| Title : Oxidative Neutralisation of Sulfur-based Chemical Warfare Agents Mediated by a Lipase: from Batch to Flow Reactor - Legros_2025_Chemistry__e202403701 |
| Author(s) : Legros J , Boddaert M , Baptista da Silva V , Mansour S , Vuluga D , Renard PY , Monbaliu JC |
| Ref : Chemistry , :e202403701 , 2025 |
|
Abstract :
The sulfur-containing chemical warfare agents sulfur mustard HD and nerve agent VX are highly toxic and persistent in the environment. Therefore, their neutralisation requires harsh oxidation conditions, but also precise selectivity. Here we report the safe and effective detoxification of surrogates CEES and PhX by selective oxidation of the sulfur atom by generating peracetic acid from AcOEt and aq. H2O2 assisted by the supported lipase CALB. Morever, it is possible to perform these neutralisations with safe 'on demand' generation of AcOOH in a flow system by using a packed bed reactor containing the supported biocatalyst. |
| PubMedSearch : Legros_2025_Chemistry__e202403701 |
| PubMedID: 39757127 |
| Gene_locus related to this paper: canar-LipB |
| Inhibitor | PhX |
| Substrate | Half-mustard-gas |
| Gene_locus | canar-LipB |
Legros J, Boddaert M, Baptista da Silva V, Mansour S, Vuluga D, Renard PY, Monbaliu JC (2025)
Oxidative Neutralisation of Sulfur-based Chemical Warfare Agents Mediated by a Lipase: from Batch to Flow Reactor
Chemistry
:e202403701
Legros J, Boddaert M, Baptista da Silva V, Mansour S, Vuluga D, Renard PY, Monbaliu JC (2025)
Chemistry
:e202403701