human-DPP9
Homo sapiens (Human) dipeptidyl peptidase 9 DPP9 DPRP2
Comment
DPP8 and DPP9 are cytosolic peptidases. Have dpp activity similar to dpp4. The first identified endogenous DPP9 substrate is the tumor epitope RU1(34-42) (VPYGSFKHV). DPP9 is important in the immune system, DNA repair and mitochondria homeostasis. Inhibition or silencing of DPP9, but not DPP8, led to increased presentation of this antigen on MHC class I alleles to cytotoxic T-cells, linking DPP9 to the MHC class I antigen presentation pathway. Small ubiquitin-like protein modifier SUMO1 acts as an allosteric activator of DPP9. By binding to an armlike motif in DPP9\; DPP9 functions as an endogenous inhibitor of NLRP1 inflammasome. DPP9 interacts with a unique autoproteolytic domain (Function to Find Domain (FIIND)) found in NLRP1 and CARD8. DPP9 acts as a molecular switch that regulates key proteins, such as the tumor-suppressor BRCA2. Hatipoglu immunodeficiency syndrome\; HATIS. The symptoms associated with this monogenic disease partially overlapped with those of AIADK caused by an NLRP1 gain-of-function mutation. These included failure to thrive (consisting of poor weight gain,growing below the third percentile),skin manifestations, pancytopenia, and susceptibility to infections, which required hematopoietic stem cell transplant. The stop-gain mutations were expected to completely abolish the enzymatic activity of DPP9.
Relationship
Family : DPP4N_Peptidase_S9
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
6EOQ - Human dipeptidyl peptidases 9 - DPP9 - Apo (replaces 6T6S withdrawn)
6EOR - Human dipeptidyl peptidases 9 - DPP9 - 1G244
6QZV - DPP9 bound to a dipeptide (MP) from the N-terminus of BRCA2
6X6A - Cryo-EM structure of NLRP1-DPP9 complex
6X6C - Cryo-EM structure of NLRP1-DPP9-VbP complex
7A3F - Crystal structure of apo DPP9
7JKQ - Human Dipeptidyl peptidase 9 (DPP9) - Caspase recruitment domain-containing protein 8 (CARD8) complex
7JN7 - Human Dipeptidyl peptidase 9 (DPP9) - Caspase recruitment domain-containing protein 8 (CARD8) complex
7SVL - Human Dipeptidyl peptidase 9 (DPP9) - ICeD-2 (inducer of cell death-2) complex
7SVN - Human Dipeptidyl peptidase 9 (DPP9) - ICeD-1 (inducer of cell death-1) complex
7ZXS - Crystal structure of DPP9 in complex with a 4-oxo-b-lactam based inhibitor, A295
9GOC - Crystal structure of DPP9 Ser730Ala in complex with sulphostin
9GOD - Crystal structure of DPP9 in complex with N-phosphono-(S)-3-aminopiperidine-2-one-based inhibitor
9GON - Crystal structure of DPP9 in complex with sulphostin
No kinetic
Sequence
Peptide
RRVPCVRRGC RPPLPPLPGS QSRAWSRDRE APLDPGRPAQ SGRRPTSRSV SHACSWNGGS LDPLEGTPAL LRSAERLMRK VKKLRLDKEN TGSWRSFSLN SEGAERMATT GTPTADRGDA AATDDPAARF QVQKHSWDGL RSIIHGSRKY SGLIVNKAPH DFQFVQKTDE SGPHSHRLYY LGMPYGSREN SLLYSEIPKK VRKEALLLLS WKQMLDHFQA TPHHGVYSRE EELLRERKRL GVFGITSYDF HSESGLFLFQ ASNSLFHCRD GGKNGFMVSP MKPLEIKTQC SGPRMDPKIC PADPAFFSFN NNSDLWVANI ETGEERRLTF CHQGLSNVLD DPKSAGVATF VIQEEFDRFT GYWWCPTASW EGSEGLKTLR ILYEEVDESE VEVIHVPSPA LEERKTDSYR YPRTGSKNPK IALKLAEFQT DSQGKIVSTQ EKELVQPFSS