Kozaki_2001_Insect.Biochem.Mol.Biol_31_991

Reference

Title : Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point mutations - Kozaki_2001_Insect.Biochem.Mol.Biol_31_991
Author(s) : Kozaki T , Shono T , Tomita T , Kono Y
Ref : Insect Biochemistry & Molecular Biology , 31 :991 , 2001
Abstract : The cDNA of AChE in the housefly, Musca domestica, was sequenced and individual flies were genotyped by this gene in an inhibition assay of AChE activity with an organophaspate, fenitroxon. Mutations at Gly(342) and Tyr(407), which are reportedly conserved in resistant strains of Drosophila, were associated with the insensitivity to fenitroxon. Two other mutations, Ile(162) and Val(260), did not have an apparent effect on insensitivity. However, the four mutations are located in the active site of the enzyme, and therefore the non-neutral mutations in this gene are considered to cause the insensitivity of AChE in the development of insecticide resistance of the housefly.
ESTHER : Kozaki_2001_Insect.Biochem.Mol.Biol_31_991
PubMedSearch : Kozaki_2001_Insect.Biochem.Mol.Biol_31_991
PubMedID: 11483435
Gene_locus related to this paper: musdo-ACHE

Related information

Gene_locus related to this paper: musdo-ACHE

Citations formats

Kozaki T, Shono T, Tomita T, Kono Y (2001)
Fenitroxon insensitive acetylcholinesterases of the housefly, Musca domestica associated with point mutations
Insect Biochemistry & Molecular Biology 31 :991

Kozaki T, Shono T, Tomita T, Kono Y (2001)
Insect Biochemistry & Molecular Biology 31 :991