| Title : An expedient synthesis and screening for antiacetylcholinesterase activity of piperidine embedded novel pentacyclic cage compounds - Kumar_2014_Med.Chem_10_228 |
| Author(s) : Kumar RS , Almansour AI , Arumugam N , Osman H , Ali MA , Basiri A , Kia Y |
| Ref : Med Chem , 10 :228 , 2014 |
|
Abstract :
The aim of this study was to synthesize and evaluate diazapentacyclic analogs for their acetylcholinesterase (AChE) inhibitory activity. The pentacyclic analogs were synthesized by one-pot three-component domino reactions in a microwave synthesizer. Most of the compounds exhibited moderate to good AChE inhibitory activity, compound 5i showed potent inhibitory activity with IC50 1.12+/-0.01 microM and this may provide a new lead for developing potential inhibitors for Alzheimer's disease. |
| PubMedSearch : Kumar_2014_Med.Chem_10_228 |
| PubMedID: 23627271 |
Kumar RS, Almansour AI, Arumugam N, Osman H, Ali MA, Basiri A, Kia Y (2014)
An expedient synthesis and screening for antiacetylcholinesterase activity of piperidine embedded novel pentacyclic cage compounds
Med Chem
10 :228
Kumar RS, Almansour AI, Arumugam N, Osman H, Ali MA, Basiri A, Kia Y (2014)
Med Chem
10 :228