LFPKVEYIAR AGWTRDGKYA WAMFLDRPQQ WLQLVLLPPA LFIPSTENEE QRLASARAVP RNVQPYVVYE EVTNVWINVH DIFYPFPQSE GEDELCFLRA NECKTGFCHL YKVTAVLKSQ GYDWSEPFSP GEDEFKCPIK EEIALTSGEW EVLARHGSKI WVNEETKLVY FQGTKDTPLE HHLYVVSYEA AGEIVRLTTP GFSHSCSMSQ NFDMFVSHYS SVSTPPCVHV YKLSGPDDDP LHKQPRFWAS MMEAASCPPD YVPPEIFHFH TRSDVRLYGM IYKPHALQPG KKHPTVLFVY GGPQVQLVNN SFKGIKYLRL NTLASLGYAV VVIDGRGSCQ RGLRFEGALK NQMGQVEIED QVEGLQFVAE KYGFIDLSRV AIHGWSYGGF LSLMGLIHKP QVFKVAIAGA PVTVWMAYDT GYTERYMDVP ENNQHGYEAG SVALHVEKLP NEPNRLLILH GFLDENVHFF HTNFLVSQLI RAGKPYQLQI YPNERHSIRC PESGEHYEVT LLHFLQEYL
References (51)
| Title : Active site-directed probes targeting dipeptidyl peptidases 8 and 9 - Espadinha_2024_Eur.J.Med.Chem_270_116389 |
| Author(s) : Espadinha M , De Loose J , Corthaut S , Thys S , Van Rymenant Y , Verhulst E , Benramdane S , Filippi N , Augustyns K , Van Wielendaele P , Pintelon I , De Meester I , Van der Veken P |
| Ref : Eur Journal of Medicinal Chemistry , 270 :116389 , 2024 |
| Abstract : |
| PubMedSearch : Espadinha_2024_Eur.J.Med.Chem_270_116389 |
| PubMedID: 38593588 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : N-terminal processing by dipeptidyl peptidase 9: Cut and Go! - Zolg_2024_Biochimie__ |
| Author(s) : Zolg S , Donzelli L , Geiss-Friedlander R |
| Ref : Biochimie , : , 2024 |
| Abstract : |
| PubMedSearch : Zolg_2024_Biochimie__ |
| PubMedID: 38461970 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer - Hess_2024_Biochim.Biophys.Acta.Mol.Basis.Dis__167133 |
| Author(s) : Hess L , Aliar K , Grunwald BT , Griffin R , Lozan A , Knoller M , Khokha R , Brummer T , Reinheckel T |
| Ref : Biochimica & Biophysica Acta Mol Basis Dis , :167133 , 2024 |
| Abstract : |
| PubMedSearch : Hess_2024_Biochim.Biophys.Acta.Mol.Basis.Dis__167133 |
| PubMedID: 38531482 |
| Gene_locus related to this paper: human-DPP9 , mouse-dpp9 |
| Title : Non-Specific Inhibition of Dipeptidyl Peptidases 8\/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation - Torrecillas-Baena_2023_J.Clin.Med_12_4632 |
| Author(s) : Torrecillas-Baena B , Camacho-Cardenosa M , Quesada-Gomez JM , Moreno-Moreno P , Dorado G , Galvez-Moreno M , Casado-Diaz A |
| Ref : J Clin Med , 12 :4632 , 2023 |
| Abstract : |
| PubMedSearch : Torrecillas-Baena_2023_J.Clin.Med_12_4632 |
| PubMedID: 37510747 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Structural and Biochemical Insights into Bis(2-hydroxyethyl) Terephthalate Degrading Carboxylesterase Isolated from Psychrotrophic Bacterium Exiguobacterium antarcticum - Hwang_2023_Int.J.Mol.Sci_24_12022 |
| Author(s) : Hwang J , Yoo W , Shin SC , Kim KK , Kim HW , Do H , Lee JH |
| Ref : Int J Mol Sci , 24 :12022 , 2023 |
| Abstract : |
| PubMedSearch : Hwang_2023_Int.J.Mol.Sci_24_12022 |
| PubMedID: 37569396 |
| Gene_locus related to this paper: human-DPP9 , exiab-k0afs0 |
| Title : DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma - Chang_2023_Cancer.Res__ |
| Author(s) : Chang K , Chen Y , Zhang X , Zhang W , Xu N , Zeng B , Wang Y , Feng T , Dai B , Xu F , Ye D , Wang C |
| Ref : Cancer Research , : , 2023 |
