| Title : Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling - Kubo_1988_FEBS.Lett_241_119 |
| Author(s) : Kubo T , Bujo H , Akiba I , Nakai J , Mishina M , Numa S |
| Ref : FEBS Letters , 241 :119 , 1988 |
|
Abstract :
Chimaeric muscarinic acetylcholine receptors (mAChR) in which corresponding portions of mAChR I and mAChR II are replaced with each other have been produced in Xenopus oocytes by expression of cDNA constructs encoding them. Functional analysis of the chimaeric mAChRs indicates that a region mostly comprising the putative cytoplasmic portion between the proposed transmembrane segments V and VI is involved in selective coupling of mAChR I and mAChR II with different effector systems. In contrast, the exchange of this region between mAChR I and mAChR II does not significantly affect the antagonist binding properties of the two mAChR subtypes. |
| PubMedSearch : Kubo_1988_FEBS.Lett_241_119 |
| PubMedID: 3197827 |
Kubo T, Bujo H, Akiba I, Nakai J, Mishina M, Numa S (1988)
Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling
FEBS Letters
241 :119
Kubo T, Bujo H, Akiba I, Nakai J, Mishina M, Numa S (1988)
FEBS Letters
241 :119