Kim_2018_Immunol.Lett_198_60

Reference

Title : DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis - Kim_2018_Immunol.Lett_198_60
Author(s) : Kim M , von Muenchow L , Le Meur T , Kueng B , Gapp B , Weber D , Dietrich W , Kovarik J , Rolink AG , Ksiazek I
Ref : Immunol Lett , 198 :60 , 2018
Abstract :

Dipeptidyl peptidase 9 (DPP9) is a ubiquitously expressed intracellular prolyl peptidase implicated in immunoregulation. However, its physiological relevance in the immune system remains largely unknown. We investigated the role of DPP9 enzyme in immune system by characterizing DPP9 knock-in mice expressing a catalytically inactive S729A mutant of DPP9 enzyme (DPP9(ki/ki) mice). DPP9(ki/ki) mice show reduced number of lymphoid and myeloid cells in fetal liver and postnatal blood but their hematopoietic cells are fully functional and able to reconstitute lymphoid and myeloid lineages even in competitive mixed chimeras. These studies demonstrate that inactivation of DPP9 enzymatic activity does not lead to any perturbations in mouse hematopoiesis.

PubMedSearch : Kim_2018_Immunol.Lett_198_60
PubMedID: 29709545
Gene_locus related to this paper: human-DPP9 , mouse-dpp9

Related information

Gene_locus human-DPP9    mouse-dpp9

Citations formats

Kim M, von Muenchow L, Le Meur T, Kueng B, Gapp B, Weber D, Dietrich W, Kovarik J, Rolink AG, Ksiazek I (2018)
DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis
Immunol Lett 198 :60

Kim M, von Muenchow L, Le Meur T, Kueng B, Gapp B, Weber D, Dietrich W, Kovarik J, Rolink AG, Ksiazek I (2018)
Immunol Lett 198 :60