| Abstract : |
| PubMedSearch : Chang_2023_Cancer.Res__ |
| PubMedID: 37713596 |
| Gene_locus related to this paper: human-DPP9 |
| Title : DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1\/IL-1 signaling - Harapas_2022_Sci.Immunol_7_eabi4611 |
| Author(s) : Harapas CR , Robinson KS , Lay K , Wong J , Moreno Traspas R , Nabavizadeh N , Rass-Rothschild A , Boisson B , Drutman SB , Laohamonthonkul P , Bonner D , Xiong JR , Gorrell MD , Davidson S , Yu CH , Fleming MD , Gudera J , Stein J , Ben-Harosh M , Groopman E , Shimamura A , Tamary H , Kayserili H , Hatipoglu N , Casanova JL , Bernstein JA , Zhong FL , Masters SL , Reversade B |
| Ref : Sci Immunol , 7 :eabi4611 , 2022 |
| Abstract : |
| PubMedSearch : Harapas_2022_Sci.Immunol_7_eabi4611 |
| PubMedID: 36112693 |
| Gene_locus related to this paper: human-DPP9 |
| Title : A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells - Moore_2022_ACS.Chem.Biol_17_2595 |
| Author(s) : Moore KP , Schwaid AG , Tudor M , Park S , Beshore DC , Converso A , Shipe WD , Anand R , Lan P , Moningka R , Rothman DM , Sun W , Chi A , Cornella-Taracido I , Adam GC , Bahnck-Teets C , Carroll SS , Fay JF , Goh SL , Lusen J , Quan S , Rodriguez S , Xu M , Andrews CL , Song C , Filzen T , Li J , Hollenstein K , Klein DJ , Lammens A , Lim UM , Fang Z , McHale C , Li Y , Lu M , Diamond TL , Howell BJ , Zuck P , Balibar CJ |
| Ref : ACS Chemical Biology , 17 :2595 , 2022 |
| Abstract : |
| PubMedSearch : Moore_2022_ACS.Chem.Biol_17_2595 |
| PubMedID: 36044633 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 - Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| Author(s) : Carvalho LAR , Ross B , Fehr L , Bolgi O , Wohrle S , Lum KM , Podlesainski D , Vieira AC , Kiefersauer R , Felix R , Rodrigues T , Lucas SD , Gross O , Geiss-Friedlander R , Cravatt BF , Huber R , Kaiser M , Moreira R |
| Ref : Angew Chem Int Ed Engl , : , 2022 |
| Abstract : |
| PubMedSearch : Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498 |
| PubMedID: 36089535 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : New insights into the role of dipeptidyl peptidase 8 and dipeptidyl peptidase 9 and their inhibitors - Cui_2022_Front.Pharmacol_13_1002871 |
| Author(s) : Cui C , Tian X , Wei L , Wang Y , Wang K , Fu R |
| Ref : Front Pharmacol , 13 :1002871 , 2022 |
| Abstract : |
| PubMedSearch : Cui_2022_Front.Pharmacol_13_1002871 |
| PubMedID: 36172198 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair - Bolgi_2022_EMBO.Rep__e54136 |
| Author(s) : Bolgi O , Silva-Garcia M , Ross B , Pilla E , Kari V , Killisch M , Spitzner M , Stark N , Lenz C , Weiss K , Donzelli L , Gorrell MD , Grade M , Riemer J , Urlaub H , Dobbelstein M , Huber R , Geiss-Friedlander R |
| Ref : EMBO Rep , :e54136 , 2022 |
| Abstract : |
| PubMedSearch : Bolgi_2022_EMBO.Rep__e54136 |
| PubMedID: 35912982 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells - Zhang_2021_Pharmacol.Res_169_105630 |
| Author(s) : Zhang Y , Li K , Li Y , Zhao W , Wang L , Chen Z , Ma X , Yao T , Wang J , Dong W , Li X , Tian X , Fu R |
