| Title : S28 peptidases: lessons from a seemingly 'dysfunctional' family of two - Kozarich_2010_BMC.Biol_8_87 |
| Author(s) : Kozarich JW |
| Ref : BMC Biol , 8 :87 , 2010 |
|
Abstract :
A recent paper in BMC Structural Biology reports the crystal structure of human prolylcarboxypeptidase (PRCP), one of the two members of the S28 peptidase family. Comparison of the substrate-binding site of PRCP with that of its family partner, dipeptidyl dipeptidase 7 (DPP7), helps to explain the different enzymatic activities of these structurally similar proteins, and also reveals a novel apparent charge-relay system in PRCP involving the active-site catalytic histidine. See research article http:\/\/www.biomedcentral.com/1472-6807/10/16/ |
| PubMedSearch : Kozarich_2010_BMC.Biol_8_87 |
| PubMedID: 20598110 |
| Family | Prolylcarboxypeptidase |
Kozarich JW (2010)
S28 peptidases: lessons from a seemingly 'dysfunctional' family of two
BMC Biol
8 :87
Kozarich JW (2010)
BMC Biol
8 :87