48 and HI-6 on human liver microsomal cytochromes P450 in vitro - Veinlichova_2009_Chem.Biol.Interact_180_449
Author(s) : Veinlichova A , Jancova P , Siller M , Anzenbacher P , Kuca K , Jun D , Fusek J , Anzenbacherova E
Ref : Chemico-Biological Interactions , 180 :449 , 2009
PubMedID: 19539805

Title : Irinotecan side effects relieved by the use of HI-6 oxime: in vivo experimental approach - Vrdoljak_2009_Basic.Clin.Pharmacol.Toxicol_105_401
Author(s) : Vrdoljak AL , Zunec S , Zeljezic D , Piljac-Zegarac J , Plestina S , Kuca K , Radic B , Mladinic M , Kopjar N
Ref : Basic Clin Pharmacol Toxicol , 105 :401 , 2009
PubMedID: 19663821

Title : A comparison of reactivating and therapeutic efficacy of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) in cyclosarin-poisoned rats and mice - Kassa_2009_Toxicol.Mech.Methods_19_346
Author(s) : Kassa J , Karasova JZ , Musilek K , Kuca K
Ref : Toxicol Mech Methods , 19 :346 , 2009
PubMedID: 19778210

Title : Cholinesterase biosensor construction - a review - Pohanka_2008_Protein.Pept.Lett_15_795
Author(s) : Pohanka M , Jun D , Kalasz H , Kuca K
Ref : Protein Pept Lett , 15 :795 , 2008
PubMedID: 18855751

Title : New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine - Pohanka_2008_Neuro.Endocrinol.Lett_29_755
Author(s) : Pohanka M , Kuca K , Kassa J
Ref : Neuro Endocrinol Lett , 29 :755 , 2008
PubMedID: 18987590

Title : Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease - Patocka_2008_Curr.Drug.Metab_9_332
Author(s) : Patocka J , Jun D , Kuca K
Ref : Curr Drug Metab , 9 :332 , 2008
PubMedID: 18473751

Title : Diagnosis of Intoxication by the Organophosphate VX: Comparison Between an Electrochemical Sensor and Ellman s Photometric Method - Pohanka_2008_Sensors.(Basel)_8_5229
Author(s) : Pohanka M , Hrabinova M , Kuca K
Ref : Sensors (Basel) , 8 :5229 , 2008
PubMedID: 27873811

Title : Amperometric Biosensors for Real Time Assays of Organophosphates - Pohanka_2008_Sensors.(Basel)_8_5303
Author(s) : Pohanka M , Jun D , Kuca K
Ref : Sensors (Basel) , 8 :5303 , 2008
PubMedID: 27873815

Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in soman, cyclosarin and tabun-poisoned rats - Kassa_2008_Chem.Biol.Interact_175_425
Author(s) : Kassa J , Jun D , Karasova J , Bajgar J , Kuca K
Ref : Chemico-Biological Interactions , 175 :425 , 2008
PubMedID: 18547554

Title : New bispyridinium oximes: in vitro and in vivo evaluation of their biological efficiency in soman and tabun poisoning - Berend_2008_Chem.Biol.Interact_175_413
Author(s) : Zunec S , Vrdoljak AL , Radic B , Kuca K
Ref : Chemico-Biological Interactions , 175 :413 , 2008
PubMedID: 18547553

Title : The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun - Kassa_2008_Mini.Rev.Med.Chem_8_1134
Author(s) : Kassa J , Kuca K , Karasova J , Musilek K
Ref : Mini Rev Med Chem , 8 :1134 , 2008
PubMedID: 18855728

Title : Interactions of butane, but-2-ene or xylene-like linked bispyridinium para-aldoximes with native and tabun-inhibited human cholinesterases - Calic_2008_Chem.Biol.Interact_175_305
Author(s) : Calic M , Bosak A , Kuca K , Kovarik Z
Ref : Chemico-Biological Interactions , 175 :305 , 2008
PubMedID: 18501885

Title : Photometric microplate assay for estimation of the efficacy of paraoxon-inhibited acetylcholinesterase reactivation - Pohanka_2008_J.Enzyme.Inhib.Med.Chem_23_781
Author(s) : Pohanka M , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 23 :781 , 2008
PubMedID: 18615283

Title : A comparison of the therapeutic and reactivating efficacy of newly developed oximes (K117, K127) and currently available oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Drug.Chem.Toxicol_31_371
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K , Jung YS
Ref : Drug & Chemical Toxicology , 31 :371 , 2008
PubMedID: 18622871

