| Title : New genotype-phenotype linkages for directed evolution of functional proteins - Leemhuis_2005_Curr.Opin.Struct.Biol_15_472 |
| Author(s) : Leemhuis H , Stein V , Griffiths AD , Hollfelder F |
| Ref : Current Opinion in Structural Biology , 15 :472 , 2005 |
|
Abstract :
The key practical consideration in directed evolution of functional biomolecules is the linkage of genotype and phenotype. In vitro selections offer the potential to select from libraries with up to 10(10)-10(14) members, with fewer constraints than current cell-based selections. New approaches such as mRNA display, ribosome display and in vitro compartmentalisation have complementary areas of application in selections for binding or catalysis. |
| PubMedSearch : Leemhuis_2005_Curr.Opin.Struct.Biol_15_472 |
| PubMedID: 16043338 |
Leemhuis H, Stein V, Griffiths AD, Hollfelder F (2005)
New genotype-phenotype linkages for directed evolution of functional proteins
Current Opinion in Structural Biology
15 :472
Leemhuis H, Stein V, Griffiths AD, Hollfelder F (2005)
Current Opinion in Structural Biology
15 :472