| Title : Synthesis of lipophilic aldehydes and study of their inhibition effect on human digestive lipases - Kotsovolou_2002_Org.Lett_4_2625 |
| Author(s) : Kotsovolou S , Verger R , Kokotos G |
| Ref : Org Lett , 4 :2625 , 2002 |
|
Abstract :
[reaction: see text] Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively. |
| PubMedSearch : Kotsovolou_2002_Org.Lett_4_2625 |
| PubMedID: 12153194 |
Kotsovolou S, Verger R, Kokotos G (2002)
Synthesis of lipophilic aldehydes and study of their inhibition effect on human digestive lipases
Org Lett
4 :2625
Kotsovolou S, Verger R, Kokotos G (2002)
Org Lett
4 :2625