Kumar_2021_Saudi.J.Biol.Sci_28_754

Two series of dimethoxyindanone imbedded novel fluorinated spiropyrrolidine heterocyclic hybrids were synthesized employing two different less explored azomethine ylides and were measured for their efficiency as inhibitors for Alzheimer's disease. Among the spiropyrrolidine heterocyclic hybrids, the indole based fluorinated compound with a methoxy substituent at the meta- position of the aryl ring exhibited the utmost potent AChE and BChE inhibitory activities with an IC(50) of 1.97 +/- 0.19 microM and 7.08 +/- 0.20 microM respectively. The plausible mechanism of inhibition on ChE receptors was unveiled via molecular docking studies.