Title : In vitro oxime protection of human red blood cell acetylcholinesterase inhibited by diisopropyl-fluorophosphate - Lorke_2008_J.Appl.Toxicol_28_422
Author(s) : Lorke DE , Hasan MY , Arafat K , Kuca K , Musilek K , Schmitt A , Petroianu GA
Ref : J Appl Toxicol , 28 :422 , 2008
PubMedID: 18344198

Title : Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro - Jun_2008_Chem.Biol.Interact_175_421
Author(s) : Jun D , Musilova L , Kuca K , Kassa J , Bajgar J
Ref : Chemico-Biological Interactions , 175 :421 , 2008
PubMedID: 18617161

Title : Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: in vivo efficacy to protect from diisopropylfluorophosphate toxicity - Lorke_2008_J.Appl.Toxicol_28_920
Author(s) : Lorke DE , Nurulain SM , Hasan MY , Kuca K , Musilek K , Petroianu GA
Ref : J Appl Toxicol , 28 :920 , 2008
PubMedID: 18548743

Title : Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex - da Silva_2008_Neurotoxicol_29_184
Author(s) : da Silva AP , Farina M , Franco JL , Dafre AL , Kassa J , Kuca K
Ref : Neurotoxicology , 29 :184 , 2008
PubMedID: 18035420

Title : RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker - Musilek_2008_Anal.Bioanal.Chem_391_367
Author(s) : Musilek K , Jampilek J , Dohnal J , Jun D , Gunn-Moore F , Dolezal M , Kuca K
Ref : Anal Bioanal Chem , 391 :367 , 2008
PubMedID: 18369602

Title : Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_Bioorg.Med.Chem_16_8218
Author(s) : Musilek K , Kucera J , Jun D , Dohnal V , Opletalova V , Kuca K
Ref : Bioorganic & Medicinal Chemistry , 16 :8218 , 2008
PubMedID: 18676153

Title : Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats - Karasova_2008_Int.J.Mol.Sci_9_2243
Author(s) : Karasova JZ , Kassa J , Jung YS , Musilek K , Pohanka M , Kuca K
Ref : Int J Mol Sci , 9 :2243 , 2008
PubMedID: 19330072

Title : A comparison of the therapeutic and reactivating efficacy of newly developed bispyridinium compounds (K206, K269) with currently available oximes against tabun in rats and mice - Kassa_2008_J.Enzyme.Inhib.Med.Chem_23_776
Author(s) : Kassa J , Karasova J , Bajgar J , Kuca K , Musilek K
Ref : J Enzyme Inhib Med Chem , 23 :776 , 2008
PubMedID: 18608751

Title : The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder - Soukup_2008_Neuro.Endocrinol.Lett_29_759
Author(s) : Soukup O , Pohanka M , Tobin G , Jun D , Fusek J , Musilek K , Marek J , Kassa J , Kuca K
Ref : Neuro Endocrinol Lett , 29 :759 , 2008
PubMedID: 18987577

Title : Potency of novel oximes to reactivate sarin inhibited human cholinesterases - Jun_2008_Drug.Chem.Toxicol_31_1
Author(s) : Jun D , Kuca K , Picha J , Koleckar V , Marek J
Ref : Drug & Chemical Toxicology , 31 :1 , 2008
PubMedID: 18161504

Title : TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate - Jun_2008_J.Chromatogr.Sci_46_316
Author(s) : Jun D , Stodulka P , Kuca K , Koleckar V , Dolezal B , Simon P , Veverka M
Ref : Journal of Chromatography Sci , 46 :316 , 2008
PubMedID: 18402722

Title : Analysis of pyridinium aldoximes - a chromatographic approach - Csermely_2008_Curr.Med.Chem_15_2401
Author(s) : Csermely T , Kalasz H , Petroianu GA , Kuca K , Darvas F , Ludanyi K , Mudhafar AA , Tekes K
Ref : Curr Med Chem , 15 :2401 , 2008
PubMedID: 18855669

Title : Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2008_J.Enzyme.Inhib.Med.Chem_23_70
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 23 :70 , 2008
PubMedID: 18341256

Title : An attempt to assess functionally minimal acetylcholinesterase activity necessary for survival of rats intoxicated with nerve agents - Bajgar_2008_Chem.Biol.Interact_175_281
Author(s) : Bajgar J , Fusek J , Kassa J , Jun D , Kuca K , Hajek P
Ref : Chemico-Biological Interactions , 175 :281 , 2008
PubMedID: 18579126

