Li_2015_Chem.Biol.Drug.Des_86_776

Reference

Title : Inhibition of Acetylcholinesterase (AChE): A Potential Therapeutic Target to Treat Alzheimer's Disease - Li_2015_Chem.Biol.Drug.Des_86_776
Author(s) : Li Y , Zhang XX , Jiang LJ , Yuan L , Cao TT , Li X , Dong L , Yin SF
Ref : Chemical Biology Drug Des , 86 :776 , 2015
Abstract :

A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. Most of the tested compounds exhibited high AChE inhibition and low toxicity, and among which compounds 1, 2, and 10 were the most potent (IC50 = 71.52 +/- 22.43, 8.28 +/- 1.45, 5.830 +/- 1.78 nm, respectively).

PubMedSearch : Li_2015_Chem.Biol.Drug.Des_86_776
PubMedID: 25736722

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Citations formats

Li Y, Zhang XX, Jiang LJ, Yuan L, Cao TT, Li X, Dong L, Yin SF (2015)
Inhibition of Acetylcholinesterase (AChE): A Potential Therapeutic Target to Treat Alzheimer's Disease
Chemical Biology Drug Des 86 :776

Li Y, Zhang XX, Jiang LJ, Yuan L, Cao TT, Li X, Dong L, Yin SF (2015)
Chemical Biology Drug Des 86 :776