Khan_2014_Bioorg.Med.Chem_22_6509

A series of Schiff base triazoles 1-25 was synthesized and evaluated for their nucleotide pyrophosphatase/phosphodiesterase-1 inhibitory activities. Among twenty-five compounds, three compounds 10 (IC50=132.20+/-2.89muM), 13 (IC50=152.83+/-2.39muM), and 22 (IC50=251.0+/-6.64muM) were identified as potent inhibitors with superior activities than the standard EDTA (IC50=277.69+/-2.52muM). The newly identified inhibitors may open a new avenue for the development of treatment of phosphodiesterase-I related disorders. These compounds were also evaluated for carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitory potential and were found to be inactive. The compounds showed non-toxic effect towards PC3 cell lines.