Title : Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes - Oh_2008_Chem.Biol.Interact_175_365
Author(s) : Oh KA , Park NJ , Park NS , Kuca K , Jun D , Jung YS
Ref : Chemico-Biological Interactions , 175 :365 , 2008
PubMedID: 18565503

Title : An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice - Kassa_2008_Toxicology_243_311
Author(s) : Kassa J , Karasova J , Musilek K , Kuca K
Ref : Toxicology , 243 :311 , 2008
PubMedID: 18054821

Title : Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications - Kuca_2007_Curr.Pharm.Des_13_3445
Author(s) : Kuca K , Jun D , Bajgar J
Ref : Curr Pharm Des , 13 :3445 , 2007
PubMedID: 18045198

Title : Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator - Kuca_2007_Molecules_12_1964
Author(s) : Kuca K , Musilek K , Paar M , Jun D , Stodulka P , Hrabinova M , Marek J
Ref : Molecules , 12 :1964 , 2007
PubMedID: 17960099

Title : Design of a potent reactivator of tabun-inhibited acetylcholinesterase--synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203) - Musilek_2007_J.Med.Chem_50_5514
Author(s) : Musilek K , Jun D , Cabal J , Kassa J , Gunn-Moore F , Kuca K
Ref : Journal of Medicinal Chemistry , 50 :5514 , 2007
PubMedID: 17924614

Title : Amperometric biosensor for pesticide methamidophos assay - Pohanka_2007_Acta.Medica.(Hradec.Kralove)_50_239
Author(s) : Pohanka M , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 50 :239 , 2007
PubMedID: 18290547

Title : Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates\/nerve agents - Bajgar_2007_Curr.Drug.Metab_8_803
Author(s) : Bajgar J , Kuca K , Jun D , Bartosova L , Fusek J
Ref : Curr Drug Metab , 8 :803 , 2007
PubMedID: 18220560

Title : Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase - Musilek_2007_Bioorg.Med.Chem_15_6733
Author(s) : Musilek K , Holas O , Jun D , Dohnal V , Gunn-Moore F , Opletalova V , Dolezal M , Kuca K
Ref : Bioorganic & Medicinal Chemistry , 15 :6733 , 2007
PubMedID: 17764957

Title : Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin - Kuca_2007_Clin.Toxicol.(Phila)_45_512
Author(s) : Kuca K , Cabal J , Jun D , Hrabinova M
Ref : Clinical Toxicology (Phila) , 45 :512 , 2007
PubMedID: 17503257

Title : A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun-poisoned rats - Kassa_2007_J.Enzyme.Inhib.Med.Chem_22_297
Author(s) : Kassa J , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 22 :297 , 2007
PubMedID: 17674811

Title : Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX) - Musilek_2007_Acta.Medica.(Hradec.Kralove)_50_203
Author(s) : Musilek K , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 50 :203 , 2007
PubMedID: 18254274

Title : In vitro reactivation potency of acetylcholinesterase reactivators--K074 and K075--to reactivate tabun-inhibited human brain cholinesterases - Kuca_2007_Neurotox.Res_11_101
Author(s) : Kuca K , Cabal J , Jun D , Musilek K
Ref : Neurotox Res , 11 :101 , 2007
PubMedID: 17449453

Title : Acetylcholinesterases--the structural similarities and differences - Wiesner_2007_J.Enzyme.Inhib.Med.Chem_22_417
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J
Ref : J Enzyme Inhib Med Chem , 22 :417 , 2007
PubMedID: 17847707

Title : Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction - Bajgar_2007_Mini.Rev.Med.Chem_7_461
Author(s) : Bajgar J , Fusek J , Kuca K , Bartosova L , Jun D
Ref : Mini Rev Med Chem , 7 :461 , 2007
PubMedID: 17504181

Title : Novel series of bispyridinium compounds bearing a (Z)-but-2-ene linker--synthesis and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2007_Bioorg.Med.Chem.Lett_17_3172
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Opletalova V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3172 , 2007
PubMedID: 17383875

Title : Inhibition of blood cholinesterases following intoxication with VX and its derivatives - Bajgar_2007_J.Appl.Toxicol_27_458
Author(s) : Bajgar J , Kuca K , Fusek J , Karasova J , Kassa J , Cabal J , Jun D , Blaha V
Ref : J Appl Toxicol , 27 :458 , 2007
PubMedID: 17299830

