| Title : Ionic liquid-enabled synthesis, cholinesterase inhibitory activity, and molecular docking study of highly functionalized tetrasubstituted pyrrolidines - Kumar_2018_Bioorg.Chem_77_263 |
| Author(s) : Kumar RS , Almansour AI , Arumugam N , Althomili DMQ , Altaf M , Basiri A , D K , Sai Manohar T , S V |
| Ref : Bioorg Chem , 77 :263 , 2018 |
|
Abstract :
A small library of novel spiropyrrolidine heterocyclic hybrids has been prepared regioselectively in 1-butyl-3-methylimidazoliumbromide ([bmim]Br) with good to excellent yields using a [3+2] cycloaddition reaction. These synthesized compounds were evaluated as potential agents for treating Alzheimer's disease. Compound 4b showed the most potent activity, with an IC50 of 7.9+/-0.25microM against acetylcholinesterase (AChE). The inhibition mechanisms for the most active compounds on AChE and butyrylcholinesterase (BChE) receptors were elucidated using molecular docking simulations. |
| PubMedSearch : Kumar_2018_Bioorg.Chem_77_263 |
| PubMedID: 29421701 |
Kumar RS, Almansour AI, Arumugam N, Althomili DMQ, Altaf M, Basiri A, D K, Sai Manohar T, S V (2018)
Ionic liquid-enabled synthesis, cholinesterase inhibitory activity, and molecular docking study of highly functionalized tetrasubstituted pyrrolidines
Bioorg Chem
77 :263
Kumar RS, Almansour AI, Arumugam N, Althomili DMQ, Altaf M, Basiri A, D K, Sai Manohar T, S V (2018)
Bioorg Chem
77 :263