| Ref : Pharmacol Res , 169 :105630 , 2021 |
| Abstract : |
| PubMedSearch : Zhang_2021_Pharmacol.Res_169_105630 |
| PubMedID: 33932609 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation - Hollingsworth_2021_Nature_592_778 |
| Author(s) : Hollingsworth LR , Sharif H , Griswold AR , Fontana P , Mintseris J , Dagbay KB , Paulo JA , Gygi SP , Bachovchin DA , Wu H |
| Ref : Nature , 592 :778 , 2021 |
| Abstract : |
| PubMedSearch : Hollingsworth_2021_Nature_592_778 |
| PubMedID: 33731932 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment - Sharif_2021_Immunity__ |
| Author(s) : Sharif H , Hollingsworth LR , Griswold AR , Hsiao JC , Wang Q , Bachovchin DA , Wu H |
| Ref : Immunity , : , 2021 |
| Abstract : |
| PubMedSearch : Sharif_2021_Immunity__ |
| PubMedID: 34019797 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Structural mechanism of CARD8 regulation by DPP9 - Sharif_2021_Biorxiv__ |
| Author(s) : Sharif H , Hollingsworth LR , Griswold AR , Hsiao JC , Wang QH , Bachovchin DA , Wu H |
| Ref : Biorxiv , : , 2021 |
| Abstract : |
| PubMedSearch : Sharif_2021_Biorxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-DPP9 |
| Title : Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair - Silva-Garcia_2020_Biorxiv__ |
| Author(s) : Silva-Garcia M , Bolgi O , Ross B , Pilla E , Kari V , Killisch M , Stark N , Lenz C , Spitzner M , Gorrell MD , Grade M , Urlaub H , Dobbelstein M , Huber R , Geiss-Friedlander R |
| Ref : Biorxiv , : , 2020 |
| Abstract : |
| PubMedSearch : Silva-Garcia_2020_Biorxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Activation of the CARD8 Inflammasome Requires a Disordered Region - Chui_2020_Cell.Rep_33_108264 |
| Author(s) : Chui AJ , Griswold AR , Taabazuing CY , Orth EL , Gai K , Rao SD , Ball DP , Hsiao JC , Bachovchin DA |
| Ref : Cell Rep , 33 :108264 , 2020 |
| Abstract : |
| PubMedSearch : Chui_2020_Cell.Rep_33_108264 |
| PubMedID: 33053349 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : DPP9 directly sequesters the NLRP1 C-terminus to repress inflammasome activation - Hollingsworth_2020_Biorxiv__ |
| Author(s) : Hollingsworth LR , Sharif H , Griswold AR , Fontana P , Mintseris J , Dagbay KB , Paulo JA , Gygi SP , Bachovchin DA , Wu |
| Ref : Biorxiv , : , 2020 |
| Abstract : |
| PubMedSearch : Hollingsworth_2020_Biorxiv__ |
| PubMedID: |
| Gene_locus related to this paper: human-DPP9 |
| Title : CARD8 inflammasome activation triggers pyroptosis in human T cells - Linder_2020_EMBO.J__e105071 |
| Author(s) : Linder A , Bauernfried S , Cheng Y , Albanese M , Jung C , Keppler OT , Hornung V |
| Ref : EMBO Journal , :e105071 , 2020 |
| Abstract : |
| PubMedSearch : Linder_2020_EMBO.J__e105071 |
| PubMedID: 32840892 |
| Gene_locus related to this paper: human-DPP9 |
| Title : The NLRP1 and CARD8 inflammasomes - Taabazuing_2020_Immunol.Rev_297_13 |
| Author(s) : Taabazuing CY , Griswold AR , Bachovchin DA |
| Ref : Immunol Rev , 297 :13 , 2020 |
| Abstract : |
| PubMedSearch : Taabazuing_2020_Immunol.Rev_297_13 |