Title : Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon - Petroianu_2007_J.Appl.Toxicol_27_453
Author(s) : Petroianu GA , Nurulain SM , Nagelkerke N , Shafiullah M , Kassa J , Kuca K
Ref : J Appl Toxicol , 27 :453 , 2007
PubMedID: 17304644

Title : Measurement of K-27, an oxime-type cholinesterase reactivator by high-performance liquid chromatography with electrochemical detection from different biological samples - Gyenge_2007_J.Chromatogr.A_1161_146
Author(s) : Gyenge M , Kalasz H , Petroianu GA , Laufer R , Kuca K , Tekes K
Ref : Journal of Chromatography A , 1161 :146 , 2007
PubMedID: 17603065

Title : Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats - Kassa_2007_Basic.Clin.Pharmacol.Toxicol_101_328
Author(s) : Kassa J , Jun D , Kuca K , Bajgar J
Ref : Basic Clin Pharmacol Toxicol , 101 :328 , 2007
PubMedID: 17910616

Title : Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase - Bajgar_2007_Drug.Chem.Toxicol_30_351
Author(s) : Bajgar J , Bartosova L , Kuca K , Jun D , Fusek J
Ref : Drug & Chemical Toxicology , 30 :351 , 2007
PubMedID: 17934924

Title : Changes of acetylcholinesterase activity in different rat brain areas following intoxication with nerve agents: biochemical and histochemical study - Bajgar_2007_Chem.Biol.Interact_165_14
Author(s) : Bajgar J , Hajek P , Slizova D , Krs O , Fusek J , Kuca K , Jun D , Bartosova L , Blaha V
Ref : Chemico-Biological Interactions , 165 :14 , 2007
PubMedID: 17145052

Title : Currently used cholinesterase reactivators against nerve agent intoxication: comparison of their effectivity in vitro - Kuca_2007_Drug.Chem.Toxicol_30_31
Author(s) : Kuca K , Jun D , Bajgar J
Ref : Drug & Chemical Toxicology , 30 :31 , 2007
PubMedID: 17364862

Title : Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2007_J.Enzyme.Inhib.Med.Chem_22_425
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 22 :425 , 2007
PubMedID: 17847708

Title : Two step synthesis of a non-symmetric acetylcholinesterase reactivator - Musilek_2007_Molecules_12_1755
Author(s) : Musilek K , Kuca K , Dohnal V , Jun D , Marek J , Koleckar V
Ref : Molecules , 12 :1755 , 2007
PubMedID: 17960085

Title : In vitro oxime reactivation of red blood cell acetylcholinesterase inhibited by methyl-paraoxon - Petroianu_2007_J.Appl.Toxicol_27_168
Author(s) : Petroianu GA , Arafat K , Nurulain SM , Kuca K , Kassa J
Ref : J Appl Toxicol , 27 :168 , 2007
PubMedID: 17265452

Title : Structural requirements of acetylcholinesterase reactivators - Kuca_2006_Mini.Rev.Med.Chem_6_269
Author(s) : Kuca K , Jun D , Musilek K
Ref : Mini Rev Med Chem , 6 :269 , 2006
PubMedID: 16515465

Title : New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin - Hrabinova_2006_J.Enzyme.Inhib.Med.Chem_21_515
Author(s) : Hrabinova M , Musilek K , Jun D , Kuca K
Ref : J Enzyme Inhib Med Chem , 21 :515 , 2006
PubMedID: 17194020

Title : Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase - Musilek_2006_Bioorg.Med.Chem.Lett_16_5673
Author(s) : Musilek K , Holas O , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5673 , 2006
PubMedID: 16934462

Title : Evaluation of reactivation test in anaesthetized dogs with experimental intoxication with nerve agents - Bajgar_2006_J.Appl.Toxicol_26_439
Author(s) : Bajgar J , Fusek J , Bartosova L , Jun D , Kuca K
Ref : J Appl Toxicol , 26 :439 , 2006
PubMedID: 16915560

Title : The Reactivating and Therapeutic Efficacy of Oximes to Counteract Russian VX Poisonings - Kassa_2006_Int.J.Toxicol_25_397
Author(s) : Kassa J , Jun D , Kuca K
Ref : Int J Toxicol , 25 :397 , 2006
PubMedID: 16940011

