Prolylcarboxypeptidase

Relationship

Family: Prolylcarboxypeptidase

Block: X

Parent Family: No family

Comment

S28 peptidases in MEROPS database. These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase. In human the S28 family of peptidases consists of three enzymes, PRCP, TSSP and DPP7. DPP7 is also called dipeptidyl peptidase 2 and quiescent cell proline dipeptidase. TSSP is thymus-specific serine protease. PRCP is a lysosomal, serine carboxypeptidase that cleaves hydrophobic C-terminal amino acids adjacent to proline. In contrast, DPP7 is a serine dipeptidyl aminopeptidase that cleaves N-terminal amino acids adjacent to proline and is localized to intracellular vesicles

Database

Interpro : IPR008758 Peptidase_S28 , IPR042269 Serine carboxypeptidase S28, SKS domain

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF05577 Peptidase_S28

Prints : No Print

EC Number : 3.4.16.2

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (7)

Genes Proteins in Prolylcarboxypeptidase family (493)

Fragments of genes in Prolylcarboxypeptidase family (52)

Structures in Prolylcarboxypeptidase family (7)

Substrates in Prolylcarboxypeptidase family (2)

Inhibitors in Prolylcarboxypeptidase family (8)

References (7)

Title : Structural and time-resolved mechanistic investigations of protein hydrolysis by the acidic proline-specific endoprotease from Aspergillus niger - Pijning_2023_Protein.Sci__e4856
Author(s) : Pijning T , Vujicic-zagar A , Laan JV , Jong RM , Ramirez-Palacios C , Vente A , Edens L , Dijkstra BW
Ref : Protein Science , :e4856 , 2023
PubMedID: 38059672
Gene_locus related to this paper: aspng-AnPEP

Title : The Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including Atherosclerosis - Waumans_2015_Front.Immunol_6_387
Author(s) : Waumans Y , Baerts L , Kehoe K , Lambeir AM , De Meester I
Ref : Front Immunol , 6 :387 , 2015
PubMedID: 26300881

Title : Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase - Soisson_2010_BMC.Struct.Biol_10_16
Author(s) : Soisson SM , Patel SB , Abeywickrema PD , Byrne NJ , Diehl RE , Hall DL , Ford RE , Reid JC , Rickert KW , Shipman JM , Sharma S , Lumb KJ
Ref : BMC Struct Biol , 10 :16 , 2010
PubMedID: 20540760
Gene_locus related to this paper: human-PRCP

Title : S28 peptidases: lessons from a seemingly 'dysfunctional' family of two - Kozarich_2010_BMC.Biol_8_87
Author(s) : Kozarich JW
Ref : BMC Biol , 8 :87 , 2010
PubMedID: 20598110

Title : Purification, molecular cloning, and immunohistochemical localization of dipeptidyl peptidase II from the rat kidney and its identity with quiescent cell proline dipeptidase - Araki_2001_J.Biochem_129_279
Author(s) : Araki H , Li Y , Yamamoto Y , Haneda M , Nishi K , Kikkawa R , Ohkubo I
Ref : J Biochem , 129 :279 , 2001
PubMedID: 11173530
Gene_locus related to this paper: ratno-dpp2

Title : Cloning and functional expression of rat kidney dipeptidyl peptidase II - Fukasawa_2001_Biochem.J_353_283
Author(s) : Fukasawa KM , Fukasawa K , Higaki K , Shiina N , Ohno M , Ito S , Otogoto J , Ota N
Ref : Biochemical Journal , 353 :283 , 2001
PubMedID: 11139392
Gene_locus related to this paper: ratno-dpp2

Title : Cloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymus - Bowlus_1999_Cell.Immunol_196_80
Author(s) : Bowlus CL , Ahn J , Chu T , Gruen JR
Ref : Cell Immunol , 196 :80 , 1999
PubMedID: 10527559
Gene_locus related to this paper: human-PRSS16