| PubMedID: 32558991 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Proteasomal degradation induced by DPP9-mediated processing competes with mitochondrial protein import - Finger_2020_EMBO.J__e103889 |
| Author(s) : Finger Y , Habich M , Gerlich S , Urbanczyk S , van de Logt E , Koch J , Schu L , Lapacz KJ , Ali M , Petrungaro C , Salscheider SL , Pichlo C , Baumann U , Mielenz D , Dengjel J , Brachvogel B , Hofmann K , Riemer J |
| Ref : EMBO Journal , :e103889 , 2020 |
| Abstract : |
| PubMedSearch : Finger_2020_EMBO.J__e103889 |
| PubMedID: 32815200 |
| Gene_locus related to this paper: human-DPP9 |
| Title : DPP8\/9 inhibitors are universal activators of functional NLRP1 alleles - Gai_2019_Cell.Death.Dis_10_587 |
| Author(s) : Gai K , Okondo MC , Rao SD , Chui AJ , Ball DP , Johnson DC , Bachovchin DA |
| Ref : Cell Death Dis , 10 :587 , 2019 |
| Abstract : |
| PubMedSearch : Gai_2019_Cell.Death.Dis_10_587 |
| PubMedID: 31383852 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : DPP8\/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages - de Vasconcelos_2019_Life.Sci.Alliance_2_ |
| Author(s) : de Vasconcelos NM , Vliegen G , Goncalves A , De Hert E , Martin-Perez R , Van Opdenbosch N , Jallapally A , Geiss-Friedlander R , Lambeir AM , Augustyns K , Van der Veken P , De Meester I , Lamkanfi M |
| Ref : Life Sciences Alliance , 2 : , 2019 |
| Abstract : |
| PubMedSearch : de Vasconcelos_2019_Life.Sci.Alliance_2_ |
| PubMedID: 30718379 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma - Brunetti_2019_Virchows.Arch_474_177 |
| Author(s) : Brunetti M , Holth A , Panagopoulos I , Staff AC , Micci F , Davidson B |
| Ref : Virchows Arch , 474 :177 , 2019 |
| Abstract : |
| PubMedSearch : Brunetti_2019_Virchows.Arch_474_177 |
| PubMedID: 30467600 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : DPP9's Enzymatic Activity and Not Its Binding to CARD8 Inhibits Inflammasome Activation - Griswold_2019_ACS.Chem.Biol_14_2424 |
| Author(s) : Griswold AR , Ball DP , Bhattacharjee A , Chui AJ , Rao SD , Taabazuing CY , Bachovchin DA |
| Ref : ACS Chemical Biology , 14 :2424 , 2019 |
| Abstract : |
| PubMedSearch : Griswold_2019_ACS.Chem.Biol_14_2424 |
| PubMedID: 31525884 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity - Gall_2019_Sci.Rep_9_7292 |
| Author(s) : Gall MG , Zhang HE , Lee Q , Jolly CJ , McCaughan GW , Cook A , Roediger B , Gorrell MD |
| Ref : Sci Rep , 9 :7292 , 2019 |
| Abstract : |
| PubMedSearch : Gall_2019_Sci.Rep_9_7292 |
| PubMedID: 31086209 |
| Gene_locus related to this paper: human-DPP9 |
| Title : DPP9 enzymatic activity in hematopoietic cells is dispensable for mouse hematopoiesis - Kim_2018_Immunol.Lett_198_60 |
| Author(s) : Kim M , von Muenchow L , Le Meur T , Kueng B , Gapp B , Weber D , Dietrich W , Kovarik J , Rolink AG , Ksiazek I |
| Ref : Immunol Lett , 198 :60 , 2018 |
| Abstract : |
| PubMedSearch : Kim_2018_Immunol.Lett_198_60 |
| PubMedID: 29709545 |
| Gene_locus related to this paper: human-DPP9 , mouse-dpp9 |
| Title : DPP8\/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia - Johnson_2018_Nat.Med_24_1151 |
