Koster_2019_Front.Synaptic.Neurosci_11_25

Reference

Title : Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration - Koster_2019_Front.Synaptic.Neurosci_11_25
Author(s) : Koster KP , Yoshii A
Ref : Front Synaptic Neurosci , 11 :25 , 2019
Abstract : Protein palmitoylation is the post-translational, reversible addition of a 16-carbon fatty acid, palmitate, to proteins. Protein palmitoylation has recently garnered much attention, as it robustly modifies the localization and function of canonical signaling molecules and receptors. Protein depalmitoylation, on the other hand, is the process by which palmitic acid is removed from modified proteins and contributes, therefore, comparably to palmitoylated-protein dynamics. Palmitoylated proteins also require depalmitoylation prior to lysosomal degradation, demonstrating the significance of this process in protein sorting and turnover. Palmitoylation and depalmitoylation serve as particularly crucial regulators of protein function in neurons, where a specialized molecular architecture and cholesterol-rich membrane microdomains contribute to synaptic transmission. Three classes of depalmitoylating enzymes are currently recognized, the acyl protein thioesterases, alpha/beta hydrolase domain-containing 17 proteins (ABHD17s), and the palmitoyl-protein thioesterases (PPTs). However, a clear picture of depalmitoylation has not yet emerged, in part because the enzyme-substrate relationships and specific functions of depalmitoylation are only beginning to be uncovered. Further, despite the finding that loss-of-function mutations affecting palmitoyl-protein thioesterase 1 (PPT1) function cause a severe pediatric neurodegenerative disease, the role of PPT1 as a depalmitoylase has attracted relatively little attention. Understanding the role of depalmitoylation by PPT1 in neuronal function is a fertile area for ongoing basic science and translational research that may have broader therapeutic implications for neurodegeneration. Here, we will briefly introduce the rapidly growing field surrounding protein palmitoylation and depalmitoylation, then will focus on the role of PPT1 in development, health, and neurological disease.
ESTHER : Koster_2019_Front.Synaptic.Neurosci_11_25
PubMedSearch : Koster_2019_Front.Synaptic.Neurosci_11_25
PubMedID: 31555119
Gene_locus related to this paper: human-PPT1

Related information

Gene_locus related to this paper: human-PPT1

Citations formats

Koster KP, Yoshii A (2019)
Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration
Front Synaptic Neurosci 11 :25

Koster KP, Yoshii A (2019)
Front Synaptic Neurosci 11 :25