Title : High-performance liquid chromatographic determination of the plasma concentration of K-27, a novel oxime-type cholinesterase reactivator - Tekes_2006_J.Chromatogr.A_1122_84
Author(s) : Tekes K , Hasan MY , Sheen R , Kuca K , Petroianu GA , Ludanyi K , Kalasz H
Ref : Journal of Chromatography A , 1122 :84 , 2006
PubMedID: 16690067

Title : Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent - Kuca_2006_Basic.Clin.Pharmacol.Toxicol_98_389
Author(s) : Kuca K , Jun D , Cabal J , Hrabinova M , Bartosova L , Opletalova V
Ref : Basic Clin Pharmacol Toxicol , 98 :389 , 2006
PubMedID: 16623863

Title : Influence of Length and Shape of the Connecting Chain of Bisquaternary Acetylcholinesterase Reactivators on Their Potency to Reactivate Enzyme Inhibited by Sarin - Kuca_2006_Mil.Med.Sci.Lett_75_37
Author(s) : Kuca K , Jun D , Musilek K
Ref : Military Medical Science Letters , 75 :37 , 2006
PubMedID:

Title : Equine butyrylcholinesterase protects rats against inhalation exposure to sublethal sarin concentrations - Bajgar_2006_Arh.Hig.Rada.Toksikol_57_391
Author(s) : Bajgar J , Bartosova L , Fusek J , Jun D , Kuca K
Ref : Arh Hig Rada Toksikol , 57 :391 , 2006
PubMedID: 17265678

Title : Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase - Musilek_2006_Bioorg.Med.Chem.Lett_16_622
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :622 , 2006
PubMedID: 16288867

Title : In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity - Calic_2006_Toxicology_219_85
Author(s) : Calic M , Vrdoljak AL , Radic B , Jelic D , Jun D , Kuca K , Kovarik Z
Ref : Toxicology , 219 :85 , 2006
PubMedID: 16332406

Title : In vitro evaluation of acetylcholinesterase reactivators as potential antidotes against tabun nerve agent poisonings - Kuca_2006_Drug.Chem.Toxicol_29_443
Author(s) : Kuca K , Cabal J , Jun D , Hrabinova M
Ref : Drug & Chemical Toxicology , 29 :443 , 2006
PubMedID: 16931445

Title : Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: in vitro reactivation of red blood cell acetylcholinesterase inhibited by paraoxon - Petroianu_2006_J.Appl.Toxicol_26_64
Author(s) : Petroianu GA , Arafat K , Kuca K , Kassa J
Ref : J Appl Toxicol , 26 :64 , 2006
PubMedID: 16193529

Title : Five oximes (K-27, K-33, K-48, BI-6 and methoxime) in comparison with pralidoxime: survival in rats exposed to the organophosphate paraoxon - Petroianu_2006_J.Appl.Toxicol_26_262
Author(s) : Petroianu GA , Nurulain SM , Nagelkerke N , Al-Sultan MA , Kuca K , Kassa J
Ref : J Appl Toxicol , 26 :262 , 2006
PubMedID: 16583462

Title : Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro - Jun_2006_J.Appl.Toxicol_26_258
Author(s) : Jun D , Kuca K , Hronek M , Opletal L
Ref : J Appl Toxicol , 26 :258 , 2006
PubMedID: 16307468

Title : Tests with Daphnia magna: a new approach to prescreen toxicity of newly synthesized acetylcholinesterase reactivators - Vesela_2006_J.Enzyme.Inhib.Med.Chem_21_427
Author(s) : Vesela S , Ondruska V , Kuca K , Patocka J
Ref : J Enzyme Inhib Med Chem , 21 :427 , 2006
PubMedID: 17059176
Gene_locus related to this paper: dapul-ACHE1

Title : The acute toxicity of acetylcholinesterase reactivators in mice in relation to their structure - Bartosova_2006_Neurotox.Res_9_291
Author(s) : Bartosova L , Kuca K , Kunesova G , Jun D
Ref : Neurotox Res , 9 :291 , 2006
PubMedID: 16782588

Title : Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases - Kuca_2006_J.Enzyme.Inhib.Med.Chem_21_663
Author(s) : Kuca K , Cabal J , Jun D , Bajgar J , Hrabinova M
Ref : J Enzyme Inhib Med Chem , 21 :663 , 2006
PubMedID: 17252938