| Author(s) : Johnson DC , Taabazuing CY , Okondo MC , Chui AJ , Rao SD , Brown FC , Reed C , Peguero E , de Stanchina E , Kentsis A , Bachovchin DA |
| Ref : Nat Med , 24 :1151 , 2018 |
| Abstract : |
| PubMedSearch : Johnson_2018_Nat.Med_24_1151 |
| PubMedID: 29967349 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Inhibition of Dpp8\/9 Activates the Nlrp1b Inflammasome - Okondo_2018_Cell.Chem.Biol_25_262 |
| Author(s) : Okondo MC , Rao SD , Taabazuing CY , Chui AJ , Poplawski SE , Johnson DC , Bachovchin DA |
| Ref : Cell Chemical Biology , 25 :262 , 2018 |
| Abstract : |
| PubMedSearch : Okondo_2018_Cell.Chem.Biol_25_262 |
| PubMedID: 29396289 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer - Ross_2018_Proc.Natl.Acad.Sci.U.S.A_115_E1437 |
| Author(s) : Ross B , Krapp S , Augustin M , Kierfersauer R , Arciniega M , Geiss-Friedlander R , Huber R |
| Ref : Proc Natl Acad Sci U S A , 115 :E1437 , 2018 |
| Abstract : |
| PubMedSearch : Ross_2018_Proc.Natl.Acad.Sci.U.S.A_115_E1437 |
| PubMedID: 29382749 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding - Zhong_2018_J.Biol.Chem_293_18864 |
| Author(s) : Zhong FL , Robinson K , Teo DET , Tan KY , Lim C , Harapas CR , Yu CH , Xie WH , Sobota RM , Au VB , Hopkins R , D'Osualdo A , Reed JC , Connolly JE , Masters SL , Reversade B |
| Ref : Journal of Biological Chemistry , 293 :18864 , 2018 |
| Abstract : |
| PubMedSearch : Zhong_2018_J.Biol.Chem_293_18864 |
| PubMedID: 30291141 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes - Koyani_2018_Front.Physiol_9_1622 |
| Author(s) : Koyani CN , Trummer C , Shrestha N , Scheruebel S , Bourgeois B , Plastira I , Kickmaier S , Sourij H , Rainer PP , Madl T , Sattler W , Pelzmann B , Malle E , von Lewinski D |
| Ref : Front Physiol , 9 :1622 , 2018 |
| Abstract : |
| PubMedSearch : Koyani_2018_Front.Physiol_9_1622 |
| PubMedID: 30487758 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages - Taabazuing_2017_Cell.Chem.Biol_24_507 |
| Author(s) : Taabazuing CY , Okondo MC , Bachovchin DA |
| Ref : Cell Chemical Biology , 24 :507 , 2017 |
| Abstract : |
| PubMedSearch : Taabazuing_2017_Cell.Chem.Biol_24_507 |
| PubMedID: 28392147 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis - Okondo_2017_Nat.Chem.Biol_13_46 |
| Author(s) : Okondo MC , Johnson DC , Sridharan R , Go EB , Chui AJ , Wang MS , Poplawski SE , Wu W , Liu Y , Lai JH , Sanford DG , Arciprete MO , Golub TR , Bachovchin WW , Bachovchin DA |
| Ref : Nat Chemical Biology , 13 :46 , 2017 |
| Abstract : |
| PubMedSearch : Okondo_2017_Nat.Chem.Biol_13_46 |
| PubMedID: 27820798 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Expression, subcellular localisation, and possible roles of dipeptidyl peptidase 9 (DPP9) in murine macrophages - Zapletal_2017_Cell.Biochem.Funct_35_124 |
| Author(s) : Zapletal E , Cupic B , Gabrilovac J |
| Ref : Cell Biochemistry & Function , 35 :124 , 2017 |
| Abstract : |
| PubMedSearch : Zapletal_2017_Cell.Biochem.Funct_35_124 |
