Title : Progress and challenges in the study of alpha6-containing nicotinic acetylcholine receptors - Letchworth_2011_Biochem.Pharmacol_82(8)_862 |
Author(s) : Letchworth SR , Whiteaker P |
Ref : Biochemical Pharmacology , 82 :862 , 2011 |
Abstract :
Recent progress has been made in the understanding of the anatomical distribution, composition, and physiological role of nicotinic acetylcholine receptors containing the alpha6 subunit. Extensive study by many researchers has indicated that a collection of alpha6-containing receptors representing a nicotinic sub-family is relevant in preclinical models of nicotine self-administration and locomotor activity. Due to a number of technical difficulties, the state of the art of in vitro model systems expressing alpha6-containing receptors has lagged behind the state of knowledge of native alpha6 nAChR subunit composition. Several techniques, such as the expression of chimeric and concatameric alpha6 subunit constructs in oocytes and mammalian cell lines have been employed to overcome these obstacles. There remains a need for other critical tools, such as selective small molecules and radioligands, to advance the field of research and to allow the discovery and development of potential therapeutics targeting alpha6-containing receptors for smoking cessation, Parkinson's disease and other disorders. |
PubMedSearch : Letchworth_2011_Biochem.Pharmacol_82(8)_862 |
PubMedID: 21736871 |
Letchworth SR, Whiteaker P (2011)
Progress and challenges in the study of alpha6-containing nicotinic acetylcholine receptors
Biochemical Pharmacology
82 :862
Letchworth SR, Whiteaker P (2011)
Biochemical Pharmacology
82 :862