| Title : An efficient ionic liquid mediated synthesis, cholinesterase inhibitory activity and molecular modeling study of novel piperidone embedded alpha,beta-unsaturated ketones - Kia_2014_Med.Chem_10_512 |
| Author(s) : Kia Y , Osman H , Kumar RS , Murugaiyah V , Basiri A , Khaw KY , Rosli MM |
| Ref : Med Chem , 10 :512 , 2014 |
|
Abstract :
A series of hitherto unreported piperidone embedded alpha,beta-unsaturated ketones were synthesized efficiently in ionic solvent and evaluated for cholinesterase inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Most of the synthesized compounds displayed good enzyme inhibition; therein compounds 7i and 7f displayed significant activity against AChE with IC50 values of 1.47 and 1.74 microM, respectively. Compound 6g showed the highest BChE inhibitory potency with IC50 value of 3.41 microM, being 5 times more potent than galanthamine. Molecular modeling simulation was performed using AChE and BChE receptors extracted from crystal structure of human AChE and human BChE to determine the amino acid residues involved in the binding interaction of synthesized compounds and their relevant receptors. |
| PubMedSearch : Kia_2014_Med.Chem_10_512 |
| PubMedID: 24138113 |
Kia Y, Osman H, Kumar RS, Murugaiyah V, Basiri A, Khaw KY, Rosli MM (2014)
An efficient ionic liquid mediated synthesis, cholinesterase inhibitory activity and molecular modeling study of novel piperidone embedded alpha,beta-unsaturated ketones
Med Chem
10 :512
Kia Y, Osman H, Kumar RS, Murugaiyah V, Basiri A, Khaw KY, Rosli MM (2014)
Med Chem
10 :512