Title : Artificial Nanometalloenzymes for Cooperative Tandem Catalysis - Li_2019_ACS.Appl.Mater.Interfaces_11_15718 |
Author(s) : Li H , Qiu C , Cao X , Lu Y , Li G , He X , Lu Q , Chen K , Ouyang P , Tan W |
Ref : ACS Appl Mater Interfaces , 11 :15718 , 2019 |
Abstract :
Artificial metalloenzymes that combine the advantages of natural enzymes and metal catalysts have been getting more attention in research. As a proof of concept, an artificial nanometalloenzyme (CALB-Shvo@MiMBN) was prepared by co-encapsulation of metallo-organic catalyst and enzyme in a soft nanocomposite consisting of 2-methylimidazole, metal ions, and biosurfactant in mild reaction conditions using a one-pot self-assembly method. The artificial nanometalloenzyme with lipase acted as the core, and the metallo-organic catalyst embedded in micropore exhibited a spherical structure of 30-50 nm in diameter. The artificial nanometalloenzyme showed high catalytic efficiency in the dynamic kinetic resolution of racemic primary amines or secondary alcohols compared to the one-pot catalytic reaction of immobilized lipase and free metallo-organic catalyst. This artificial nanometalloenzyme holds great promise for integrated enzymatic and heterogeneous catalysis. |
PubMedSearch : Li_2019_ACS.Appl.Mater.Interfaces_11_15718 |
PubMedID: 30986032 |
Li H, Qiu C, Cao X, Lu Y, Li G, He X, Lu Q, Chen K, Ouyang P, Tan W (2019)
Artificial Nanometalloenzymes for Cooperative Tandem Catalysis
ACS Appl Mater Interfaces
11 :15718
Li H, Qiu C, Cao X, Lu Y, Li G, He X, Lu Q, Chen K, Ouyang P, Tan W (2019)
ACS Appl Mater Interfaces
11 :15718