| Title : Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations - Kurosaki_1987_FEBS.Lett_214_253 |
| Author(s) : Kurosaki T , Fukuda K , Konno T , Mori Y , Tanaka K , Mishina M , Numa S |
| Ref : FEBS Letters , 214 :253 , 1987 |
|
Abstract :
The four kinds of subunits of the Torpedo californica nicotinic acetylcholine receptor have been produced in various combinations by injecting Xenopus oocytes with the corresponding subunit-specific mRNAs synthesized by transcription in vitro of the cloned cDNAs. Functional analysis suggests that association of the alpha-subunit with either the gamma- or the delta-subunit is a prerequisite for generating the conformation necessary for agonist binding. The acetylcholine receptor devoid of either the beta-, gamma- or delta-subunit exhibits weak channel activity. |
| PubMedSearch : Kurosaki_1987_FEBS.Lett_214_253 |
| PubMedID: 2436944 |
Kurosaki T, Fukuda K, Konno T, Mori Y, Tanaka K, Mishina M, Numa S (1987)
Functional properties of nicotinic acetylcholine receptor subunits expressed in various combinations
FEBS Letters
214 :253
Kurosaki T, Fukuda K, Konno T, Mori Y, Tanaka K, Mishina M, Numa S (1987)
FEBS Letters
214 :253