| Title : In vitro reactivation of acetylcholinesterase using the oxime K027 - Kuca_2004_Vet.Hum.Toxicol_46_15 |
| Author(s) : Kuca K , Kassa J |
| Ref : Vet Hum Toxicol , 46 :15 , 2004 |
| Abstract : The ability of a new bisquaternary oxime, K027 (1-[4-hydroxyiminomethylpyridinium]-3-[carbamoylpyridinium] propane dibromide), to reactivate the enzyme acetylcholinesterase (AChE) inhibited by the nerve agents Tabun, sarin and VX was evaluated. Its reactivation potency was compared to the AChE reactivators pralidoxime (2-PAM), obidoxime and HI-6; K027 seems a good reactivator of organophosphates-inhibited AChE. Its reactivation potency is lower compared to the other oximes for reactivation of sarin-inhibited AChE, but it is sufficient to significantly increase the activity of sarin-inhibited AChE. Its reactivation ability is comparable to obidoxime for reactivation of VX- and tabun-inhibited AChE and is higher than the reactivation potency of HI-6, for tabun-inhibited AChE. HI-6 is currently regarded the most promising reactivator of organophosphates-inhibited AChE. |
| ESTHER : Kuca_2004_Vet.Hum.Toxicol_46_15 |
| PubMedSearch : Kuca_2004_Vet.Hum.Toxicol_46_15 |
| PubMedID: 14748409 |
Kuca K, Kassa J (2004)
In vitro reactivation of acetylcholinesterase using the oxime K027
Vet Hum Toxicol
46 :15
Kuca K, Kassa J (2004)
Vet Hum Toxicol
46 :15