Title : Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes - Kuca_2006_J.Med.Toxicol_2_141
Author(s) : Kuca K , Jun D
Ref : J Med Toxicol , 2 :141 , 2006
PubMedID: 18072133

Title : Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning - Lucic_2006_Toxicology_228_41
Author(s) : Lucic Vrdoljak A , Calic M , Radic B , Zunec S , Jun D , Kuca K , Kovarik Z
Ref : Toxicology , 228 :41 , 2006
PubMedID: 16982122

Title : A comparison of the efficacy of new asymmetric bispyridinium oximes (K027, K048) with currently available oximes against tabun by in vivo methods - Kassa_2006_J.Toxicol.Environ.Health.A_69_1875
Author(s) : Kassa J , Kuca K , Cabal J , Paar M
Ref : J Toxicol Environ Health A , 69 :1875 , 2006
PubMedID: 16952906

Title : In vitro potency of H oximes (HI-6, HLo-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase - Kuca_2006_J.Toxicol.Environ.Health.A_69_1431
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : J Toxicol Environ Health A , 69 :1431 , 2006
PubMedID: 16766478

Title : Substituted monoquaternary oximes as reactivators of cyclosarin--and chlorpyrifos--inhibited acetylcholinesterase - Racakova_2006_Arh.Hig.Rada.Toksikol_57_387
Author(s) : Racakova V , Hrabinova M , Jun D , Kuca K
Ref : Arh Hig Rada Toksikol , 57 :387 , 2006
PubMedID: 17265677

Title : Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes - Kuca_2006_Acta.Medica.(Hradec.Kralove)_49_233
Author(s) : Kuca K , Picha J , Jun D
Ref : Acta Medica (Hradec Kralove) , 49 :233 , 2006
PubMedID: 17438836

Title : [Synthesis of reactivators of phosphorylated acetylcholinesterase of bis-pyridiniumdialdoxime type with a 3-oxapentane connecting chain and their testing in vitro on a model of the enzyme inhibited by chlorpyrifos and methylchlorpyrifos] - Musilek_2006_Ceska.Slov.Farm_55_115
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Kim TH , Jung YS , Dolezal M
Ref : Ceska a Slovenska Farmacie , 55 :115 , 2006
PubMedID: 16838488

Title : A comparison of the potency of the oxime HLo-7 and currently used oximes (HI-6, pralidoxime, obidoxime) to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_Acta.Medica.(Hradec.Kralove)_48_81
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : Acta Medica (Hradec Kralove) , 48 :81 , 2005
PubMedID: 16259317

Title : Bispyridinium oximes as antidotal treatment of cyclosarin poisoning-in vitro and in vivo testing - Bartosova_2005_Int.J.Toxicol_24_399
Author(s) : Bartosova L , Kuca K , Jun D , Kunesova G
Ref : Int J Toxicol , 24 :399 , 2005
PubMedID: 16393932

Title : Computer Modeling and Simulation - New Technologies in Development of Means against Combat Chemical Substances - Wiesner_2005_Mil.Med.Sci.Lett_74_165
Author(s) : Wiesner J , Kriz Z , Kuca K , Jun D , Koca J
Ref : Military Medical Science Letters , 74 :165 , 2005
PubMedID:

Title : A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2005_J.Toxicol.Environ.Health.A_68_677
Author(s) : Kuca K , Cabal J , Kassa J
Ref : J Toxicol Environ Health A , 68 :677 , 2005
PubMedID: 15901095

Title : A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents - Picha_2005_J.Enzyme.Inhib.Med.Chem_20_233
Author(s) : Picha J , Kuca K , Kivala M , Kohout M , Cabal J , Liska F
Ref : J Enzyme Inhib Med Chem , 20 :233 , 2005
PubMedID: 16119193

Title : New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications - Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_75
Author(s) : Kuca K , Bartosova L , Jun D , Patocka J , Cabal J , Kassa J , Kunesova G
Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :75 , 2005
PubMedID: 16170392

Title : In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions - Kuca_2005_J.Appl.Toxicol_25_296
Author(s) : Kuca K , Cabal J , Jun D , Kassa J , Bartosova L , Kunesova G
Ref : J Appl Toxicol , 25 :296 , 2005
PubMedID: 16025528

Title : Effective bisquaternary reactivators of tabun-inhibited AChE - Kuca_2005_J.Appl.Toxicol_25_491
Author(s) : Kuca K , Cabal J , Musilek K , Jun D , Bajgar J
Ref : J Appl Toxicol , 25 :491 , 2005
PubMedID: 16092078