| PubMedID: 28256001 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Dipeptidyl peptidase 9 (DPP9) in human skin cells - Gabrilovac_2017_Immunobiology_222_327 |
| Author(s) : Gabrilovac J , Cupic B , Zapletal E , Kraus O , Jakic-Razumovic J |
| Ref : Immunobiology , 222 :327 , 2017 |
| Abstract : |
| PubMedSearch : Gabrilovac_2017_Immunobiology_222_327 |
| PubMedID: 27682012 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Dipeptidyl peptidase 9 substrates and their discovery: current progress and the application of mass spectrometry-based approaches - Wilson_2016_Biol.Chem_397_837 |
| Author(s) : Wilson CH , Zhang HE , Gorrell MD , Abbott CA |
| Ref : Biol Chem , 397 :837 , 2016 |
| Abstract : |
| PubMedSearch : Wilson_2016_Biol.Chem_397_837 |
| PubMedID: 27410463 |
| Gene_locus related to this paper: human-DPP9 |
| Title : The SUMO1-E67 Interacting Loop Peptide Is an Allosteric Inhibitor of the Dipeptidyl Peptidases 8 and 9 - Pilla_2013_J.Biol.Chem_288_32787 |
| Author(s) : Pilla E , Kilisch M , Lenz C , Urlaub H , Geiss-Friedlander R |
| Ref : Journal of Biological Chemistry , 288 :32787 , 2013 |
| Abstract : |
| PubMedSearch : Pilla_2013_J.Biol.Chem_288_32787 |
| PubMedID: 24072711 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : A Novel SUMO1-specific Interacting Motif in Dipeptidyl Peptidase 9 (DPP9) That Is Important for Enzymatic Regulation - Pilla_2012_J.Biol.Chem_287_44320 |
| Author(s) : Pilla E , Moller U , Sauer G , Mattiroli F , Melchior F , Geiss-Friedlander R |
| Ref : Journal of Biological Chemistry , 287 :44320 , 2012 |
| Abstract : |
| PubMedSearch : Pilla_2012_J.Biol.Chem_287_44320 |
| PubMedID: 23152501 |
| Gene_locus related to this paper: human-DPP9 |
| Title : A novel role of dipeptidyl peptidase 9 in epidermal growth factor signaling - Yao_2011_Mol.Cancer.Res_9_948 |
| Author(s) : Yao TW , Kim WS , Yu DM , Sharbeen G , McCaughan GW , Choi KY , Xia P , Gorrell MD |
| Ref : Mol Cancer Research , 9 :948 , 2011 |
| Abstract : |
| PubMedSearch : Yao_2011_Mol.Cancer.Res_9_948 |
| PubMedID: 21622624 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? - Van Goethem_2011_J.Med.Chem_54_5737 |
| Author(s) : Van Goethem S , Matheeussen V , Joossens J , Lambeir AM , Chen X , De Meester I , Haemers A , Augustyns K , Van der Veken P |
| Ref : Journal of Medicinal Chemistry , 54 :5737 , 2011 |
| Abstract : |
| PubMedSearch : Van Goethem_2011_J.Med.Chem_54_5737 |
| PubMedID: 21711053 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9 - Tang_2011_FEBS.Lett_585_3409 |
| Author(s) : Tang HK , Chen KC , Liou GG , Cheng SC , Chien CH , Tang HY , Huang LH , Chang HP , Chou CY , Chen X |
| Ref : FEBS Letters , 585 :3409 , 2011 |
| Abstract : |
| PubMedSearch : Tang_2011_FEBS.Lett_585_3409 |
| PubMedID: 22001206 |
| Gene_locus related to this paper: human-DPP4 , human-DPP9 |
| Title : The cytoplasmic peptidase DPP9 is rate-limiting for degradation of proline-containing peptides - Geiss-Friedlander_2009_J.Biol.Chem_284_27211 |
| Author(s) : Geiss-Friedlander R , Parmentier N , Moller U , Urlaub H , Van den Eynde BJ , Melchior F |
| Ref : Journal of Biological Chemistry , 284 :27211 , 2009 |