Title : A comparison of the potency of trimedoxime and other currently available oximes to reactivate tabun-inhibited acetylcholinesterase and eliminate acute toxic effects of tabun - Kassa_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_419
Author(s) : Kassa J , Kuca K , Cabal J
Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :419 , 2005
PubMedID: 16601802

Title : Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents - Kim_2005_Bioorg.Med.Chem.Lett_15_2914
Author(s) : Kim TH , Kuca K , Jun D , Jung YS
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :2914 , 2005
PubMedID: 15911280

Title : In vitro inactivation of rat brain acetylcholinesterase by DSP-4 and its derivatives OS-21 and OS-23 and protective activity of tacrine (9-amino-1,2,3,4-tetrahydroacridine) - Patocka_2005_Acta.Medica.(Hradec.Kralove)_48_145
Author(s) : Patocka J , Jun D , Kuca K
Ref : Acta Medica (Hradec Kralove) , 48 :145 , 2005
PubMedID: 16640027

Title : Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo - Kuca_2005_Chem.Biol.Interact_157-158_367
Author(s) : Kuca K , Bartosova L , Kassa J , Cabal J , Bajgar J , Kunesova G , Jun D
Ref : Chemico-Biological Interactions , 157-158 :367 , 2005
PubMedID: 16429489

Title : Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings - Kuca_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_429
Author(s) : Kuca K , Cabal J , Jun D , Kassa J , Bartosova L , Kunesova G , Dohnal V
Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :429 , 2005
PubMedID: 16601804

Title : [A comparison of the efficacy of the reactivators of acetylcholinesterase inhibited with tabun] - Cabal_2005_Ceska.Slov.Farm_54_192
Author(s) : Cabal J , Kuca K , Jun D , Bajgar J , Hrabinova M
Ref : Ceska a Slovenska Farmacie , 54 :192 , 2005
PubMedID: 16124202

Title : Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain - Kuca_2005_J.Appl.Toxicol_25_271
Author(s) : Kuca K , Cabal J , Kassa J , Jun D , Hrabinova M
Ref : J Appl Toxicol , 25 :271 , 2005
PubMedID: 16021679

Title : Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats - Bartosova_2005_Biomed.Pap.Med.Fac.Univ.Palacky.Olomouc.Czech.Repub_149_425
Author(s) : Bartosova L , Kuca K , Kunesova G
Ref : Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub , 149 :425 , 2005
PubMedID: 16601803

Title : Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin nerve agent - Kuca_2005_Toxicol.Mech.Methods_15_247
Author(s) : Kuca K , Cabal J
Ref : Toxicol Mech Methods , 15 :247 , 2005
PubMedID: 20021089

Title : Antidotal treatment of GF-agent intoxication in mice with bispyridinium oximes - Sevelova_2005_Toxicology_207_1
Author(s) : Sevelova L , Kuca K , Krejcova-Kunesova G
Ref : Toxicology , 207 :1 , 2005
PubMedID: 15590116

Title : Comparison of ability of some oximes to reactivate sarin-inhibited brain acetylcholinesterase from different species - Jun_2005_Chem.Biol.Interact_157-158_385
Author(s) : Jun D , Kuca K , Cabal J , Bartosova L , Kunesova G , Kassa J
Ref : Chemico-Biological Interactions , 157-158 :385 , 2005
PubMedID: 16429518

Title : Signs of cyclosarin-induced neurotoxicity and its pharmacological treatment with quaternary pyridinium-oximes reactivators - Krejcova-Kunesova_2005_Toxicology_216_32
Author(s) : Krejcova-Kunesova G , Bartosova L , Kuca K
Ref : Toxicology , 216 :32 , 2005
PubMedID: 16126317

Title : Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase - Musilek_2005_J.Enzyme.Inhib.Med.Chem_20_409
Author(s) : Musilek K , Kuca K , Jun D , Dohnal V , Dolezal M
Ref : J Enzyme Inhib Med Chem , 20 :409 , 2005
PubMedID: 16335048

Title : In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximes - Kuca_2005_J.Enzyme.Inhib.Med.Chem_20_227
Author(s) : Kuca K , Cabal J , Kassa J
Ref : J Enzyme Inhib Med Chem , 20 :227 , 2005
PubMedID: 16119192

Title : Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body - Patocka_2004_Acta.Medica.(Hradec.Kralove)_47_215
Author(s) : Patocka J , Kuca K , Jun D
Ref : Acta Medica (Hradec Kralove) , 47 :215 , 2004
PubMedID: 15841900

Title : In vitro reactivation of acetylcholinesterase inhibited by cyclosarin using bisquaternary pyridinium aldoximes K005, K033, K027 AND K048 - Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_107
Author(s) : Kuca K , Sevelova-Bartosova L , Krejcova-Kunesova G
Ref : Acta Medica (Hradec Kralove) , 47 :107 , 2004
PubMedID: 15446359

Title : 1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents - Kuca_2004_Acta.Medica.(Hradec.Kralove)_47_167
Author(s) : Kuca K , Dohnal V
Ref : Acta Medica (Hradec Kralove) , 47 :167 , 2004
PubMedID: 15568733

Title : In vitro reactivation of tabun-inhibited acetylcholinesterase using new oximes--K027, K005, K033 and K048 - Kuca_2004_Cent.Eur.J.Public.Health_12 Suppl_S59
Author(s) : Kuca K , Cabal J
Ref : Central European Journal of Public Health , 12 Suppl :S59 , 2004
PubMedID: 15141981

Title : In vitro reactivation of acetylcholinesterase using the oxime K027 - Kuca_2004_Vet.Hum.Toxicol_46_15
Author(s) : Kuca K , Kassa J
Ref : Vet Hum Toxicol , 46 :15 , 2004
PubMedID: 14748409

Title : Oximes-induced reactivation of rat brain acetylcholinesterase inhibited by VX agent - Kuca_2004_Hum.Exp.Toxicol_23_167
Author(s) : Kuca K , Kassa J
Ref : Hum Exp Toxicol , 23 :167 , 2004
PubMedID: 15171567

Title : A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods - Kuca_2004_Pharmazie_59_795
Author(s) : Kuca K , Cabal J , Kassa J
Ref : Pharmazie , 59 :795 , 2004
PubMedID: 15544060

Title : Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes - Kuca_2004_Neurotox.Res_6_565
Author(s) : Kuca K , Patocka J , Cabal J , Jun D
Ref : Neurotox Res , 6 :565 , 2004
PubMedID: 15639788

Title : Pharmacological Prophylaxis and Antidotal Treatment of Acute Tabun Poisoning - Kassa_2004_Mil.Med.Sci.Lett_73_107
Author(s) : Kassa J , Kunesova G , Vachek J , Kuca K , Cabal J
Ref : Military Medical Science Letters , 73 :107 , 2004
PubMedID:

Title : Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase - Cabal_2004_Basic.Clin.Pharmacol.Toxicol_95_81
Author(s) : Cabal J , Kuca K , Kassa J
Ref : Basic Clin Pharmacol Toxicol , 95 :81 , 2004
PubMedID: 15379785

Title : Cyclodextrines as functional agents for decontamination of the skin contaminated by nerve agents - Cabal_2004_Acta.Medica.(Hradec.Kralove)_47_115
Author(s) : Cabal J , Kuca K , Sevelova-Bartosova L , Dohnal V
Ref : Acta Medica (Hradec Kralove) , 47 :115 , 2004
PubMedID: 15446361

Title : Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes - Kuca_2004_J.Enzyme.Inhib.Med.Chem_19_39
Author(s) : Kuca K , Patocka J
Ref : J Enzyme Inhib Med Chem , 19 :39 , 2004
PubMedID: 15202491

Title : Therapeutic efficacy of different antidotal mixtures against poisoning with GF-agent in mice - Bartosova_2004_Acta.Medica.(Hradec.Kralove)_47_249
Author(s) : Bartosova L , Kunesova G , Kuca K , Vachek J
Ref : Acta Medica (Hradec Kralove) , 47 :249 , 2004
PubMedID: 15841904

Title : A comparison of the ability of a new bispyridinium oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods - Kuca_2003_J.Enzyme.Inhib.Med.Chem_18_529
Author(s) : Kuca K , Kassa J
Ref : J Enzyme Inhib Med Chem , 18 :529 , 2003
PubMedID: 15008517

Title : Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase - Kuca_2003_Bioorg.Med.Chem.Lett_13_3545
Author(s) : Kuca K , Bielavsky J , Cabal J , Kassa J
Ref : Bioorganic & Medicinal Chemistry Lett , 13 :3545 , 2003
PubMedID: 14505667