| Abstract : |
| PubMedSearch : Geiss-Friedlander_2009_J.Biol.Chem_284_27211 |
| PubMedID: 19667070 |
| Gene_locus related to this paper: human-DPP9 |
| Title : The in vivo expression of dipeptidyl peptidases 8 and 9 - Yu_2009_J.Histochem.Cytochem_57_1025 |
| Author(s) : Yu DM , Ajami K , Gall MG , Park J , Lee CS , Evans KA , McLaughlin EA , Pitman MR , Abbott CA , McCaughan GW , Gorrell MD |
| Ref : Journal of Histochemistry & Cytochemistry , 57 :1025 , 2009 |
| Abstract : |
| PubMedSearch : Yu_2009_J.Histochem.Cytochem_57_1025 |
| PubMedID: 19581630 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Biochemical properties and expression profile of human prolyl dipeptidase DPP9 - Tang_2009_Arch.Biochem.Biophys_485_120 |
| Author(s) : Tang HK , Tang HY , Hsu SC , Chu YR , Chien CH , Shu CH , Chen X |
| Ref : Archives of Biochemistry & Biophysics , 485 :120 , 2009 |
| Abstract : |
| PubMedSearch : Tang_2009_Arch.Biochem.Biophys_485_120 |
| PubMedID: 19268648 |
| Gene_locus related to this paper: human-DPP9 |
| Title : DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis - |
| Author(s) : Yu DM , Wang XM , Ajami K , McCaughan GW , Gorrell MD |
| Ref : Advances in Experimental Medicine & Biology , 575 :63 , 2006 |
| PubMedID: 16700509 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis - Yu_2006_FEBS.J_273_2447 |
| Author(s) : Yu DM , Wang XM , McCaughan GW , Gorrell MD |
| Ref : Febs J , 273 :2447 , 2006 |
| Abstract : |
| PubMedSearch : Yu_2006_FEBS.J_273_2447 |
| PubMedID: 16704418 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Dipeptidyl peptidases 8 and 9: specificity and molecular characterization compared with dipeptidyl peptidase IV - Bjelke_2006_Biochem.J_396_391 |
| Author(s) : Bjelke JR , Christensen J , Nielsen PF , Branner S , Kanstrup AB , Wagtmann N , Rasmussen HB |
| Ref : Biochemical Journal , 396 :391 , 2006 |
| Abstract : |
| PubMedSearch : Bjelke_2006_Biochem.J_396_391 |
| PubMedID: 16475979 |
| Gene_locus related to this paper: human-DPP9 |
| Title : Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases - Qi_2003_Biochem.J_373_179 |
| Author(s) : Qi SY , Riviere PJ , Trojnar J , Junien JL , Akinsanya KO |
| Ref : Biochemical Journal , 373 :179 , 2003 |
| Abstract : |
| PubMedSearch : Qi_2003_Biochem.J_373_179 |
| PubMedID: 12662155 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 , human-DPP10 , mouse-dpp9 , mouse-dpp10 |
| Title : Structural requirements for catalysis, expression, and dimerization in the CD26\/DPIV gene family - Ajami_2003_Biochemistry_42_694 |
| Author(s) : Ajami K , Abbott CA , Obradovic M , Gysbers V , Kahne T , McCaughan GW , Gorrell MD |
| Ref : Biochemistry , 42 :694 , 2003 |
| Abstract : |
| PubMedSearch : Ajami_2003_Biochemistry_42_694 |
| PubMedID: 12534281 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV - Olsen_2002_Gene_299_185 |
| Author(s) : Olsen C , Wagtmann N |
| Ref : Gene , 299 :185 , 2002 |
| Abstract : |
| PubMedSearch : Olsen_2002_Gene_299_185 |
| PubMedID: 12459266 |
| Gene_locus related to this paper: human-DPP9 |